College Lecturer
Anatomy & Neuroscience
Room 4.07
Department of Anatomy and Neuroscience
Western Gateway Building
University College Cork

T: +353 21 420 5477
F: +353 21 420 5471
E: a.toulouse@ucc.ie

André Toulouse received a BSc degree in Biology from Université Laval (Québec, Canada) in 1991. He developed his expertise in the cellular and molecular biology of diseases by completing a MSc (1993) and a PhD (1998) in Molecular Biology at Université de Montréal (Montréal, Canada). His interest in Neuroscience led him to undertake post-doctoral work with Dr Guy Rouleau in the Centre for Research in Neuroscience at McGill University (Montréal, Canada) where he also worked as a research associate in the Neurogenetics Laboratory. His research areas included the identification and cloning of genes involved in neurodevelopmental disorders and the development of cellular models of neurodegeneration. In 2003, he moved to University College Cork to pursue post-doctoral work on the molecular biology of neurotrophic factors in the laboratory of Dr Aideen Sullivan in the Biosciences Institute.

 

Dr Toulouse was appointed as College Lecturer in Clinical Anatomy and Principal Investigator in the Department of Anatomy and Neuroscience in September 2005. He is currently involved in teaching systematic anatomy, human development and molecular neuroscience to students in medicine, dentistry, biological sciences, clinical therapies and neuroscience. In 2008, he was awarded a post-graduate certificate in Teaching and Learning in Higher Education (UCC) followed by a post-graduate diploma in the same discipline in 2009.

 

His research is focused on the development of cellular models for the study of the molecular mechanisms of neuroprotection and neurodegenereation, with a particular emphasis on Parkinson’s disease and the polyglutamine disorders. His work has been funded through personal fellowships from the Fonds pour la formation des chercheurs et l'aide à la recherche and the Fonds de la recherche en santé du Québec as well as research grants from the Health Research Board of Ireland and the Irish Research Council for Science, Engineering and Technology.

Research Interests

Development of cellular models for the study of neurodegeneration and neuroprotection
The exact nature of cell death mechanisms remains unclear for a large proportion of neurological disorders. Despite the identification of causative genes and chemical agents, the reason why certain neurons are more sensitive to insult than others remains elusive. In addition, despite intensive research efforts, symptomatic treatments often have limited efficiency and cannot prevent further degeneration and progression of the disease. Neuroprotective strategies are being developed, which combined with symptomatic treatment could improve the disease outcomes for patients.  
Using cell culture models, we replicate important steps in the neurodegenerative process, manipulate them, using drugs and neurotrophic factors, and aim to identify the genes that are responsible for neuronal cell death or that could be used to prevent this process.  

Mechanisms of neurodegeneration in CAG trinucleotide repeat expansion disorders
The polyglutamine disorders are a group of neurodegenerative disorders caused by the expansion of a coding CAG trinucleotide repeat and include some of the autosomal dominant spinocerebellar ataxias and Huntington’s disease. Although the causative proteins are widely expressed, these disorders are characterized by the degeneration of specific neuronal populations. Several hypotheses have been proposed to explain degeneration, including transcriptional impairment, altered protein interactions, direct polyglutamine toxicity and accumulation of toxic protein by-products following the alteration of the protein degradation pathways but no unifying mechanism has emerged yet. 

We have identified a new mechanism of cell toxicity in these disorders where aberrant decoding through ribosomal frameshifting results in the production of highly toxic polyalanine-containing peptides. Recent studies suggest that this mechanism may be involved in many disorders and may be caused by RNA secondary structures, depletion of specific amino acids and the cell’s metabolic rate. Our current studies aim at refining these findings and to further study the mechanism by which the ribosome changes its translational frame. We are developing a cellular model that will allow us to manipulate the translational shifting and explore how cell toxicity can be modulated.


Lab Alumni
Post-Doctoral Fellow

Dr David O'Sullivan (2005-2006, co-supervised with Dr Aideen Sullivan)
Embryonic stem cells for Parkinson's disease

Ph.D. Students

Grace Collins (2007-2012, co-supervised with Dr Aideen Sullivan)
Generation of suicide-gene system for cell replacement therapy

Louise Collins (2008-2013, co-supervised with Dr Yvonne Nolan)
The role of mitogen activated protein kinase phosphatase-1 in neurotoxic and inflammatory-induced changes in the development of midbrain dopaminergic neurons: Relevance to Parkinson's disease

M.Sc. Students

Emma McDonnell (2005-2006,  co-supervised with Dr Aideen Sullivan)
Sub-cloning and expression analysis of the Ki-67 promoter

Lorna Farrelly (2009-2010,  co-supervised with Dr Deniz Yilmazer-Hanke)
In vitro / in vivo modulation of the neuropeptide Y (NPY) system by antiepileptic and antidepressive drugs

