Research Profile

Orla P Barry

Biography

Dr. Órla P. Barry graduated with an Honours Degree in Biochemistry in 1991 from University College Cork (UCC). This was followed by a Ph.D. investigating novel mechanisms of transcellular lipid metabolism at the University of Pennsylvania (UPENN), Philadelphia, USA. A post-doctoral fellowship also at UPENN, involved investigating isoprostanes as indices of oxidant stress. Upon returning to Ireland at the end of 1999, she joined the Cork Cancer Research Centre as a Health Research Board post-doctoral fellow. Dr. Barry was appointed Lecturer in Pharmacology, UCC, in 2002. In 2014, Dr. Barry graduated with an MA in Teaching and Learning, UCC, in Higher Education.

Research Interests

Cell Signalling and Cancer 
Dr. Barry's research focuses on cancers with few treatment strategies and with no significant improvement in overall survival rate, namely, oesophageal and renal cancers. The paucity of therapeutic options, and their associated morbidity, has led to vital research for new therapeutic strategies. Research focuses on the study of different families of serine/threonine kinases that play key roles in signalling mechanisms following activation of seven-transmembrane and tyrosine-kinase receptors. In particular, our area of research focuses on the role of Paks, p38 MAPKs, and PKCs which exert a variety of cellular effects including changes in proliferation, malignant transformation, cell death and differentiation. Briefly, we have exploited the activation of PKC as a pro-apoptotic and anti-proliferative agent in oesophageal cancer. In addition we have re-introduced p38delta MAPK into different cancers which lack this isoform including oesophageal, renal, prostate, lung and liver which has profound effects on cell proliferation and apoptosis. Finally, we have identified different Pak isoforms which are pro-apoptotic in oesophageal and renal cancer. An important aspect of our research is to elucidate the signalling pathways underlying the apoptotic effect of these kinases using both pharmacological and molecular strategies. In addition, the use of athymic nude mice to study their effects is necessary to translate in vitro results to in vivo models of tumourigenesis in order to validate our experimental hypothesis in a physiological setting.  The identification of different kinase isoforms involved in cell proliferation and cell death in different types of cancer may have important therapeutic implications for the treatment of the disease.

Epigenetics and Cancer
Research on epigenetic gene silencing and on epigenetic drug-induced re-expression of tumour suppressor genes may influence future optimal treatment strategies and predict responses in oesophageal and renal cancer patients. Our research identified that epigenetic alterations are partly responsible for the promotion of tumourigenesis in oesophageal squamous cell carcinoma (OESCC). Given that epigenetic changes are reversible, we can investigate the utility of epigenetic modifiers - DNA methyltransferase inhibitors (DNMTi), histone deacetylase inhibitors (HDACi) and Bromodomain and Extra-Terminal motif inhibitors (BETi) as possible therapeutic strategies in the treatment of drug resistant OESCC.  Our work to-date has uniquely identified that some FDA cancer approved and investigational epigenetic modifiers (not all) can prevent the growth of drug resistant p38δ MAPK negative OESCC cell growth.  

Cardiovascular Research 
Cardiovascular research involved investigating the biological roles of platelet microparticles (PMP) formed from the plasma membrane and released into the extracellular space. Prior to my investigations their physiological role(s) remained ill-defined. My research highlighted a novel mechanism of transcellular lipid metabolism whereby platelet activation may be amplified or modulated by concentrated delivery of PMP arachidonic acid (AA) to adjacent platelets, endothelial cells, and monocytes. The demonstration that PMPs may modulate important aspects of endothelial and monocyte function provided a novel mechanism by which platelets may interact with such cells in human atherosclerosis and inflammation. In addition to my cellular and molecular studies of AA signalling and gene transcription, I have also studied the roles of isoprostanes (iPs) as indices of oxidant stress in patients with alcohol-induced hepatitis or alcohol-induced chronic liver disease. iPs are free radical-catalyzed products of AA formed in a COX-independent manner and have proved useful markers for lipid peroxidation.

Research Training
The aim within my laboratory is to train future investigators in an intellectually exciting and supportive work environment to carry out independent, high quality research. Our goal is to educate undergraduate, PhDs and post-doctoral fellows to a level where they have the research knowledge, understanding, critical analytical skills, and the know how to apply appropriate experimental design and state-of-the-art techniques to whatever emerging questions they are attempting to address. In summary, we concentrate on developing analytical, technical and interpersonal skills.
Our laboratory strives to train research scientists in cancer cell and molecular biology focusing on the pharmacological principles of how drugs work and why some are toxic. Our research is conducted at the molecular, cellular, organ, whole organism, and clinical levels. Thus, through individual research driven projects within the department in conjunction with national and international collaborative groups we provide abundant educational opportunities in the broader area of Pharmacology for both undergraduate and postgraduate students.

