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4. Frank Van Pelt

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Biography

Frank van Pelt received a BSc in Chemistry and MSc in Biochemistry with Toxicology from the University of Nijmegen, the Netherlands. This was followed by a PhD project at the Research Institute of Toxicology, University of Utrecht in collaboration with RCC Notox,`s-Hertogenbosch, the Netherlands investigating the use of  cultured human keratinocytes for toxicological screenings methods and was awarded a PhD in Toxicology from the University of Utrecht, the Netherlands in 1991. Subsequently he held a Wellcome Trust Research Fellowship at the Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, London, UK for two years where he investigated the mechanisms halothane-induced liver disease. He then spend one year as a research scientist at the Academic Department of Anaesthetics, St. Mary's Hospital Medical School, London UK investigating the formation of a toxic degradation product of sevoflurane in closed and low-flow anaesthetic systems. This was followed by an Alexander von Humboldt Fellowship at the Department of Gastroenterology and Hepatology, Medical School Hannover, Germany where his research involved the investigation of the mechanisms underlying anticonvulsant induced hepatitis. In October 1995, he joined Department of Pharmacology and Therapeutics, University College Cork as a lecturer in Toxicology/ Biochemical Pharmacology and he was promoted to senior lecturer in October 2004.

Dr. van Pelt is a Registered Toxicologist in Ireland and an Eurotox Registered Toxicologist. He was Vice-president of the Irish Society of Toxicology 2005-2007 and President of the Irish Society of Toxicology 2007-2009

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Research Interests

                                              Research Interests

My research spans various aspects of toxicology with an emphasis of the biochemical and immunological mechanisms underlying adverse drug reaction, biomarkers  and mechanisms  of toxicity cause by chemicals and environmental pollutants.Most research projects are interdisciplinary, collaborative project with other departments in UCC and other institutions.Ecotoxicological and growth-promoting properties of wood ashToxicology and exotoxicology of biotoxins (algal toxins)Biochemical and immunological mechanisms adverse drug reactionsImmuno-modulation by environmental pollutantsInvestigation of the toxicity caused combinatory exposure to solventsIdentification and validation of biomarkers for environmental exposure in terrestrial and aquatic organisms for risk assessment purposes

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Publications

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Book Chapters

	Year	Publication
	(2014)	'Anatoxin: Chemistry, Effects, Source, Metabolism, and Detection Chapter 37' Dauphard, J., Lehane, M., van Pelt, F., O’Halloran, J. and Furey (2014) 'Anatoxin: Chemistry, Effects, Source, Metabolism, and Detection Chapter 37' In: Luis M. Botana (eds). Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection 3rd Edition. . FL, USA: Taylor & Francis, . [Details]
	(2007)	'Acute and Chronic Liver Diseases Induced by Drugs or Xenobiotics' F. N. A. M van Pelt,., J. B. Carey and M. A. Carey ; (2007) 'Acute and Chronic Liver Diseases Induced by Drugs or Xenobiotics' In: Liver Immunology, Principles and Practice. Totowa, New Jersey: Humana Press. [Details]
	(2005)	'Development and Application of Sediment Toxicity Tests for Regulatory Purposes' M.G.J. Hartl, F.N.A.M van Pelt, J O¿Halloran; (2005) 'Development and Application of Sediment Toxicity Tests for Regulatory Purposes' In: The Encyclopedia of Water. US: John Wiley & Sons. [Details]
	(2002)	'Drug-Induced Immune Mediated Liver Disease' F.N.A.M. van Pelt, P. and MP Manns; (2002) 'Drug-Induced Immune Mediated Liver Disease' In: Liver Immunology. Philadelphia: Hanley&Belfus Inc. [Details]
	(2000)	'Arzneimittelinduzierte Leberschäden (Drug-induced liver injury)' F.N.A.M. van Pelt, P. Obermayer and MP Manns. ; (2000) 'Arzneimittelinduzierte Leberschäden (Drug-induced liver injury)' In: Klinische Gastroenterologie und Stoffwechsel. Heidelberg: Springer Verlag. [Details]
	(1990)	'Chemical-induced terminal differentiation of cultured human keratinocytes as measured by cell size distribution' F.N.A.M. van Pelt, M. Stelling, I. Hasssing, R. van der Heijden and BJ Blaauboer ; (1990) 'Chemical-induced terminal differentiation of cultured human keratinocytes as measured by cell size distribution' In: NATO ASI series, `Skin Pharmacology and Toxicology: Recent Advances. New York: Plenum Press. [Details]

