Ken O'Halloran

Professor & Chair
Physiology
University College Cork
3-079, Western Gateway Building
Western Road
Cork

T: +353-21-4205433
E: k.ohalloran@ucc.ie

Ken D. O'Halloran is a native of Cork city and a graduate of Coláiste Chríost Rí (1988) and University College Cork (1992). After reading Physiology for the BSc (Hons.) degree at UCC he completed his doctoral studies in the laboratory of Professor Aidan Bradford at the Royal College of Surgeons in Ireland (1995). After 5 years as a postdoctoral research fellow in the USA at the University of North Carolina - Chapel Hill (1995-6) and the University of Wisconsin - Madison under the guidance of Professor Jerry Bisgard (1996-2000), Dr. O'Halloran returned to Ireland in 2000 to take a lectureship in Physiology at University College Dublin; he was appointed Senior Lecturer in the School of Medicine and Medical Science at UCD in 2006. He was appointed Professor and Chair of Physiology at University College Cork in 2011.  

Professor O'Halloran is Head of Department of Physiology and Director of UCC's Biological Services Unit encompassing the Science Foundation Ireland-funded National Transgenic & Germ Free Facility. He is a faculty member of the APC Microbiome Institute. He was appointed Research Integrity Officer (2015-2018) by UCC President, Dr. Michael Murphy.

Professor O'Halloran's primary research interest is the control of breathing in health and disease. His research group utilise experimental models of common human respiratory diseases such as COPD and sleep apnoea to explore the physiological and pathophysiological effects of hypoxia on the respiratory system, with a current focus on hypoxic adaptation in respiratory and skeletal muscle. Through collaborative work with scientists and clinicians their aim is to characterise hypoxia-related remodelling in the respiratory control system with a view to gaining a better understanding of mechanisms of adaptation and disease. The experimental models allow an exploration of the efficacy of potential therapeutic interventions that may have application in the treatment of human respiratory diseases. Professor O'Halloran has published more than 110 articles as original research papers, book chapters, invited review articles and editorials in leading peer-reviewed international journals together with more than 160 conference publications. He has been an invited speaker and has organised and chaired symposia at international conferences in Europe, Asia, Australia and North America. 

Professor O'Halloran is Director of the pre-clinical sciences stream in the Medicine programme at UCC, and as head of department he oversees the delivery of the BSc Physiology degree programme, in addition to significant contributions by the department to several other allied health programmes in the College of Medicine & Health. He teaches on the BSc Physiology, BSc Neuroscience, and Medicine programmes at UCC.


Professor O'Halloran is an elected Trustee and Council member of The Physiological Society (UK and Ireland); he was appointed Meetings Secretary (Chair of Meetings Committee) in 2014 and he is a member of The Society's Executive Committee and Publications Committee. He is a member of the international programme committee for the IUPS 2017 meeting in Brazil. He is a member of the American Physiological Society, the International Society for Arterial Chemoreception and the American Thoracic Society serving on the Sleep and Respiratory Neurobiology Program Committee. He is a Fellow of the Royal Academy of Medicine in Ireland and serves on the Academy Executive as General Secretary and Honorary Treasurer. He is an editor of Experimental Physiology, review editor for Frontiers in Physiology, honorary editor of Hypoxia and executive editor of the Irish Journal of Medical Science. He has served as external expert reviewer for national and international research project and programme grant applications (e.g. MRC, EU/ERC). He served as external examiner at Imperial College, London (2010-2013) and Trinity College Dublin (2013-2015). Professor O'Halloran is a consultant to the medical devices industry.

Research Interests

The major focus of our research is cardiorespiratory function in health and disease.


Current projects:

Respiratory control in animal models of sleep-disordered breathing.

Effect of chronic intermittent hypoxia on cardiac contractility in vivo.

Hypoxic adaptation in respiratory muscle (animal and human studies).

Respiratory control and muscle function in the mdx mouse model of Duchenne muscular dystrophy.

Effects of exercise on immune and cognitive function in multiple sclerosis.

Capnography in dental sedation.

Cardiorespiratory control in a rat model of Alzheimer's disease.

Effect of chronic intermittent hypoxia on cardiac calcium regulatory proteins. 

Bugs and breathing: Cardiorespiratory control in animal models of disrupted microbiota.


Animal models of sleep-disordered breathing

Obstructive sleep apnoea (OSA) is a common respiratory disorder associated with significant cardiovascular, metabolic and cognitive dysfunction. OSA is characterised by repeated occlusion of the pharyngeal airway during sleep resulting in periods of obstructed airflow to the lungs (apnoea). As such, OSA patients experience intermittent hypoxia/reoxygenation due to recurrent apnoea. We use translational models to explore the effects of cyclical hypoxia on the cardiovascular and respiratory systems. Our findings highlight that chronic intermittent hypoxia (CIH) has deleterious effects on cardiorespiratory control. CIH causes respiratory muscle weakness and fatigue. Moreover, CIH impairs motor control of respiratory muscles regulating upper airway calibre. In addition, CIH destabilizes ventilatory control giving rise to disordered breathing during sleep. Our work has revealed that CIH alters redox status in muscle and the neural networks controlling them. Studies aimed at identifying the molecular mechanisms driving aberrant remodelling in respiratory control and strategies employed to interrupt or break the cycle of hypoxia-induced impairments will have important implications for the treatment of patients with debilitating respiratory disorders. We have established that CIH-induced dysfunction in the respiratory system is amenable to antioxidant interventions. 


Effect of chronic intermittent hypoxia on respiratory muscle structure and function.

We are examining the effects of episodic hypoxia on respiratory muscle structure and function across the age spectrum. We are testing the efficacy of antioxidant treatments in preventing CIH-induced muscle dysfunction. In collaboration with Vincent Healy (Physiology) we are examining the effect of chronic intermittent hypoxia on muscle NADPH oxidase expression and metabolic enzyme activities.


Respiratory control in an animal model of sleep-disordered breathing.

We are exploring the effects of chronic intermittent hypoxia on breathing and respiratory motor control of the pharyngeal airway.

Effect of chronic intermittent hypoxia on cardiac contractility in vivo.

We have established that CIH increases cardiac output, contributing to elevated blood pressure in the absence of vasomotor effects on the circulation. We are currently exploring the effects of CIH on left ventricular pressure-volume relationships in vivo. Dr. Eric Lucking leads this project.


Hypoxic adaptation in respiratory muscle (animal and human studies).

We have established that chronic sustained hypoxia causes structural and functional remodelling. We are extending this work to further explore the molecular mechanisms that underpin hypoxic adaptation in respiratory muscle. In collaboration with Prof Dave Sheehan (School of Biochemistry and Cell Biology) we are exploring redox proteomics in animal models of hypoxia. We are profiling respiratory muscle proteomes in samples from animal models of chronic sustained and chronic intermittent hypoxia. In collaboration with Mr John Hinchion (cardiothoracic surgeon at Cork University Hospital) we are exploring metabolic enzyme activities and redox remodelling in respiratory and skeletal muscle biopsies from patients undergoing elective thoracic surgery. 


Respiratory control and muscle function in the mdx mouse model of Duchenne muscular dystrophy.

We have recently initiated studies exploring the control of breathing and hypoxic adaptation in respiratory muscles of the mdx mouse. 

Effects of exercise on immune and cognitive function in multiple sclerosis.

In collaboration with Dr Eric Downer (Anatomy & Neuroscience) and Alison Barry (MSc student) together with several clinical colleagues we are examining the effects of a prescribed exercise intervention on immune and cognitive function in MS patients.

Capnography in dental sedation.

Collaboration with Dr Paul Brady (CUH Dental School):  I am academic advisor to Dr Brady and collaborator on this clinical trial assessing the efficacy of capnography versus pulse oximetry during midazolam sedation in patients undergoing elective dental procedures.


Effect of chronic intermittent hypoxia on cardiac calcium regulatory proteins. 

Collaboration with Dr John Mackrill (Physiology) and Ruth Carey (MSc student). 


Cardiorespiratory control in a rat model of Alzheimer's disease.

New collaboration with Dr Mark Rae (Physiology). Respiratory motor control is adversely affected in a number of neurodegenerative conditions with implications for the pathophysiology of the disease and management of patients. 

Bugs and breathing: Cardiorespiratory control in animal models of disrupted microbiota.

New collaboration with Professor John F. Cryan and Karen O'Connor (PhD student). We are keen to explore the potential interplay between respiratory control and the microbiota. Dysregulated breathing, sleep disruption and hypoxia can affect the microbiota. Early life stress impacts both the microbiota and breathing, with correlations suggesting potential interaction. Do disruptions to the microbiota (antibiotics, mode of delivery etc) affect cardiorespiratory control?

Funding:

Projects funded by the Health Research Board, Irish Research Council, Muscular Dystrophy Ireland, and Science Foundation Ireland.
 
 

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
National Transgenic & Germ Free FacilityScience Foundation Ireland01-JAN-1330-JUN-15€1,088,119.00
Respiratory muscle dysfunction following chronic intermittent hypoxiaHealth Research Board01-OCT-0830-SEP-13€235,671.00
Respiratory plasticity in an animal model of sleep-disordered breathingHealth Research Board01-OCT-0830-SEP-11€219,543.00
Vascular reactivity in an animal model of sleep-disordered breathingIrish Research Council01-OCT-1030-SEP-13€72,009.00
Respiratory muscle dysfunction following chronic intermittent hypoxiaIrish Research Council01-OCT-0830-SEP-11€72,009.00
Upper airway function across the age spectrum in a rodent model of sleep-disordered breathingHealth Research Board01-OCT-0630-SEP-09€160,801.00
Oxycycler Environmental Oxygen Control SystemHealth Research Board01-OCT-06€46,643.00
Molecular mechanisms of respiratory muscle adaptation to hypoxiaUCC Strategic Research Fund01-JAN-1331-DEC-13€7,500.00
Establishing a core facility for translational studies of chronic hypoxiaUCC Strategic Research Fund01-OCT-1330-SEP-14€10,878.00
Inflammation in hypoxia-induced exacerbation of respiratory muscle dysfunction in Duchenne Muscular DystrophyOther: Not Listed01-JAN-1431-DEC-14€10,000.00
Does crosstalk between corticotropin-releasing factor and interleukin-6 underlie skeletal and smooth muscle inflammation and dysfunction in the mdx mouse model of Duchenne Muscular Dystrophy?Other: Not Listed01-JAN-1331-DEC-13€10,000.00
Hypoxic adaptation in respiratory muscle (Major & Strategic Initiative Funding, University College Dublin)Other: Not Listed01-JAN-1031-DEC-10€20,000.00
Tissue oxygen monitoring in health and disease (Commercialisation Grant, Seed Funding Programme, University College Dublin)Other: Not Listed01-JAN-1031-DEC-10€12,000.00
UCD School of Medicine & Medical Science Postgraduate Scholarship (awarded to D. Edge)01-OCT-1130-SEP-12€16,000.00
UCD School of Medicine & Medical Science Postgraduate Scholarship (awarded to F. McDonald))€64,000.00
UCD School of Medicine & Medical Science Postgraduate Scholarship (awarded to C. Shortt)01-OCT-0730-SEP-11€64,000.00
UCD Ad Astra PhD scholarship (awarded to J. R. Skelly)01-OCT-0630-SEP-10€64,000.00
School of Medicine & Medical Science Postgraduate Scholarship (awarded to J. Carberry)01-OCT-0630-SEP-10€64,000.00
Measurement of metabolism in small rodents (Seed Funding: Equipment; University College Dublin)Other: Not Listed01-JAN-0831-DEC-08€18,037.00
Does oxidative stress contribute to upper airway dilator muscle dysfunction following chronic intermittent hypoxia?Health Research Board01-OCT-0530-SEP-06€14,888.00
Vascular dysfunction in a rodent model of sleep apnoea01-JAN-0731-DEC-07€6,500.00

