Lecturer In Pharmaceutical Chemistry
School of Pharmacy
Cavanagh Pharmacy Building
University College Cork
Cork
Ireland

T: 353 (0)21 4901655
F: 353 (0)21 4901656
E: Tim.OSullivan@ucc.ie


Dr Tim O’Sullivan received his BSc Degree in Industrial Chemistry from the University of Limerick in 1997. He then went on to do a PhD in natural products synthesis under the supervision of Prof. Lew Mander at the Research School of Chemistry of the Australian National University from 1998 to 2001. He worked as a postdoctoral researcher on the synthesis of Tamoxifen analogues with Prof. Mary Meegan in Trinity College Dublin from 2001 before taking up another postdoctoral fellowship with Prof. Pat Guiry in University College Dublin on the synthesis of novel Lipoxin analogues in 2003 . Following a period as research manager in UCD, he was appointed as Lecturer in Pharmaceutical Chemistry in the School of Pharmacy/Department of Chemistry/ABCRF in UCC in 2006. He is currently a member of both COST Action CM1307 'Targeted chemotherapy towards diseases caused by endoparasites' and the Royal Society of Chemistry.



Postgraduate and postdoctoral positions:

We welcome applications from suitably qualified candidates seeking PhD and postdoctoral funding via the Irish Research Council or EU Marie Curie Fellowships.





Research Interests

Synthesis of Natural Products and Medicinal Compounds

Our research is focused on developing new methods and strategies for the synthesis of bioactive, natural products. The underlying goal in this work is to improve upon existing techniques and to discover novel methods for assembling complex molecular targets. Ultimately, we aim to apply this knowledge to the development of more potent analogues of existing compounds, with a view to producing pharmaceutically relevant therapeutic agents.

 


New Drugs for Chagas Disease

The infectious agent of Chagas disease is Trypanosoma cruzi, which is closely related to the parasites which cause African sleeping sickness and leishmaniasis. The parasite usually enters the bloodstream of mammals through blood-sucking insects e.g. assassin bugs. Between 8 to 11 million people in Mexico, Central America, and South America are estimated to have Chagas disease, most of whom do not know they are infected. If untreated, infection is lifelong and can be life threatening. The acute phase of the disease is characterised by symptoms such as fever, fatigue, body aches, headache, rash, loss of appetite, diarrhoea and vomiting. In the chronic phase, the disease may result in cardiac complications, such as heart failure, or intestinal problems. The average life-time risk of developing one or more of these complications is about 30% with a fatality rate of around 50,000 people per annum.


More than 600 peroxides have been isolated from natural sources to date. Many have been found to be biologically active, displaying anti-cancer, anti-bacterial and anti-parasitic effects e.g. artemisinin. Recently, Plakortide P was reported to be highly selective against T. cruzi, in addition to displaying anti-leishmanial (L. chagasi) and anti-neuroinflammatory effects. We have developed a methodology for the asymmetric peroxidation of unsaturated aldehydes which has direct application to the synthesis of cycloperoxides. We are exploiting this chemistry to develop more potent analogues of Plakortide P.



Signalling Molecules - Disrupting Biofilm Formation in Cystic Fibrosis lung

Cystic Fibrosis (CF) is an inherited disease which affects about 1,500 Irish people. CF causes the body to produce an abnormally sticky fluid in the lungs which makes CF patients susceptible to serious bacterial infection.CF patients are faced with frequent stays in hospital as they are prone to infection by antibiotic-resistant bacteria. Approximately 60% CF patients have a chronic respiratory infection co-infected with multiple bacteria that settle into the thick mucus trapped in the airways. These bacteria have evolved a special type of defence where they excrete a chemical messenger on treatment with an antibiotic. These chemical messengers are cis-2-unsaturated fatty acids, with the most important being Diffusible Signal Factor (DSF). DSF leads to increased biofilm formation and resistance to antibiotics, factors that prolong the infection. We are developing compounds which inhibit the effects of DSF and thereby  shut down the bacterias’ defence mechanism.



