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4. Lorraine Bateman

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Biography

Lecturer in Pharmaceutical Chemistry

Dr Lorraine Bateman obtained her degree in Chemistry & Applied Chemistry from NUI, Galway where she also studied for her PhD, graduating in 2006.  Her doctoral research was conducted in the area of chiral diamide ligand synthesis and asymmetric catalysis under the supervision of Dr. Simon W. Breeden and Dr. Patrick O’Leary.  She subsequently worked as an industrial research chemist in the area of chiral phosphine ligand synthesis with Celtic Catalysts Ltd.  She joined University College Cork as a NMR Spectroscopist at the Analytical and Biological Research Facility at University College Cork.  In 2014, Lorraine was awarded an SFI Advance Award to pursue independent research in the area of Quantitative NMR Spectroscopy. In 2017, she was appointed as Lecturer in Pharmaceutical Chemistry. ‍

Research Interests

Nuclear Magnetic Resonance Spectroscopy encompassing the following areas of application:

• Small Molecule Characterisation
• Quantitative NMR
• Molecular Structure and Stereochemistry Determination
• Conformational Analysis
• Pharmaceutical/Biological/Food Science Applications
• Multidimensional & Multinuclear Techniques
• Reaction Monitoring
• Reaction Kinetics
• Dynamic Processes
• Metabolomics/Metabonomics

Research Grants

	Project	Funding Body	Start Date	End Date	Award
	ENSNARE Expanding NMR Spectroscopy as a key technique in pharmaceutical process chemistry through New Advancements across Research and Enterprise	Science Foundation Ireland