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Peer Reviewed Journals

	Year	Publication
	(2014)	'Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?' McCarthy, M. O'Halloran, J. O'Brien, N. M. van Pelt, F. N. (2014) 'Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?'. Marine Environmental Research, 101 :153-160 [Details]
	(2014)	'Application of passive (SPATT) and active sampling methods in the profiling and monitoring of marine biotoxins' McCarthy, M. van Pelt, F. N. A. M. Bane, V. O'Halloran, J. Furey, A. (2014) 'Application of passive (SPATT) and active sampling methods in the profiling and monitoring of marine biotoxins'. Toxicon, 89 :77-86 [Details]
	(2012)	'Elucidation of the mass fragmentation pathways of the polyether marine toxins, dinophysistoxins, and identification of isomer discrimination processes' Carey, B.,Fidalgo Saez, M. J.,Hamilton, B.,O'Halloran, J.,van Pelt, F. N.,James, K. J. (2012) 'Elucidation of the mass fragmentation pathways of the polyether marine toxins, dinophysistoxins, and identification of isomer discrimination processes'. Rapid Commun Mass Spectrom, 26 (1616):1793-8021793 [Details]
	(2011)	'Mussels Increase Xenobiotic (Azaspiracid) Toxicity Using a Unique Bioconversion Mechanism' O'Driscoll, D.,Skrabakova, Z.,O'Halloran, J.,van Pelt, F. N.,James, K. J.; (2011) 'Mussels Increase Xenobiotic (Azaspiracid) Toxicity Using a Unique Bioconversion Mechanism'. Environmental Science and Technology, 45 :3102-3108   [Details]
	(2011)	'Alumina nanoparticles enhance growth of Lemna minor' Guillaume Juhel, Emeline Batisse, Quitterie Hugues, Deirdre Daly, Frank N.A.M. van Pelt, John O¿Halloran, and Marcel A.K. Jansen; (2011) 'Alumina nanoparticles enhance growth of Lemna minor'. Aquatic Toxicology, [Details]
	(2010)	'Shellfish toxicity: human health implications of marine algal toxins' James, K. J.,Carey, B.,O'Halloran, J.,van Pelt, F. N.,Skrabakova, Z.; (2010) 'Shellfish toxicity: human health implications of marine algal toxins'. Epidemiology And Infection, 138 (77):927-40927   [Details]
	(2010)	'Food contaminant analysis at ultra-high mass resolution: application of hybrid linear ion trap - orbitrap mass spectrometry for the determination of the polyether toxins, azaspiracids, in shellfish' Skrabakova, Z.,O'Halloran, J.,van Pelt, F. N.,James, K. J.; (2010) 'Food contaminant analysis at ultra-high mass resolution: application of hybrid linear ion trap - orbitrap mass spectrometry for the determination of the polyether toxins, azaspiracids, in shellfish'. Rapid Commun Mass Spectrom, 24 (2020):2966-742966   [Details]
	(2009)	'Effects of contaminated sediment from CorkHarbour,Ireland on the cytochromeP450system of turbot' M. Kilemade , M.G.J.Hartl , J.O¿Halloran , N.M.O¿Brien , D.Sheehan , C. Mothersill , F.N.A.M.van Pelt ; (2009) 'Effects of contaminated sediment from CorkHarbour,Ireland on the cytochromeP450system of turbot'. Ecotoxicology and Environmental Safety, 72 (3):747-755 [Details]
	(2009)	'The effects of salinity on the Manila clam (Ruditapes philippinarum) using the neutral red retention assay with adapted physiological saline solutions' Coughlan, B. M.,Moroney, G. A.,van Pelt, F. N.,O'Brien, N. M.,Davenport, J.,O'Halloran, J.; (2009) 'The effects of salinity on the Manila clam (Ruditapes philippinarum) using the neutral red retention assay with adapted physiological saline solutions'. Marine Pollution Bulletin, 58 (1111):1680-41680   [Details]
	(2008)	'In vitro exposure of jurkat T-cells to industrially important organic solvents in binary combination: interaction analysis' McDermott, C., A. Allshire, F. van Pelt and J. J. Heffron ; (2008) 'In vitro exposure of jurkat T-cells to industrially important organic solvents in binary combination: interaction analysis'. Toxicological Sciences, 101 (2):263-274 [Details]
