Research Profile

Brendan Griffin

Biography

                        Currently a Senior Lecturer in Pharmaceutics at the School of Pharmacy as University College Cork. Having completed his BSc. Pharm. degree at the School of Pharmacy in Trinity College Dublin (TCD), he proceeded to a PhD. in the Pharmaceutics at TCD.  After working in pharmaceutical industry for a number of years (at Élan and Servier), he returned to academia in 2005.  He is also Course Director of the MSc in Pharmaceutical Technology and Quality Systems, an on line masters course designed to train graduates working in the pharmaceutical industry to become a Qualified Person (QP).    Dr. Griffin research interests focus on the development of optimised and targeted drug delivery systems.  This includes lipid based formulations for enhancing oral bioavailability of poorly soluble drug compounds; design of nanoparticulate based drug delivery systems; targeted drug delivery to the brain and to the intestinal lymphatics.  He continues to interact closely with the pharmaceutical industry and has a number of research collaborations with industrial partners.   Dr. Griffin  currently coordinates the PEARRL (Pharmaceutical Education And Research with Regulatory Links) project (www.pearrl.eu).  PEARRL  is a European Training Network (ETN) funded under the EU Horizon 2020 research and innovation programme (Marie Sklodowska-Curie actions). The PEARRL ETN brings together 18 leading European institutions and is co-ordinated by Dr. Brendan Griffin from UCC. The programme is funded (€ 4 million) under the European Union’s Horizon 2020 research and innovation programme (Marie Sklodowska-Curie actions). The main research objectives of the PEARRL research programme are to deliver novel bio-enabling formulations and new biopharmaceutics tools to predict their in vivo performance as a means to improve efficiency and cost-competitiveness in drug development, thus facilitating earlier access of patients to “breakthrough therapies”.

Research Interests

My Research interests can be broken down into three broad and overlapping themes.
  • Factors influencing design and performance of pharmaceutical dosage forms
  • Formulation technology: novel approaches to enhance oral drug delivery
  • In vitro, in-silico and in vivo models for predicting Bioavailability and pharmacokinetics in humans

My related Research Objectives, which translate from these research interests are:

  • Oral Drug Delivery  - Novel Formulation approaches to enhance bioavailability
  • Colonic Drug Delivery - Design and assessment of colonic release dosage forms
  • Brain Drug Delivery - Strategies to enhance drug delivery to the brain

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Development of novel Lipid based solid dispersion (LBSD) formulations for enhancing and bioavailabilityEnterprise Irl10-MAY-1024-JUN-11€96,544.00
Systematic evaluation of the bioavailability and therapeutic efficacy of a novel lipid based formulation of lycopene for use in the chemoprevention of prostate cancerOther: Not Listed01-OCT-0601-OCT-09€110,249.00
Addressing the problem of variable food effect bioavailability for emerging new drug candidates: how to predict and how to produce.Irish Research Council01-OCT-1830-SEP-22€96,000.00
Food for Health Ireland (FHI) - Appetite ModulationEnterprise Ireland01-OCT-1430-SEP-16€371,011.00
Biodegradable microparticles for drug deliveryTyndall National Institute National Access Programme01-OCT-0801-OCT-09€36,600.00
Pharmaceutical Education and Research with Regulatory Links: Innovative Drug Development Strategies and Regulatory Tools Tailored to Fcailitate Earlier Access to Medicines.Horizon 202001-MAY-1630-APR-20€531,349.00
Drug loaded nanoparticles produced using Microfluidics: precise control of size, shape and surface characteristics of single ‘Lab-on-Chip’ deviceTyndall National Institute National Access Programme01-OCT-1101-OCT-12€18,000.00
Investigation of the effect of Bumetanide on NKCC1 and development of strategies to enhance Bumetanide delivery to the brain in neonatal seizures.Irish Research Council01-DEC-1230-NOV-15€72,000.00