Contract Researchers

 Researcher NameProjectRoleFunding Body
Dr. Eric LuckingMechanisms of chronic intermittent hypoxia induced hypertensionPostdoctoral Researcher

Peer Reviewed Journals

YearPublication
(2017)'Sensorimotor control of breathing in the mdx mouse model of Duchenne Muscular Dystrophy'
Burns DP, Roy A, Lucking EF, McDonald FB, Gray S, Wilson RJA, Edge D, O'Halloran KD (2017) 'Sensorimotor control of breathing in the mdx mouse model of Duchenne Muscular Dystrophy'. Journal of Physiology, [Details]
(2017)'Respiratory muscle dysfunction in animal models of hypoxic disease: Antioxidant therapy goes from strength to strength'
O'Halloran KD, Lewis P (2017) 'Respiratory muscle dysfunction in animal models of hypoxic disease: Antioxidant therapy goes from strength to strength'. Hypoxia, [Details]
(2017)'Restoration of pharyngeal dilator muscle force in mdx mice following co-treatment with neutralising IL-6 receptor antibodies and Urocortin-2'
David P Burns, Jane Rowland, Leonie Canavan, Kevin Murphy, Molly Brannock, Dervla O'Malley, Ken D O'Halloran, and Deirdre Edge (2017) 'Restoration of pharyngeal dilator muscle force in mdx mice following co-treatment with neutralising IL-6 receptor antibodies and Urocortin-2'. Experimental Physiology, [Details]
(2017)'High adventure shunts old notions of pulmonary vascular control during hypoxic exercise: contrasting views that might just burst your bubble!'
O'Halloran KD (2017) 'High adventure shunts old notions of pulmonary vascular control during hypoxic exercise: contrasting views that might just burst your bubble!'. Experimental Physiology, 102 (6):617-618 [Details]
(2017)'Squamous papilloma causing airway obstruction during conscious sedation'
Brady P, McCreary C, Gallagher C, O'Halloran KD (2017) 'Squamous papilloma causing airway obstruction during conscious sedation'. Anesthesia progress, [Details]
(2017)'Combined xIL-6R and urocortin-2 treatment restores mdx diaphragm muscle force'
Manning J, Buckley MM, O'Halloran KD, O'Malley D (2017) 'Combined xIL-6R and urocortin-2 treatment restores mdx diaphragm muscle force'. Muscle & Nerve, [Details]
(2017)'A randomized control trial of end-tidal carbon dioxide monitoring of preterm infants in the delivery room'
Hawkes GA, Finn D, Kenosi M, Livingstone V, O'Toole JM, Boylan GB, O'Halloran KD, Ryan AC, Dempsey EM. (2017) 'A randomized control trial of end-tidal carbon dioxide monitoring of preterm infants in the delivery room'. Journal of Pediatrics, 182 :74-78.e2 Globe icon [DOI] [Details]
(2016)'Diaphragm muscle adaptation to sustained hypoxia: lessons from animal models with relevance to high altitude and chronic respiratory diseases'
Lewis, Philip; O'Halloran Ken D. (2016) 'Diaphragm muscle adaptation to sustained hypoxia: lessons from animal models with relevance to high altitude and chronic respiratory diseases'. Frontiers in Physiology, 7 [DOI] [CORA Link] [Details]
(2016)'Sex, stress and sleep apnoea: decreased susceptibility to upper airway muscle dysfunction following intermittent hypoxia in females'
O’Halloran, Ken D.; Lewis, Philip; McDonald, Fiona (2016) 'Sex, stress and sleep apnoea: decreased susceptibility to upper airway muscle dysfunction following intermittent hypoxia in females'. Respiratory Physiology & Neurobiology, :1-7 Globe icon [DOI] [CORA Link] [Details]
(2016)'The health of physiology: a perspective'
O'Halloran KD (2016) 'The health of physiology: a perspective'. Physiological Mini Reviews, 9 (6):50-59 [Details]
(2016)'Measure what is measurable: IJMS comes of age as the baton changes hands'
O'Halloran KD (2016) 'Measure what is measurable: IJMS comes of age as the baton changes hands'. Irish Journal of Medical Science, 185 (4):769-769 [Details]
(2016)'Physiology in fine fettle in the fair city'
O'Halloran KD (2016) 'Physiology in fine fettle in the fair city'. Irish Journal of Medical Science, [Details]
(2016)'Capnography monitoring during dental conscious sedation'
Brady P, Gallagher C, McCarthy C, O'Halloran K, McGreary C, Ioham G. (2016) 'Capnography monitoring during dental conscious sedation'. Oral Surgery, [Details]
(2016)'A paradigm shift in oxygen sensing with a twist in the tale!'
O'Halloran, Ken D. (2016) 'A paradigm shift in oxygen sensing with a twist in the tale!'. Biochemical Journal, :2687-2689 [DOI] [CORA Link] [Details]
(2016)'Counter-regulatory control of homeostasis during hypoglycaemia: adrenaline hits the sweet spot in the controversy concerning carotid body glucose sensing'
O'Halloran KD (2016) 'Counter-regulatory control of homeostasis during hypoglycaemia: adrenaline hits the sweet spot in the controversy concerning carotid body glucose sensing'. The Journal of Physiology, 594 :4091-4092 [Details]
(2016)'Effects of gestational and postnatal exposure to chronic intermittent hypoxia on diaphragm muscle contractile function in the rat'
McDonald, Fiona B.; Dempsey, Eugene M.; O'Halloran Ken D. (2016) 'Effects of gestational and postnatal exposure to chronic intermittent hypoxia on diaphragm muscle contractile function in the rat'. Frontiers in Physiology, 7 [DOI] [CORA Link] [Details]
(2016)'Sex differences in murine sternohyoid muscle tolerance of acute severe hypoxic stress'
Lewis P, O'Halloran KD (2016) 'Sex differences in murine sternohyoid muscle tolerance of acute severe hypoxic stress'. Physiological Research, [Details]
(2016)'Impact of exercise on innate immunity in multiple sclerosis progression and symptomatology'
Barry, Alison; Cronin, Owen; Ryan, Aisling M; Sweeney, Brian; Yap, Siew M.; O'Toole, Orna; Allen, Andrew P.; Clarke, Gerard; O'Halloran, Ken D.; Downer, Eric J. (2016) 'Impact of exercise on innate immunity in multiple sclerosis progression and symptomatology'. Frontiers in Physiology, 7 [DOI] [CORA Link] [Details]
(2016)'Engineering a solution to explore the cardiorespiratory limits to exercise performance --- take a load off!'
O'Halloran KD (2016) 'Engineering a solution to explore the cardiorespiratory limits to exercise performance --- take a load off!'. Experimental Physiology, 101 :695-696 [Details]
(2016)'Early life exposure to chronic intermittent hypoxia primes increased susceptibility to hypoxia-induced weakness in rat sternohyoid muscle during adulthood'
McDonald Fiona B.; Dempsey Eugene M.; O'Halloran Ken D. (2016) 'Early life exposure to chronic intermittent hypoxia primes increased susceptibility to hypoxia-induced weakness in rat sternohyoid muscle during adulthood'. Frontiers in Physiology, 7 [DOI] [CORA Link] [Details]
(2016)'In vivo neutralisation of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice'
Manning J, Buckley MM, O'Halloran KD, O'Malley D (2016) 'In vivo neutralisation of IL-6 receptors ameliorates gastrointestinal dysfunction in dystrophin-deficient mdx mice'. Neurogastroenterology and Motility, 28 (7):1016-1026 [Details]
(2016)'Tetany during intravenous conscious sedation in dentistry resulting from hyperventilation-induced hypocapnia'
McCarthy C, Brady P, O'Halloran KD, McCreary C (2016) 'Tetany during intravenous conscious sedation in dentistry resulting from hyperventilation-induced hypocapnia'. Anesthesia progress, 63 :25-30 [Details]
(2016)'Blast from the past! Phrenic motor memory of antecedent episodic hypercapnia is serotonin dependent: Relevance to respiratory rehabilitation and sleep-disordered breathing?'
O'Halloran KD (2016) 'Blast from the past! Phrenic motor memory of antecedent episodic hypercapnia is serotonin dependent: Relevance to respiratory rehabilitation and sleep-disordered breathing?'. Experimental Physiology, 101 (2):258-259 [Details]
(2016)'Evidence of hypoxic tolerance in weak upper airway muscle from young mdx mice'
Burns DP, O'Halloran KD (2016) 'Evidence of hypoxic tolerance in weak upper airway muscle from young mdx mice'. Respiratory Physiology & Neurobiology, 226 :68-75 [Details]
(2016)'Redox remodeling is pivotal in murine diaphragm muscle adaptation to chronic sustained hypoxia'
Lewis P, Sheehan D, Soares R, Varela Coelho A, O'Halloran KD (2016) 'Redox remodeling is pivotal in murine diaphragm muscle adaptation to chronic sustained hypoxia'. American Journal of Respiratory Cell and Molecular Biology, 55 :12-23 [Details]
(2016)'Diaphragm muscle weakness and increased UCP-3 gene expression following acute hypoxic stress in the mouse'
O'Leary AJ, O'Halloran KD (2016) 'Diaphragm muscle weakness and increased UCP-3 gene expression following acute hypoxic stress in the mouse'. Respiratory Physiology & Neurobiology, 226 :76-80 [Details]
(2016)'Chronic intermittent hypoxia creates the perfect storm with calamitous consequences for respiratory control'
O'Halloran KD (2016) 'Chronic intermittent hypoxia creates the perfect storm with calamitous consequences for respiratory control'. Respiratory Physiology & Neurobiology, 226 :63-67 [Details]
(2016)'Delivery room end tidal CO2 monitoring in preterm infants less than 32 weeks'
Hawkes GA, Kenosi M, Finn D, O'Toole JM, O'Halloran KD, Boylan GB, Ryan AC, Dempsey EM (2016) 'Delivery room end tidal CO2 monitoring in preterm infants less than 32 weeks'. Archives Of Disease In Childhood-Fetal And Neonatal Editionarchives Of Disease In Childhood-Fetal And Neonatal Edition, 101 (1):F62-F65 [Details]
(2015)'Playing your heart out'
O'Halloran KD (2015) 'Playing your heart out'. Irish Journal of Medical Science, 184 :725-726 [Details]
(2015)'Effects of fractional inspired oxygen on cerebral oxygenation in preterm infants following delivery'
Kenosi M, O'Toole JM, Livingstone V, Hawkes GA, Boylan GB, O'Halloran KD, Ryan AC, Dempsey EM (2015) 'Effects of fractional inspired oxygen on cerebral oxygenation in preterm infants following delivery'. Journal of Pediatrics, 167 (5):1007-1012 [Details]
(2015)'Chronic intermittent hypoxia blunts the expression of ventilatory long term facilitation in sleeping rats'
Edge D, O'Halloran KD (2015) 'Chronic intermittent hypoxia blunts the expression of ventilatory long term facilitation in sleeping rats'. Advances In Experimental Medicine and Biology, 860 :35-42 [Details]
(2015)'Respiratory control in the mdx mouse model of Duchenne muscular dystrophy'
Burns DP, Edge D, O'Malley D, O'Halloran KD (2015) 'Respiratory control in the mdx mouse model of Duchenne muscular dystrophy'. Advances In Experimental Medicine and Biology, 860 :239-244 [Details]
(2015)'Piling on the pressure to combat acute respiratory distress syndrome: A PEEP into the future?'
O'Halloran KD (2015) 'Piling on the pressure to combat acute respiratory distress syndrome: A PEEP into the future?'. Experimental Physiology, [Details]
(2015)'Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood'
Golubeva AV, Crampton S, Desbonnet L, Edge D, O’Sullivan O, Lomasney KW, Zhdanov AV, Crispie F, Moloney RD, Borre YE, Cotter PD, Hyland NP, O'Halloran KD,Dinan TG, O'Keeffe GW, Cryan JF (2015) 'Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood'. Psychoneuroendocrinology, 60 :58-74 [Details]
(2015)'Commentaries on Viewpoint: Precedence and autocracy in breathing control'
O'Halloran KD (2015) 'Commentaries on Viewpoint: Precedence and autocracy in breathing control'. Journal of Applied Physiology, 118 :1557-1559 [Details]
(2015)'Early life exposure to chronic intermittent hypoxia causes upper airway dilator muscle weakness which persists into young adulthood'
McDonald FB, Williams R, Sheehan D, O'Halloran KD (2015) 'Early life exposure to chronic intermittent hypoxia causes upper airway dilator muscle weakness which persists into young adulthood'. Experimental Physiology, [Details]
(2015)'Improved tolerance of acute severe hypoxic stress in chronic hypoxic diaphragm is nitric oxide dependent'
Lewis P, McMorrow C, Bradford A, O'Halloran KD (2015) 'Improved tolerance of acute severe hypoxic stress in chronic hypoxic diaphragm is nitric oxide dependent'. Journal of Physiological Sciences, [Details]