Ian O'Brien (2010-2012,  co-supervised with Dr Yvonne Nolan)
Transcription factor regulation of dopaminergic neural stem cell fate in an inflammatory environment

B.Sc. Internships

Perrine Chapotot (2009, Ecole Polytechnique Lasalle, Beauvais, France)
Ian O'Brien (2009)
Amandine Even (2014, Universite de Nantes, Nantes, France)

Undergraduate students

2005/2006: Niamh Daly, Raymond O’Sullivan
2006/2007: John Williams, Hazel O’Shea, Aoife Kiely
2007/2008: Aoife Healy, Nicole Scully, Michael Lynch
2008/2009: David Andrew, Sean Crampton, Rhona Hyland
2009/2010: Ian O’Brien, Peter Bourke, Piaras O’Murchu
2010/2011: Conor Murphy, Katherine Turner
2011/2012: Darren Coughlan, Cian Dolan
2012/2013: Amy Cole, Laura Kenny
2013/2014: Rachel Furlong, Eimear O’Leary
2014/2015: Jessica Brophy, Patrick Hennessy

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Embryonic Stem Cells for Parkinson's DiseaseHealth Research Board01-OCT-0530-SEP-10€202,568.00
Embryonic Stem Cells for Parkinson's DiseaseHealth Research Board01-OCT-06€32,667.00
Embryonic Stem Cells for Parkinson's DiseaseHealth Research Board08-JUN-0931-JUL-09€2,000.00
Transcription factor regulation of dopaminergic neural stem cell fate in an inflammatory environmentIrish Research Council01-OCT-1030-JUN-12€72,000.00
Investigation of Morphological and Functional Aspects of Syncytiotrophoblast Nuclear Organization Patterns in the Human Placenta.01-JUN-1330-JUN-14€6,000.00

Book Chapters

YearPublication
(2012)'Inflammation in Parkinson's disease: causes and consequences'
Collins L.M., Toulouse A., Nolan Y.M. (2012) 'Inflammation in Parkinson's disease: causes and consequences' In: Mechanisms in Parkinson's Disease - Models and Treatments. Croatia: InTech. Globe icon [Full Text] [Details]
(2011)'The potential of Neurotrophic Factors for the Treatment of Parkinson's Disease'
Sullivan A.M., Toulouse A. (2011) 'The potential of Neurotrophic Factors for the Treatment of Parkinson's Disease' In: Towards New Therapies for Parkinson's Disease. Croatia: InTech. Globe icon [Full Text] [Details]
(1997)'Retinoic Acid Receptor beta: An Exploration of its Role in Lung Cancer Suppression and its Potential in Cancer Prevention'
Toulouse A., Morin J., Ying Y., Ayoub J., Bradley W.E.C. (1997) 'Retinoic Acid Receptor beta: An Exploration of its Role in Lung Cancer Suppression and its Potential in Cancer Prevention' In: Clinical and Biological Basis of Lung Cancer Prevention. Basel, Switzerland: Birkhäuser-Verlag. [Details]