	(2007)	'Hepatic biomarkers of sediment-associated pollution in juvenile turbot, Scophthalmus maximus L' Hartl, M. G., M. Kilemade, D. Sheehan, C. Mothersill, J. O'Halloran, N. M. O'Brien and F. N. van Pelt ; (2007) 'Hepatic biomarkers of sediment-associated pollution in juvenile turbot, Scophthalmus maximus L'. Marine Environmental Research, 64 (2):191-208 [Details]
	(2007)	'Validation of a method for acute and subchronic exposure of cells in vitro to volatile organic solvents' McDermott, C., A. Allshire, F. N. van Pelt and J. J. Heffron ; (2007) 'Validation of a method for acute and subchronic exposure of cells in vitro to volatile organic solvents'. Toxicology In Vitro, 21 (1):116-124 [Details]
	(2007)	'Sub-chronic toxicity of low concentrations of industrial volatile organic pollutants in vitro' McDermott, C., A. Allshire, F. N. van Pelt and J. J. Heffron ; (2007) 'Sub-chronic toxicity of low concentrations of industrial volatile organic pollutants in vitro'. Toxicology and Applied Pharmacology, 219 (1):85-94 [Details]
	(2006)	'Immune-modulation by cadmium and lead in the acute RA-PLNA' J. B. Carey, A. Allshire and F. N. van Pelt ; (2006) 'Immune-modulation by cadmium and lead in the acute RA-PLNA'. Toxicological Sciences, 91 (1):113-122 [Details]
	(2006)	'A two-species biomarker model for the assessment of sediment toxicity in the marine and estuarine environment using the comet assay' Hartl MG, Kilemade M, Coughlan BM, O'Halloran J, van Pelt FN, Sheehan D, Mothersill C, O'Brien NM. ; (2006) 'A two-species biomarker model for the assessment of sediment toxicity in the marine and estuarine environment using the comet assay'. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 41 (5):939-953 [Details]
	(2006)	'Two-dimensional electrophoresis analysis of glutathione affinity-selected proteins from the clam Tapes semidecussatus: Evidence for tissue-specific expression of redox proteins' Dowling, V., B. McDonagh, E. M. Cotter, N. O'Brien, F. van Pelt, J. O'Halloran and D. Sheehan ; (2006) 'Two-dimensional electrophoresis analysis of glutathione affinity-selected proteins from the clam Tapes semidecussatus: Evidence for tissue-specific expression of redox proteins'. Comparative Biochemistry and Physiology D-Genomics & Proteomics, 1 (3):267-272 [Details]
	(2006)	'Protein carbonylation and heat shock response in Ruditapes decussatus following p,pŒ-dichlorodiphenyldichloroethylene (DDE) exposure: a proteomic approach reveals DDE causes oxidative stress' Dowling, V., Hoarau, P., Romeo, M., OfHalloran, J., F. van Pelt, F. N. A. M., OfBrien, N.M., and Sheehan, D. ; (2006) 'Protein carbonylation and heat shock response in Ruditapes decussatus following p,pŒ-dichlorodiphenyldichloroethylene (DDE) exposure: a proteomic approach reveals DDE causes oxidative stress'. Aquatic Toxicology, 77 (*):11-18 [Details]
	(2005)	'Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity' S. N. Ni Shuilleabhain, M. Davoren, C. Mothersill, D. Sheehan, M. G. Hartl, M. Kilemade, M. O'Brien N, J. O'Halloran, F. N. van Pelt and F. M. Lyng Aquat Toxicol ; (2005) 'Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity'. Aquatic Toxicology, 73 (2):115-127 [Details]
	(2005)	'Effect of atorvastatin and fluvastatin on the metabolism of midazolam by cytochrome P450 in vitro' Mc Donnell CG, Shorten G, Van Pelt FN; (2005) 'Effect of atorvastatin and fluvastatin on the metabolism of midazolam by cytochrome P450 in vitro'. Anaesthesia, 60 (8):747-753 [DOI] [Details]
	(2005)	'Immunochemical detection of flucloxacillin adduct formation in livers of treated rats' M. A. Carey and F. N. van Pelt; (2005) 'Immunochemical detection of flucloxacillin adduct formation in livers of treated rats'. Toxicology, 216 (1):41-48 [Details]