(2015)'Chronic sustained hypoxia-induced redox remodeling causes contractile dysfunction in mouse sternohyoid muscle'
Lewis, Philip; Sheehan, David; Soares, Renata; Coelho, Ana Varela; O'Halloran, Ken D. (2015) 'Chronic sustained hypoxia-induced redox remodeling causes contractile dysfunction in mouse sternohyoid muscle'. Frontiers in Physiology, 6 (122) [DOI] [CORA Link] [Details]
(2015)'Chronic intermittent hypoxia orchestrates cardiorespiratory cacophony - adapting melody to malady'
O'Halloran KD (2015) 'Chronic intermittent hypoxia orchestrates cardiorespiratory cacophony - adapting melody to malady'. Experimental Physiology, 100 :227-228 (Editorial) [Details]
(2015)'Chronic intermittent hypoxia increases rat sternohyoid muscle NADPH oxidase expression with attendant modest oxidative stress'
Williams, Robert; Lemaire, Paul; Lewis, Philip; McDonald, Fiona B.; Lucking, Eric; Hogan, Sean; Sheehan, David; Healy, Vincent; O'Halloran Ken D. (2015) 'Chronic intermittent hypoxia increases rat sternohyoid muscle NADPH oxidase expression with attendant modest oxidative stress'. Frontiers in Physiology, 6 [DOI] [CORA Link] [Details]
(2014)'Getting jittery about the mechanism of hypertension in sleep apnoea'
O'Halloran KD (2014) 'Getting jittery about the mechanism of hypertension in sleep apnoea'. Experimental Physiology, 99 :1283-1284 (Editorial) [Details]
(2014)'Modulation of enteric neurons by Interleukin‐6 and CRF contributes to visceral hypersensitivity and altered colonic motility in a rat model of Irritable Bowel Syndrome'
Buckley MM, O'Halloran KD, Rae MG, Dinan TG, and O'Malley D (2014) 'Modulation of enteric neurons by Interleukin‐6 and CRF contributes to visceral hypersensitivity and altered colonic motility in a rat model of Irritable Bowel Syndrome'. Journal of Physiology, 592 :5235-5250 [Details]
(2014)'Increased cardiac output contributes to the development of chronic intermittent hypoxia induced hypertension'
Lucking EF, O'Halloran KD, Jones JF (2014) 'Increased cardiac output contributes to the development of chronic intermittent hypoxia induced hypertension'. Experimental Physiology, 99 :1312-1324 [Details]
(2014)'Effect of chronic intermittent hypoxia on the reflex recruitment of the genioglossus during airway obstruction in the anaesthetized rat'
Edge D, McDonald FB, Jones JFX, Bradford A, O'Halloran KD (2014) 'Effect of chronic intermittent hypoxia on the reflex recruitment of the genioglossus during airway obstruction in the anaesthetized rat'. Progress In Brain Research, 209 :147-168 [Details]
(2014)'Chronic nitric oxide synthase inhibition does not impair upper airway muscle adaptation to chronic intermittent hypoxia in the rat'
McDonald FB, Edge D, O'Halloran KD (2014) 'Chronic nitric oxide synthase inhibition does not impair upper airway muscle adaptation to chronic intermittent hypoxia in the rat'. Progress In Brain Research, 212 :237-251 [Details]
(2014)'Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus'
Wall A, Corcoran AE, O'Halloran KD, O'Connor JJ (2014) 'Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus'. Neurobiology of Disease, 62C :8-17 [Details]
(2014)'Sweet success should set tongues wagging: A portrait of airway muscle injury in sleep apnea'
O'Halloran KD (2014) 'Sweet success should set tongues wagging: A portrait of airway muscle injury in sleep apnea'. American Journal of Respiratory and Critical Care Medicine, (189):1299-1300 (Editorial) [Details]
(2014)'Reactive oxygen species mediated diaphragm fatigue in a rat model of chronic intermittent hypoxia'
Shortt CM, Fredsted F, Chow HB, Williams R, Skelly JR, Edge D, Bradford A, O'Halloran KD (2014) 'Reactive oxygen species mediated diaphragm fatigue in a rat model of chronic intermittent hypoxia'. Experimental Physiology, 99 :688-700 [Details]
(2014)'The β2 adrenoceptor agonist terbutaline recovers pharyngeal dilator muscle force decline during severe hypoxia'
McDonald FB, Skelly JR, O'Halloran KD (2014) 'The β2 adrenoceptor agonist terbutaline recovers pharyngeal dilator muscle force decline during severe hypoxia'. Oral Diseases, doi: 10.1111/odi.12247 ([Epub ahead of print) [Details]
(2014)'Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development'
Carberry J, McMorrow C, Bradford A, Jones JFX, O'Halloran KD (2014) 'Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development'. The European Respiratory Journal, 43 :1149-1158 [Details]
(2013)'Obstructive sleep apnoea, intermittent hypoxia, and respiratory muscle structure and function'
Bradford A and O'Halloran KD (2013) 'Obstructive sleep apnoea, intermittent hypoxia, and respiratory muscle structure and function'. Anatomy & Physiology: Current Research, 3 [DOI] [Details]
(2013)'Diaphragm Muscle Remodelling in a Rat Model of Chronic Intermittent Hypoxia'
Shortt CM, Fredsted A, Bradford A, O'Halloran KD (2013) 'Diaphragm Muscle Remodelling in a Rat Model of Chronic Intermittent Hypoxia'. Journal of Histochemistry & Cytochemistry, 61 :487-499 [Details]
(2013)'Sternohyoid and diaphragm muscle form and function during postnatal development in the rat'
O'Connell RA, Carberry J, O'Halloran KD (2013) 'Sternohyoid and diaphragm muscle form and function during postnatal development in the rat'. Experimental Physiology, 98 (9):1386-1400 [Details]
(2013)'Hydrogen peroxide alters sternohyoid muscle function'
Shortt CM, O'Halloran KD (2013) 'Hydrogen peroxide alters sternohyoid muscle function'. Oral Diseases, 61 :487-499 [DOI] [Details]
(2013)'Upper airway dilator muscle weakness following intermittent and sustained hypoxia in the rat: effects of a superoxide scavenger'
Skelly JR, Rowan SC, Jones JFX, O'Halloran KD (2013) 'Upper airway dilator muscle weakness following intermittent and sustained hypoxia in the rat: effects of a superoxide scavenger'. Physiological Research, 62 :187-196 [Details]
(2012)'Chronic hypobaric hypoxia increases isolated rat fast-twitch and slow-twitch limb muscle force and fatigue'
El-Khoury R, Bradford A, O'Halloran KD (2012) 'Chronic hypobaric hypoxia increases isolated rat fast-twitch and slow-twitch limb muscle force and fatigue'. Physiological Research, 61 :195-201 [Details]
(2012)'Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia'
Skelly JR, Edge D, Shortt CM, Jones JFX, Bradford A, O'Halloran KD. (2012) 'Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia'. American Journal of Respiratory Cell and Molecular Biology, 46 :139-148 [Details]
(2012)'Respiratory control and sternohyoid muscle structure and function in aged male rats: Decreased susceptibility to chronic intermittent hypoxia'
Skelly JR, Edge D, Shortt CM, Jones JFX, Bradford A, O'Halloran KD. (2012) 'Respiratory control and sternohyoid muscle structure and function in aged male rats: Decreased susceptibility to chronic intermittent hypoxia'. Respiratory Physiology & Neurobiology, 180 (2-3):175-182 [Details]
(2012)'Chronic intermittent hypoxia increases apnoea index in sleeping rats'
Edge D, Bradford A, O'Halloran KD (2012) 'Chronic intermittent hypoxia increases apnoea index in sleeping rats'. Advances In Experimental Medicine and Biology, 758 :359-363 [Details]
(2012)'Propranolol does not affect the hindlimb vasodilatation elicited by stimulation of superior laryngeal nerve paraganglia'
O'Connor ET, O'Halloran KD, Jones JFX (2012) 'Propranolol does not affect the hindlimb vasodilatation elicited by stimulation of superior laryngeal nerve paraganglia'. Advances In Experimental Medicine and Biology, 758 :273-277 [Details]
(2012)'Pro-inflammatory cytokines do not affect basal or hypoxia stimulated discharge of rat vagal paraganglia'
O'Connor ET, O'Halloran KD, Jones JFX (2012) 'Pro-inflammatory cytokines do not affect basal or hypoxia stimulated discharge of rat vagal paraganglia'. Experimental Physiology, 97 :1203-1210 [Details]
(2012)'Comparison of the motor discharge to the voluntary sphincters of continence in the rat'
Buffini M, O'Halloran KD, O'Herlihy C, O'Connell PR, Jones JFX (2012) 'Comparison of the motor discharge to the voluntary sphincters of continence in the rat'. Neurogastroenterology and Motility, 24 :e175-184 [Details]
(2012)'Chronic intermittent hypoxia alters genioglossus motor unit discharge patterns in the anaesthetized rat'
Edge D, Bradford A, Jones JFX, O'Halloran KD (2012) 'Chronic intermittent hypoxia alters genioglossus motor unit discharge patterns in the anaesthetized rat'. Advances In Experimental Medicine and Biology, 758 :295-300 [Details]
(2011)'Structural and functional properties of an upper airway dilator muscle in aged obese male rats'
Skelly JR, O'Connell RA, Jones JFX, O'Halloran KD. (2011) 'Structural and functional properties of an upper airway dilator muscle in aged obese male rats'. Respiration, 82 :539-549 [Details]
(2011)'Chronic hypoxia increases rat diaphragm muscle endurance and sodium-potassium ATPase pump content'
McMorrow C, Fredsted A, O'Connell RA, Carberry J, Bradford A, Jones JFX, O'Halloran KD. (2011) 'Chronic hypoxia increases rat diaphragm muscle endurance and sodium-potassium ATPase pump content'. European Respiratory Journal: the offical journal of the European Respiratory Society, 37 :1474-1481 [Details]
(2011)'Double-trouble for respiratory control in Pompe disease'
O'Halloran, Ken D. (2011) 'Double-trouble for respiratory control in Pompe disease'. Frontiers in Physiology, 2 [DOI] [CORA Link] [Details]
(2010)'Superoxide scavengers improve rat pharyngeal dilator muscle performance'
Skelly JR, Bradford A, Jones JFX, O'Halloran KD. (2010) 'Superoxide scavengers improve rat pharyngeal dilator muscle performance'. American Journal of Respiratory Cell and Molecular Biology, 42 :725-731 [Details]
(2010)'Antioxidant treatment does not prevent hypoxia-induced impairment of respiratory muscle function in developing rats'
Carberry J, Bradford A, O'Halloran KD (2010) 'Antioxidant treatment does not prevent hypoxia-induced impairment of respiratory muscle function in developing rats'. Advances in Experimental Medicine and Biology, 669 :263-266 [Details]
(2010)'Comparison of the contractile properties, oxidative capacities and fibre type profiles of the voluntary sphincters of continence in the rat'
Buffini M, O'Halloran KD, O'Herlihy C, O'Connell R, Jones JF. (2010) 'Comparison of the contractile properties, oxidative capacities and fibre type profiles of the voluntary sphincters of continence in the rat'. Journal of Anatomy, 217 :187-195 [Details]
(2010)'Effects of pro-inflammatory cytokines on the discharge rate of vagal nerve paraganglia in the rat'
MacGrory B, O'Connor ET, O'Halloran KD, Jones JFX. (2010) 'Effects of pro-inflammatory cytokines on the discharge rate of vagal nerve paraganglia in the rat'. Respiratory Physiology & Neurobiology, 171 :122-127 [Details]
(2010)'Intermittent hypoxia impairs pharyngeal dilator muscle function in male but not female rats'
Skelly JR, Bradford A, O'Halloran KD. (2010) 'Intermittent hypoxia impairs pharyngeal dilator muscle function in male but not female rats'. Advances In Experimental Medicine and Biology, 669 :285-287 [Details]
(2010)'Respiratory plasticity in the behaving rat following chronic intermittent hypoxia'
Edge D, Skelly JR, Bradford A, O'Halloran KD (2010) 'Respiratory plasticity in the behaving rat following chronic intermittent hypoxia'. Advances in Experimental Medicine and Biology, 669 :267-270 [Details]
(2009)''Ventilatory drive is enhanced in male and female rats following chronic intermittent hypoxia'
Edge D, Skelly JR, Bradford A, O'Halloran KD (2009) ''Ventilatory drive is enhanced in male and female rats following chronic intermittent hypoxia'. Advances in Experimental Medicine and Biology, 648 :337-344 [Details]
(2008)'Upper airway pressure-flow relationships and pharyngeal constrictor EMG activity during prolonged expiration in awake goats'