Peer Reviewed Journals

YearPublication
(2014)'Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease'
Collins, L.M., Downer, E.J., Toulouse, A., Nolan, Y.M. (2014) 'Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease'. Molecular Neurobiology, Globe icon [DOI] [Details]
(2014)'Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson’s disease'
Collins L. M., Gavin A.M., Walsh S., Sullivan A.M., Wyatt S.L., O’Keeffe G.W., Nolan Y.M, Toulouse A. (2014) 'Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson’s disease'. SpringerPlus, 3 (1):205-206 Globe icon [DOI] [Full Text] [Details]
(2013)'Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide Y (NPY) expression in the human SH-SY5Y neuroblastoma cell line'
Farelly L.A., Savage N.T.P., O'Callaghan C., Toulouse A., Yilmazer-Hanke D.M. (2013) 'Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide Y (NPY) expression in the human SH-SY5Y neuroblastoma cell line'. Regulatory Peptides, 186 :123-130 Globe icon [DOI] [Details]
(2013)'Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 as a Neuroprotective Agent: Promotion of the Morphological Development of Midbrain Dopaminergic Neurons'
Collins L.M., O'Keeffe G.W., Long-Smith C.M., Wyatt S.L., Sullivan A.M., Toulouse A., Nolan Y.M. (2013) 'Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 as a Neuroprotective Agent: Promotion of the Morphological Development of Midbrain Dopaminergic Neurons'. NeuroMolecular Medicine, 15 (2):435-446 Globe icon [DOI] [Details]
(2013)'The bisulfite genomic sequencing protocol'
Pappas J.J., Toulouse A., Bradley W.E.C. (2013) 'The bisulfite genomic sequencing protocol'. Advances in Lung Cancer, 1 (2):21-25 Globe icon [DOI] [Details]
(2013)'Parkinson's Disease in the Nuclear Age of Neuroinflammation'
Nolan Y.M., Sullivan A.M., Toulouse A. (2013) 'Parkinson's Disease in the Nuclear Age of Neuroinflammation'. Trends In Molecular Medicine, 19 :187-196 [DOI] [Details]
(2012)'Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease'
Collins L.M., Toulouse A., Connor T.J., Nolan Y.M. (2012) 'Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease'. Neuropharmacology, 62 (7):2154-2168 [DOI] [Full Text] [Details]
(2012)'Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?'
Crampton S.J., Collins L.M., Toulouse A., Nolan Y.M., O'Keeffe G.W. (2012) 'Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?'. Journal of Neurochemistry, 120 (6):964-973 [DOI] [Details]
(2012)'Neurotrophic Effects of Growth / Differentiation Factor 5 in a Neuronal Cell Line'
Toulouse A., Collins G.C., Sullivan A.M. (2012) 'Neurotrophic Effects of Growth / Differentiation Factor 5 in a Neuronal Cell Line'. Neurotoxicity Research, 21 (3):256-265 [DOI] [Full Text] [Details]
(2011)'Neurotrophic factors for the treatment of Parkinson's disease'
Sullivan A.M., Toulouse A. (2011) 'Neurotrophic factors for the treatment of Parkinson's disease'. Cytokine & Growth Factor Reviews, 22 (3):157-165 [DOI] [Full Text] [Details]
(2011)'Knockdown of RARB2 Identifies a Dual Role in Cancer'
Pappas J.J., Toulouse A., Basik M., Lévesque L., Bradley W.E.C. (2011) 'Knockdown of RARB2 Identifies a Dual Role in Cancer'. Genes Chromosomes and Cancer, 50 :700-714 [DOI] [Details]
(2010)'Interleukin-1beta released from lipopolysaccharide-stimulated rat glia contributes to the exacerbation of dopaminergic neuronal death induced by 6-hydroxydopamine'
Long-Smith C.M., Collins L.M., Toulouse A., Sullivan A.M., Nolan Y.M. (2010) 'Interleukin-1beta released from lipopolysaccharide-stimulated rat glia contributes to the exacerbation of dopaminergic neuronal death induced by 6-hydroxydopamine'. Journal of Neuroimmunology, 226 :20-26 [DOI] [Details]
(2009)'A Modified Protocol for Bisulfite Genomic Sequencing of Difficult Samples'
Pappas J.J., Toulouse A., Bradley W.E.C. (2009) 'A Modified Protocol for Bisulfite Genomic Sequencing of Difficult Samples'. Biological Procedures Online, 11 :99-112 Globe icon [DOI] [Details]
(2008)'Allelic methylation bias of the RARB2 tumor suppressor gene promoter in cancer'
Pappas J.J.,Toulouse A., Hebert J., Fetni R., Bradley W.E.C. (2008) 'Allelic methylation bias of the RARB2 tumor suppressor gene promoter in cancer'. Genes Chromosomes and Cancer, 47 :978-993 [DOI] [Details]
(2008)'TAT-PAX6 protein transduction in neural progenitor cells: a novel approach for generation of dopaminergic neurones in vitro'