Lab Members and Alumni
Ph.D. Students
Róisín M. Cassidy (2019-Present)
Chemosensitisation of oesophageal squamous cell carcinoma using epigenetic modifiers and cytotoxic drug polytherapy.

Carol O’ Callaghan (2010-2015)
Novel insights into the expression and function of p38d MAPK in oesophageal squamous cell carcinoma.

Monica Ambrose (2003-2008)
Investigation of Novel Therapeutic Targets for the Treatment of Oesophageal and Renal Cancer.

Ph.D. HRB Scholars Programme in Cancer Biology
Selina Lam (2012)
Analysis of p-p38δ MAPK activation, expression and subcellular localisation in oesophageal squamous cell carcinoma.

Ioanna Tzani (2012)
Generation of a constitutively active fusion construct to investigate the role of p-p38δ MAPK on the tumourigenicity of primary and metastatic oesophageal squamous carcinoma (OESCC).  

Kate Foley (2008)
Targeting p38δ MAPK in Metastatic Oesophageal Squamous cell carcinoma: a possible future therapeutic goal.

William Byrne (2008)
Generation of a series of fusion constructs to investigate the role(s) of p38δ and p-p38δ MAPK on the tumourigenicity of primary and metastatic oesophageal squamous carcinoma.



M.Sc. Students

Lea Herzel (2022)
An investigation of combining epigenetics and immunotherapies in oesophageal cancer treatment.

Ciara McCarthy (2021)
Ethanolamine: a cardioprotectant and chemosensitiser in oesophageal cancer.

Marie O’ Dea (2020)
Short-term cytotoxicity induced by epigenetic drugs in H9C2 cells.

Kyle Sadik (2019)
3D Tumour Spheroid Models for Epigenetic Drug Screening.

Rósín Cassidy (2018)
Epigenetic modulating compounds as potential therapeutic agents for treatment of oesophageal cancer.

M. Pharm. Students

Ailbhe Reilly (2022)
Combining epigenetics and immunotherapies in oesophageal cancer treatment: A match made in heaven?.

Internships

Mritunjay Mukherjee (2022)
Combining epigenetics and immunotherapy in the treatment of oesophageal cancer.

William O' Conor (2022)
Uncovering the mechanisms underlying DNMTi induced cardiotoxicity.

Alanna Denny (2021)
Epigenetic compounds as a therapeutic strategy in oesphageal cancer.

Kiran Pirambil (2019)
HDAC modulating compounds as potential therapeutic agents for treatment of p38d MAPK-negative oesophageal squamous cell carcinoma.

Vincent Caulier (2013)
Investigation of serine/threonine kinases in oesophageal carcinoma.

Intercalated BSc Students

Seamus Boyle (2011)
The anti-cancer effects of thyroid, renal and cardiac hormones.

David Antoine Lachmansingh (2006)
Investigation of the expression of p21-activated kinases 1 and 4 (Pak1, 4), serine/threonine kinases, in oesophageal carcinoma.  

Undergraduate FYPs
AY1314
Aoife Foley: Development of a methyl 2- (3,6-Diamino-9H-Xanthen-9-yl)Benzoate (Dihydrorhodamine 123) Assay To Measure The Production Of Reactive Oxygen Species Following Cytotoxic Anticancer Drug Treatment.
David J. Jones: An investigation of the anti-cancer effect(s) of docosahenaenoic acid derviatives Resolvin D1 and D2 in oesophageal cancer.

AY1213
Christine Roche: Does the presence or absence of p38δ MAPK affect the sensitivity of OESCC to cytotoxic drugs?.

AY1112
Aoife Hart: Analysis of a fusion plasmid pcDNA3-FLAG-MKK6 (E)-(Gly-Glu)5 -p38δ MAPK in Oesophageal Squamous Cell Carcinoma.
Aoibheann McNally: Characterization of p38 MAPK and MAPKK expression in pancreatic adenocarcinoma and squamous carcinoma cell lines.

AY1011
Jessica Anthony: Analysis of p38MAPK isoform subcellular localization in oesophageal cancer cells.
Patrick O Sullivan: Investigation of Angiotensin II as a possible future therapeutic target for the treatment of oesophageal cancer.

AY0910
Michelle Cotter: Targeting of p38 MAPK in prostate cancer.

AY0809
Claire Duggan: Investigation of the role of cyclooxygenase isoforms in Renal Cell Carcinoma apoptosis.