	(2005)	'A test battery approach for the ecotoxicological evaluation of estuarine sediments' Davoren M, Shúilleabháin SN, O'Halloran J, Hartl MG, Sheehan D, O'Brien NM, van Pelt FN, Mothersill C; (2005) 'A test battery approach for the ecotoxicological evaluation of estuarine sediments'. Ecotoxicology, 14 (7):741-755 [DOI] [Details]
	(2005)	'Resazurin assay of radiation response in cultured cells' Anoopkumar-Dukie S, Carey JB, Conere T, O'sullivan E, van Pelt FN, Allshire A; (2005) 'Resazurin assay of radiation response in cultured cells'. The British Journal of Radiology, 78 (934):945-947 [DOI] [Details]
	(2005)	'Tipping the balance towards tolerance: The basis for therapeutic immune modulation by gold?' J. B. Carey, M. A. Carey, A. Allshire and F. N. van Pelt ; (2005) 'Tipping the balance towards tolerance: The basis for therapeutic immune modulation by gold?'. Autoimmunity, 38 (6):393-397 [Details]
	(2005)	'Cellular responses in primary epidermal cultures from rainbow trout exposed to zinc chloride' S. Ni Shuilleabhain, C. Mothersill, D. Sheehan, M. O'Brien N, O. H. J, F. N. van Pelt, M. Kilemade and M. Davoren ; (2005) 'Cellular responses in primary epidermal cultures from rainbow trout exposed to zinc chloride'. Ecotoxicology and Environmental Safety, 65 (3):332-341 [Details]
	(2005)	'Assessing the potential of fish cell lines as tools for the cytotoxicity testing of estuarine sediment aqueous elutriates' M. Davoren, S. Ni-Shuilleabhain, M. G. J. Hartl, D. Sheehan, N. M. O'Brien, J. O'Halloran, F. van Pelt and C. Mothersill ; (2005) 'Assessing the potential of fish cell lines as tools for the cytotoxicity testing of estuarine sediment aqueous elutriates'. Toxicology In Vitro, 19 (3):421-431 [Details]
	(2005)	'A Test Battery Approach for the Ecotoxicological Evaluation of Estuarine Sediments' Davoren, M., S.N. Shuilleabhain, J. O’Halloran, M.G.J. Hartl, D. Sheehan, N.M. O’Brien, F.N.A.M. van Pelt and C. Mothersill; (2005) 'A Test Battery Approach for the Ecotoxicological Evaluation of Estuarine Sediments'. Ecotoxicology, * (*):*-* [Details]
	(2004)	'An assessment of the pollutant status of surficial sediment in Cork Harbour in the South East of Ireland with particular reference to polycyclic aromatic hydrocarbons' M. Kilemade, M. G. Hartl, D. Sheehan, C. Mothersill, F. N. van Pelt, N. M. O'Brien and J. O'Halloran ; (2004) 'An assessment of the pollutant status of surficial sediment in Cork Harbour in the South East of Ireland with particular reference to polycyclic aromatic hydrocarbons'. Marine Pollution Bulletin, 49 (11-12):1084-1096 [Details]
	(2004)	'In vitro cytotoxicity testing of three zinc metal salts using established fish cell lines' S. Ni Shuilleabhain, C. Mothersill, D. Sheehan, N. M. O'Brien, J. O' Halloran, F. van Pelt and M. Davoren ; (2004) 'In vitro cytotoxicity testing of three zinc metal salts using established fish cell lines'. Toxicology In Vitro, 18 (3):365-376 [Details]
	(2004)	'Genotoxicity of field-collected inter-tidal sediments from Cork Harbor, Ireland, to juvenile turbot (Scophthalmus maximus L.) as measured by the Comet assay' M. F. Kilemade, M. G. Hartl, D. Sheehan, C. Mothersill, F. N. van Pelt, J. O'Halloran and N. M. O'Brien ; (2004) 'Genotoxicity of field-collected inter-tidal sediments from Cork Harbor, Ireland, to juvenile turbot (Scophthalmus maximus L.) as measured by the Comet assay'. Environmental and Molecular Mutagenesis, 44 (1):56-64 [Details]
	(2004)	'Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments' M. G. Hartl, B. M. Coughlan, D. Sheehan, C. Mothersill, F. N. van Pelt, S. J. O'Reilly, J. J. Heffron, J. O'Halloran and N. M. O'Brien ; (2004) 'Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments'. Marine Environmental Research, 57 (4):295-310 [Details]