Publications

Peer Reviewed Journals

 YearPublication
(2019)'Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions'
Clarke G;Sandhu KV;Griffin BT;Dinan TG;Cryan JF;Hyland NP; (2019) 'Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions'. Pharmacological reviews, 71 (2) [DOI] [Details]
(2019)'New Insights into Using Lipid Based Suspensions for "Brick Dust' Molecules: Case Study of Nilotinib'
Koehl, NJ;Holm, R;Kuentz, M;Griffin, BT (2019) 'New Insights into Using Lipid Based Suspensions for "Brick Dust' Molecules: Case Study of Nilotinib'. Pharmaceutical Research, 36 [DOI] [Details]
(2019)'The PEARRL reviews – innovative drug development strategies tailored to facilitate earlier access to new oral medicines [Editorial]'
Griffin, Brendan T.; Dressman, Jennifer B. (2019) 'The PEARRL reviews – innovative drug development strategies tailored to facilitate earlier access to new oral medicines [Editorial]'. Journal of Pharmacy and Pharmacology, 71 (4):439-440   [DOI] [CORA Link] [Details]
(2019)'Food for thought: formulating away the food effect - a PEARRL review'
O'Shea JP;Holm R;O'Driscoll CM;Griffin BT; (2019) 'Food for thought: formulating away the food effect - a PEARRL review'. Journal of Pharmacy and Pharmacology, 71 (4)   [DOI] [Details]
(2018)'Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches – a PEARRL review'
Ditzinger, F. and Price, D.J. and Ilie, A.-R. and Köhl, N.J. and Jankovic, S. and Tsakiridou, G. and Aleandri, S. and Kalantzi, L. and Holm, R. and Nair, A. and Saal, C. and Griffin, B. and Kuentz, M. (2018) 'Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches – a PEARRL review'. Journal of Pharmacy and Pharmacology,   [DOI] [Details]
(2016)'Effect of P-Glycoprotein Inhibition on the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'
O'Brien, FE;O'Connor, RM;Clarke, G;Dinan, TG;Griffin, BT;Cryan, JF (2016) 'Effect of P-Glycoprotein Inhibition on the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'. IRISH JOURNAL OF MEDICAL SCIENCE, 185 :36-36 [Details]
(2016)'Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives'
Donovan, Maria D.; Griffin, Brendan T.; Kharoshankaya, Liudmila; Cryan, John F.; Boylan, Geraldine B. (2016) 'Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives'. Drugs, 76 :647-661 [DOI] [CORA Link] [Details]
(2016)'Impact of body composition parameters on clinical outcomes in patients with metastatic castrate-resistant prostate cancer treated with docetaxel'
Cushen, SJ;Power, DG;Murphy, KP;McDermott, R;Griffin, BT;Lim, M;Daly, L;MacEneaney, P;Sullivan, KO;Prado, CM;Ryan, AM (2016) 'Impact of body composition parameters on clinical outcomes in patients with metastatic castrate-resistant prostate cancer treated with docetaxel'. Clinical Nutrition Espen, 13 :39-45 [DOI] [Details]
(2016)'Effect of P-Glycoprotein Inhibition on the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'
O'Brien, FE,O'Connor, RM,Clarke, G,Dinan, TG,Griffin, BT,Cryan, JF (2016) 'Effect of P-Glycoprotein Inhibition on the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'. Irish journal of medical science, 185 :36-36 [Details]
(2016)'In vitro bidirectional permeability studies identify pharmacokinetic limitations of NKCC1 inhibitor bumetanide'
Donovan, MD;Schellekens, H;Boylan, GB;Cryan, JE;Griffin, BT (2016) 'In vitro bidirectional permeability studies identify pharmacokinetic limitations of NKCC1 inhibitor bumetanide'. European Journal of Pharmacology, 770 :117-125 [DOI] [Details]
(2016)'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'
Enright EF;Gahan CG;Joyce SA;Griffin BT; (2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'. The Yale journal of biology and medicine, 89 (3) [Details]
(2015)'The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat'
Donovan, MD;O'Brien, FE;Boylan, GB;Cryan, JF;Griffin, BT (2015) 'The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat'. Journal of Pharmacy and Pharmacology, 67 :501-510 [DOI] [Details]
(2015)'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments'
O'Shea, JP;Faisal, W;Ruane-O'Hora, T;Devine, KJ;Kostewicz, ES;O'Driscoll, CM;Griffin, BT (2015) 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments'. European Journal Of Pharmaceutics And Biopharmaceutics, 96 :207-216 [DOI] [Details]
(2015)'Exploring the Impact of Drug Properties on the Extent of Intestinal Lymphatic Transport - In Vitro and In Vivo Studies'
Lawless, E;Griffin, BT;O'Mahony, A;O'Driscoll, CM (2015) 'Exploring the Impact of Drug Properties on the Extent of Intestinal Lymphatic Transport - In Vitro and In Vivo Studies'. Pharmaceutical Research, 32 :1817-1829 [DOI] [Details]
(2015)'Chronic P-glycoprotein inhibition increases the brain concentration of escitalopram: potential implications for treating depression'
O'Brien, FE;Moloney, GM;Scott, KA;O'Connor, RM;Clarke, G;Dinan, TG;Griffin, BT;Cryan, JF (2015) 'Chronic P-glycoprotein inhibition increases the brain concentration of escitalopram: potential implications for treating depression'. Pharmacology Research &Amp; Perspectives, 3 [DOI] [Details]
(2014)'Silicon microfluidic flow focusing devices for the production of size-controlled PLGA based drug loaded microparticles'
Keohane, K;Brennan, D;Galvin, P;Griffin, BT (2014) 'Silicon microfluidic flow focusing devices for the production of size-controlled PLGA based drug loaded microparticles'. International Journal of Pharmaceutics, 467 :60-69 [DOI] [Details]