O'Halloran KD, Bisgard GE. (2008) 'Upper airway pressure-flow relationships and pharyngeal constrictor EMG activity during prolonged expiration in awake goats'. Journal of Applied Physiology, 105 :100-108 [Details]
(2008)'Oxidative stress impairs upper airway muscle endurance in an animal model of sleep-disordered breathing'
Dunleavy M, Bradford A, O'Halloran KD. (2008) 'Oxidative stress impairs upper airway muscle endurance in an animal model of sleep-disordered breathing'. Advances in Experimental Medicine and Biology, 605 :458-462 [Details]
(2007)'Respiratory plasticity after changes in oxygen supply and demand'
Bavis RW, Powell FL, Bradford A, Hsia CCW, Peltonen JE, Soliz J, Zeis B, Fergusson EK, Fu Z, Gassmann M, Kim CB, Maurer J, Miller BM, O'Halloran KD, Paul RJ, Reid SG, Rusko HK, Tikkanen HO, Wilkinson KA. (2007) 'Respiratory plasticity after changes in oxygen supply and demand'. Integrative and Comparative Biology, 47 :532-551 [Details]
(2007)'The pathophysiology of sleep apnoea: what we have learned from animal models of chronic intermittent hypoxia'
O'Halloran KD, Bradford A. (2007) 'The pathophysiology of sleep apnoea: what we have learned from animal models of chronic intermittent hypoxia'. Current Respiratory Medicine Reviews, 3 :19-27 [Details]
(2007)'The effects of breath-holds and Muller manoeuvres on upper airway carbon dioxide concentration in humans'
Raza A, Farrell T, O'Halloran KD, Bradford A. (2007) 'The effects of breath-holds and Muller manoeuvres on upper airway carbon dioxide concentration in humans'. Respiration, 74 :533-536 [Details]
(2006)'Effects of nicotine on rat sternohyoid muscle contractile properties'
O'Halloran KD. (2006) 'Effects of nicotine on rat sternohyoid muscle contractile properties'. Respiratory Physiology & Neurobiology, 150 :200-210 [Details]
(2005)'Does episodic hypoxia affect upper airway dilator muscle function? Implications for the pathophysiology of obstructive sleep apnoea'
Bradford A, McGuire M, O'Halloran KD. (2005) 'Does episodic hypoxia affect upper airway dilator muscle function? Implications for the pathophysiology of obstructive sleep apnoea'. Respiratory Physiology & Neurobiology, 147 :223-234 [Details]
(2003)'Dopaminergic excitation of the goat carotid body is mediated by the serotonin type 3 receptor subtype'
Herman JK, O'Halloran KD, Janssen PL, Bisgard GE. (2003) 'Dopaminergic excitation of the goat carotid body is mediated by the serotonin type 3 receptor subtype'. Respiratory Physiology & Neurobiology, 136 :1-12 [Details]
(2003)'Upper airway EMG responses to acute hypoxia and asphyxia are impaired in streptozotocin-induced diabetic rats'
O'Halloran KD, McGuire M, O'Hare T, MacDermott M, Bradford A. (2003) 'Upper airway EMG responses to acute hypoxia and asphyxia are impaired in streptozotocin-induced diabetic rats'. Respiratory Physiology & Neurobiology, 138 :301-308 [Details]
(2003)'Effects of chronic hypobaric hypoxia on contractile properties of rat sternohyoid and diaphragm muscles'
El-Khoury R, O'Halloran KD, Bradford A. (2003) 'Effects of chronic hypobaric hypoxia on contractile properties of rat sternohyoid and diaphragm muscles'. Clinical and Experimental Pharmacology and Physiology, 30 :551-554 [Details]
(2002)'Chronic intermittent asphyxia impairs rat upper airway muscle responses to acute hypoxia and asphyxia'
O'Halloran KD, McGuire M, O'Hare T, Bradford A. (2002) 'Chronic intermittent asphyxia impairs rat upper airway muscle responses to acute hypoxia and asphyxia'. Chest, 122 :269-275 [Details]
(2001)'Effect of 8-OH DPAT and ketanserin on the ventilatory acclimatization to hypoxia in awake goats'
Herman JK, O'Halloran KD, Bisgard GE. (2001) 'Effect of 8-OH DPAT and ketanserin on the ventilatory acclimatization to hypoxia in awake goats'. Respiratory Physiology & Neurobiology, 124 :95-104 [Details]
(2001)'Activation of medullary post-inspiratory related neurons during clonidine-induced central apnea in anesthetized goats'
O'Halloran KD, Herman JK, Bisgard GE. (2001) 'Activation of medullary post-inspiratory related neurons during clonidine-induced central apnea in anesthetized goats'. Advances in Experimental Medicine and Biology, 499 :75-79 [Details]
(2001)'Pharmacological and immunochemical evidence for dopamine D3 receptors in the goat carotid body'
Wang Z-Y, Herman JK, O'Halloran KD, Keith IM, Bisgard GE. (2001) 'Pharmacological and immunochemical evidence for dopamine D3 receptors in the goat carotid body'. Advances in Experimental Medicine and Biology, 499 :49-53 [Details]
(2001)'Ventilatory effects of alpha2-adrenoceptor blockade in awake goats'
O'Halloran KD, Herman JK, Bisgard GE. (2001) 'Ventilatory effects of alpha2-adrenoceptor blockade in awake goats'. Respiratory Physiology & Neurobiology, 126 :29-41 [Details]
(2001)'Alpha2A-adrenoceptor mediated tachypnea in awake goats'
O'Halloran KD, Herman JK, Bisgard GE. (2001) 'Alpha2A-adrenoceptor mediated tachypnea in awake goats'. Respiratory Physiology & Neurobiology, 125 :169-179 [Details]
(2001)'Sustained moderate hyperoxia augments the acute hypoxic response in awake goats'
Herman JK, O'Halloran KD, Bisgard GE. (2001) 'Sustained moderate hyperoxia augments the acute hypoxic response in awake goats'. Advances in Experimental Medicine and Biology, 499 :325-330 [Details]
(2000)'Clonidine induces upper airway closure in awake goats'
O'Halloran KD, Herman JK, Bisgard GE. (2000) 'Clonidine induces upper airway closure in awake goats'. Respiratory Physiology & Neurobiology, 123 :165-176 [Details]
(2000)'Serotonin and the hypoxic ventilatory response in awake goats'
Herman JK, O'Halloran KD, Bisgard GE. (2000) 'Serotonin and the hypoxic ventilatory response in awake goats'. Advances in Experimental Medicine and Biology, 475 :559-569 [Details]
(2000)'Effects of upper airway carbon dioxide on upper airway resistance and muscle activity in young guinea-pigs'
Curran AK, O'Halloran KD, Bradford A. (2000) 'Effects of upper airway carbon dioxide on upper airway resistance and muscle activity in young guinea-pigs'. European Respiratory Journal: the offical journal of the European Respiratory Society, 15 :902-905 [Details]
(2000)'Dopaminergic excitation in goat carotid body may be mediated by serotonin receptors'
O'Halloran KD, Herman JK, Janssen PL, Bisgard GE. (2000) 'Dopaminergic excitation in goat carotid body may be mediated by serotonin receptors'. Advances in Experimental Medicine and Biology, 475 :581-588 [Details]
(1999)'Respiratory-related pharyngeal constrictor muscle activity in awake goats'
O'Halloran KD, Herman JK, Bisgard GE. (1999) 'Respiratory-related pharyngeal constrictor muscle activity in awake goats'. Respiratory Physiology & Neurobiology, 116 :9-23 [Details]
(1999)'Methysergide augments the acute, but not the sustained, hypoxic ventilatory response in goats'
Herman JK, O'Halloran KD, Bisgard GE. (1999) 'Methysergide augments the acute, but not the sustained, hypoxic ventilatory response in goats'. Respiratory Physiology & Neurobiology, 118 :25-37 [Details]
(1999)'Nonvagal tachypnea following alpha2-adrenoceptor stimulation in awake goats'
O'Halloran KD, Herman JK, Bisgard GE (1999) 'Nonvagal tachypnea following alpha2-adrenoceptor stimulation in awake goats'. Respiratory Physiology & Neurobiology, 118 :15-24 [Details]
(1999)'Differential effects of clonidine on upper airway abductor and adductor muscle activity in awake goats'
O'Halloran KD, Herman JK, Bisgard GE. (1999) 'Differential effects of clonidine on upper airway abductor and adductor muscle activity in awake goats'. Journal of Applied Physiology, 87 :590-597 [Details]
(1998)'Inhibitory dopaminergic mechanisms are functional in peripherally chemodenervated goats'
O'Halloran KD, Janssen PL, Bisgard GE. (1998) 'Inhibitory dopaminergic mechanisms are functional in peripherally chemodenervated goats'. Advances in Experimental Medicine and Biology, 450 :7-15 [Details]
(1998)'Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats'
Janssen PL, O'Halloran KD, Pizarro J, Dwinell MR, Bisgard GE. (1998) 'Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats'. Respiratory Physiology & Neurobiology, 111 :25-32 [Details]
(1998)'Dopaminergic modulation of respiratory motor output in peripherally chemodenervated goats'
O'Halloran KD, Janssen PL, Bisgard GE. (1998) 'Dopaminergic modulation of respiratory motor output in peripherally chemodenervated goats'. Journal of Applied Physiology, 85 :946-954 [Details]
(1998)'Upper airway cooling reduces upper airway resistance in anaesthetized young guinea-pigs'
Curran AK, O'Halloran KD, Bradford A. (1998) 'Upper airway cooling reduces upper airway resistance in anaesthetized young guinea-pigs'. European Respiratory Journal: the offical journal of the European Respiratory Society, 11 :1257-1262 [Details]
(1998)'Influence of cervical sympathetic nerves on ventilation and upper airway resistance in the rat'
O'Halloran KD, Curran AK, Bradford A. (1998) 'Influence of cervical sympathetic nerves on ventilation and upper airway resistance in the rat'. European Respiratory Journal: the offical journal of the European Respiratory Society, 12 :177-184 [Details]
(1997)'Effects of partial nerve injury on the responses of C-fiber polymodal nociceptors to adrenergic agonists'
O'Halloran KD, Perl ER. (1997) 'Effects of partial nerve injury on the responses of C-fiber polymodal nociceptors to adrenergic agonists'. Brain Research, 759 :233-240 [Details]
(1996)'Ventilatory and upper airway muscle responses to upper airway CO2 in anaesthetized neonatal guinea-pigs'
Curran AK, O'Halloran KD, Bradford A. (1996) 'Ventilatory and upper airway muscle responses to upper airway CO2 in anaesthetized neonatal guinea-pigs'. Advances in Experimental Medicine and Biology, 410 :449-453 [Details]
(1996)'Effect of upper airway cooling and CO2 on diaphragm and geniohyoid muscle activity in the rat'
O'Halloran KD, Curran AK, Bradford A (1996) 'Effect of upper airway cooling and CO2 on diaphragm and geniohyoid muscle activity in the rat'. The European Respiratory Journal, 9 :2323-2327 [Details]
(1996)'The effect of sympathetic nerve stimulation on ventilation and upper airway resistance in the anaesthetized rat'
O'Halloran KD, Curran AK, Bradford A. (1996) 'The effect of sympathetic nerve stimulation on ventilation and upper airway resistance in the anaesthetized rat'. Advances in Experimental Medicine and Biology, 410 :443-447 [Details]
(1996)'Effect of almitrine on ventilation and on diaphragm and geniohyoid muscle activity in the rat'
O'Halloran KD, Curran AK, Bradford A. (1996) 'Effect of almitrine on ventilation and on diaphragm and geniohyoid muscle activity in the rat'. Clinical Science, 91 :337-345 [Details]
(1995)'Effects of superior laryngeal nerve section on ventilation in neonatal guinea-pigs'
Curran AK, O'Halloran KD, Bradford A. (1995) 'Effects of superior laryngeal nerve section on ventilation in neonatal guinea-pigs'. Respiratory Physiology & Neurobiology, 101 :23-29 [Details]
(1994)'The effects of laryngeal CO2 and cooling on ventilation and laryngeal resistance in the anaesthetized rat'
O'Halloran KD, Curran AK, Bradford A. (1994) 'The effects of laryngeal CO2 and cooling on ventilation and laryngeal resistance in the anaesthetized rat'. Advances in Experimental Medicine and Biology, 360 :389-391 [Details]
(1994)'The effects of airway CO2 and cooling on ventilation and upper airway resistance in anaesthetized rats'
Curran AK, O'Halloran KD, Bradford A. (1994) 'The effects of airway CO2 and cooling on ventilation and upper airway resistance in anaesthetized rats'. Advances in Experimental Medicine and Biology, 360 :393-395 [Details]
(1994)'Ventilatory and upper airway resistance responses to upper-airway cooling and CO2 in anaesthetised rats'
O'Halloran KD, Curran AK, Bradford A. (1994) 'Ventilatory and upper airway resistance responses to upper-airway cooling and CO2 in anaesthetised rats'. Pflugers Archives : European journal of physiology, 429 :262-266 [Details]