Spitere K., Toulouse A., O'Sullivan D.B., Sullivan A.M. (2008) 'TAT-PAX6 protein transduction in neural progenitor cells: a novel approach for generation of dopaminergic neurones in vitro'. Brain Research, 1208 :25-34 [DOI] [Details]
(2008)'Progress in Parkinson's disease-where do we stand?'
Toulouse A., Sullivan A.M. (2008) 'Progress in Parkinson's disease-where do we stand?'. Progress In Neurobiology, 85 (4):376-392 [DOI] [Details]
(2008)'Mutations in the nervous system-specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II'
Shekarabi M,. Girard N., Riviere J.B., Dion P., Houle M,. Toulouse A., Lafreniere R.G., Vercauteren F., Hince P., Laganiere J., Rochefort D., Faivre L., Samuels M., Rouleau G.A. (2008) 'Mutations in the nervous system-specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II'. Journal of Clinical Investigation, 118 (7):2496-2505 [DOI] [Details]
(2005)'Transgenic expression of an expanded (GCG)(13) repeat PABPN1 leads to weakness and coordination defects in mice. Neurobiology of Disease'
Dion P., Shanmugam V., Gaspar C., Messaed C., Meijer I., Toulouse A., Laganiere J., Roussel J., Rochefort D., Laganiere S., Allen C., Karpati G., Bouchard J.P. , Brais B., Rouleau, G.A. (2005) 'Transgenic expression of an expanded (GCG)(13) repeat PABPN1 leads to weakness and coordination defects in mice. Neurobiology of Disease'. Neurobiology of Disease, 18 (3):528-536 Globe icon [Details]
(2005)'Ribosomal frameshifting on MJD-1 transcripts with long CAG tracts'
Toulouse A., Au-Yeung F., Gaspar C., Roussel J., Dion, P., Rouleau, G. A. (2005) 'Ribosomal frameshifting on MJD-1 transcripts with long CAG tracts'. Human Molecular Genetics, 14 (18):2649-2660 [DOI] [Details]
(2003)'Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia'
Toulouse A., Rochefort D., Roussel J., Joober R., Rouleau G.A. (2003) 'Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia'. Genomics, 82 (2):162-171 [Details]
(2000)'DRD3 and DAT1 genes in schizophrenia: an association study'
Joober R.,Toulouse A., Benkelfat C., Lafreniere R. G., Lal S., Ajroud S., Turecki G., Bloom D., Labelle A., Lalonde P., Alda M., Morgan K., Palmour R., Rouleau G.A. (2000) 'DRD3 and DAT1 genes in schizophrenia: an association study'. Journal of Psychiatric Research, 34 :285-291 [Details]
(2000)'Enhancement of lung tumour cell immunogenicity upon transduction of retinoic acid receptor beta'
Toulouse A., Loubeau M., Morin J., Pappas J.J., Wu J., Bradley W.E.C. (2000) 'Enhancement of lung tumour cell immunogenicity upon transduction of retinoic acid receptor beta'. Faseb Journal, 14 (9):1224-1232 [Details]
(2000)'RAR beta 2 specificity in mediating RA inhibition of growth of lung cancer-derived cells'
Toulouse A., Morin J., Dion P.A., Houle B., Bradley W.E.C. (2000) 'RAR beta 2 specificity in mediating RA inhibition of growth of lung cancer-derived cells'. Lung Cancer, 28 (2):127-137 Globe icon [Details]
(1999)'T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability. J Psychiatry Neurosci'
Joober R. Benkelfat C., Brisebois K., Toulouse A., Turecki G., Lal S., Bloom D., Labelle A., Lalonde P., Fortin D., Alda M., Palmour R., Rouleau G.A.; (1999) 'T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability. J Psychiatry Neurosci'. J Psychiatry Neurosci, 24 (2):141-146 [Details]
(1999)'Analysis of 14 CAG repeat-containing genes in schizophrenia'
Joober R., Benkelfat C., Toulouse A., Lafreniere R.G., Lal S., Ajroud S., Turecki G., Bloom D., Labelle A., Lalonde P., Alda M., Morgan K., Palmour R., Rouleau G.A (1999) 'Analysis of 14 CAG repeat-containing genes in schizophrenia'. American Journal of Medical Genetics, 88 (6):694-699 [Details]
(1999)'Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophrenia'
Joober R., Benkelfat C., Brisebois K., Toulouse A., Lafreniere R.G., Turecki G., Lal S., Bloom D., Labelle A., Lalonde P., Fortin D., Alda M., Palmour R., Rouleau G.A. (1999) 'Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophrenia'. American Journal of Medical Genetics, 88 (2):154-157 [Details]
(1996)'Structure of the human retinoic acid receptor beta 1 gene'
Toulouse A., Morin J., Pelletier M., Bradley W. E. C. (1996) 'Structure of the human retinoic acid receptor beta 1 gene'. Biochem Biophys Acta, 1309 :1-4 [Details]
(1992)'Dissociation of the antimicrobial activity of bacitracin USP from its renovascular effects'
Drapeau G., Petitclerc E., Toulouse A., Marceau, F. (1992) 'Dissociation of the antimicrobial activity of bacitracin USP from its renovascular effects'. Antimicrobial Agents and Chemotherapy, 36 (5):955-961 [Details]