(2014)'The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram'
O'Brien, FE;O'Connor, RM;Clarke, G;Donovan, MD;Dinan, TG;Griffin, BT;Cryan, JF (2014) 'The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram'. Behavioural Brain Research, 261 :17-25 [DOI] [Details]
(2014)'PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability'
Godinho BM;Ogier JR;Quinlan A;Darcy R;Griffin BT;Cryan JF;O'Driscoll CM; (2014) 'PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability'. International Journal of Pharmaceutics, 473 (1-2) [DOI] [Details]
(2013)'A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene - In vivo evaluation using a pig model'
Faisal, W;Ruane-O'Hora, T;O'Driscoll, CM;Griffin, BT (2013) 'A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene - In vivo evaluation using a pig model'. International Journal of Pharmaceutics, 453 :307-314 [DOI] [Details]
(2013)'P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'
O'Brien, FE;O'Connor, RM;Clarke, G;Dinan, TG;Griffin, BT;Cryan, JF (2013) 'P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'. Neuropsychopharmacology, 38 :2209-2219 [DOI] [Details]
(2010)'Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport'
Faisal, W;O'Driscoll, CM;Griffin, BT (2010) 'Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport'. Journal of Pharmacy and Pharmacology, 62 :323-331 [DOI] [Details]
(2008)'Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8(+) T cells against Listeria monocytogenes in the murine infection model'
Bahey-El-Din, M,Casey, PG,Griffin, BT,Gahan, CGM; (2008) 'Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8(+) T cells against Listeria monocytogenes in the murine infection model'. Vaccine, 26 :5304-5314 [DOI] [Details]
(2006)'A comparison of intestinal lymphatic transport and systemic bioavailability of saquinavir from three lipid-based formulations in the anaesthetised rat model'
Griffin, BT,O'Driscoll, CM; (2006) 'A comparison of intestinal lymphatic transport and systemic bioavailability of saquinavir from three lipid-based formulations in the anaesthetised rat model'. Journal of Pharmacy and Pharmacology, 58 :917-925 [DOI] [Details]
(2018)'Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - a PEARRL review'
Jankovic, S. and Tsakiridou, G. and Ditzinger, F. and Koehl, N.J. and Price, D.J. and Ilie, A.-R. and Kalantzi, L. and Kimpe, K. and Holm, R. and Nair, A. and Griffin, B. and Saal, C. and Kuentz, M. (2018) 'Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - a PEARRL review'. Journal of Pharmacy and Pharmacology,   [DOI] [Details]
(2018)'Drug-gut microbiota interactions: implications for neuropharmacology'
Walsh, Jacinta; Griffin, Brendan T.; Clarke, Gerard; Hyland, Niall P. (2018) 'Drug-gut microbiota interactions: implications for neuropharmacology'. British journal of pharmacology,   [DOI] [CORA Link] [Details]
(2018)'A dairy-derived ghrelinergic hydrolysate modulates food intake in vivo'
Howick, K. and Wallace-Fitzsimons, S.E. and Kandil, D. and Chruscicka, B. and Calis, M. and Murphy, E. and Murray, B.A. and Fernandez, A. and Barry, K.M. and Kelly, P.M. and Ryan, A.M. and Cryan, J.F. and Griffin, B.T. and Schellekens, H. (2018) 'A dairy-derived ghrelinergic hydrolysate modulates food intake in vivo'. International Journal of Molecular Sciences, 19 (9)   [DOI] [Details]
(2018)'Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism'
Enright, E.F. and Griffin, B.T. and Gahan, C.G.M. and Joyce, S.A. (2018) 'Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism'. Pharmacological Research, 133 :170-186   [DOI] [Details]
(2018)'Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS): A rapid test for enteric coating thickness and integrity of controlled release pellet formulations'
Alfarsi, A. and Dillon, A. and McSweeney, S. and Krüse, J. and Griffin, B. and Devine, K. and Sherry, P. and Henken, S. and Fitzpatrick, S. and Fitzpatrick, D. (2018) 'Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS): A rapid test for enteric coating thickness and integrity of controlled release pellet formulations'. International Journal of Pharmaceutics, 544 (1):31-38   [DOI] [Details]
(2018)'Sustained-release multiparticulates for oral delivery of a novel peptidic ghrelin agonist: Formulation design and in vitro characterization'
Howick, K. and Alam, R. and Chruscicka, B. and Kandil, D. and Fitzpatrick, D. and Ryan, A.M. and Cryan, J.F. and Schellekens, H. and Griffin, B.T. (2018) 'Sustained-release multiparticulates for oral delivery of a novel peptidic ghrelin agonist: Formulation design and in vitro characterization'. International Journal of Pharmaceutics, 536 (1):63-72   [DOI] [Details]
(2018)'Regulation of biosimilar medicines and current perspectives on interchangeability and policy'
O’Callaghan, John; Barry, Sean P.; Bermingham, Margaret; Morris, J. Michael; Griffin, Brendan T. (2018) 'Regulation of biosimilar medicines and current perspectives on interchangeability and policy'. European Journal of Clinical Pharmacology,   [DOI] [CORA Link] [Details]
(2018)'Knowledge of Adverse Drug Reaction Reporting and the Pharmacovigilance of Biological Medicines: A Survey of Healthcare Professionals in Ireland'