AY0607
Patrick Quille: Role of p38δ mitogen activated protein kinase as a regulator in oesophageal cancer proliferation.
Bernadette Queally: Role of p38δ mitogen activated protein kinase in conferring resistance and sensitivity in oesophageal cancer to various chemotherapeutic drugs.
Aisling Shanahan: Role of p38δ mitogen activated protein kinase in COX-2 activation in oesophageal cancer.

AY0506
Susan o’ Sullivan: Investigation of the role(s) of p38δ MAPK in cancer. 

AY0405 
Sinéad Milner: Investigation of the sonic hedgehog signalling pathway in oesophageal cancer.
Meadhbh Cronin:  Targeting oesophageal cancer with siRNA Paks.
Leanne Timpson:  Investigation of the differential role(s) of p38 MAPK isoforms in Renal Cell Carcinoma.

AY0304
Patricia Corkery:PKCs as critical mediators of cell growth and apoptosis in Renal Cell Carcinoma.
Tina-Marie Brennan: p38 MAPK as a critical mediator of cell growth and apoptosis in Renal Cell
Carcinoma.
Sarah Ormond: Role of Paks in Renal Cell Carcinoma.

AY0203
Cathal Lucey: Novel Approaches to the inhibition of renal carcinoma cell growth.
Cormac O' Keeffe: PKC and Oesophageal cancer.


















Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
[M.Sc. Medicine] {Barry Dr. Orla} NMiscellaneous Non Exchequer01-OCT-0330-SEP-05€33,000.00
ChemosensitisationIrish Funded Research Non Exchequer01-OCT-1930-JUN-23€102,846.00
Breakthrough Cancer Research: Epigenetic Modulating Compounds as Potential Therapeutic Agents for Treatment of Oesophagal CancerIrish Funded Research Non Exchequer01-OCT-1830-SEP-19€32,355.00
HEACOVID1901-APR-2131-MAR-22€6,000.00
Targeting p38delta MAPK in oesophageal cancer, a possible future therapeutic goal?Health Research Board01-SEP-1031-AUG-14€184,003.00

Publications

Book Chapters

 YearPublication
(2011)'Exploitation of aberrant signalling pathways as useful targets for renal clear cell carcinoma therapy'
Orla Patricia Barry and Carol O' Callaghan; (2011) 'Exploitation of aberrant signalling pathways as useful targets for renal clear cell carcinoma therapy' In: Renal Cancer. Croatia: InTECH. [Details]
(1997)'Urinary 8-Epi PGF2:An Index Of Oxidant Stress In Vivo. In: Fibrinolysis and Protelysis'
M.P. Reilly, P. Barry, J.A. Lawson, and G.A.FitzGerald; (1997) 'Urinary 8-Epi PGF2:An Index Of Oxidant Stress In Vivo. In: Fibrinolysis and Protelysis' In: Urinary 8-Epi PGF2:An Index Of Oxidant Stress In Vivo. In: Fibrinolysis and Protelysis. *: *. [Details]
(1997)'Markers Of Platelet Activation And Oxidant Stress In Atherothrombotic Disease. In: Thrombosis and Haemostasis'
Garret A. FitzGerald, Jessica Tigges and Patricia Barry, and John A. Lawson. ; (1997) 'Markers Of Platelet Activation And Oxidant Stress In Atherothrombotic Disease. In: Thrombosis and Haemostasis' In: Markers Of Platelet Activation And Oxidant Stress In Atherothrombotic Disease. In: Thrombosis and Haemostasis. *: *. [Details]