Other Journals

YearPublication
(2002)'Advances in Research on Neurodegeneration. - Book Review'
Toulouse A., Rouleau G.A.; (2002) 'Advances in Research on Neurodegeneration. - Book Review' Canadian Journal of Neurological Sciences, 29 (4) . [Details]

Conference Publications

YearPublication
(2014)New Horizons in Medical Research
Fives C., McCarthy J., Kenny L., Toulouse A., FitzGerald B. (2014) Fine Needle Aspiration Cytology - A Novel Tool for Investigating Placental Structural Organization New Horizons in Medical Research University College Cork, , 11-DEC-14 [Details]
(2014)60th Pediatric Pathology Society Annual Meeting
Fives C., McCarthy J., Kenny L., Toulouse A., FitzGerald B. (2014) Fine Needle Aspiration - A Novel Tool for Investigating Placental Structural Organization 60th Pediatric Pathology Society Annual Meeting Birmingham, UK, , 04-SEP-14 - 06-SEP-14 [Details]
(2014)NECTAR 2014
Nolan Y.M., O'Brien I.S., Toulouse A. (2014) TNFα inhibits survival of midbrain neural precursor cells: an antiinflammatory NECTAR 2014 Galway, Ireland, , 27-NOV-14 - 28-NOV-14 [Details]
(2014)38th European Cytology Conference
Fives C., McCarthy J., Kenny L., Toulouse A., FitzGerald B. (2014) Placental Cytology- A Description of Features and Comparison of Preparations 38th European Cytology Conference Geneva, Switzerland, , 27-SEP-14 - 30-SEP-14 [Details]
(2013)8th Neuroscience Ireland Annual Conference
Collins L.M., O'Keeffe G.W., Gavin A.M., Wyatt S.L., Sullivan A.M., Toulouse A., Nolan Y.M. (2013) Expression of endogenous Mkp-1 in the adult rat nigrostriatal system following a unilateral 6-hydroxydopamine striatal and medial forebrain lesion 8th Neuroscience Ireland Annual Conference University College Cork, Ireland, , 12-SEP-13 - 13-SEP-13 [Details]
(2012)7th Neuroscience Ireland Annual Conference
Collins L.M., O'Keeffe G.W., Long-Smith C.M., Sullivan A.M., Toulouse A., Nolan Y.M. (2012) Mitogen-activated protein kinase phosphatase (Mkp)-1 promotes the morphological development of midbrain dopaminergic neurons 7th Neuroscience Ireland Annual Conference Royal College of Surgeons Ireland, , 05-SEP-12 - 06-SEP-12 [Details]
(2011)41st Annual Meeting of the Society for Neuroscience
Collins L.M., Toulouse A., Nolan Y.M. (2011) Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression in 6-hydroxydopamine-treated embryonic rat mesencephalic neural precursor cells 41st Annual Meeting of the Society for Neuroscience Washington DC, , 12-NOV-11 - 16-NOV-11 [Details]
(2011)8th IBRO World Congress of Neuroscience
Collins L.M., Toulouse A., Nolan Y.M. (2011) Effect of 6-hydroxydopamine on MKP-1 expression in differentiated embryonic rat ventral mesencephalic neural precursor cells 8th IBRO World Congress of Neuroscience Florence, Italy, , 14-JUL-11 - 18-JUL-11 [Details]
(2011)8th IBRO World Congress of Neuroscience
O'Brien I.S., Sullivan A.M., Nolan Y.M., Toulouse A. (2011) Expression of the 2F7 epitope in the rat embryo, and adult brain 8th IBRO World Congress of Neuroscience Florence, Italy, , 14-JUL-11 - 18-JUL-11 [Details]
(2011)6th Neuroscience Ireland Annual Conference
Collins L.M., Toulouse A., Nolan Y.M. (2011) 6-hydroxydopamine affects MKP-1 expression in differentiated embryonic rat ventral mesencephalic neural precursor cells 6th Neuroscience Ireland Annual Conference National University of Ireland Maynooth, , 01-SEP-11 - 02-SEP-11 [Details]
(2010)5th Neuroscience Ireland Annual Conference
Collins L. M., Toulouse A., Nolan Y. M. (2010) Effect of Interleukin-1b and 6-Hydroxydopamine on MKP-1 Expression in Embryonic Rat Ventral Mesencephalic Precursor Cells 5th Neuroscience Ireland Annual Conference University College Dublin, , 02-SEP-10 - 03-SEP-10 [DOI] [Details]
(2010)5th Neuroscience Ireland Annual Conference
Farrelly L. A., Toulouse A., Yilmazer-Hanke D. (2010) Effect of Amitriptyline and Sodium Valproate on Neuropeptide Y Expression in the SH-SY5Y cell line 5th Neuroscience Ireland Annual Conference University College Dublin, , 02-SEP-10 - 03-SEP-10 [DOI] [Details]
(2009)Translational Health Conference, UCC
Collins L., Long C., Sullivan A., Toulouse A., Nolan Y. (2009) The effect of pharmacological and endogenous p38 inhibition on 6-hydroxydopamine-treated rat ventral mesencephalic neurons in vitro Translational Health Conference, UCC [Details]
(2009)International Conference on Alzheimer's and Parkinson's Diseases
Toulouse A., Collins G.C., Sullivan, A.M. (2009) The neurotrophic effects of Growth/Differentiation Factor 5 in a neuronal cell line International Conference on Alzheimer's and Parkinson's Diseases Prague, Czech Republic, , 11-MAR-09 - 15-MAR-09 [Details]
(2006)Microsat 2006 - 2nd International Tandem Repeat Consortium Workshop
Toulouse A., Au-Yeung F., Gaspar C., Roussel J., Dion P. A., Rouleau G.A. (2006) Ribosomal frameshifting in long CAG trinucleotide repeats in neurological disorders Microsat 2006 - 2nd International Tandem Repeat Consortium Workshop Budapest, Hungary, , 08-SEP-06 - 11-SEP-06 [Details]
(2006)Mechanisms Underlying Emerging Themes in Neurobiology
Toulouse A., Gaspar C., Au-Yeung F., Roussel J., Dion P., Rouleau G.A. (2006) Polyglutamine disorders - Slipping to disease Mechanisms Underlying Emerging Themes in Neurobiology Cork, Ireland, , 06-JUN-06 - 07-JUN-06 [Details]
(2005)Albany 2005: Conversation 14
Rouleau G.A., Toulouse A., Au-Yeung F., Gaspar C., Roussel J., Dion P. A. (2005) Role of Translational Slippage of Long CAG Tracts in Neurological Disorders Albany 2005: Conversation 14 Albany NY, USA, , 14-JUN-05 - 18-JUN-05 [Details]
(2005)35th Annual Meeting of the Society for Neuroscience
Spitere K., Toulouse A.,Sullivan, A.M. (2005) TAT-PAX6 protein transduction in neural progenitor cells: A novel strategy for dopaminergic neuron generation 35th Annual Meeting of the Society for Neuroscience Wahington DC, USA, , 12-NOV-05 - 16-NOV-05 [Details]