Novel Anti-viral Therapies

There is a huge demand for new anti-retroviral drugs to increase patients treatment options, especially for drugs with enhanced safety profiles that display reduced side-effects and which are competitively priced. Given that NRTIs (Nucleotide Reverse Transcriptase Inhibitors) are currently used in first-line treatment in combination therapies, we are investigating their mode of action at a molecular level with the aim discovering  more potent NRTIs.The NRTIs currently marketed operate by prematurely terminating the HIV life cycle. A key step in this process involves the in vivo cleavage of the very strong Phosphorous-Oxygen bond which is either present in the original NRTI (e.g. Tenofovir) or is added by in vivo phorsphorylation. We believe that a more efficient inhibitor should result if the stronger Phosphorous-Oxygen bond is replaced with a more labile Phosphorous-Sulfur bond . The P-S bond is considered a bioisostere of the P-O bond, thus representing an excellent candidate for strategic substitution.



Postgraduate and postdoctoral positions

We welcome applications from suitably qualified candidates seeking PhD and postdoctoral funding via the Irish Research Council or EU Marie Sklodowska Curie Fellowships (Individual Fellowships).





Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
H2020"655508 COMMANDEER MSCA-IF-2014"Dr T O'Sullivan :Horizon 202001-JUL-1530-JUN-17€187,866.00
Design and synthesis of novel sulfur-containing anti-HIV compoundsUCC Strategic Research Fund06-OCT-1405-OCT-17€47,310.00
Investigating the structure-activity relationship of current NRTIs with a view towards synthesising novel antiviral drug compounds.Irish Research Council01-OCT-1430-SEP-18€96,000.00
Rationally designed chiral cycloperoxides - new drugs for neglected diseases.Irish Research Council01-JAN-1431-DEC-17€96,000.00
Equipment bid - CEM Microwave reactorUCC Strategic Research Fund29-OCT-13€10,688.00
New therapies for cystic fibrosis lung infectionsScience Foundation Ireland23-JUL-1222-JUL-14€50,569.00
Towards an enantioselective synthesis of Plackortide P and its application to the development of drugs for the treatment of Chagas disease.European Union05-SEP-1104-SEP-13€204,584.00
Opensource chemistry questionbank for flexible, online teaching and assessment of students using SMILESNAIRTL31-AUG-1130-AUG-12€5,595.00
Towards an enantioslective synthesis of Plakortide P and its application to the development of drugs for the treatment of Chagas diseaseIrish Research Council for Science, Engineering & Technology (IRCSET)31-DEC-0930-DEC-13€72,009.00

Contract Researchers

 Researcher NameProjectRoleFunding Body
Dr Pavan KumarCOMMANDEERResearch FellowHorizon 2020
Dr Manoj GuptaPLAKORTIDEResearch FellowEuropean Framework Programme Seven (FP7)
Dr Julie MurtaghNew therapies for cystic fibrosis lung infectionsResearch AssistantScience Foundation Ireland

Book Chapters

YearPublication
(2011)'Di-t-butylchlorosilane'
Hardgaden GC, O'Sullivan TP (2011) 'Di-t-butylchlorosilane' In: Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis. Chichester: Wiley. [Details]