Peer Reviewed Journals

 YearPublication
(2016)'Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies'
Aileen Houston, John M. Williams, Tihana Lenac Rovis, Daniel K. Shanley, Ronan T. O'Riordan, Patrick A. Kiely, Melanie Ball, Orla P. Barry, Jacquie Kelly, Aine Fanning, John MacSharry, Ofer Mandelboim, Bernhard B. Singer, Stipan Jonjic & Tom Moore (2016) 'Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies'. mAbs, 8 (2):405-413 [Details]
(2015)'p38δ MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma'
O' Callaghan C, Fanning LJ, Barry OP (2015) 'p38δ MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma'. Anti Cancer Drugs, [Details]
(2015)'Periodic review sessions contribute to student learning across the disciplines in pharmacology'
Barry, O.P., O'Sullivan, E. and McCarthy, M. (2015) 'Periodic review sessions contribute to student learning across the disciplines in pharmacology'. Journal of The Scholarship of Teaching and Learning, [Details]
(2014)'p38�� MAPK: Emerging Roles of a Neglected Isoform. International Journal of Cell Biology'
O' Callaghan C, Fanning LJ, Barry OP (2014) 'p38�� MAPK: Emerging Roles of a Neglected Isoform. International Journal of Cell Biology'. International Journal of Cell Biology, [Details]
(2013)'Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth'
O'Callagahan C, Fanning LJ, Houston A and Barry OP. (2013) 'Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth'. International Journal of Oncology, [Full Text] [Details]
(2007)'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. Int J Cancer'
O'Sullivan GC, Tangney M, Casey G, Ambrose M, Houston A and Barry OP. ; (2007) 'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. Int J Cancer'. International Journal of Cancer, [Details]
(2007)'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma'
O'Sullivan, G. C.,Tangney, M.,Casey, G.,Ambrose, M.,Houston, A.,Barry, O. P.; (2007) 'Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma'. Int J Cancer, 121 (99):1930-401930   [Details]
(2006)'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'
Ambrose M, Ryan A, O¿ Sullivan GC, Dunne C, and Barry OP; (2006) 'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'. Mol Pharmacol, [Details]
(2001)'Effects of Vitamin E on Lipid Peroxidation in Healthy Persons'
Emma A. Meagher, Orla P. Barry, John A. Lawson, Joshua Rokach, and Garret A. FitzGerald; (2001) 'Effects of Vitamin E on Lipid Peroxidation in Healthy Persons'. JAMA : the journal of the American Medical Association, [Details]
(2001)'Protein Kinase C Isozymes, Novel Phorbol Ester Receptors and Cancer Chemotherapy'
Barry, O.P., and Kazanietz, M.G; (2001) 'Protein Kinase C Isozymes, Novel Phorbol Ester Receptors and Cancer Chemotherapy'. Curr. Pharm. Des, [Details]
(2001)'Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent'
Barry, O. P.,Mullan, B.,Sheehan, D.,Kazanietz, M. G.,Shanahan, F.,Collins, J. K.,O'Sullivan, G. C. (2001) 'Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent'. Journal of Biological Chemistry, 276 (181):15537-15546   [Details]
(1999)'Increased Oxidant Stress In Alcohol Liver Disease'
Emma A. Meagher, Orla P. Barry, Anne Burke, Michael R. Lucey, Joshua Rokach, and Garret A. FitzGerald; (1999) 'Increased Oxidant Stress In Alcohol Liver Disease'. J. Clin. Invest, [Details]
(1999)'Iron-Dependent Human Platelet Activation And Hydroxyl Radical Formation'
Domenico Pratico, Orla P. Barry, Andrea Ghiselli, Luigi Iuliano, Guiseppi Sabatino, Garret A. FitzGerald, and Francesco Violi. ; (1999) 'Iron-Dependent Human Platelet Activation And Hydroxyl Radical Formation'. Circulation, 99, [Details]
(1999)'Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a Protein Kinase C/Mitogen-Activated Protein Kinase-Dependent Pathway'
Orla P. Barry, Marcelo G. Kazanietz, Domenico Pratico, and Garret A. FitzGerald. ; (1999) 'Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a Protein Kinase C/Mitogen-Activated Protein Kinase-Dependent Pathway'. J. Biol. Chem, [Details]
(1999)'Alcohol-induced generation of lipid peroxidation products in humans'
Meagher, E.A., Barry, O.P., Burke, A., Lucey, M.R., Lawson, J.A., Rokach, J. and FitzGerald, G.A. (1999) 'Alcohol-induced generation of lipid peroxidation products in humans'. Journal of Clinical Investigation, [Details]
(1999)'Mechanisms Of Cellular Activation By Platelet Microparticles'
Orla P. Barry and Garret A. FitzGerald.; (1999) 'Mechanisms Of Cellular Activation By Platelet Microparticles'. Thrombosis and Haemostasis, [Details]
(1998)'IPF2 Alpha-1:An Index Of Lipid Peroxidation In Humans'
Domenico Pratico, ¶Orla P. Barry, John A. Lawson, Mustafa Adiyaman, Seong-Woo Huang, Subash P. Khanapure, Luigi Iuliano, Joshua Rokach, and Garret A. FitzGerald.; (1998) 'IPF2 Alpha-1:An Index Of Lipid Peroxidation In Humans'. Proceedings of the National Academy of Science, [Details]
(1998)'Modulation Of Monocyte-Endothelial Cell Interactions By Platelet Microparticles'
Orla P. Barry, Domenico Pratico, Rashmin C. Savani, and Garret A. FitzGerald. ; (1998) 'Modulation Of Monocyte-Endothelial Cell Interactions By Platelet Microparticles'. J. Clin. Invest, [Details]
(1998)'Effects of chronic therapy with vitamin E on lipid peroxidation in vivo in healthy humans'
Meagher, E.A., Barry, O.P., Bensinger, S., Rokach, J. and FitzGerald, G.A. (1998) 'Effects of chronic therapy with vitamin E on lipid peroxidation in vivo in healthy humans'. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, [Details]
(1997)'Transcellular Activation Of Platelets And Endothelial Cells By Bioactive Lipids In Platelet Microparticles'
Orla P. Barry, Domenico Pratico, John A. Lawson, and Garret A. Fitzgerald. ; (1997) 'Transcellular Activation Of Platelets And Endothelial Cells By Bioactive Lipids In Platelet Microparticles'. J. Clin. Invest, [Details]
(1997)'Urinary excretion of IPF2 alpha-1 and 8-epi PGF(2 alpha): Specific analysis of distinct F-2 isoprostanes as noninvasive indices of oxidant stress in vivo'
Pratico, D., Barry, O.P., Lawson, J.A., Rokach, J, and FitzGerald, G.A. (1997) 'Urinary excretion of IPF2 alpha-1 and 8-epi PGF(2 alpha): Specific analysis of distinct F-2 isoprostanes as noninvasive indices of oxidant stress in vivo'. Circulation, [Details]
(1997)'Dietary Factors In Thrombosis And Haemostasis:Summary And Conclusions'
Garret A. FitzGerald and Patricia Barry; (1997) 'Dietary Factors In Thrombosis And Haemostasis:Summary And Conclusions'. Am. J. Clin. Nutr, [Details]
(1997)'Platelet microparticles stimulate adhesion and migration of monocytes in a PKC-dependent manner'
Barry, O.P., Pratico, D., Savani, R.C. and FitzGerald, G.A. (1997) 'Platelet microparticles stimulate adhesion and migration of monocytes in a PKC-dependent manner'. Circulation, [Details]
(1996)'Transcellular signaling by platelet microvesicles in human endothelial cells and platelets'
Barry, O.P., Pratico, D. and FitzGerald, G.A. (1996) 'Transcellular signaling by platelet microvesicles in human endothelial cells and platelets'. Circulation, [Details]