O'Callaghan J;Griffin BT;Morris JM;Bermingham M; (2018) 'Knowledge of Adverse Drug Reaction Reporting and the Pharmacovigilance of Biological Medicines: A Survey of Healthcare Professionals in Ireland'. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, [DOI] [CORA Link] [Details]
(2018)'Application of a Physiologically-Based Pharmacokinetic Model for the Prediction of Bumetanide Plasma and Brain Concentrations in the Neonate'
Donovan, Maria D.,Abduljalil, Khaled,Cryan, John F.,Boylan, Geraldine B.,Griffin, Brendan T. (2018) 'Application of a Physiologically-Based Pharmacokinetic Model for the Prediction of Bumetanide Plasma and Brain Concentrations in the Neonate'. Biopharmaceutics & Drug Disposition,   [DOI] [Details]
(2018)'Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide'
Henze, Laura J.; Griffin, Brendan T.; Christiansen, Martin; Bundgaard, Christoffer; Langguth, Peter; Holm, Rene (2018) 'Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide'. European Journal of Pharmaceutical Sciences,   [DOI] [CORA Link] [Details]
(2018)'The pig as a pre-clinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms - a PEARRL review'
Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Kostewicz Edmund; Holm, Rene; Griffin, Brendan T. (2018) 'The pig as a pre-clinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms - a PEARRL review'. Journal of Pharmacy and Pharmacology,   [DOI] [CORA Link] [Details]
(2017)'In vitro dissolutionmodels for the prediction of in vivo performance of an oral mesoporous silica formulation'
McCarthy, CA;Faisal, W;O'Shea, JP;Murphy, C;Ahern, RJ;Ryan, KB;Griffin, BT;Crean, AM (2017) 'In vitro dissolutionmodels for the prediction of in vivo performance of an oral mesoporous silica formulation'. Journal Of Controlled Release, 250 :86-95 [DOI] [Details]
(2017)'Assessing awareness and attitudes of healthcare professionals on the use of biosimilar medicines: A survey of physicians and pharmacists in Ireland'
O'Callaghan, Joan; Bermingham, Margaret; Leonard, Maurice; Hallinan, Frank; Morris, J. Michael; Moore, Una; Griffin, Brendan T. (2017) 'Assessing awareness and attitudes of healthcare professionals on the use of biosimilar medicines: A survey of physicians and pharmacists in Ireland'. Regulatory toxicology and pharmacology : RTP, 88 :252-261   [DOI] [CORA Link] [Details]
(2017)'From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation'
Howick, Ken; Griffin, Brendan; Cryan, John; Schellekens, Harriët (2017) 'From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation'. International Journal of Molecular Sciences, 18 (2) [DOI] [CORA Link] [Details]
(2017)'Impact of Gut Microbiota-Mediated Bile Acid Metabolism on the Solubilization Capacity of Bile Salt Micelles and Drug Solubility'
Enright, EF;Joyce, SA;Gahan, CGM;Griffin, BT (2017) 'Impact of Gut Microbiota-Mediated Bile Acid Metabolism on the Solubilization Capacity of Bile Salt Micelles and Drug Solubility'. Molecular Pharmaceutics, 14 :1251-1263 [DOI] [Details]
(2017)'Mesoporous silica based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate'
Joseph P. O’Shea, Kalpa Nagarsekar, Alena Wieber, Vanessa Witt3, Elisabeth Herbert, Caitriona M. O’Driscoll, Christoph Saal, Dieter Lubda, Brendan T. Griffin, Jennifer B. Dressman (2017) 'Mesoporous silica based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate'. Journal of Pharmacy and Pharmacology,   [DOI] [Details]
(2016)'Lipid-based nanocarriers for oral peptide delivery'
Niu, Z.,Conejos-Sánchez, I.,Griffin, Brendan T.,O’Driscoll, C.,Alonso, M. J. (2016) 'Lipid-based nanocarriers for oral peptide delivery'. Advanced Drug Delivery Reviews,   [Details]
(2016)'Regulatory Science Ireland: Bridging the information gap on biosimilar medicines'
O'Callaghan, Joan; Barry, Sean; Moore, Una; Bermingham, Margaret; Morris, J. Michael; Hallinan, Frank; Griffin, Brendan T (2016) 'Regulatory Science Ireland: Bridging the information gap on biosimilar medicines'. Gabi Journal, 5 (4):168-170 [DOI] [CORA Link] [Details]
(2016)'Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo'
Evans, J. C.,Malhotra, M.,Guo, J.,O'Shea, J. P.,Hanrahan, K.,O'Neill, A.,Landry, W. D.,Griffin, B. T.,Darcy, R.,Watson, R. W.,O'Driscoll, C. M. (2016) 'Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo'. Nanomedicine, 12 (8):2341-2351   [DOI] [Details]
(2016)'Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs'
Griffin, B. T.,Guo, J.,Presas, E.,Donovan, M. D.,Alonso, M. J.,O'Driscoll, C. M. (2016) 'Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs'. Advanced Drug Delivery Reviews,   [DOI] [Details]
(2016)'Lipid-based nanocarriers for oral peptide delivery'
Niu Z;Conejos-Sánchez I;Griffin BT;O'Driscoll CM;Alonso MJ; (2016) 'Lipid-based nanocarriers for oral peptide delivery'. Advanced Drug Delivery Reviews, [DOI] [Details]
(2016)'In vitro bidirectional permeability studies identify pharmacokinetic limitations of NKCC1 inhibitor bumetanide'
Donovan, MD;Schellekens, H;Boylan, GB;Cryan, JE;Griffin, BT (2016) 'In vitro bidirectional permeability studies identify pharmacokinetic limitations of NKCC1 inhibitor bumetanide'. European Journal of Pharmacology, 770 :117-125 [DOI] [Details]
(2016)'Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on antiepileptics'
Donovan MD;Boylan GB;Murray DM;Cryan JF;Griffin BT; (2016) 'Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on antiepileptics'. British Journal of Clinical Pharmacology, 81 (1) [DOI] [Details]