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Publications

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Peer Reviewed Journals

	Year	Publication
	(2020)	'Competition between N and O: use of diazineN-oxides as a test case for the Marcus theory rationale for ambident reactivity' Sheehy, KJ;Bateman, LM;Flosbach, NT;Breugst, M;Byrne, PA (2020) 'Competition between N and O: use of diazineN-oxides as a test case for the Marcus theory rationale for ambident reactivity'. Chemical Science, 11 :9630-9647 [DOI] [Details]
	(2020)	'Identification of N- or O-Alkylation of Aromatic Nitrogen Heterocycles and N-Oxides Using 1H–15N HMBC NMR Spectroscopy' Sheehy K.J.;Bateman L.M.;Flosbach N.T.;Breugst M.;Byrne P.A. (2020) 'Identification of N- or O-Alkylation of Aromatic Nitrogen Heterocycles and N-Oxides Using 1H–15N HMBC NMR Spectroscopy'. European Journal of Organic Chemistry, [DOI] [Details]
	(2020)	'One-Pot Cross-Coupling/C-H Functionalization Reactions: Quinoline as a Substrate and Ligand through N-Pd Interaction' Shanahan RM;Hickey A;Bateman LM;Light ME;McGlacken GP; (2020) 'One-Pot Cross-Coupling/C-H Functionalization Reactions: Quinoline as a Substrate and Ligand through N-Pd Interaction'. Journal of Organic Chemistry, [DOI] [Details]
	(2020)	'A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy' Biagia Musio; Rosa Ragone; Stefano Todisco; Antonino Rizzuti; Mario Latronico; Piero Mastrorilli; Stefania Pontrelli; Nicola Intini; Pasquale Scapicchio; Maurizio Triggiani; Tommaso Di Noia; Domenico Acquotti; Cristina Airoldi; Michael Assfalg; Alessandro Barge; Lorraine Bateman; Francesca Benevelli; Davide Bertelli; Fabio Bertocchi; Aurimas Bieliauskas; Anna Borioni; Augusta Caligiani; Emanuela Callone; Ales Čamra; Flaminia Cesare Marincola; Dinesh Chalasani; Roberto Consonni; Paolo Dambruoso; Silvia Davalli; Taylor David; Bernd Diehl; James Donarski; Ana M. Gil; Roberto Gobetto; Luca Goldoni; Erwann Hamon; John S. Harwood; Andrea Kobrlová; Francesco Longobardi; Renzo Luisi; Domenico Mallamace; Stefano Mammi; Magali Martin-Biran; Pierluigi Mazzei; Andrea Mele; Salvatore Milone; Dolores Molero Vilchez; Roger J. Mulder; Claudia Napoli; Daniele Ragno; Antonio Randazzo; Maria Cecilia Rossi; Archimede Rotondo; Algirdas Šačkus; Elena Sáez Barajas; Elisabetta Schievano; Bhavaraju Sitaram; Livio Stevanato; Panteleimon G. Takis; Jan Teipel; Freddy Thomas; Elisabetta Torregiani; Daniela Valensin; Marina Veronesi; John Warren; Julien Wist; Elina Zailer; Cristiano Zuccaccia; Vito Gallo (2020) 'A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy'. Talanta, [DOI] [Details]
	(2019)	'Mechanistic Study of In Situ Generation and Use of Methanesulfonyl Azide as a Diazo Transfer Reagent with Real-Time Monitoring by FlowNMR' Lynch, D;O'Mahony, RM;McCarthy, DG;Bateman, LM;Collins, SG;Maguire, AR (2019) 'Mechanistic Study of In Situ Generation and Use of Methanesulfonyl Azide as a Diazo Transfer Reagent with Real-Time Monitoring by FlowNMR'. European Journal of Organic Chemistry, :3575-3580 [DOI] [Full Text] [Details]
	(2018)	'Integration of high and low field 1H NMR to analyse the effects of bovine dietary regime on milk metabolomics and protein-bound moisture characterisation of the resulting mozzarella cheeses during ripening' Boiani, Mattia; Sundekilde, Ulrik; Bateman, Lorraine M.; McCarthy, Daniel G.; Maguire, Anita R.; Gulati, Arunima; Guinee, Timothy P.; Fenelon, Mark; Hennessy, Deirdre; FitzGerald, Richard J.; Kelly, Phil M. (2018) 'Integration of high and low field 1H NMR to analyse the effects of bovine dietary regime on milk metabolomics and protein-bound moisture characterisation of the resulting mozzarella cheeses during ripening'. International Dairy Journal,   [DOI] [Full Text] [Details]
	(2017)	'Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives' Muimhneachain, EO;Pardo, LM;Bateman, LM;Khandavilli, UBR;Lawrence, SE;McGlacken, GP (2017) 'Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives'. Advanced Synthesis and Catalysis, 359 :1529-1534 [DOI] [Details]
	(2016)	'Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C-H Activation' Mackey K;Pardo LM;Prendergast AM;Nolan MT;Bateman LM;McGlacken GP; (2016) 'Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C-H Activation'. Organic letters, 18 (11) [DOI] [Details]
	(2015)	'A study of the norcaradiene–cycloheptatriene equilibrium in a series of azulenones by NMR spectroscopy; the impact of substitution on the position of equilibrium' Bateman, L. M.; McNamara, O. A.; Buckley, N. R.; O'Leary, P.; Harrington, F.; Kelly, N.; O'Keeffe, S.; Stack, A.; O'Neill, S.; McCarthy, D. G.; Maguire, A. R. (2015) 'A study of the norcaradiene–cycloheptatriene equilibrium in a series of azulenones by NMR spectroscopy; the impact of substitution on the position of equilibrium'. Organic and Biomolecular Chemistry, 13 :11026-11038 [DOI] [Details]
	(2012)	'Investigating the influence of the sulfur oxidation state on solid state' Daly, Carla A.; Eccles, Kevin S.; Bateman, Lorraine M.; O'Boyle, Noel M.; Lawrence, Simon E.; Maguire, Anita R. (2012) 'Investigating the influence of the sulfur oxidation state on solid state'. CrystEngComm, 14 (23):7848-7850   [Full Text] [Details]
	(2011)	'Selective beta-oxidation of alpha-sulfanyl amides' Kissane, Marie and Murphy, Maureen and Bateman, Lorraine M. and McCarthy, Daniel G. and Maguire, Anita R. (2011) 'Selective beta-oxidation of alpha-sulfanyl amides'. Tetrahedron, 67 (30):5494-5499 [DOI] [Full Text] [Details]
	(2008)	'Recent advances in aryl–aryl bond formation by direct arylation' Gerard P. McGlacken and Lorraine M. Bateman (2008) 'Recent advances in aryl–aryl bond formation by direct arylation'. Chemical Society Reviews, 38 :2447-2464 [DOI] [Details]
	(2008)	'New chiral diamide ligands: synthesis and application in allylic alkylation' Lorraine Bateman, Simon W. Breeden†, Patrick O’Leary (2008) 'New chiral diamide ligands: synthesis and application in allylic alkylation'. Tetrahedron: Asymmetry, 19 (3):391-396 [DOI] [Details]