Conference Publications

 YearPublication
(2013)104th Annual Meeting of the American-Association-for-Cancer-Research (AACR)
O' Callaghan, C., Fanning, L., Houston, A. and Barry, O.P. (2013) New paradigms for the modulatory actions of p38 delta MAPK restorative expression in esophageal squamous cancer cell growth, migration and response to chemotherapy: A possibel future therapeutic target 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR) [Details]
(2012)24th EORTC-NCI-AACR symposium on molecular targets and cancer therapeutics
O'Callaghan, C., Fanning, L., Houston, A. and Barry, O.P. (2012) Targeting p38 delta MAPK in oesophageal cancer: a possible future therapeutic goal? 24th EORTC-NCI-AACR symposium on molecular targets and cancer therapeutics [Details]
(2005)96th Annual Meeting of the American-Association-for-Cancer-Research
Ambrose, M., Ryan, A., Dunne, C., O' Sullivan, G. and Barry, O.P. (2005) Induction of apoptosis in 786-0 renal cell carcinoma by reactive oxygen species is ERK1/2-, p38 delta and gamma MAPK- and Pak-1-independent but JNK-independent 96th Annual Meeting of the American-Association-for-Cancer-Research [Details]
(1999)Gastroenterology and Haematology
Meagher, E.A., Barry, O.P., Lucey, M.R., Rokach, J. and FitzGerald, GA. (1999) Antioxidant modulation of free radical generation in cirrhosis Gastroenterology and Haematology [Details]
(1996)69th Scientific Sessions of the American Heart Association
Barry, O.P., Pratico, D. and FitzGerald, G.A. (1996) Transcellular signaling by platelet micovesicles in human endothelial cells and platelets 69th Scientific Sessions of the American Heart Association [Details]
(1997)Annual Meeting of the Association of American Physicians, the American Society for Clinical Investigation, and the American Federation for Medical Research: Biomedicine '97 Medical Research from Bench to Bedside
Barry, O.P., Pratico, D. and FitzGerald, G.A. (1997) Platelet mircoparticles enhance adhesive interactions between monocytes and endothelial cells Annual Meeting of the Association of American Physicians, the American Society for Clinical Investigation, and the American Federation for Medical Research: Biomedicine '97 Medical Research from Bench to Bedside [Details]
(1998)71st Scientific Sessions of the American Heart Association
Pratico, D., Luliano, L., Ferro, D., Barry, O.P., Valesini, G., Rokach, J., FitzGerald, G.A. and Violi, F. (1998) Ongoing thrombotic state in patients with antiphospholipid antibodies: a role for increased lipid peroxidation 71st Scientific Sessions of the American Heart Association [Details]
(1998)18th Annual Meeting of the Society of Perinatal Obstetricians
Regan, C., Barry, O.P., Lawson, J.A., Morgan, M.A. and FitzGerald, G.A. (1998) Isoprostane formation in normal pregnancy 18th Annual Meeting of the Society of Perinatal Obstetricians [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2022VISTA Programme Awardee UCC
2008A finalist in the JMS Doctor Awards Oncology section. JMS Doctor Awards, Health Research Board & Eireann Healthcare Publications, Dublin.
2004Research on Innovative Forms of Teaching University College Cork
2002Overall winner of the JMS Doctor Awards JMS Doctor Awards, Health Research Board & Eireann Healthcare Publications, Dublin.
1998Trainee Investigator Award for Excellence in Scientific Research. Biomedicine, Washington DC, USA
1997Trainee Investigator Award for Excellence in Scientific Research. Biomedicine, Washington DC, USA