(2016)'Enhanced colonic delivery of ciclosporin A self-emulsifying drug delivery system encapsulated in coated minispheres'
Keohane, K.,Rosa, M.,Coulter, I. S.,Griffin, B. T. (2016) 'Enhanced colonic delivery of ciclosporin A self-emulsifying drug delivery system encapsulated in coated minispheres'. Drug Development and Industrial PharmacyDrug Development and Industrial Pharmacy, 42 (22):245-253   [Details]
(2014)'Biopharmaceutical Modeling of Drug Supersaturation During Lipid-Based Formulation Digestion Considering an Absorption Sink'
Stillhart C, Imanidis G, Griffin BT, Kuentz M (2014) 'Biopharmaceutical Modeling of Drug Supersaturation During Lipid-Based Formulation Digestion Considering an Absorption Sink'. Pharmaceutical research, [DOI] [Details]
(2014)'Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: Case studies with fenofibrate'
Griffin, BT,Kuentz, M,Vertzoni, M,Kostewicz, ES,Fei, Y,Faisal, W,Stillhart, C,O'Driscoll, CM,Reppas, C,Dressman, JB (2014) 'Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: Case studies with fenofibrate'. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 86 :427-437 [DOI] [Details]
(2013)'Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability'
O'Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2013) 'Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability'. International Journal of Neuropsychopharmacology, :1-14 [DOI] [Details]
(2012)'Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat'
O'Brien FE, Clarke G, Fitzgerald P, Dinan TG, Griffin BT, Cryan JF (2012) 'Inhibition of P-glycoprotein Enhances Transport of the Antidepressant Imipramine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat'. British Journal of Pharmacology, [DOI] [Details]
(2012)'Advances in lipid-based formulations: Overcoming the challenge of low bioavailability for poorly water soluble drug compounds'
Griffin, BT (2012) 'Advances in lipid-based formulations: Overcoming the challenge of low bioavailability for poorly water soluble drug compounds'. American pharmaceutical review, 15 (2):41-47 [DOI] [Details]
(2011)'Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: Clinical significance of in vitro and in vivo findings'
O'Brien FE, Dinan TG, Griffin BT, Cryan JF; (2011) 'Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: Clinical significance of in vitro and in vivo findings'. British Journal of Pharmacology, [DOI] [Details]
(2011)'Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies'
Griffin BT, O'Driscoll CM (2011) 'Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies'. Therapeutic Delivery, 2 (12):1633-1653 [Details]
(2010)'Efficacy of a Lactococcus lactis ΔpyrG vaccine delivery platform expressing chromosomally integrated hly from Listeria monocytogenes'
Bahey-EL-Din, M; Caset, PG; Griffin, BT; Gahan, C; (2010) 'Efficacy of a Lactococcus lactis ΔpyrG vaccine delivery platform expressing chromosomally integrated hly from Listeria monocytogenes'. Bioengineered Bugs, 1 (1):66-74   [Details]
(2010)'Expression of two Listeria monocytogenes antigens (P60 and LLO) in Lactococcus lactis and examination for use as live vaccine vectors'
Bahey-EL-Din, M; Caset PG; Griffin, BT; Gahan, C; (2010) 'Expression of two Listeria monocytogenes antigens (P60 and LLO) in Lactococcus lactis and examination for use as live vaccine vectors'. Journal of Medical Microbiology, [DOI] [Details]
(2010)'Lactococcus lactis as a cell factory for delivery of therapeutic proteins'
Bahey-El-Din, M; Gahan, CG; Griffin, BT; (2010) 'Lactococcus lactis as a cell factory for delivery of therapeutic proteins'. Current Gene Therapy, 10 (1):34-45   [DOI] [Details]
(2010)'A Methodology for Knowledge Management in Biopharmaceutical Production'
Coakley, Jennifer; Hogan, Nicola; McGuire, Linda; Griffin, Brendan; Casey, Colman; Campbell, Cliff; Crean, Abina; (2010) 'A Methodology for Knowledge Management in Biopharmaceutical Production'. Pharmaceutical Engineering, 30 (3):30-40   [Details]
(2008)'Nisin inducible production of listeriolysin O in Lactococcus lactis NZ9000'
Bahey-El-Din M, Griffin BT, Gahan CG; (2008) 'Nisin inducible production of listeriolysin O in Lactococcus lactis NZ9000'. Microbial Cell Factories, 7 [DOI] [CORA Link] [Details]
(2008)'An examination of the effect of intestinal first pass extraction on intestinal lymphatic transport of saquinavir in the rat'
Griffin BT, O'Driscoll CM; (2008) 'An examination of the effect of intestinal first pass extraction on intestinal lymphatic transport of saquinavir in the rat'. Pharmaceutical Research, 25 (5):1125-1133 [DOI] [Details]
(2008)'Biopharmaceutical challenges associated with drugs with low aqueous solubility--the potential impact of lipid-based formulations'
O'Driscoll CM, Griffin BT; (2008) 'Biopharmaceutical challenges associated with drugs with low aqueous solubility--the potential impact of lipid-based formulations'. Advanced Drug Delivery Reviews, 60 (6):617-624 [DOI] [Details]
(2008)'Lactococcus Lactis-Expressing Listeriolysin O (Llo) Provides Protection and Specific Cd8(+) T Cells Against Listeria Monocytogenes In The Murine Infection Model'
Bahey-El-Din, M, Casey, PG, Griffin, BT, Gahan, CGM; (2008) 'Lactococcus Lactis-Expressing Listeriolysin O (Llo) Provides Protection and Specific Cd8(+) T Cells Against Listeria Monocytogenes In The Murine Infection Model'. Vaccine, 26 (41):5304-5314 [DOI] [Details]