(2005)16th International Congress on Parkinson's Disease and Related Disorders
Toulouse A., Sullivan A.M. (2005) Investigation of the neurotrophic effects of growth/differentiation factor 5 in an in vitro model of Parkinson's disease 16th International Congress on Parkinson's Disease and Related Disorders Berlin, Germany, , 05-JUN-05 - 09-JUN-05 [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting
Toulouse A., Sullivan, A.M. (2004) Investigation of the effects of the neurotrophin GDF5 on the growth and differentiation of SHSY-5Y cells Anatomical Society of Great Britain and Ireland Summer Meeting Cork, Ireland, , 06-JUL-04 - 08-JUL-04 [Details]
(2004)34th Annual Meeting of the Society for Neuroscience
O'Keeffe G.W., Toulouse A., Sullivan A.M. (2004) Dopaminergic induction from expanded rat ventral mesencephalic progenitor cells by GDF5 and BMP2 requires signalling through BMPR1b 34th Annual Meeting of the Society for Neuroscience San Diego CA, USA, , 23-OCT-04 - 27-OCT-04 [Details]
(2004)34th Annual Meeting of the Society for Neuroscience
Toulouse A., Sullivan, A.M. (2004) Roles of type 1 BMP receptors in the induction of midbrain dopaminergic neurones by GDF5 34th Annual Meeting of the Society for Neuroscience San Diego CA, USA, , 23-OCT-04 - 27-OCT-04 [Details]
(2004)4th Forum of European Neuroscience
Toulouse A., Sullivan A.M. (2004) Investigation of the role of GDF5 in the growth and differentiation of human neuroblastoma cells 4th Forum of European Neuroscience Lisbon, Portugal, , 10-JUL-04 - 14-JUL-04 [Details]
(2003)Canadian Genetic Diseases Network Annual Scientific Meeting
Toulouse A., Au-Yeung F., Gaspar C., Roussel J., Rouleau G.A. (2003) Translational slippage in long CAG tracts, a potential pathological mechanism in neurological disorders Canadian Genetic Diseases Network Annual Scientific Meeting Kananaskis AB, Canada, , 15-MAY-03 - 18-MAY-03 [Details]
(2002)34th European Human Genetics Conference
Toulouse A., Gaspar C., Rochefort D., Roussel J., Rouleau G.A. (2002) Polyalanine accumulation and toxicity in a CAG tract disorder, Machado-Joseph Disease 34th European Human Genetics Conference Strasbourg, France, , 25-MAY-02 - 28-MAY-02 [Details]
(2002)Canadian Genetic Diseases Network Annual Scientific Meeting
Gros-Louis F., Toulouse A., Rochefort D., Roussel J., Lachapelle K., Tremblay M., Nagy A., Rouleau G.A. (2002) Development of transgenic mice expressing mutant SOD1 in a cell and tissue specific manner Canadian Genetic Diseases Network Annual Scientific Meeting St-Sauveur, Qc, Canada, , 04-APR-02 - 07-APR-02 [Details]
(2000)American Epilepsy Society, 54th Annual Meeting
Brisebois K., Cossette P., Hand C.K., Toulouse A., Andermann E., Berkovic S.F., Andermann F., Faught E., Kuzniecky, R.I., Donaldsen J.O., Leonberg S.C., Rouleau G.A. (2000) Adult Neuronal Ceroid Lipofucinosis with autosomal dominant transmission (Kuf's disease):suggestion of linkage at the CLN2 locus American Epilepsy Society, 54th Annual Meeting Los Angeles, USA, , 01-DEC-00 - 06-DEC-00 [Details]
(2000)8th World Congress on Psychiatric Genetics
Joober R., Toulouse A., Benkelfat C., Lal S., Bloom D., Labelle A., Lalonde P., Turecki G., Rozen R., Rouleau G.A. (2000) DRD3 and DAT1 genes in schizophrenia: a pharmacogenetic association study 8th World Congress on Psychiatric Genetics Versailles, France, , 27-AUG-00 - 31-AUG-00 [Details]
(1998)3rd Canadian Gene Therapy Conference
Toulouse A., Loubeau M., Morin J., Wu J., Bradley W.E.C. (1998) Enhancement of lung tumour immunogenicity upon transduction of retinoic acid receptor beta 3rd Canadian Gene Therapy Conference Montreal, Canada, , 26-JUN-98 - 28-JUN-98 [Details]
(1996)IASLC Workshop on The Biological Basis of Lung Cancer Prevention
Toulouse A., Morin J., Bradley W.E.C. (1996) Overexpression of hRARA1 or hRARB1 in NSCLC cell line CALU-1 does not inhibit its tumorigenic properties IASLC Workshop on The Biological Basis of Lung Cancer Prevention Nancy, France, , 20-OCT-96 - 22-OCT-96 [Details]
(1995)XXIIème Forum des Jeunes Chercheurs. Société Française de Biochimie et de Biologie Moléculaire
Toulouse A., Morin J., Pelletier M., Houle B., Bradley W.E.C. (1995) Clonage et caractérisation du gène humain codant le récepteur B1 de l'acide rétinoïque XXIIème Forum des Jeunes Chercheurs. Société Française de Biochimie et de Biologie Moléculaire Grenoble, France, , 04-JUL-95 - 07-JUL-95 [Details]
(1994)44th annual meeting of the American Society of Human Genetics
Toulouse A., Morin J., Pelletier M., Bradley W.E.C. (1994) Involvement of the RARB1 and Dlk genes in small cell lung carcinogenesis and in human development 44th annual meeting of the American Society of Human Genetics Montreal, Canada, , 18-OCT-94 - 22-OCT-94 [Details]
(1994)XXXVIème réunion annuelle du Club de Recherches Cliniques du Québec
Toulouse A., Morin J., Pelletier M., Bradley W.E.C. (1994) Implication potentielle des gènes RARB1 et Dlk dans l'embryogénèse et la tumorigénèse humaines XXXVIème réunion annuelle du Club de Recherches Cliniques du Québec [Details]
(1990)XXXIIème réunion annuelle du Club de Recherches Cliniques du Québec
Marceau F., Deblois D., Toulouse A., Bouthillier J. (1990) La Bacitracine U.S.P., un agent antibiotique, est un agent vasoconstricteur agoniste des récepteurs de type 5-HT2 de la 5-Hydroxytryptamine XXXIIème réunion annuelle du Club de Recherches Cliniques du Québec [Details]
(1990)13th Scientific Meeting of the International Society for Hypertension
Deblois D., Toulouse A., Bouthillier J., Marceau F. (1990) Bacitracin U.S.P. behaves as an agonist of the 5-HT2 type receptors for 5-Hydroxytryptamine (5-HT) in rabbit isolated smooth muscle and in perfused rat and rabbit kidneys 13th Scientific Meeting of the International Society for Hypertension [Details]