Book Chapters

YearPublication
(2009)'Effects of intermittent hypoxia on pulmonary arterial pressure and right ventricular mass'
Bradford A, O'Halloran KD. (2009) 'Effects of intermittent hypoxia on pulmonary arterial pressure and right ventricular mass' In: Intermittent hypoxia: From molecular mechanisms to clinical applications. New York: Nova Science. [Details]
(2009)'Upper airway dysfunction following chronic intermittent hypoxia - implications for the pathophysiology of sleep-disordered breathing'
O'Halloran KD (2009) 'Upper airway dysfunction following chronic intermittent hypoxia - implications for the pathophysiology of sleep-disordered breathing' In: Intermittent hypoxia: From molecular mechanisms to clinical applications. New York: Nova Science. [Details]
(2007)'Tempol increases rat upper airway muscle force'
Skelly JR, Bradford A, O'Halloran KD. (2007) 'Tempol increases rat upper airway muscle force' In: Proceedings of the Joint Meeting of the Slovak Physiological Society, the Physiological Society and the Federation of European Physiological Sciences. Italy: Medimond S.r.l. [Details]
(2007)'Respiratory plasticity following chronic intermittent hypercapnic hypoxia in conscious rats'
O'Halloran KD, McGuire M, Bradford A. (2007) 'Respiratory plasticity following chronic intermittent hypercapnic hypoxia in conscious rats' In: Proceedings of the Joint Meeting of the Slovak Physiological Society, the Physiological Society and the Federation of European Physiological Sciences. Italy: Medimond S.r.l. [Details]
(2007)'Effects of chronic hypobaric hypoxia on rat diaphragm muscle contractile properties'
McMorrow C, Bradford A, O'Halloran KD. (2007) 'Effects of chronic hypobaric hypoxia on rat diaphragm muscle contractile properties' In: Proceedings of the Joint Meeting of the Slovak Physiological Society, the Physiological Society and the Federation of European Physiological Sciences. Italy: Medimond S.r.l. [Details]
(2005)'Intermittent airway occlusion increases serum [K+] and the incidence of cardiac arrhythmias in anaesthetized rats'
Dunleavy M, Lane D, O'Halloran KD, Bradford A. (2005) 'Intermittent airway occlusion increases serum [K+] and the incidence of cardiac arrhythmias in anaesthetized rats' In: Proceedings of the 2nd Interim Congress of the World Federation of Sleep Research and Sleep Medicine Societies. Bologna, Italy: Medimond S.r.l. [Details]