Other Journals

 YearPublication
(2007)'Review of Endotoxins - Pyrogens, LAL testing and Depyrogenation'
Griffin BT; (2007) 'Review of Endotoxins - Pyrogens, LAL testing and Depyrogenation' Informa Healthcare, . [Details]

Book Chapters

 YearPublication
(2016)''Oral delivery of macromolecules – highlighting the challenges to maximize opportunities''
O'Mahony, A. M., Griffin, B. T., and O'Driscoll, C. M. (2016) ''Oral delivery of macromolecules – highlighting the challenges to maximize opportunities'' In: Advances and challenges in the oral delivery of macromolecules. Unitec House, 2 Albert Place, London, N3 1QB, UK: Future Science Ltd. [DOI] [Details]
(2014)'Advances and challenges in the oral delivery of macromolecules'
AM O'Mahony, BT Griffin and CM O'Driscoll (2014) 'Advances and challenges in the oral delivery of macromolecules' In: Greg Russell-Jones (eds). 1. Oral delivery of macromolecules – highlighting the challenges to maximize opportunities. London: Future Science Ltd. [Details]
(2008)'Models of the small intestine'
Griffin, Brendan and O’Driscoll, Caitriona (2008) 'Models of the small intestine' In: Springer. [Details]
(2008)'Attack and counter-attack: targeted immunomodulation using bacterial virulence factors'
Bahey-El-Din M, Griffin BT and CGM Gahan; (2008) 'Attack and counter-attack: targeted immunomodulation using bacterial virulence factors' In: Patho-Biotechnology. Austin: Landes BioSciences. [Details]