Peer Reviewed Journals

YearPublication
(2017)'Advances in the synthesis of acyclic peroxides'
Gandhi, Hirenkumar; O'Reilly, Kate; Gupta, Manoj K.; Horgan, C.; O'Leary, Eileen M.; O'Sullivan, Timothy P. (2017) 'Advances in the synthesis of acyclic peroxides'. RSC Advances, 7 (32):19506-19556 [DOI] [CORA Link] [Details]
(2016)'Cinchona-catalysed, Enantioselective Synthesis of β-Peroxycarboxylic Acids, β-Peroxyesters and β-Peroxyalcohols'
Kate O’Reilly, Manoj K. Gupta, Hirenkumar Gandhi, Vydyula P. Kumar, Kevin S. Eccles, Simon E. Lawrence and Timothy P. O’Sullivan (2016) 'Cinchona-catalysed, Enantioselective Synthesis of β-Peroxycarboxylic Acids, β-Peroxyesters and β-Peroxyalcohols'. Current Organic Chemistry, 20 (24):2633-2638 [DOI] [Details]
(2016)'The Application of Molecular Tethers in Controlling Axial Chirality'
Michael Reen and Timothy P. O'Sullivan (2016) 'The Application of Molecular Tethers in Controlling Axial Chirality'. Mini-Reviews in Organic Chemistry, 13 (3):206-218 [DOI] [CORA Link] [Details]
(2015)'Synthesis of fluorinated oxygen- and sulfur-containing heteroaromatics'
Eileen M. O’Leary, David J. Jones, Fıona P. O’Donovan, Timothy P. O’Sullivan (2015) 'Synthesis of fluorinated oxygen- and sulfur-containing heteroaromatics'. Journal of Fluorine Chemistry, 176 :93-120 [DOI] [CORA Link] [Details]
(2014)'Using Structure-Based Organic Chemistry Online Tutorials with Automated Correction for Student Practice and Review'
Timothy P. O’Sullivan and Gráinne C. Hargaden (2014) 'Using Structure-Based Organic Chemistry Online Tutorials with Automated Correction for Student Practice and Review'. Journal Of Chemical Education, 91 (11):1851-1854 [DOI] [CORA Link] [Details]
(2013)'Recent applications of gallium and gallium halides as reagents in organic synthesis'
Gupta, MK,O'Sullivan, TP (2013) 'Recent applications of gallium and gallium halides as reagents in organic synthesis'. RSC Advances, :25498-25522 [DOI] [CORA Link] [Details]
(2013)'Production of a chiral alcohol, 1-(3,4-dihydroxyphenyl)'
Sarah J. Brooks, Jasmina Nikodinovic, Leona Martin, Evelyn M. Doyle, Timothy O’Sullivan, Patrick J. Guiry, Lydie Coulombel, Zhi Li, Kevin E. O’Connor (2013) 'Production of a chiral alcohol, 1-(3,4-dihydroxyphenyl)'. Biotechnology Letters, 35 (5):779-783 [DOI] [Details]
(2011)'Lipoxin A4 and benzo-lipoxin A4 attenuate experimental renal fibrosis'
Börgeson E, Docherty NG, Murphy M, Rodgers K, Ryan R, O'Sullivan TP, Guiry PJ, Goldschmeding R, Higgins DF, Godson C; (2011) 'Lipoxin A4 and benzo-lipoxin A4 attenuate experimental renal fibrosis'. The Faseb Journal, 25 (9):2967-2979 [DOI] [Details]
(2008)'Synthesis of non-symmetric bis(oxazoline)-containing ligands and their application in the catalytic enantioselective Nozaki-Hiyama-Kishi allylation of benzaldehyde'
Hargaden GC, O'Sullivan TP, Guiry PJ; (2008) 'Synthesis of non-symmetric bis(oxazoline)-containing ligands and their application in the catalytic enantioselective Nozaki-Hiyama-Kishi allylation of benzaldehyde'. Organic and Biomolecular Chemistry, 6 (3):562-566 [DOI] [Details]
(2007)'Model studies toward the synthesis of the bioactive diterpenoid, harringtonolide'
O'Sullivan TP, Zhang H, Mander LN; (2007) 'Model studies toward the synthesis of the bioactive diterpenoid, harringtonolide'. Organic and Biomolecular Chemistry, 5 (16):2627-2635 [DOI] [CORA Link] [Details]
(2007)'Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities'
O'Sullivan TP, Vallin KS, Shah ST, Fakhry J, Maderna P, Scannell M, Sampaio AL, Perretti M, Godson C, Guiry PJ; (2007) 'Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities'. Journal of Medicinal Chemistry, 50 (24):5894-5902 [DOI] [Details]
(2006)'Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes: synthesis, structure-activity relationships and molecular modeling study for flexible estrogen receptor agonists'
Lloyd, D. G., Smith, H. M., O'Sullivan, T. P., Knox, A. S., Zisterer, D. M. and M. J. Meegan.; (2006) 'Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes: synthesis, structure-activity relationships and molecular modeling study for flexible estrogen receptor agonists'. Medicinal Chemistry, 2 (2):147-168 [DOI] [Details]
(2005)'Synthesis, structure-activity relationships and antagonistic effects in human MCF-7 breast cancer cells of flexible estrogen receptor modulators'
Lloyd DG, Smith HM, O'Sullivan T, Zisterer DM, Meegan MJ; (2005) 'Synthesis, structure-activity relationships and antagonistic effects in human MCF-7 breast cancer cells of flexible estrogen receptor modulators'. Medicinal Chemistry, 1 (4):335-353 [DOI] [Details]
(2005)'Synthesis of dihydrofurans substituted in the 2-position'
Kilroy, T. G.,O'Sullivan, T. P.,Guiry, P. J.; (2005) 'Synthesis of dihydrofurans substituted in the 2-position'. European Journal of Organic Chemistry, (23):4929-4949 [DOI] [Details]
(2005)'The development of enantioselective rhodium-catalysed hydroboration of olefins'
Carroll, A. M.,O'Sullivan, T. P.,Guiry, P. J.; (2005) 'The development of enantioselective rhodium-catalysed hydroboration of olefins'. Advanced Synthesis and Catalysis, 347 (5):609-631 [DOI] [Details]
(2005)'Synthesis of quinazolinones and quinazolines'
Connolly, D. J.,Cusack, D.,O'Sullivan, T. P.,Guiry, P. J.; (2005) 'Synthesis of quinazolinones and quinazolines'. Tetrahedron, 61 (43):10153-10202 [DOI] [Details]
(2003)'An exploration of the potential of 4+2 cycloadditions of alpha-pyrones with indenones for the synthesis of the norditerpenoid tropone, Harringtonolide'
Mander, L. N.,O'Sullivan, T. P.; (2003) 'An exploration of the potential of 4+2 cycloadditions of alpha-pyrones with indenones for the synthesis of the norditerpenoid tropone, Harringtonolide'. Synlett, (9):1367-1369 [DOI] [Details]