Honours and Awards

 YearTitleAwarding Body
1992Scholarship of Excellence from Fonds pour la Formation des Chercheurs et l'Aide à la Recherche Fonds pour la Formation des Chercheurs et l'Aide à la Recherche, FCAR
1993Scholarship of Excellence from the Faculty of Graduate Studies of Université de Montréal Université de Montréal
1994Canderel Doctoral Scholarship from the Montreal Cancer Institute Montreal Cancer Institute
1995Canderel Doctoral Scholarship from the Montreal Cancer Institute Montreal Cancer Institute
1996Canderel Doctoral Scholarship from the Montreal Cancer Institute Montreal Cancer Institute
1999Postdoctoral Research Fellowship Fonds de Recherche en Santé du Québec, FRSQ
2000Postdoctoral Research Fellowship Fonds de Recherche en Santé du Québec, FRSQ
2005Best Poster Presentation Award of the 16th International Congress on Parkinson's Disease and Related Disorders. 16th International Congress on Parkinson's Disease and Related Disorders.

Professional Associations

 AssociationFunctionFrom / To
Anatomical Society Member/
European Federation of Biotechnology Member/
Neuroscience Ireland Member/

Committees

 CommitteeFunctionFrom / To
School of Clinical Therapies Curriculum Committee Module coordinator2005 /
School of Medicine Library Committee Committee member2005 /
Department of Anatomy and Neuroscience Graduate Studies Committee Committee member2005 /
School of Medicine Quality Review Committee Committee member2013 / 2014
Department of Anatomy and Neuroscience Research Committee Chair2011 / 2014
School of Clinical Therapies Student Affairs Committee Committee member2006 /
B.Sc. Neuroscience Curriculum Committee Committee member2005 /
Neuroscience Ireland Board member2014 /
School of Medicine Curriculum Committee Departmental representative2014 /
Dental School Curriculum Committee Departmental representative2006 /
Department of Anatomy and Neuroscience Curriculum Committee Chair2014 /