	(2003)	'Variability of heat shock proteins and glutathione S-transferase in gill and digestive gland of blue mussel, Mytilus edulis' C. Lyons, V. Dowling, M. Tedengren, J. Gardestrom, M. G. Hartl, N. O'Brien, F. N. van Pelt, J. O'Halloran and D. Sheehan ; (2003) 'Variability of heat shock proteins and glutathione S-transferase in gill and digestive gland of blue mussel, Mytilus edulis'. Marine Environmental Research, 56 (5):585-597 [Details]
	(2003)	'Elimination of alfentanil delivered by infusion is not altered by the chronic administration of atorvastatin' C. G. McDonnell, D. Malkan, F. N. van Pelt and G. D. Shorten ; (2003) 'Elimination of alfentanil delivered by infusion is not altered by the chronic administration of atorvastatin'. European Journal of Anaesthesiology, 20 (8):662-667 [Details]
	(2003)	'The effects of concurrent atorvastatin therapy on the pharmacokinetics of intravenous midazolam' C. G. McDonnell, S. Harte, J. O'Driscoll, C. O'Loughlin, F. N. Van Pelt and G. D. Shorten ; (2003) 'The effects of concurrent atorvastatin therapy on the pharmacokinetics of intravenous midazolam'. Anaesthesia, 58 (9):899-904 [Details]
	(2002)	'Detecting genotoxicity using the Comet assay following chronic exposure of Manila clam Tapes semidecussatus to polluted estuarine sediments' B. M. Coughlan, M. G. Hartl, S. J. O'Reilly, D. Sheehan, C. Morthersill, F. N. van Pelt, J. O'Halloran and N. M. O'Brien; (2002) 'Detecting genotoxicity using the Comet assay following chronic exposure of Manila clam Tapes semidecussatus to polluted estuarine sediments'. Marine Pollution Bulletin, 44 (12):1359-1365 [Details]
	(1997)	'Accidental intoxication with methylene dianiline p,p'-diaminodiphenylmethane: acute liver damage after presumed ecstasy consumption' H. L. Tillmann, F. N. van Pelt, W. Martz, T. Luecke, H. Welp, F. Dorries, A. Veuskens, M. Fischer and M. P. Manns ; (1997) 'Accidental intoxication with methylene dianiline p,p'-diaminodiphenylmethane: acute liver damage after presumed ecstasy consumption'. Journal of Toxicology-Clinical Toxicology, 35 (1):35-40 [Details]
	(1996)	'Sevoflurane degradation by soda lime in a circle breathing system' I. T. Munday, P. M. Ward, N. D. Foden, R. M. Jones, F. N. Van Pelt and J. G. Kenna ; (1996) 'Sevoflurane degradation by soda lime in a circle breathing system'. Anaesthesia, 51 (7):622-626 [Details]
	(1995)	'Heterogeneity of liver-kidney microsomal autoantibodies in chronic hepatitis C and D virus infection' M. Durazzo, T. Philipp, F. N. Van Pelt, B. Luttig, E. Borghesio, G. Michel, E. Schmidt, S. Loges, M. Rizzetto and M. P. Manns ; (1995) 'Heterogeneity of liver-kidney microsomal autoantibodies in chronic hepatitis C and D virus infection'. Gastroenterology, 108 (2):455-462 [Details]
	(1995)	'Sera from Patients with Halothane Hepatitis Contain Antibodies to Halothane-Induced Liver Antigens Which Are Not Detectable by Immunoblotting (Vol 270, Pg 1325, 1994)' T. L. Knight, K. M. Scatchard, F. van Pelt and J. G. Kenna; (1995) 'Sera from Patients with Halothane Hepatitis Contain Antibodies to Halothane-Induced Liver Antigens Which Are Not Detectable by Immunoblotting (Vol 270, Pg 1325, 1994)'. Journal of Pharmacology and Experimental Therapeutics, 272 (2):962-962 [Details]
	(1994)	'Sera from patients with halothane hepatitis contain antibodies to halothane-induced liver antigens which are not detectable by immunoblotting' T. L. Knight, K. M. Scatchard, F. N. van Pelt and J. G. Kenna; (1994) 'Sera from patients with halothane hepatitis contain antibodies to halothane-induced liver antigens which are not detectable by immunoblotting'. Journal of Pharmacology and Experimental Therapeutics, 270 (3):1325-1333 [Details]
	(1994)	'Formation of trifluoroacetylated protein antigens in cultured rat hepatocytes exposed to halothane in vitro' F. N. van Pelt and J. G. Kenna ; (1994) 'Formation of trifluoroacetylated protein antigens in cultured rat hepatocytes exposed to halothane in vitro'. Biochemical Pharmacology, 48 (3):461-471 [Details]