Conference Publications

YearPublication
(2013)5th Eurovariety in Chemistry Education Conference
Timothy P. O'Sullivan and Grainne C. Hargaden (2013) Flexible, online teaching and assessment of organic chemistry using MarvinSketch and SMILES 5th Eurovariety in Chemistry Education Conference Limerick, Ireland, [Details]
(2013)5th Eurovariety in Chemistry Education Conference
J.J. Keating, E.M. O'Leary and T.P. O'Sullivan (2013) Teaching Chemistry Through ‘Discipline’ Eyes’ 5th Eurovariety in Chemistry Education Conference Limerick, Ireland, [Details]
(2013)5th Eurovariety in Chemistry Education Conference
Eileen M. O’Leary and Timothy P. O’Sullivan (2013) A PACT with pharmacy students 5th Eurovariety in Chemistry Education Conference Limerick, Ireland, [Details]

Honours and Awards

 YearTitleAwarding Body
2016Best Poster Prize - RSC Organic Division Ireland Regional Meeting (Fiona O'Donovan) Royal Society of Chemistry
2016UCC Digital Champion Award UCC
2013President’s Awards for Research Into Innovative Forms of Teaching UCC
2008Tetrahedron Award for ‘Most Cited Paper 2005 – 2008' Tetrahedron