Employment

 EmployerPositionFrom / To
University College Cork College Lecturer in Anatomy01-SEP-05 /
Dr Aideen Sullivan, University College Cork Post-Doctoral Fellow01-AUG-03 / 31-AUG-05
Dr Guy Rouleau, McGill University Research Associate01-JAN-02 / 30-JUN-03
Dr Guy Rouleau, McGill University Post-Doctoral Fellow14-OCT-97 / 31-DEC-01

Education

 YearInstitutionQualificationSubject
1991Université Laval, Canada B.Sc.Biology
1993Université de Montréal, Canada M.Sc.Molecular Biology
1998Université de Montréal, Canada Ph.D.Molecular Biology
2008University College Cork, Ireland Postgraduate Certificate in Teaching and Learning in Higher Ed.Teaching and Learning in Higher Education
2009University College Cork, Ireland Postgraduate Diploma Teaching & Learning in Higher EducationTeaching and Learning in Higher Education

Languages

 LanguageReadingWritingSpeaking
English FluentFluentFluent
French FluentFluentFluent

Outreach Activities

 Description

Adjudicator and Advisor for the Debating Science Issues School Competition.



Organiser of the art exhibition "1514-2014 - The Legacy of Andreas Vesalius - The art of anatomy in education" presented at the Jennings Gallery in University College Cork from the 21st October to 1st December 2014.

Organiser of the symposium "1514-2014 - The Legacy of Andreas Vesalius - Challenging Medical Education", held in University College Cork on the 21st October 2014 to mark the 500th anniversary of the famous anatomist.

Journal Activities

 JournalRoleTo / From
Journal Of Pharmacy And Pharmacology Referee-
Brain Research Referee-
Food And Chemical Toxicology Referee-
Neural Regeneration Research Referee01-SEP-11 -
The Scientific World Journal Member of Editorial Board01-MAR-12 -
Journal Of Neuroscience Research Referee-
Journal Of Biological Chemistry Referee-

Other Activities

 Description

2009, Examiner - Postgraduate committee, Department of Physiology, University College Cork

2010, 2011, Internal MSc examiner, University College Cork

2013 - External PhD examiner - Università degli Studi di Siena

2006, 2007, 2009, 2012, 2013, Internal PhD examiner, University College Cork

Teaching Interests

Module Teaching
Over the years, I have taught a wide variety of subjects (systematic and topographical anatomy, embryology and developmental anatomy, molecular biology, genetics, molecular and cellular neuroscience, research methods, neuroanatomy) to students from various disciplines (dental hygiene, dentistry, medicine, nursing, clinical therapies, sport studies and education, pharmacy, biological sciences and neuroscience). In addition to coordinating, teaching and examining a large number of modules, I currently contribute to teaching and examination on the following modules: AN1004, AN3001, AN3011, AN3013, AN4010, AN4013, AN4014, FM1010, FM1020, FM1030, FM1040 and FM2102.
 
Undergraduate research projects
I have surpervised a large number of undergraduate research projects and litterature reviews from a variety of disciplines including the B.Sc. Neuroscience litterature review (AN3011) and research projects (AN4010), B.Sc. Genetics litterature review (GN3002) and research projects (GN4002), as well as medical degree research projects (MX1006 and MX5090).

Post-graduate teaching
At post-graduate level, I contribute teaching to the M.Sc in Molecular Cell Biology with Bioinnovation and the M.Sc in Obstetrics and Gynaecology.                      

Modules Taught

 Term (ID))TitleLinkSubject
2015Advanced Anatomical Skills AN3000Advanced Anatomical Skills
2015Neuroanatomy & Embryology for Dental Students AN2006Neuroanatomy & Embryology for Dental Students
2015Neuroanatomy and Embryology for Speech and Language Therapy AN2061Neuroanatomy and Embryology for Speech and Language Therapy
2015Developmental Neuro-anatomy for Occupational Therapy AN2060Developmental Neuro-anatomy for Occupational Therapy
2015Principles of Human Structure for Dentistry AN1005Principles of Human Structure for Dentistry
2015Human Embryology and Developmental Anatomy AN2062Human Embryology and Developmental Anatomy
2015Human Embryology and Developmental Anatomy AN3009Human Embryology and Developmental Anatomy
2015Principles of Human Structure AN2003Principles of Human Structure
2015The Anatomical Basis of Dental Hygiene AN1004The Anatomical Basis of Dental Hygiene
2015Biology for Public Health EH1008Biology for Public Health

Internal Collaborators

 NameInstituteCountry
Dr Yvonne Nolan University College CorkIRELAND
Dr Aideen Sullivan University College CorkIRELAND
Dr Brendan FitzGerald Cork University HospitalIRELAND

External Collaborators

 NameOrganisation/ InstitutionCountry
Dr Guy Rouleau Montreal Neurological InstituteCANADA