	(1993)	'Generation of Trifluoroacetylated Protein Antigens in Cultured Rat Hepatocytes Exposed to Halothane in-Vitro' F. van Pelt, T. L. Knight and J. G. Kenna ; (1993) 'Generation of Trifluoroacetylated Protein Antigens in Cultured Rat Hepatocytes Exposed to Halothane in-Vitro'. Toxicology In Vitro, 7 (4) [Details]
	(1992)	'duction of Terminal Differentiation in Cultured Human Keratinocytes by Polychlorinated Aromatic-Hydrocarbons as Measured by Cell-Size Analysis' F. van Pelt, I. Hassing, M. A. Stelling, W. Seinen and B. J. Blaauboer; (1992) 'duction of Terminal Differentiation in Cultured Human Keratinocytes by Polychlorinated Aromatic-Hydrocarbons as Measured by Cell-Size Analysis'. Toxicology and Applied Pharmacology, 113 (2):240-245 [Details]
	(1991)	'Micronucleus formation in cultured human keratinocytes following exposure to mitomycin C and cyclophosphamide' F. N. van Pelt, R. M. Haring, M. J. Overkamp and P. J. Weterings ; (1991) 'Micronucleus formation in cultured human keratinocytes following exposure to mitomycin C and cyclophosphamide'. Mutation Research, 252 (1):45-50 [Details]
	(1991)	'Micronucleus Formation in Cultured Human Keratinocytes - Involvement of Intercellular Bioactivation' F. Van Pelt, R. M. Haring and P. Weterings ; (1991) 'Micronucleus Formation in Cultured Human Keratinocytes - Involvement of Intercellular Bioactivation'. Toxicology In Vitro, 5 (5-6):515-518 [Details]
	(1990)	'The Effect of Beclobric Acid and Clofibric Acid on Peroxisomal Beta-Oxidation and Peroxisome Proliferation in Primary Cultures of Rat, Monkey and Human Hepatocytes' B. J. Blaauboer, C. W. M. Vanholsteijn, R. Bleumink, W. C. Mennes, F. van Pelt, S. H. Yap, J. F. Vanpelt, A. A. J. Vaniersel, A. Timmerman and B. P. Schmid ; (1990) 'The Effect of Beclobric Acid and Clofibric Acid on Peroxisomal Beta-Oxidation and Peroxisome Proliferation in Primary Cultures of Rat, Monkey and Human Hepatocytes'. Biochemical Pharmacology, 40 (3):521-528 [Details]
	(1990)	'Immunohistochemical Detection of Cytochrome-P450 Isoenzymes in Cultured Human Epidermal-Cells' F. van Pelt, Y. Meierink, B. J. Blaauboer and P. Weterings ; (1990) 'Immunohistochemical Detection of Cytochrome-P450 Isoenzymes in Cultured Human Epidermal-Cells'. Journal of Histochemistry & Cytochemistry, 38 (12):1847-1851 [Details]
	(1989)	'Application of High-Performance Liquid-Chromatographic Analysis of Scoparone and Its Metabolites in the Study of Cytochrome-P450 Differentiation Invitro' F. van Pelt, W. C. Mennes, I. Hassing and B. J. Blaauboer ; (1989) 'Application of High-Performance Liquid-Chromatographic Analysis of Scoparone and Its Metabolites in the Study of Cytochrome-P450 Differentiation Invitro'. Journal of Chromatography-Biomedical Applications, 487 (2):489-495 [Details]
	(1988)	'Immunolocalization of Cytochrome-P-450 Isoenzymes in Human Epithelial-Cells' F. van Pelt and Y. Meierink; (1988) 'Immunolocalization of Cytochrome-P-450 Isoenzymes in Human Epithelial-Cells'. Mutation Research, 203 (3):210-210 [Details]
	(1985)	'A Highly Sensitive Assay for Glutathione Transferase Using 4,5-Dihydro-Epoxybenzo(a)Pyrene as Substrate' M. Hukkelhoven, F. van Pelt, A. C. Dijkstra and A. J. M. Vermorken ; (1985) 'A Highly Sensitive Assay for Glutathione Transferase Using 4,5-Dihydro-Epoxybenzo(a)Pyrene as Substrate'. Biochemical Pharmacology, 34 (5):703-705 [Details]
	(1984)	'In vivo Induction of Aryl-Hydrocarbon Hydroxylase in Human Scalp Hair-Follicles by Topical Application of a Commercial Coal-Tar Preparation' M. Hukkelhoven, L. W. M. Vromans, F. van Pelt, R. A. C. Keulers and A. J. M. Vermorken ; (1984) 'In vivo Induction of Aryl-Hydrocarbon Hydroxylase in Human Scalp Hair-Follicles by Topical Application of a Commercial Coal-Tar Preparation'. Cancer letters, 23 (3):135-143 [Details]