Conference Publications

 YearPublication
(2011)College of Medicine and Health Research Day (Brookfield, UCC, June 2011)
O’Brien FE, Clarke G, Fitzgerald P, Griffin BT, Cryan JF (2011) An integrated microdialysis model for the analysis of blood-brain barrier drug transport in the conscious freely moving rat College of Medicine and Health Research Day (Brookfield, UCC, June 2011) [Details]
(2010)2nd Conference on Innovation in Drug Delivery, International Society of Drug Delivery Sciences and Technology (APGI)
Keohane, K., Brennan, D., Galvin, P., Griffin, B.T.; (2010) Microfluidics based approaches to preparation of biodegradable microparticles 2nd Conference on Innovation in Drug Delivery, International Society of Drug Delivery Sciences and Technology (APGI) [Details]
(2008)American Association of Pharmaceutical Scientists (AAPS)
Faisal, W., O'Driscoll, C.M., Griffin, B.T.; (2008) Solubility and Stability of lycopene in lipid based formulations American Association of Pharmaceutical Scientists (AAPS) [Details]
(2008)UK & Ireland Controlled Release Society (UKICRS)
Faisal, W., O'Driscoll, C.M., Griffin, B.T.; (2008) Investigation of Lycopene absorption mechanisms from the Gastro-intestinal tract of the rat UK & Ireland Controlled Release Society (UKICRS) [Details]
(2007)Excipient Fest Ireland
Faisal W, O'Driscoll CM, Griffin BT; (2007) Comparison of the intestinal lymphatic transport of lycopene in anaesthetised rat Excipient Fest Ireland Cork, Ireland, , 19-JUN-07 - 20-JUN-07 [Details]
(2007)All Ireland School of Pharmacy Conference
Faisal W, O'Driscoll CM, Griffin BT; (2007) Comparison of the intestinal lymphatic transport of lycopene in anaesthetised rat from a range of lipid based formulations All Ireland School of Pharmacy Conference Dublin, Ireland, [Details]
(2004)Amer Assoc Pharm Sci., (AAPS) Annual meeting
Griffin BT, Lawless E and O¿Driscoll CM; (2004) Comparision of the degree of lymphatic transport of a range of lipophilic compounds in the presence of an oleic acid based microemulsion Amer Assoc Pharm Sci., (AAPS) Annual meeting Baltimore, USA, [Details]
(2013)Royal Academy of Medicine in Ireland (RAMI) Annual Meeting, University College Cork, June 2013
O’Brien FE, O’Connor RM, Clarke G, Dinan TG, Griffin BT, Cryan JF (2013) Effect of P-glycoprotein Inhibition on the brain distribution and antidepressant-like activity of escitalopram in rodents Royal Academy of Medicine in Ireland (RAMI) Annual Meeting, University College Cork, June 2013 [Details]
(2012)American Association of Pharmaceutical Scientists Annual Meeting and Exposition (AAPS) Chicago, USA, October 2012
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) P-glycoprotein limits antidepressant transport across the blood-brain barrier: converging evidence from in vitro and in vivo studies American Association of Pharmaceutical Scientists Annual Meeting and Exposition (AAPS) Chicago, USA, October 2012 [Details]
(2012)Neuroscience Ireland, RCSI, Dublin, September 2012
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) P-glycoprotein restricts blood-brain barrier transport of the antidepressant escitalopram: converging evidence from in vitro and in vivo studies Neuroscience Ireland, RCSI, Dublin, September 2012 [Details]
(2012)British Pharmacological Society (BPS) Winter Meeting, London, December 2012
O’Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT (2012) The Influence of P-glycoprotein on the Blood-Brain Barrier Transport of the Antidepressant Escitalopram: Converging Evidence from In Vivo and In Vitro Studies British Pharmacological Society (BPS) Winter Meeting, London, December 2012 [Details]
(2013)3rd Annual UK & Ireland Early Career BBB Symposium, Cambridge, UK, 22 November 2013
O’Brien FE, Clarke G, Dinan TG, Griffin BT, Cryan JF. (2013) P-glycoprotein inhibition as a strategy to augment antidepressant delivery across the blood-brain barrier: preclinical pharmacokinetic and pharmacodynamic studies 3rd Annual UK & Ireland Early Career BBB Symposium, Cambridge, UK, 22 November 2013 [Details]
(2014)27th ECNP Congress
Donovan, MD and O'Brien, FE and Boylan, GB and Griffin, BT and Cryan, JF (2014) An in vitro, in vivo, in silico approach to investigate effects of OAT3 inhibition on bumetanide levels in the brain 27th ECNP Congress Berlin, [Details]

Editorship

 YearPublication
(2019)The PEARRL reviews - innovative drug development strategies tailored to facilitate earlier access to new oral medicines.
Griffin, BT;Dressman, JB (2019) The PEARRL reviews - innovative drug development strategies tailored to facilitate earlier access to new oral medicines. HOBOKEN: Editorship [DOI] [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2007FMC BioPolymer Award ExcipientFest Europe
1998Mendel Award Pharmaceutical Technology Conference and Exhibition