Professional Associations

 AssociationFunctionFrom / To
Irish Association of Pharmacology Treasurer01-JAN-20 /

Conference Contributions

 YearPublication
(2015)EuroSoTL Bridging Boundaries Through the Scholarship of Teaching and Learning,
Orla P. Barry, Eleanor O'Sullivan, Marian McCarthy (2015) A retrospecitve eight year study of assessment type in evaluationg performance of multidisciplinary students in pharmacology. [Poster Presentation], EuroSoTL Bridging Boundaries Through the Scholarship of Teaching and Learning, Univeristy College Cork . [Details]
(2008)¿Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿,
O. Barry; (2008) ¿Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿. [Oral Presentation], ¿Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿, PhD Scholars Cancer Research Programme, National University of Ireland, Cork , 01-JAN-08 - 01-JAN-08. [Details]
(2008)Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿,
O. Barry; (2008) Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿. [Oral Presentation], Targeting Oesophageal Cancer with p38d MAPK: a possible future therapeutic target?¿, PhD Scholars Cancer Research Programme, National University of Ireland, Cork , 01-JAN-08 - 01-JAN-08. [Details]
(2006)Targeting oesophageal, renal and prostate cancer with p38 MAPK: a possible future therapeutic approach?¿,
O. Barry; (2006) Targeting oesophageal, renal and prostate cancer with p38 MAPK: a possible future therapeutic approach?¿. [Oral Presentation], Targeting oesophageal, renal and prostate cancer with p38 MAPK: a possible future therapeutic approach?¿, Cork Cancer Research Open Day, Ireland , 01-JAN-06 - 01-JAN-06. [Details]
(2004)From Bench to Bedside, Lecture series. ¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿,
O. Barry; (2004) From Bench to Bedside, Lecture series. ¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿. [Oral Presentation], From Bench to Bedside, Lecture series. ¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿, Mercy University Hospital, Cork , 01-JAN-04 - 01-JAN-04. [Details]
(2004)Cork Cancer Research Open Day, Cork, Ireland. ¿An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿,
O. Barry; (2004) Cork Cancer Research Open Day, Cork, Ireland. ¿An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿. [Oral Presentation], Cork Cancer Research Open Day, Cork, Ireland. ¿An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿, Mercy University Hospital, Cork , 01-JAN-04 - 01-JAN-04. [Details]
(2004)Induction of apoptosis in 786-0 Renal Cell Carcinoma by Reactive Oxygen Species is ERK1/2, Pak-1 and p38 MAPK  and --dependent but JNK-independent¿,
O. Barry; (2004) Induction of apoptosis in 786-0 Renal Cell Carcinoma by Reactive Oxygen Species is ERK1/2, Pak-1 and p38 MAPK  and --dependent but JNK-independent¿. [Oral Presentation], Induction of apoptosis in 786-0 Renal Cell Carcinoma by Reactive Oxygen Species is ERK1/2, Pak-1 and p38 MAPK  and --dependent but JNK-independent¿, National University of Ireland, Cork, Medical Research Open Day , 01-JAN-04 - 01-JAN-04. [Details]
(2004)¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿,
O. Barry; (2004) ¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿. [Oral Presentation], ¿Targeting oesophageal cancer with siRNA Paks: a possible future therapeutic target?¿, From Bench to Bedside¿ Lecture series, Mercy Hospital Cork, Ireland , 01-JAN-04 - 01-JAN-04. [Details]
(2004)An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿,
O. Barry; (2004) An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿. [Oral Presentation], An investigation of the role(s) of kinases in oesophageal and renal carcinogenesis¿, Cork Cancer Research Open Day, Ireland , 01-JAN-04 - 01-JAN-04. [Details]
(2002)Detection of Bone Marrow Micrometastasis Following Bone Neoadjuvant Chemoradiotherapy In Patients with Esophagogastric Malignancy¿,
O. Barry; (2002) Detection of Bone Marrow Micrometastasis Following Bone Neoadjuvant Chemoradiotherapy In Patients with Esophagogastric Malignancy¿. [Oral Presentation], Detection of Bone Marrow Micrometastasis Following Bone Neoadjuvant Chemoradiotherapy In Patients with Esophagogastric Malignancy¿, AACR American Association for Cancer Research, 93rd Annual Meeting, San Francisco, California , 01-JAN-02 - 01-JAN-02. [Details]
(2001)Deparment of Biochemistry Seminar, Lee Maltings. ¿Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer¿,
O. Barry; (2001) Deparment of Biochemistry Seminar, Lee Maltings. ¿Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer¿. [Oral Presentation], Deparment of Biochemistry Seminar, Lee Maltings. ¿Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer¿, National University of Ireland, Cork , 01-JAN-01 - 01-JAN-01. [Details]