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Conference Publications

	Year	Publication
	(1994)	Journal of Investigative Dermatology R. P. Tonge, J. G. Kenna, F. van Pelt and S. A. M. Hotchkiss ; (1994) An Immunochemical Investigation into Covalent Binding of Hydroxycitronellal to Human Skin Proteins in-Vitro . In: Journal of Investigative Dermatology 102(4) eds. Journal of Investigative Dermatology , pp.637-637 [Details]
	(1994)	Anesthesiology N. D. Foden, F. van Pelt and R. M. Jones ; (1994) Dose-Dependent Degradation of Sevoflurane to Compound-A . In: Anesthesiology 81(3A) eds. Anesthesiology , pp.A432-A432 [Details]
	(1994)	Anesthesiology T. Munday, N. D. Foden, P. M. Ward, F. van Pelt and R. M. Jones ; (1994) Sevoflurane Degradation in a Circle System at 2 Different Fresh Gas-Flow Rates . In: Anesthesiology 81(3A) eds. Anesthesiology , pp.A433-A433 [Details]

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Invited Review Articles

	Year	Publication
	(1995)	Molecular basis of drug-induced immunological liver injury. F. N. Van Pelt, P. Straub and M. P. Manns ; (1995) Molecular basis of drug-induced immunological liver injury. Invited Review Articles [Details]
	(1993)	Immunity to halothane metabolite-modified proteins in halothane hepatitis. J. G. Kenna, T. L. Knight and F. N. van Pelt ; (1993) Immunity to halothane metabolite-modified proteins in halothane hepatitis. Invited Review Articles [Details]

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Professional Activities

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Honours and Awards

	Year	Title	Awarding Body
	2004	Award for Research on Innovative Forms of Teaching and Learning	UCC

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Professional Associations

	Association	Function	From / To
	Irish Society of Toxicology	Councillor of the Irish Society of Toxicology (1996-1998, 2003-2005)	01-JAN-03 / 31-DEC-05
	Register of Toxicologists in Ireland	Member of Register of Toxicologists in Ireland (since 2004)	01-JAN-04 /
	EUROTOX	European Registered Toxicologist (since 2005)	01-JAN-05 /
	Irish Society of Toxicology	Vice-President the Irish Society of Toxicology (2005-2007)	01-JAN-05 / 31-DEC-07
	Irish Society of Toxicology	President the Irish Society of Toxicology (2007-2009)	01-JAN-07 / 31-DEC-09
	UCC	Internal PhD examiner (non supervisor)	01-JAN-96 /
	Enterprise Ireland	Grant reviewer for the Applied Research Grant Scheme of Enterprise Ireland	01-JAN-03 / 31-DEC-07
	Register of Toxicologists in Ireland	Member of Assessment Panel for the Register of Toxicologists in Ireland (2004-2007)	01-JAN-04 / 31-DEC-07

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Committees

	Committee	Function	From / To
	College Council of College of Medicine and Health (2007-2013)	member	/
	Exectutive/Head of Department committee in School of Medicine (2007-2013)	member	/
	Departmental Graduate Studies Committee	member	/
	Curriculum Committee School of Medicine (2007-2013)	member	/
	Academic Council (2007-2013)	member	/
	Executive of School of Pharmacy (2011-2013)	member	/
	Member of Scientific Subcommittee on GMOs and Novel Foods of the Food Safety Authority of Ireland(2004-2007)	member	1998 / 2006
	Member of Pre-Clinical Sub Committee for Human Medicines of the Irish Medicine Board (since2001)	member	2001 /
	Member of Dangerous Substances Advisory Committee ,Health Safety Authority (2004-2007)	member, IST representative	2004 / 2007

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Employment

	Employer	Position	From / To
	Research Institute of Toxicology, University of Utrecht, the Netherlands.	Research Scientist (1990-1991)	/
	UCC	Head of Department (2007-2013)	01-MAR-07 /
	UCC	Senior Lecturer (since 2004)	01-OCT-04 /
	UCC	Lecturer (1995-2004)	01-OCT-95 / 30-SEP-04
	Medical School Hannover, Germany	Alexander von Humboldt Fellow (1994- 1995)	01-APR-94 / 31-OCT-95
	St. Mary's Hospital Medical School, London, UK	Senior Research Scientist (1993-1994)	01-APR-93 / 01-APR-94
	St. Mary's Hospital Medical School, London, UK	Wellcome Trust Research Fellow (1991-1993)	01-APR-91 / 01-APR-93

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Education

	Year	Institution	Qualification	Subject
	1982	University of Nijmegen, The Netherlands	BSC CHEMISTRY	Chemistry
	1985	University of Nijmegen, The Netherlands	MSc	Biochemistry
	1990	University of Utrecht, the Netherlands	PhD	Toxicology

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Languages

	Language	Reading	Writing	Speaking
	Dutch	Fluent	Fluent	Fluent
	English	Fluent	Fluent	Fluent
	German	Fluent	Basic	Fluent

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Journal Activities

	Journal	Role	To / From
	Toxicology In Vitro	Referee	01-JAN-00 -
	Expert Opinion On Drug Metabolism & Toxicology	Referee	01-JAN-00 -
	Food And Chemical Toxicology	Referee	01-JAN-00 -
	Journal Of Hepatology	Referee	01-JAN-00 -
	Aquatic Toxicology	Referee	01-JAN-00 -
	Journal Of Pharmacy And Pharmacology	Referee	01-JAN-00 -

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Other Activities

	Description
	Examiner of PhD candidates: Oct 2014 external examiner Nottingham Trent University (UK)

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Teaching Activities

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Teaching Interests

Dr. van Pelt currently teaches various aspects of drug metabolism, adverse drug reactions and toxicology to undergraduate science, pharmacy, medical, and dental hygienist students.  