Conference Publications

YearPublication
(2015)Royal Academy of Medicine in Ireland Section of Biomedical Sciences Annual Meeting
O’Connor KM, Lewis P, O’Leary AJ, NiHici T, Mayooran N, Hinchion J, O’Halloran KD (2015) OXIDATIVE ENZYME ACTIVITY IN RESPIRATORY AND NON-RESPIRATORY MUSCLE OF HYPOXIC MICE AND HUMAN RESPIRATORY PATIENTS Royal Academy of Medicine in Ireland Section of Biomedical Sciences Annual Meeting [Details]
(2015)Royal Academy of Medicine in Ireland Sectíon of Biomedical Sciences Annual Meeting
Barry A, Cronin O, Allen AP, Clarke G, O’Toole O, Yap S-M, Sweeney B, Ryan AM, O’ Halloran KD, Downer EJ (2015) EFFECT OF AEROBIC EXERCISE ON COGNITION AND QUALITY OF LIFE IN MULTIPLE SCLEROSIS Royal Academy of Medicine in Ireland Sectíon of Biomedical Sciences Annual Meeting [Details]
(2015)Royal Academy of Medicine in Ireland Sectíon of Biomedical Sciences Annual Meeting
Carey R., Lai F.A., Lucking E.F., O'Halloran K.D., Mackrill J.J. (2015) Investigation of alterations in cardiac muscle excitation-contraction coupling proteins in a rodent model of chronic intermittent hypoxia Royal Academy of Medicine in Ireland Sectíon of Biomedical Sciences Annual Meeting [Details]
(2015)Royal Academy of Medicine in Ireland Section of Biomedical Sciences Annual
Casey E, O'Halloran KD, Edge D (2015) The effects of upper airway obstruction on sternohyoid muscle PO2 in the anaesthetised rat Royal Academy of Medicine in Ireland Section of Biomedical Sciences Annual [Details]
(2015)Royal Academy of Medicine in Ireland Sectíon of Biomedical Sciences Annual Meeting
A.J. O'Leary, K.D. O'Halloran (2015) Respiratory muscle remodelling following acute sustained hypoxic stress in the mouse Royal Academy of Medicine in Ireland Sectíon of Biomedical Sciences Annual Meeting [Details]
(2015)Royal Academy of Medicine in Ireland Sectíon of Biomedical Sciences Annual Meeting
Ali I, Burns D, Lewis P, O'Malley D, O'Halloran KD (2015) THE SUPEROXIDE SCAVENGER TEMPOL DOES NOT IMPROVE DIAPHRAGM MUSCLE WEAKNESS IN THE MDX MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY Royal Academy of Medicine in Ireland Sectíon of Biomedical Sciences Annual Meeting [Details]
(2015)Experimental Biology (Boston, USA)
Burns DP, Manning J, O'Malley D, O'Halloran KD (2015) Respiratory function in the mdx mouse model of Duchenne muscular dystrophy: role of hypoxia, stress and immune factors Experimental Biology (Boston, USA) [Details]
(2015)Experimental Biology (Boston, USA)
O'Halloran KD, Sheehan D, Lewis P (2015) Redox remodelling in diaphragm muscle adaptation to chronic sustained hypoxia Experimental Biology (Boston, USA) [Details]
(2015)International Hypoxia Symposium (Lake Louise, Canada)
O'Leary AJ, O'Halloran KD (2015) Respiratory muscle weakness following acute sustained hypoxic stress in the mouse International Hypoxia Symposium (Lake Louise, Canada) [Details]
(2015)International Hypoxia Symposium (Lake Louise, Canada)
Lewis P, Sheehan D, O'Halloran KD (2015) Redox-dependent metabolic and functional remodelling in mouse diaphragm following chronic sustained hypoxia International Hypoxia Symposium (Lake Louise, Canada) [Details]
(2014)Oxford Conference on the Control of Breathing (Sydney, Australia)
O'Halloran KD, Bradford A (2014) Chronic intermittent hypoxia - the perfect storm for respiratory control Oxford Conference on the Control of Breathing (Sydney, Australia) [Details]
(2014)Oxford Conference on the Control of Breathing (Sydney, Australia)
Edge D, Jones JF, Bradford A, O'Halloran KD (2014) Sternohyoid motor unit properties and recruitment during airway obstruction in the anaesthetised rat: effects of chronic intermittent hypoxia Oxford Conference on the Control of Breathing (Sydney, Australia) [Details]
(2014)Oxford Conference on the Control of Breathing (Sydney, Australia)
Burns D, O'Leary AJ, O'Malley D, O'Halloran KD (2014) Effects of acute sustained hypoxic stress on sternohyoid and diaphragm muscle function in the mdx mouse model of Duchenne muscular dystrophy Oxford Conference on the Control of Breathing (Sydney, Australia) [Details]
(2014)Oxford Conference on the Control of Breathing (Sydney, Australia)
O'Leary AJ, O'Halloran KD (2014) Differential sarcoplasmic reticilum gene expression in mouse respiratory and limb muscle following exposure to acute sustained hypoxia Oxford Conference on the Control of Breathing (Sydney, Australia) [Details]
(2014)International Society for Arterial Chemoreception (Leeds, UK)
Burns D, Edge D, O'Halloran KD (2014) Respiratory control in the mdx mouse model of Duchenne muscular dystrophy International Society for Arterial Chemoreception (Leeds, UK) [Details]
(2014)International Society for Arterial Chemoreception (Leeds, UK)
Edge D, O'Halloran KD (2014) Chronic intermittent hypoxia blunts the expression of ventilatory long term facilitation in sleeping rats International Society for Arterial Chemoreception (Leeds, UK) [Details]
(2014)Physiological Society Annual Meeting, London, July 2014. Proc Physiol Soc 31 (2014)
Lewis P, Sheehan D, O'Halloran KD (2014) Chronic sustained hypoxia induces temporal redox and metabolic remodelling and atrophy signalling in mouse diaphragm muscle Physiological Society Annual Meeting, London, July 2014. Proc Physiol Soc 31 (2014) [Details]
(2014)Royal Academy of Medicine in Ireland Annual Meeting, Dublin, July 2014
Higgins J, Gallagher C, O'Halloran KD (2014) Effects of postural and exercise challenges on heart rate variability in trained and untrained healthy male and female volunteers Royal Academy of Medicine in Ireland Annual Meeting, Dublin, July 2014 [Details]
(2014)Royal Academy of Medicine in Ireland Annual Meeting, Dublin, July 2014
O'Leary AJ, O'Halloran KD (2014) Transcriptional responses of the mouse diaphragm to acute sustained hypoxic stress Royal Academy of Medicine in Ireland Annual Meeting, Dublin, July 2014 [Details]
(2014)Royal Academy of Medicine in Ireland Annual Meeting, Dublin, July 2014
Lemaire P, Lewis P, O'Halloran KD (2014) Effects of chronic intermittent hypoxia on rat respiratory muscle metabolic and antioxidant enzyme activities Royal Academy of Medicine in Ireland Annual Meeting, Dublin, July 2014 [Details]
(2013)Sleep & Breathing (Montreal, Canada)
McDonald F, O'Halloran KD (2013) Developmental programming of rat upper airway muscle function by chronic intermittent hypoxia is long-lasting and sex-dependent Sleep & Breathing (Montreal, Canada) [Details]
(2013)Sleep & Breathing (Montreal, Canada)
Shortt CM, Bradford A, O'Halloran KD (2013) Diaphragm fatigue in a rat model of chronic intermittent hypoxia: Protective effects of antioxidant supplementation Sleep & Breathing (Montreal, Canada) [Details]
(2013)Sleep & Breathing (Montreal, Canada)
Lewis P, Sheehan D, O'Halloran KD (2013) Oxidative stress in murine respiratory muscle following chronic sustained hypoxia: a redox proteomics approach Sleep & Breathing (Montreal, Canada) [Details]
(2013)Sleep & Breathing (Montreal, Canada)
Williams R, Lewis P, Hogan S, Healy V, O'Halloran KD (2013) NADPH oxidase inhibits rat sternohyoid muscle performance and expression is increased following chronic intermittent hypoxia Sleep & Breathing (Montreal, Canada) [Details]
(2013)ECNP Workshop
Golubeva AV, Crampton S, Desbonnet L, Edge D, Lomasney KW, Hyland NP, O'Halloran KD, Dinan TG, O'Keeffe GW, Cryan JF (2013) Differential negative impact of prenatal stress on physiological systems in adulthood ECNP Workshop [Details]
(2013)Neuroscience Ireland
O'Driscoll DJ, O'Shea ER, Edge D, O'Halloran KD, O'Keeffe GW (2013) Ventilatory pattern of an immature rat model of hypoxic ischemic encephalopathy Neuroscience Ireland [Details]
(2013)International Hypoxia Symposia (Lake Louise, Canada)
Williams R, Healy V, O'Halloran KD (2013) Chronic intermittent hypoxia increases NADPH oxidase expression in rat sternohyoid International Hypoxia Symposia (Lake Louise, Canada) [Details]
(2013)International Hypoxia Symposia (Lake Louise, Canada)
Lucking E, O'Halloran KD, Jones JFX (2013) Chronic intermittent hypoxia induces systemic hypertension through increased cardiac output, not increased peripheral vascular resistance International Hypoxia Symposia (Lake Louise, Canada) [Details]
(2013)International Hypoxia Symposia (Lake Louise, Canada)
Lewis P, Sheehan D, O'Halloran KD (2013) Chronic hypoxia induces differential time-dependent and muscle-specific oxidative changes to the skeletal muscle proteome International Hypoxia Symposia (Lake Louise, Canada) [Details]
(2013)International Union of Physiological Sciences (Birmingham, UK)
Lucking E, O'Halloran KD, Jones JFX (2013) The lumbar sympathetic nervous sytem does not contribute to chronic intermittent hypoxia induced hypertension International Union of Physiological Sciences (Birmingham, UK) [Details]
(2013)International Union of Physiological Sciences (Birmingham, UK)
McDonald F, O'Halloran KD (2013) Neonatal conditioning of rat upper airway dilator muscle by chronic intermittent hypoxia International Union of Physiological Sciences (Birmingham, UK) [Details]
(2013)Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting (Cork)
Williams R, Lucking E, Sheehan D, Healy V, O'Halloran KD (2013) Chronic intermittent hypoxia increases NADPH oxidase subunit expression in rat sternohyoid muscle Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting (Cork) [Details]
(2013)Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting (Cork)
Lewis P, Sheehan D, O'Halloran KD (2013) Investigating the molecular mechanisms that underpin mouse respiratory muscle adaptation to chronic hypoxia: a redox proteomics approach Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting (Cork) [Details]
(2013)Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting (Cork)
Burns D, Lewis P, O'Halloran KD (2013) Xanthine oxidase inhibition improves rat pharyngeal dilator muscle function in vitro Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting (Cork) [Details]
(2013)Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting (Cork)
Corcoran M, Bradley J, Woods T, O'Halloran KD (2013) An investigation of the effect of green tea extract (camellia sinensis) supplementation on fat metabolism in exercising humans Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting (Cork) [Details]
(2013)Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting (Cork)
Williams R, McDonald F, Healy V, Sheehan D, O'Halloran KD (2013) Effects of neonatal exposure to chronic intermittent hypoxia on respiratory muscle function and redox status Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting (Cork) [Details]
(2012)XIIth Oxford Conference on Breathing, Emotion and Evolution, Almelo, Netherlands
Edge D, McDonald FB, Bradford A, Jones JFX, O'Halloran KD (2012) Effect of chronic intermittent hypoxia on the reflex recruitment of the genioglossus during airway obstruction in the anaesthetised rat XIIth Oxford Conference on Breathing, Emotion and Evolution, Almelo, Netherlands [Details]
(2012)XIIth Oxford Conference on Breathing, Emotion and Evolution, Almelo, Netherlands
Shortt CM, Bradford A, Jones JFX, O'Halloran KD (2012) Diaphragm remodelling in a rat model of chronic intermittent hypoxia XIIth Oxford Conference on Breathing, Emotion and Evolution, Almelo, Netherlands [Details]
(2012)XIIth Oxford Conference on Breathing, Emotion and Evolution, Almelo, Netherlands
O'Halloran KD & Bisgard GE (2012) Serotonergic facilitation of upper airway tone in the awake goat XIIth Oxford Conference on Breathing, Emotion and Evolution, Almelo, Netherlands [Details]
(2012)XIIth Oxford Conference on Breathing, Emotion and Evolution, Almelo, Netherlands
Edge D, McDonald FB, Fitzpatrick S, McNicholas WT, Taylor CT, O'Halloran KD (2012) Effects of CIH +/- NOS inhibition on mouse diaphragm NFKB activity XIIth Oxford Conference on Breathing, Emotion and Evolution, Almelo, Netherlands [Details]
(2012)XIIth Oxford Conference on Breathing, Emotion and Evolution, Almelo, Netherlands
McDonald FB & O'Halloran KD (2012) Neonatal exposure to chronic intermittent hypoxia causes persistent respiratory muscle weakness in male and female rats XIIth Oxford Conference on Breathing, Emotion and Evolution, Almelo, Netherlands [Details]
(2012)Biomedical Basis of Elite Performance, London, UK
Chow HB, McDonald FB, Shortt CM, Bradford A, O'Halloran KD (2012) Chronic intermittent hypoxia does not increase lipid peroxidation in rat diaphragm Biomedical Basis of Elite Performance, London, UK [Details]
(2012)Irish Thoracic Society Annual Meeting (Limerick) 2012
Lewis P, Sheehan D, O'Halloran KD (2012) Chronic hypoxia alters redox homeostasis in mouse respiratory muscle Irish Thoracic Society Annual Meeting (Limerick) 2012 [Details]
(2012)Royal Academy of Medicine in Ireland: Section of Biomedical Sciences Annual Meeting, NUIG
McDonald FB & O'Halloran KD (2012) THE EFFECTS OF EARLY LIFE EXPOSURE TO CHRONIC INTERMITTENT HYPOXIA ON ISOLATED STERNOHYOID MUSCLE FORCE Royal Academy of Medicine in Ireland: Section of Biomedical Sciences Annual Meeting, NUIG [Details]
(2012)Royal Academy of Medicine in Ireland: Section of Biomedical Sciences Annual Meeting, NUIG
Lucking EF, O'Halloran KD, Jones JFX (2012) Lumbar sympathetic activity does not contribute to chronic intermittent hypoxia induced hypertension Royal Academy of Medicine in Ireland: Section of Biomedical Sciences Annual Meeting, NUIG [Details]
(2012)Physiological Society Annual Meeting (Edinburgh, UK) Proc Physiol Soc 27: C51
Lucking E, O'Halloran KD, Jones JFX (2012) Chronic intermittent hypoxia induces hypertension and alters lumbar sympathetic control of haemodynamic responses to airway occlusion Physiological Society Annual Meeting (Edinburgh, UK) Proc Physiol Soc 27: C51 [Details]
(2012)Physiological Society Annual Meeting (Edinburgh, UK) Proc Physiol Soc 27: PC38
Lewis P, O'Halloran KD (2012) Sex difference in hypoxic tolerance of mouse sternohyoid muscle Physiological Society Annual Meeting (Edinburgh, UK) Proc Physiol Soc 27: PC38 [Details]
(2012)Physiological Society Annual Meeting (Edinburgh, UK) Proc Physiol Soc 27: PC220
O'Connell RA, O'Halloran KD (2012) Respiratory plasticity following chronic intermittent hypoxia during early neonatal life Physiological Society Annual Meeting (Edinburgh, UK) Proc Physiol Soc 27: PC220 [Details]
(2012)Physiological Society Annual Meeting (Edinburgh, UK) Proc Physiol Soc 27: PC223
Edge D, Jones JFX, Bradford A, O'Halloran KD (2012) Effect of chronic intermittent hypoxia on reflex recruitment of sternohyoid EMG during airway obstruction in the anaesthetised rat Physiological Society Annual Meeting (Edinburgh, UK) Proc Physiol Soc 27: PC223 [Details]
(2012)Experimental Biology (San Diego)
O'Halloran KD, Bradford A, Jones JFX, Edge D (2012) Genioglossus motor unit properties in a rat model of sleep apnoea Experimental Biology (San Diego) [Details]
(2011)International Hypoxia Symposium (Lake Louise, Canada)
McMorrow C, Bradford A, Jones JFX, O'Halloran KD (2011) Improved anoxic tolerance in chronic hypoxic rat diaphragm is nitric oxide dependent International Hypoxia Symposium (Lake Louise, Canada) [Details]
(2011)International Society for Arterial Chemoreception (Hamilton, Canada)
Edge D, Bradford A, O'Halloran KD (2011) Chronic Intermittent Hypoxia Increases Apnoea Index in Sleeping Rats International Society for Arterial Chemoreception (Hamilton, Canada) [Details]
(2011)International Society for Arterial Chemoreception (Hamilton, Canada)
Edge D, Bradford A, Jones JFX, O'Halloran KD (2011) Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat International Society for Arterial Chemoreception (Hamilton, Canada) [Details]
(2011)International Society for Arterial Chemoreception (Hamilton, Canada)
O'Connor ET, O'Halloran KD, Jones JFX (2011) Propranolol Does Not Affect the Hindlimb Vasodilatation Elicited by Stimulation of Superior Laryngeal Nerve Paraganglia International Society for Arterial Chemoreception (Hamilton, Canada) [Details]
(2011)European Muscle Conference (Berlin)
McDonald F, O'Halloran KD (2011) Is nitric oxide implicated in respiratory muscle adaptation to chronic intermittent hypoxia? European Muscle Conference (Berlin) [Details]
(2011)European Muscle Conference (Berlin)
Lewis P, McMorrow C, Jones JFX, O'Halloran KD (2011) Chronic hypoxia does not affect rat respiratory muscle fibre oxidative capacity European Muscle Conference (Berlin) [Details]
(2011)International Hypoxia Symposium (Lake Louise, Canada)
O'Connor ET, O'Halloran KD, Jones JFX (2011) Vagal paraganglia of the rat International Hypoxia Symposium (Lake Louise, Canada) [Details]
(2011)European Muscle Conference (Berlin)
Chow HB, Shortt C, Bradford A, Jones JFX, O'Halloran KD (2011) Chronic intermittent hypoxia alters diaphragm MHC fibre distribution but not oxidative capacity in the rat European Muscle Conference (Berlin) [Details]
(2011)Physiological Society (Oxford): Proc Physiol Soc 23: SA93
Shortt C, McMorrow C, Fredsted A, Jones JFX, Bradford A, O'Halloran KD (2011) The effects of chronic sustained and intermittent hypoxia on muscle physiology Physiological Society (Oxford): Proc Physiol Soc 23: SA93 [Details]
(2011)Physiological Society (Oxford): Proc Physiol Soc: PC 275
Shortt C, Bradford A, O'Halloran KD (2011) Chronic intermittent hypoxia-induced respiratory muscle fatigue is mediated by reactive oxygen species Physiological Society (Oxford): Proc Physiol Soc: PC 275 [Details]
(2011)Physiological Society (Oxford): Proc Physiol Soc 23: PC 280
O'Connell RA, O'Halloran KD (2011) Chronic intermittent hypoxia induces respiratory muscle weakness in neonatal rats which persists into early adult life Physiological Society (Oxford): Proc Physiol Soc 23: PC 280 [Details]
(2011)Irish Thoracic Society (Dublin)
Edge D, Bradford A, Jones JFX, O'Halloran KD (2011) Genioglossus and Sternohyoid Motor Unit Properties in a Rat Model of Chronic Intermittent Hypoxia Irish Thoracic Society (Dublin) [Details]
(2010)Physiological Society (Manchester): Proc Physiol Soc 19: C102
O'Connell RA, O'Halloran KD (2010) Intermittent hypoxia/reoxygenation increases respiratory muscle fatigability in neonatal rats: No role for reactive oxygen species Physiological Society (Manchester): Proc Physiol Soc 19: C102 [Details]
(2010)Physiological Society (Birmingham): Proc Physiol Soc 20: PC33
Carberry J, Bradford A, O'Halloran KD (2010) Sternohyoid muscle function and MHC isoform expression in normoxic and chronic hypoxic rats during postnatal development Physiological Society (Birmingham): Proc Physiol Soc 20: PC33 [Details]
(2010)Physiological Society (Birmingham): Proc Physiol Soc 20: C14
O'Connell RA, O'Halloran KD (2010) Respiratory muscle weakness following chronic intermittent hypoxia during early development in the rat Physiological Society (Birmingham): Proc Physiol Soc 20: C14 [Details]
(2010)Physiological Society (Birmingham): Proc Physiol Soc 20: PC34
Edge D, O'Halloran KD (2010) Ventilatory effects of chronic intermittent hypoxia in the rat Physiological Society (Birmingham): Proc Physiol Soc 20: PC34 [Details]
(2010)Physiological Society (Birmingham): Proc Physiol Soc 20: C13
Shortt C, O'Halloran KD, Bradford A (2010) Effects of chronic intermittent hypoxia on rat respiratory muscle structure and function Physiological Society (Birmingham): Proc Physiol Soc 20: C13 [Details]
(2010)Physiological Society (Birmingham): Proc Physiol Soc20: C19
O'Connor ET, O'Halloran KD, Jones JFX (2010) The cardiorespiratory effects of stimulation of superior laryngeal nerve paraganglia in the urethane anaesthetised rat Physiological Society (Birmingham): Proc Physiol Soc20: C19 [Details]
(2010)Physiological Society (Manchester): Proc Physiol Soc 19: PC 28
Skelly JR, Bradford A, O'Halloran KD (2010) Chronic intermittent hypoxia does not affect upper airway dilator muscle function in aged male rats Physiological Society (Manchester): Proc Physiol Soc 19: PC 28 [Details]
(2010)Physiological Society (Manchester): Proc Physiol Soc 19: PC 26
McMorrow C, Fredsted A, Carberry J, O'Connell RA, Bradford A, Jones JFX, O'Halloran KD (2010) Chronic hypoxia increases rat diaphragm muscle endurance and Na+-K+ ATPase pump content Physiological Society (Manchester): Proc Physiol Soc 19: PC 26 [Details]
(2010)Physiological Society (Manchester): Proc Physiol Soc 20 :PC 25
O'Connell RA, O'Halloran KD (2010) Chronic intermittent hypoxia induces respiratory muscle dysfunction in neonatal rats Physiological Society (Manchester): Proc Physiol Soc 20 :PC 25 [Details]
(2010)Physiological Society (Manchester): Proc Physiol Soc 19: PC 27
Shortt C, O'Halloran KD (2010) Effects of chronic intermittent hypoxia on rat sternohyoid muscle structure and function Physiological Society (Manchester): Proc Physiol Soc 19: PC 27 [Details]
(2010)American Thoracic Society; Am J Respir Crit Care Med 181: A3704
Garvey JF, Fitzpatrick S, Tambuwala M, Edge D, O’Connor A, Ryan S, Jones JF, O’Halloran KD, McNicholas WT, Taylor CT (2010) In vivo intermittent hypoxia induces NFKB activity in an organ specific manner American Thoracic Society; Am J Respir Crit Care Med 181: A3704 [Details]