(2001)Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer,
O. Barry; (2001) Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer. [Oral Presentation], Characterisation and Manipulation of Mitogenic Signalling Cascades in Esophagogastric Micrometastatic Cancer, Deparment of Biochemistry Seminar, Lee Maltings, National University of Ireland, Cork , 01-JAN-01 - 01-JAN-01. [Details]
(2001)Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿,
O. Barry; (2001) Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿. [Oral Presentation], Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿, AACR American Association for Cancer Research, 92rd Annual Meeting, San Francisco, California , 01-JAN-01 - 01-JAN-01. [Details]
(2000)¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent,
O. Barry; (2000) ¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent. [Oral Presentation], ¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent, SYNCAN EU Program, ¿00, Florence, Italy , 01-JAN-00 - 01-JAN-00. [Details]
(2000)SYNCAN EU Program, ¿00, Florence, Italy. ¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿,
O. Barry; (2000) SYNCAN EU Program, ¿00, Florence, Italy. ¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿. [Oral Presentation], SYNCAN EU Program, ¿00, Florence, Italy. ¿Constitutive ERK1/2 Activation In Esophagogastric Rib Bone Marrow Micrometastatic Cells is MEK-Independent¿, Florence, Italy , 01-JAN-00 - 01-JAN-00. [Details]
(1998)Signal Transduction and Lipid Second Messenger III, Keystone Symposia. ¿Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿,
O. Barry; (1998) Signal Transduction and Lipid Second Messenger III, Keystone Symposia. ¿Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿. [Oral Presentation], Signal Transduction and Lipid Second Messenger III, Keystone Symposia. ¿Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿, Toas, New Mexico, USA , 01-JAN-98 - 01-JAN-98. [Details]
(1998)Signal Transduction Retreat. ¿Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿,
O. Barry; (1998) Signal Transduction Retreat. ¿Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿. [Oral Presentation], Signal Transduction Retreat. ¿Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿, Philadelphia, USA , 01-JAN-98 - 01-JAN-98. [Details]
(1998)Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿,
O. Barry; (1998) Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿. [Oral Presentation], Signal Transduction Pathways Induced by the Transcellular Delivery of Platelet Microparticle Arachidonic Acid¿, Signal Transduction and Lipid Second Messenger III, Keystone Symposia, Toas, New Mexico, USA , 01-JAN-98 - 01-JAN-98. [Details]
(1998)Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿,
O. Barry; (1998) Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿. [Oral Presentation], Arachidonic Acid in Platelet Microparticles Upregulates Cyclooxygenase-2 Dependent Prostaglandin Formation Via a PKC/MAPK-Dependent Pathway¿, Signal Transduction Retreat, Philadelphia, USA , 01-JAN-98 - 01-JAN-98. [Details]
(1997)Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿,
O. Barry; (1997) Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿. [Oral Presentation], Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿, American Heart Association, Florida, USA , 01-JAN-97 - 01-JAN-97. [Details]
(1997)American Heart Association. ¿Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿,
O. Barry; (1997) American Heart Association. ¿Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿. [Oral Presentation], American Heart Association. ¿Platelet Microparticles Stimulate Adhesion and Migration of Monocytes in a PKC-Dependent Manner¿, Florida, USA , 01-JAN-97 - 01-JAN-97. [Details]
(1997)¿Platelet Microparticles Enhance Adhesive Interactions Between Monocytes and Endothelial Cells,
O. Barry; (1997) ¿Platelet Microparticles Enhance Adhesive Interactions Between Monocytes and Endothelial Cells. [Oral Presentation], ¿Platelet Microparticles Enhance Adhesive Interactions Between Monocytes and Endothelial Cells, Biomedicine ¿97, Washington, DC, USA , 01-JAN-97 - 01-JAN-97. [Details]
(1996)Transcellular Signaling By Platelet Microparticles In Human Endothelial Cells and Platelets¿,
o; (1996) Transcellular Signaling By Platelet Microparticles In Human Endothelial Cells and Platelets¿. [Oral Presentation], Transcellular Signaling By Platelet Microparticles In Human Endothelial Cells and Platelets¿, American Heart Association, New Orleans, USA , 01-JAN-96 - 01-JAN-96. [Details]