Contribute to:

GM1001 Fundamentals of Medicine I

FM2003 Foundations of Medicine: Medical Pharmacology
 

FM3003 Foundations of Medicine: Fundamentals of Therapy

PT3446 Clinical Pharmacology and Toxicology

RD2001 Periodontology

EV4013 Environmental Risk Assessment and Auditing

He also supervise PhD, MSc and MD research students and undergraduate laboratory research for BSc (Chemistry of Pharmaceutical Compounds) students.                  

In 2004 Dr. van Pelt, together with Drs. A. Allshire and O.P. Barry, received an Award for Research on Innovative Forms of Teaching and Learning from University College Cork for the project: The use of animated graphics for teaching Pharmacology and Toxicology.

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Recent Postgraduates

	Graduation Year	Student Name	Institution	Degree Type	Thesis Title
	2014	Barbara Valentina Dörr	University College Cork	PHD	Investigation of the genotoxic potential of the marine biotoxins okadaic acid and azaspiracids.
	2014	David Shane Groeger	University College Cork	PHD	The Use of Different Blood Sample Preparations in the Development of Biomarkers for the Environmental Monitoring of Domestic Farm Animals
	2014	Brian Dineen	Cork Institute of Technology	PhD	The Development of Liquid Chromatography Mass Spectrometry Methods for the Analysis of Cyanobacterial Toxins and Their Freshwaters
	2013	Moira Mc Carthy	University College Cork	PhD	Ecotoxicology of marine biotoxins in bivalve shellfish
	2013	Bebhine Carey	Cork Institute of Technology	PhD	Novel Liquid Chromatography - Fourier Transform Mass Spectrometry (MS) and Triple Quadrupole MS Methods for the Determination of Diarrhetic Shellfish Poisoning (DSP) Toxins
	2011	Zuzana Skrabáková	Cork Institute of Technology	PhD	High Resolution Hybrid Mass Spectrometry for Determination of Marine Biotoxins Azaspiracids and their Biotransformation Products.
	2008	Ben Matthew Coughlan	University College Cork	PHD	A hierarchial biomarker approach investigating effects on the Manila clam (ruditapes philippinarum) following exposure to estuarine sediments
	2005	Catherine McDermott	University College Cork	PhD	Sub-Chronic Toxicity of Organic Solvents in vitro
	2005	Alice D’Arcy	University College Cork	MSc	Pesticide Regulation & Risk Assessment in Ireland A Review of ecological and ecotoxicological information available on Non target species
	2005	John Carey	University College Cork	PhD	Immunomodulation by Heavy Metals
	2004	Pauline Ryan	University College Cork.	PhD	An Investigation of Phenytoin adduct formation in vivo
	2004	Conor McDonnell	University College Cork	Doctor of Medicine	Drug-drug interactions and the hepatic cytochrome P450 system – the effects of HMG Co-enzyme A inhibitors on the metabolism of intravenous anaesthetic agents
	2000	Michelle Carey	University College Cork	PhD	The Immunological Basis of Flucloxacillin-Induced Cholestasis
	1991	Marion Stelling	University of Utrecht	MSc	In vitro assay for dioxin activity based on changes in cell size of human keratinocytes
	1990	Marleen van Os	University of Utrecht	MSc	Purification of Involucrine
	1989	Ruud van der Heijden	University of Utrecht	MSc	The effects of dioxins on culture human keratinocytes

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Current Postgraduate Students

	Student	Degree Type
	Jagodzinski Lucas Simon	Doctoral Degree

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Modules Taught

	Term (ID))	Title	Link	Subject
	2015	Introduction to Toxicology	PT3002	Introduction to Toxicology
	2015	Applied Pharmacology & Toxicology	PT4012	Applied Pharmacology & Toxicology

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Research Information

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Internal Collaborators

	Name	Institute	Country
	Prof John O'Halloran	School of BEES, UCC	IRELAND
	Dr Marcel Jansen	School of BEES, UCC	IRELAND
	Prof Nora O'Brien	School of Food and Nutritional Sciences, UCC	IRELAND
	Prof Jim Heffron	School of Biochemistry and Cell Biology, UCC	IRELAND

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External Collaborators

	Name	Organisation/ Institution	Country
	Dr Ambrose Fury	Cork Institute of Technology	IRELAND
	Prof Kevin Park	MRC Centre for Drug Safety Science ,Institute for Translational Medicine ,University of Liverpool	UNITED KINGDOM
	Dr Rosalind Jenkins	MRC Centre for Drug Safety Science, ,Institute for Translational Medicine, University of Liverpool	UNITED KINGDOM