Magazine article

YearPublication
(2014)We know where we are going, but how do we get there? The Society's Meetings Committee (Published in Physiology News 97; pp20.).
O'Halloran KD (2014) We know where we are going, but how do we get there? The Society's Meetings Committee (Published in Physiology News 97; pp20.). Magazine article [Details]

Honours and Awards

 YearTitleAwarding Body
1992Donegan Medal Royal Academy of Medicine in Ireland
2000Fellow Royal Academy of Medicine in Ireland
2001President's Prize (Research) University College Dublin
2007Teaching Award University College Dublin

Professional Associations

 AssociationFunctionFrom / To
Royal Academy of Medicine in Ireland Fellow; General Secretary; Member of the Executive Committee/
Physiological Society Member; Trustee & Council member/
Physiological Society Meetings Secretary (Chair of Meetings Committee)/
American Physiological Society Member/
American Thoracic Society Member/
International Society for Arterial Chemoreception Member/

Committees

 CommitteeFunctionFrom / To
Council (Physiological Society) Member (Trustee)/
Executive Committee (Physiological Society) Member/
Meetings Committee (Physiological Society) Chair/
Publications Committee (Physiological Society) Member/
Executive Committee (Royal Academy of Medicine) Member (General Secretary of the Academy)/
Editorial Board of Experimental Physiology Member/
Executive Editor (Irish J Med Sci) Member (Editorial Board)/
Biomedical Science Council Member (Secretary)/
Programme Committee: Ageing & Degeneration - A Physiological Perspective (Physiological Society) Chair/
Programme Committee: Physiology 2015 (Annual Meeting of The Physiological Society), Cardiff, 2015. Chair/
Physiological Society: Scientific Programme Committee for Joint Meeting of TPS and APS, Dublin, 2016 Co-Chair/
Programme Committee: Biomedical Sciences Annual Meeting, Galway (NUIG), 2012 Chair/
Programme Committee: Biomedical Sciences Annual Meeting, Cork (UCC), 2013 Chair/
Programme Committee: Biomedical Sciences Annual Meeting, Dublin (UCD), 2014 Chair/
Programme Committee: Biomedical Sciences Annual Meeting, Dublin (RCSI), 2015 Chair/
University: Academic Council Member (Professor)/
University: Research Integrity Officer Chair/
University: Governing Body Committee on Students Member/
University: Graduate Studies Committee Member/
University: Ethics Committee Member/
University: Biological Services Unit Director/
University: BSU Management Committee Chair/
University: BSU Policy Committee Member/
University: Work Package Leader, PRTLI 5 funding 4M euro (BSU redevelopment) WP5 Leader/
University: Biological Safety Committee Member/
University: Heads & Managers Forum Member/
School: Executive Committee Member (Head of Department)/
School: Senior Management Committee Member (Pre-clinical sciences)/
School: Stream 1 (pre-clinical) Director Chair/
School: Programme Oversight Committee Member (Stream 1 Director)/
School: Curriculum Committee Member/
School: Research Committee Member/
School: Board Member/
Department of Physiology Chair/
Boolean Journal 2015 Reviewer/
Ad Hoc: UCC Disciplinary Hearing Committee Member/
Ad Hoc: Chair of Selection Committee for Lectureship in Nursing Chair/
Ad Hoc: Member of Selection Committee for UCC Dean of Medicne Member (Head of College Nominee)/
Ad Hoc: Member of Selection Committee for UCC Chair in Restorative Dentistry and Periodontology Member (Head of College Nominee)/
Ad Hoc: Member of Selection Committee for UCC Lectureship in Pharmacology Member/
Ad Hoc: Chair of Selection Committee for Technical Officer in BSU Chair/
Ad Hoc: Member of Selection Committee for UCC Lectureship in Anatomy & Neuroscience Member (Head of Cognate Discipline)/
Ad Hoc: Chair of Selection Committee for Lectureship in Anatomy & Neuroscience Chair/
Ad Hoc: Chair of Selection Committee for Technical Officer in Anatomy & Neuroscience Chair/
Ad Hoc: SL in Sports & Exercise Medicine Member/
Ad Hoc: College Programme Approval Panel Member/
Ad hoc: Interview panel for recruitment of overseas students (Jan 2012, Kuala Lumpur) Member/

Employment

 EmployerPositionFrom / To
University of North Carolina - Chapel Hill Postdoctoral Fellow01-SEP-95 / 31-AUG-96
University of Wisconsin-Madison, USA Postdoctoral Fellow01-SEP-96 / 01-JUL-00
University College Dublin Lecturer/Senior Lecturer01-AUG-00 / 30-SEP-11
University College Cork Professor of Physiology03-OCT-11 /

Education

 YearInstitutionQualificationSubject
1995University College Dublin PhDRespiratory Physiology
1992University College Cork BSC (HONS)Physiology

Consultancy

 ClientDescription
Bluebridge Technologies & Covidien

1. Small and large animal in vivo trials with application to medical devices. 2. Assessment of respiration from photoplethysmographic signals. Two invention disclosures: 1. “Method of using a PPG signal to monitor respiratory effort”. The other inventors were Prof. Aidan Bradford (RCSI) and Mark Cleary and Patrick Dowling of BlueBridge Technologies. 2. “Forehead probe and headband configuration for respiratory effort”. The other inventors were Prof. Aidan Bradford (RCSI) and Paul Addison and James Watson of Covidien.