Professional Associations

 AssociationFunctionFrom / To
Royal Society of Chemistry Member/

Conference Contributions

YearPublication
(2017)XVII International Conference on Heterocycles in Bioorganic Chemistry,
Fíona O’Donovan, Eileen M. O’Leary, Timothy P. O’Sullivan (2017) Towards the Synthesis of Novel Sulfur-Containing Antiviral Analogues. [Oral Presentation], XVII International Conference on Heterocycles in Bioorganic Chemistry, NUIG, Galway , 31-MAY-17 - 31-MAY-17. [Details]
(2016)Antiparasitic Chemotherapy for Human and Veterinary Use - 3rd COST Action CM1307 Conference,
Hirenkumar Gandhi, Timothy P. O’Sullivan, Ligia F. Ceole, Luz H. Villamizar, Maurilio J. Soares (2016) Modelling, synthesis and evaluation of novel quinine analogues new drugs for chagas disease. [Poster Presentation], Antiparasitic Chemotherapy for Human and Veterinary Use - 3rd COST Action CM1307 Conference, Madrid, Spain , 24-OCT-16 - 25-OCT-16. [Details]
(2016)31st International Symposium on Chromatography (ISC2016),
Jones, D.; O’Leary, E.M.; O’Sullivan, T.P. (2016) Dithiophosphonate Analogues of Acyclic Nucleoside Reverse Transcriptase Inhibitors Synthesis, Isolation and Analysis of Key Intermediates. [Poster Presentation], 31st International Symposium on Chromatography (ISC2016), University College Cork, Cork , 29-AUG-16. [Details]
(2016)31st International Symposium on Chromatography (ISC2016),
O’Donovan, F.P.; O’Leary, E.M.; O’Sullivan, T.P. (2016) Synthesis and analysis of novel sulfur-containing antiviral analogues. [Poster Presentation], 31st International Symposium on Chromatography (ISC2016), University College Cork, Cork , 29-AUG-16. [Details]
(2016)31st International Symposium on Chromatography (ISC2016),
Horgan, C., Kumar, V. P. and O’Sullivan T. P. (2016) Synthesis And Characterisation Of Novel Analogues Of Diffusible Signal Factor. [Poster Presentation], 31st International Symposium on Chromatography (ISC2016), University College Cork, Cork , 29-AUG-16. [Details]
(2016)31st International Symposium on Chromatography (ISC2016),
Gandhi, H., and O’Sullivan T. P. (2016) Asymmetric Peroxidation Of a,b-Unsaturated Aldehydes And Determination Of Enantioselectivity By Chiral HPLC. [Poster Presentation], 31st International Symposium on Chromatography (ISC2016), University College Cork, Cork , 29-AUG-16. [Details]
(2016)RSC Organic Division Ireland Regional Meeting 2016,
Fíona P. O’Donovan, Timothy P. O’Sullivan, Eileen M. O’Leary (2016) Towards the synthesis of novel sulfur-containing antiviral analogues. [Poster Presentation], RSC Organic Division Ireland Regional Meeting 2016, Dublin . [Details]
(2015)Variety in Chemistry Education Physics Higher Education Conference 2015,
Timothy P. O'Sullivan (2015) The use of online, formative assessment for contextualising key physicochemical concepts for pharmacy students. [Oral Presentation], Variety in Chemistry Education Physics Higher Education Conference 2015, University of Nottingham, UK , 20-AUG-15 - 20-AUG-15. [Details]
(2015)Pharmacy Education Conference 2015,
Eileen M. O'Leary, J. J. Keating and Timothy P. O'Sullivan (2015) The use of online, formative assessment for contextualising key physicochemical concepts underpinning drug action. [Poster Presentation], Pharmacy Education Conference 2015, Manchester , 29-JUN-15 - 29-JUN-15. [Details]
(2015)Royal Society of Chemistry Organic Division Regional Symposium,
Timothy P. O'Sullivan (2015) New methods for the synthesis of chiral peroxides. [Oral Presentation], Royal Society of Chemistry Organic Division Regional Symposium, University College Cork, Cork , 17-APR-15 - 17-APR-15. [Details]
(2014)Recent Advances in Synthesis and Chemical Biology XIII,
Timothy P. O’Sullivan and Hirenkumar Gandhi (2014) SYNTHESIS AND MOLECULAR-DOCKING STUDIES OF QUININE ANALOGUES AS POTENTIAL INHIBITORS OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE (TcTR). [Poster Presentation], Recent Advances in Synthesis and Chemical Biology XIII, Dublin , 12-DEC-14. [Details]
(2014)Adopting Courses from Traditional Face-to-Face to Online and Blended Learning,
T. P. O'Sullivan (2014) How to create meaningful continuous assessment questions with feedback on Blackboard. [Invited Lectures (Workshops)], Adopting Courses from Traditional Face-to-Face to Online and Blended Learning, University College Cork, Cork , 13-JUN-14 - 13-JUN-14. [Details]
(2013)5th Eurovariety in Chemistry Education Conference,
Timothy P. O'Sullivan (2013) Flexible, online teaching and assessment of organic chemistry using MarvinSketch and SMILES. [Oral Presentation], 5th Eurovariety in Chemistry Education Conference, Limerick, Ireland , 03-JUL-13 - 05-JUL-13. [Details]
(2013)Synthesis of Bioactive Molecules VIII,
Dr Andrew J Whitehead, GlaxoSmithKline; Prof Mary Meegan, Trinity College Dublin; Dr Marie Kissane, Eli Lilly; Prof David O’Hagan, University of St Andrews; Dr Hugues Miel, Almac Discovery; Dr AnnMarie O'Donoghue, University of Durham. (2013) Synthesis of Bioactive Molecules. [Conference Organising Committee Member], Synthesis of Bioactive Molecules VIII, University College Cork, Cork , 14-JUN-13 - 14-JUN-13. [Details]
(2013)RICT 2013 - Discovery and Selection - When Chemical Biology meets Drug Design,
Julie Murtagh, Robert Ryan, Timothy P. O’Sullivan (2013) INTERFERENCE WITH BACTERIAL CELL-CELL SIGNALLING USING SYNTHETICALLY GENERATED UNSATURATED FATTY ACIDS. [Poster Presentation], RICT 2013 - Discovery and Selection - When Chemical Biology meets Drug Design, Nice, France . [Details]
(2013)65th Irish Universities Chemistry Research Colloquium,
Kate O’ Reilly, Manoj K. Gupta, Timothy P. O’ Sullivan (2013) Enantioselective Peroxidaton of Unsaturated Aldehydes – A New Route to Plakortide P. [Poster Presentation], 65th Irish Universities Chemistry Research Colloquium, Dublin, Ireland . [Details]
(2012)North West Organic Chemistry Symposium,
G.C. Hargaden and T.P. O’Sullivan (2012) Chemnet - Open source chemistry question bank for flexible, online teaching and assessment of students using SMILES. [Poster Presentation], North West Organic Chemistry Symposium, Liverpool . [Details]
(2012)North West Organic Chemistry Symposium,
Michael Reen and Timothy P. O'Sullivan (2012) Development of Novel Chiral Tethers for Controlling Intermolecular Aryl-Aryl Coupling and Application in the Synthesis of Gomisin M1. [Poster Presentation], North West Organic Chemistry Symposium, Liverpool . [Details]
(2012)North West Organic Chemistry Symposium,
Kate O'Reilly, Manoj K. Gupta and Timothy P. O'Sullivan (2012) Organocatalytic enantioselective peroxidation of unsaturated aldehydes - a new route to bioactive cycloperoxides. [Poster Presentation], North West Organic Chemistry Symposium, Liverpool . [Details]
(2011)XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique,
Kate O'Reilly and Timothy P. O'Sullivan (2011) Towards an enantioselective systhesis of Plakortide P and its application towards drug development. [Poster Presentation], XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique, Cork . [Details]