Professional Associations

 AssociationFunctionFrom / To
Parenteral Drug Association Comittee member of the Irish Chapter01-JAN-05 / 30-DEC-99
American association of Pharmaceutical Scientists *01-JAN-98 / 30-DEC-99

Conference Contributions

 YearPublication
(2008)The AAPS Annual Meeting,
W. Faisal, C.M. O'Driscoll, B. Griffin ; (2008) Solubility and stability of lycopene in lipid-based formulations. [Oral Presentation], The AAPS Annual Meeting, Atlanta, USA , 15-NOV-08 - 15-NOV-08. [Details]
(2007)The 3rd Pharmaceutical Sciences World Congress PSWC,
W. Faisal, C.M. O'Driscoll, B. Griffin; (2007) Investigations of the mechanisms of absorption of lycopene from the gastro-intestinal tract of the rat. [Oral Presentation], The 3rd Pharmaceutical Sciences World Congress PSWC, Amsterdam , 25-APR-07 - 25-APR-07. [Details]
(2004)Pharm Sci S 2172 Poster Presented at APPS,
Griffin, B., Lawless, E. O¿Driscoll, C; (2004) Comparison of the Degree of Lymphatic Transport of a Range of Lipophilic Compounds in the Presence of an Oleic Acid-Based Microemulsion. [Oral Presentation], Pharm Sci S 2172 Poster Presented at APPS, USA , 01-NOV-04 - 01-NOV-04. [Details]

Employment

 EmployerPositionFrom / To
School of Pharmacy, UCC Lecturer01-NOV-04 /
University College Cork Senior Lecturer02-NOV-14 / 02-DEC-14
School of Pharmacy, TCD Lecturer (part-time) in MSc in Pharmaceutical Technology01-JAN-98 / 01-JAN-01
Servier Ireland Industries Qualified Person (QP) Deputy Site QP01-JAN-02 / 29-OCT-04
Servier Ireland Industries Industrial Pharmacist - Technical Services03-SEP-01 / 30-SEP-04

Education

 YearInstitutionQualificationSubject
2001Trinity College Dublin PHDPharmaceutics
1998Trinity College Dublin Postgraduate DiplomaQuality control and Statistics
1996Trinity College Dublin BSCPharmacy

Consultancy

 ClientDescription
Contract QP work for Pharmaceutical industry
GMP standards for the Pharmaceutical industry

Teaching Activities

Teaching Interests

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2018Joseph O'Shea University College CorkDOCTOR OF PHILOSOPHYMechanistic understanding of bioenabling formulation approaches to improve oral bioavailability using porcine in vivo and in silico models
2016Maria Donovan University College CorkDOCTOR OF PHILOSOPHYNovel Strategoies to Enhance Bumetanide Concentrations in teh Brain in the treatment of Neonatal Seizures
2014Kieran Keohane University College CorkPHDDESIGN AND EVALUATION OF NOVEL MICROENCAPSULATION TECHNOLOGIES TO ENHANCE DELIVERY OF CICLOSPORIN
2009Mohammed Bahey El-din University College CorkPHDInvestigation of Lactococcus Lactis-based vaccines against Listeria monocytogenes
2014Fionn O'Brien University College CorkPHDP-glycoprotein Inhibition as a Strategy to Increase Drug Delivery across the Blood-Brain Barrier: Focus on Antidepressants
2009Waleed Faisal University College CorkPhDLipid based formulation approaches to enhance bioavailability fo lycopene

Current Postgraduate Students

 StudentDegree Type
Howick Kenneth Patrick Doctoral Degree
Walsh Jacinta Doctoral Degree
Ilie Alexandra Roxana Doctoral Degree

Modules Taught

 Term (ID))TitleLinkSubject
2020Quality Management Systems and Regulatory Affairs PF6208Quality Management Systems and Regulatory Affairs
2020GXP - The Fundamentals for Working in a Regulatory Environment PF6601GXP - The Fundamentals for Working in a Regulatory Environment
2020Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance PF6301Biopharmaceuticals: Formulation Design, Secondary Processing and Regulatory compliance
2020Pharmaceutical Microbiology and Sterile Manufacturing PF6203Pharmaceutical Microbiology and Sterile Manufacturing
2020Role and Professional Duties of the Qualified Person PF6209Role and Professional Duties of the Qualified Person
2020Dissertation in Pharmaceutical Technology and Quality Systems PF6210Dissertation in Pharmaceutical Technology and Quality Systems

Research Information

External Collaborators

 NameOrganisation / InstituteCountry
Professor Jennifer Dressman .W. Goethe University in FrankfurtGERMANY
Prof. Christos Reppas National and Kapodestrian University of AthensGREECE
Professor Martin Kuentz University of Applied Sciences North-western SwitzerlandSWITZERLAND

Contact details

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School of Pharmacy

Cógaisíocht

Cavanagh Pharmacy Building Room UG06 University College Cork

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