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Conference Publications

	Year	Publication
	(2015)	SMASH NMR Bateman, L. M., McNamara, O. A., Buckley, N. R., O'Leary, P., Harrington, F., Kelly, N., O'Keeffe, S., Stack, A., O'Neill, S., McCarthy, D. G. & Maguire, A. R. (2015) The norcaradiene-cycloheptatriene equilibrium in a series of azulenones by NMR spectroscopy; the impact of substitution on the position of equilibrium . In: SMASH NMR 2015 committee eds. SMASH NMR Baveno, Italy, [Details]
	(2013)	Conference on Analytical Sciences, Ireland (CASi) Lorraine Bateman (2013) Development and Potential of Quantitative NMR Spectroscopy Conference on Analytical Sciences, Ireland (CASi) University College Cork, [Details]
	(2010)	239th ACS National Meeting Gilheany, Declan G.; Bergin, Enda; Cumming, Graham R.; Dunne, Katherine S.; Granander, Johan; Kaik, Magdalena; Bateman, Lorraine; Kelly, Brian G.; King, Gary; Larichev, Vladimir (2010) Asymmetric catalytic hydrogenation using a library of DiPAMP analogs: Ligand tuning leads to dramatic improvements in selectivity and turnover 239th ACS National Meeting San Francisco, [Details]
	(2010)	239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 Gilheany, Declan G.; Bergin, Enda; Cumming, Graham R.; Dunne, Katherine S.; Granander, Johan; Kaik, Magdalena; Bateman, Lorraine; Kelly, Brian G.; King, Gary; Larichev, Vladimir; et a (2010) Asymmetric catalytic hydrogenation using a library of DiPAMP analogs: Ligand tuning leads to dramatic improvements in selectivity and turnover 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 [Details]
	(2007)	15th European Symposium on Organic Chemistry Gilheany, Declan G.; Bergin, Enda; Cumming, Graham R.; Dunne, Katherine S.; Granander, Johan; Kaik, Magdalena; Bateman, Lorraine; Kelly, Brian G.; King, Gary; Larichev, Vladimir (2007) Asymmetric hydrogenation using novel DiPAMP analogues 15th European Symposium on Organic Chemistry [Details]

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Professional Activities

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Conference Contributions

	Year	Publication
	(2016)	NMR Discussion Group Spring Meeting: In Situ Monitoring by NMR: what is it all about? RSC NMR Discussion Group, Bateman, L. M. (2016) Reaction monitoring by NMR discussion. [Visiting Critic], NMR Discussion Group Spring Meeting: In Situ Monitoring by NMR: what is it all about? RSC NMR Discussion Group, University of York . [Details]

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Teaching Activities

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Teaching Interests

Lecturer on:

• PF2011  (Research Methods and Applied Data Analysis)
• PF2012  (Pharmaceutical Analysis)
• PF3016  (Pharmacognosy and Phytopharmaceuticals)
• PF4014  (Central Nervous System)
• PF4016  (Pharmacy Research Dissertation)
• PF4021  (Drug Design, Emerging Drugs and Mechanism of Action)
• CM4022  (Advanced Organic Synthesis, Biosynthesis and Reactivity)
• CM4103  (Heterocycles, Biosynthesis and Asymmetric Synthesis)
• CM4108  (Advanced Pharmaceutical Chemistry)
• CM4203  (Research Project: Chemistry of Pharmaceutical Compounds)
• PF6419  (Research Dissertation in Pharmacy)
• PF6200 (Pharmaceutical Chemistry)
• PF6420  (Oncology and Malignant Diseases: Drug Design, Advanced Therapies and Clinical Management)
• CM6101 / 7002 / 7003 / 7006 (Organic and Pharmaceutical Chemistry Postgraduate Research Seminars)

Module Co-ordinator:

• CM7007 (Research Standard Spectroscopic Methods for Organic and Pharmaceutical Chemistry Research : Molecular Structure Determination, Compound Characterisation and Analysis)

Teaching interests:

• Nuclear Magnetic Resonance (NMR) Spectroscopy; Spectroscopy
• Structural Analysis; Conformational Analysis
• Equilibrating systems
• Quantitative NMR (qNMR)
• Organic Synthesis; Asymmetric Synthesis
• Analytical Chemistry; In situ reaction monitoring
• Organic and Pharmaceutical Chemistry
• Antiviral Agents
• Biosynthesis of Natural Products