Outreach Activities

 Description

Featured article in Heart & Blood, which was published March 17th and circulated as a supplement in the Irish Independent newspaper. http://www.healthnews.ie/cardiology/high-blood-pressure-in-sleep-apnoea-getting-to-the-heart-of-the-...





Irish Times
Snoring study: the danger behind the annoyance

Interview with Prof. Aidan Bradford (RCSI)

http://www.irishtimes.com/news/health/snoring-study-the-danger-behind-the-annoyance-1.905257


Radio interviews on Lyric FM (Culture File) and Newstalk (Futureproof).

The Physiological Society (UK & Ireland)

UCC College of Science, Enginneering and Food Science Open Days

Commentary on science education published in the Sunday Times.

Journal Activities

 JournalRoleTo / From
Experimental Physiology Editor01-JAN-15 -
Irish Journal Of Medical Science Editor-
Frontiers In Physiology Member of Editorial Board-
Acta Neurobiologiae Experimentalis Referee-
American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology Referee-
American Journal Of Respiratory Cell And Molecular Biology Referee-
American Journal Of Respiratory And Critical Care Medicine Referee-
Chest Referee-
Experimental Physiology Referee-
Journal Of Applied Physiology Referee-
Journal Of Cell Biochemistry Referee-
Journal Of Clinical Investigation Referee-
Journal Of Neurophysiology Referee-
Journal Of Physiology Referee-
Life Sciences Referee-
Obesity Research Referee-
Oral Diseases Referee-
Plos One Referee-
Respiratory Physiology & Neurobiology Referee-
Respiration Referee-

Other Activities

 Description

Selected Talk: O'Halloran KD. Redox remodelling in diaphragm muscle adaptation to chronic sustained hypoxia. APS Hypoxia Group featured topic: Cellular, molecular and systems integration underlying adaptation and maladaptation to hypoxia. Experimental Biology 2015, Boston, USA.



Invited Talk: Research Horizons, School of Medicine, UCC, December 2014.

Invited Talk: Oxford Conference on the Control of Breathing, Sydney, Australia (October 2014).

Conference Organiser: Biomedical Sciences Annual Meeting, Dublin (June 2014)

Symposium Organiser: Physiological Society Main Meeting. QE2 Conference Centre, London, UK July (2014).

Invited Talk: Sleep & Breathing International Conference, Montreal, Canada (September 2013).

Symposium Organiser: On the constancy of the internal environment. A celebration of the bicentenial anniversary of the birth of Claude Bernard. University College Cork, Ireland (June 2013).

Conference Organiser: Biomedical Sciences Annual Meeting, Cork (June 2013).

Invited Seminar: University of Birmingham, UK (February 2013).

Invited Seminar: University of Calgary, Canada (March 2013).

Keynote Seminar: Trinity College Dublin Postgraduate Research Day (September 2012)

Conference Organiser: Biomedical Sciences Annual Meeting, Galway (June 2012).

Invited Seminar: Allianze University/Royal College of Surgeons in Ireland, Kuala Lumpur, Malaysia (January 2012).

Invited Talk: Cork University Hospital Grand Rounds Series, March 2012.

Symposium co-organiser: Physiological Society Main Meeting, Oxford University, UK (July 2011).

Invited Talk: Effects of chronic sustained and intermittent hypoxia on muscle physiology. Physiological Society Main Meeting, Oxford University, UK (July 2011).

Invited Seminar: University of British Columbia, Kelowna, Canada (March 2011).

Symposium Organiser: Physiological Society Main Meeting, University College Dublin, Ireland (July 2009).

Invited Talk: fMRI and the Control of Breathing International Meeting, Oxford University (October 2008).

Invited Talk: International Society for Arterial Chemoreception, Valladollid, Spain (July 2008).

Invited Talk: The effect of intermittent hypoxia on maintenance of upper airway tone. World Sleep Apnea Congress, Montreal, Canada (September 2006).

External Examiner: PhD thesis, University of Edinburgh, 2015.

External Examiner: PhD thesis, University of Birmingham, 2013.

External Examiner: PhD thesis, Imperial College, London, 2013.

Invited Expert Contributor: American Thoracic Society Sleep & Respiratory Neurobiology Journal Club (webinar), November 2013.

Grant Reviewer: Health Research Board

Grant Reviewer: Human Frontier Science Programme (EU)

Grant Reviewer: Medical Research Council (UK)

Extern: Lectureship in Physiology, Trinity College Dublin, 2008

External Examiner: Physiology (Medicine, Physiotherapy, Clinical Therapies), Trinity College Dublin (2013-2016)

External Examiner: Year 1 Medicine, Imperial College, London (2010-2013)

Selected Talk: Burns DP. 

Respiratory function in the mdx mouse model of Duchenne muscular dystrophy: role of hypoxia, stress and immune factors. 

APS Respiration Section featured topic: Respiratory related disorders in aging and neurodegeneration. Experimental Biology 2015, Boston, USA.

Selected Talk: David Burns, Oxford conference on the control of breathing, Sydney, Australia, October, 2014.

Selected Talk: David Burns, International Society of Arterial Chemoreception, Leeds, UK, July 2014.

Selected Talk: Philip Lewis, Physiological Society Annual Meeting, London, UK, 2014.

Selected Talk: Fiona McDonald, Oxford conference on the control of breathing, Almelo, Netherlands, July 2013.

Selected Talk: Philip Lewis, Sleep and Breathing International Conference, Montreal, Canada, October 2013.

Selected Talk: Fiona McDonald, Sleep and Breathing International Conference, Montreal, Canada, October 2013.

Selected Talk: Philip Lewis. Donegan Medal Competition, Royal Academy of Medicine in Ireland (June 2013). Runner-up prize.

Selected Talk: Eric Lucking, Physiological Society Annual Meeting, Edinburgh, 2012. Winner of Pfizer prize.

Selected Talk. Fiona McDonald. Donegan Medal Competition, Royal Academy of Medicine in Ireland (June 2012).

Selected Talk. Eric Lucking. Donegan Medal Competition, Royal Academy of Medicine in Ireland (June 2012). Winner.

Selected Talk: Deirdre Edge, International Society for Arterial Chemoreception, Hamilton, Canada, July 2011.

Selected Talk. Chrissie Shortt. Donegan Medal Competition, Royal Academy of Medicine in Ireland (June 2011).

Selected Talk: Ruth O'Connell, Physiological Society Themed Meeting (Hypoxia), Birmingham, UK, September 2010.

Selected Talk: Chrissie Shortt, Physiological Society Themed Meeting (Hypoxia), Birmingham, September 2010.

Selected Talk: Jayne Carberry, Physiological Society Annual Meeting, Cambridge, UK, July 2008.

Selected Talk. Clodagh McMorrow. Donegan Medal Competition, Royal Academy of Medicine in Ireland (June 2008).

Selected Talk: RIchard Skelly, Joint Meeting of Slovak Physiological Society, FEPS and the Physiological Society, Bratislava, Slovakia, September, 2007.

Teaching Interests

Undergraduate

Stream 1 Director
Foundations of Medicine Modules: 
(FM1010, FM1020, FM1030, FM1040, FM2101, FM2102)

FM1030 Foundations of Medicine: Respiratory Biology & Metabolism (module coordinator)

FM2102 Foundations of Medicine: Bone metabolism, Renal Mechanisms of Homeostasis & Associated Anatomy (module coordinator)

PL 3025 Literature Review, Experimental Design and Data Analysis

PL 3022 Respiratory Physiology

PL 4010 Control of Breathing in Health & Disease (module co-ordinator)

PL 4020 Research Project (final year BSc Physiology)

AN 3003 Neurobiology of Regulatory Systems 

Postgraduate:




 

 

 

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2015Philip Lewis UCCPhDRedox remodelling in diaphragm muscle adaptation to chronic sustained hypoxia. Extern: Prof. Hans Hoppeler, University of Bern, Switzerland.
2014Robert Williams UCCMScIs NADPH oxidase expression increased in rat respiratory muscle following chronic intermittent hypoxia? Extern: Prof. Trevor Day, Mount Royal University, Canada.
2013Eric Lucking UCDPhDThe lumbar sympathetic nervous system does not contribute to chronic intermittent hypoxia induced hypertension. Extern: Prof. Janice Marshall, University of Birmingham, UK.
2013Fiona McDonald UCDPhDSex specific early life programming of respiratory muscle contractility by chronic intermittent hypoxia. Extern: Dr. Lucy Green, University of Southampton, UK.
2012Deirdre Edge UCDPhDRespiratory control in an animal model of sleep-disordered breathing. Extern: Prof. Tracy Baker-Herman, University of Wisconsin-Madison, USA.
2011Han Bing Chow UCDMScHypoxic stress in respiratory muscle – a radical view. Extern: Prof. David Fuller, University of Gainesville, Florida, USA.
2011Chrissie Shortt UCDPhDFree radical mediated respiratory muscle dysfunction in a rodent model of sleep-disordered breathing. Extern: Prof. Paul Greenhaff, University of Nottingham, UK.
2011Ruth O'Connell UCDPhDComparative analysis of neonatal and adult respiratory muscle structure and function in a rodent model of chronic intermittent hypoxia. Extern: Prof. Richard Kinkead, Laval University, Quebec, Canada.
2011Jayne Carberry UCDPhDRespiratory muscle adaptation to chronic hypoxia in early development. Extern: Prof. Stuart Egginton, University of Leeds, UK.
2010J. Richard Skelly UCDPhDRespiratory muscle remodelling in an animal model of sleep-disordered breathing: Protective effects of antioxidant treatment. Extern: Prof. Prem Kumar, University of Birmingham, UK.
2010Clodagh McMorrow UCDPhDEffects of chronic hypoxia on respiratory muscle structure and function. Extern: Prof Mary Morell, Imperial College, London, UK.

Current Postgraduate Students

 StudentDegree Type
O Connor Karen Mairead Doctoral Degree
O Brien Rebecca Doctoral Degree
Murphy Kevin Masters Degree by Research
Brady Paul John Anthony Doctoral Degree
Burns David Patrick Doctoral Degree
Barry Alison Masters Degree by Research
Drummond Sarah Elizabeth Masters Degree by Research

Modules Taught

 Term (ID))TitleLinkSubject
2018Control of Breathing in Health and Disease PL4010Control of Breathing in Health and Disease

Internal Collaborators

 NameInstituteCountry
Dr. Paul Brady University College Cork Dental SchoolIRELAND
Professor John Cryan Department of Anatomy & NeuroscienceIRELAND
Professor Eugene Dempsey Cork University Maternity HospitalIRELAND
Dr. Vincent Healy University College CorkIRELAND
Mr. John Hinchion Cork University HospitalIRELAND
Dr. John Mackrill University College CorkIRELAND
Dr. Dervla O'Malley University College CorkIRELAND
Professor Dave Sheehan University College CorkIRELAND
Professor Thomas Walther Department of Pharmacology & Therapeutics, UCCIRELAND

External Collaborators

 NameOrganisation / InstituteCountry
Professor Aidan Bradford Royal College of Surgeons in IrelandIRELAND
Professor Trevor Day Mount Royal UniversityCANADA
Dr. Deirdre Edge Trinity College DublinIRELAND
Dr. Anne Fredsted University of AarhusDENMARK
Professor Dave Fuller University of FloridaU.S.A.
Professor James Jones University College DublinIRELAND
Dr. John O'Connor University College DublinIRELAND
Professor Richard Wilson University of CalgaryCANADA