Committees

 CommitteeFunctionFrom / To
UCC RPAC Member2021 /
Dental School Teaching and Learning Curriculum Pharmacology and Therapeutics representative2018 /
Pharmacology and Therapeutics Graduate Studies Committee Chair2010 /

Employment

 EmployerPositionFrom / To
University College Cork Lecturer Deparment of Pharmacology and Therapeutics/
National University of Ireland, Cork Post-Doctoral Research Fellow01-DEC-99 / 01-AUG-02
University of Pennsylvania, Philadelphia, PA, USA Post-Doctoral Research Fellow01-MAR-99 / 01-NOV-99
University of Pennsylvania, Philadelphia, PA, USA Pre-Doctoral Research Fellow01-JUN-95 / 01-JAN-99

Education

 YearInstitutionQualificationSubject
1999University Pennsylvania, Philadelphia, USA PHD*
2013UCC Postgrad Dip in Teaching & Learning in HEEducation: Teaching and Learning
2012UCC Postgrad Cert. in Teaching & Learning in HEEducation: Teaching and Learning
2014University College Cork Masters in Teaching and Learning in Higher EducationTeaching & Learning in Higher Education - Third Level
1991National University of Ireland, Cork BSC (HONS)*

Journal Activities

 JournalRoleTo / From
International Journal Of Cancer Peer Reviewer-
European Journal Of Clinical Pharmacology Peer Reviewer-
Journal Of Pharmacy And Pharmacology Peer Reviewer-
Circulation Peer Reviewer-
Cancer Research Peer Reviewer-

Languages

 LanguageReadingWritingSpeaking
Gaeilge FluentFluentBasic
English FluentFluentFluent
Spanish FunctionalFunctionalFunctional

Teaching Activities

Teaching Interests


Undergraduate Teaching:
Module Co-ordinator and Teach:
     PT2201 Principles of Dental Pharmacology
     PT3201 Dental Pharmacology
     PT2101 Chemotherapy and Pharmacology of Inflammation
     PT3005 Chemotherapy and Pharmacology of Inflammation
     RD2001 Periodontology

Contribute to:
     PT2448 Cellular and Molecular Basis of Drug Action and Toxicity
     PT4021 Immunopharmacology and Chemotherapy
     MH3010 Structured Literature Project in Medical and Health Sciences
     MH4010 Research Project in Medical and Health Sciences
     
Postgraduate Teaching: 
GM1001 Fundamentals of Medicine I
GM1002 Fundamentals of Medicine II
GM1003 Fundamentals of Medicine III
PF4016 Pharmacy Research Project
ML6002 Biological and Clinical Perspectives of Human Disease

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2019Kyle Sadik University College CorkMSc Health SciencesA 3D spheroid model for the study of dual cytotoxic-epigenetic drug therapy on oesophageal cancer cell growth.
2020Marie O' Dea University College CorkMSc Health SciencesShort-term cytotoxicity induced by epigenetic drugs in H9c2 cells.
2021Ciara McCarthy University College CorkMSc Health SciencesEthanolamine: a cardioprotectant and chemosensitizer in oesophageal cancer.
2008Monica Ambrose University College CorkPHDInvestigation of Novel Therapeutic Targets for the Treatment of Oesophageal and Renal Cancer.
2015Carol O'Callaghan University College CorkPHDNovel insights into the expression and function of p38delta MAPK in oesophageal squamous cell carcinoma.

Research Information

Internal Collaborators

 NameInstituteCountry
Dr. Sharon McKenna University College CorkIRELAND
Dr. Kellie Dean University College CorkIRELAND

External Collaborators

 NameOrganisation / InstituteCountry
Professor Domenico Pratico Temple UniversityU.S.A.
Professor Marcelo G. Kazanietz University of PennsylvaniaU.S.A.

Contact details

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Department of Pharmacology and Therapeutics

Cógaseolaíocht agus Teiripic

Room 2.36B, 2nd floor floor, T12XF62

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