Committees

 CommitteeFunctionFrom / To
Working group on PSI MPharm accreditation Member2015 / 2016
Pharmacy Timetable Working Group Chair2014 /
Chemistry Teaching and Examinations Committee Member2015 /
COST Action CM1307 Targeted chemotherapy towards diseases caused by endoparasites Member2014 /
Chemistry Staff/Student Committee Member2014 /
SOP Promotion of Pharmacy Committee Member2014 /
MPharm Curriculum Planning Group Member2010 / 2010
School of Pharmacy Board Member2006 /
Chemistry Departmental Committee Member2006 /
BSc Chemistry of Pharmaceutical Compounds Management Committee CPC3 Year Co-ordinator2006 /

Employment

 EmployerPositionFrom / To
University College Cork Lecturer in Pharmaceutical Chemistry20-SEP-06 / 20-FEB-15
Centre for Synthesis and Chemical Biology, University College Dublin Research Manager07-FEB-05 / 15-SEP-06
Centre for Synthesis and Chemical Biology, University College Dublin Postdoctoral Fellow10-FEB-03 / 06-FEB-05
School of Pharmacy, Trinity College Dublin Postdoctoral Fellow05-NOV-01 / 24-JAN-03

Education

 YearInstitutionQualificationSubject
2015UCC Postgrad Cert. in Teaching & Learning in HETeaching and Learning in HE
2001ANU, Canberra PhDOrganic Synthesis
2001Charles Sturt University, NSW Graduate DiplomaInformation Technology
1997UL, Limerick BScIndustrial Chemistry

Journal Activities

 JournalRoleTo / From
International Journal Of Pharmaceutical Sciences Research Member of Editorial Board01-DEC-15 -
Future Medicinal Chemistry Referee-
Monatshefte Für Chemie - Chemical Monthly Referee-
Tetrahedron Letters Referee-
Chemical Society Reviews Referee-
Chemical Communications Referee-
Organic Chemistry Frontiers Referee-
Organic And Biomolecular Chemistry Referee-

Other Activities

 Description

2016: Hosted SEFS summer research bursary student (Conor Horgan, Chemistry 3)

2016: Hosted Erasmus summer exchange research student from École des Mines d'Albi-Carmaux (Maël Brehonnet)

2015: Hosted Erasmus summer exchange research student from Université de Nantes (Jessica Robin)


2011: Hosted Erasmus summer exchange research student from Ecole Nationale Supérieure de Chimie de Clermont-Ferrand (Fallia Aribi)

2009: Hosted Erasmus summer exchange research student from Ecole Nationale Supérieure de Chimie de Clermont-Ferrand (Clementine Bouvet).

2008: Hosted Erasmus summer exchange research student from Ecole Nationale Supérieure de Chimie de Clermont-Ferrand (Julie Movellan).                   

Teaching Interests

Currently

PF1009 - Introduction to Pharmaceutical Chemistry

PF2012 - Pharmaceutical Analysis

PF3012 - Respiratory, Musculoskeletal and Dermatology Systems

CM1005 - Introductory Chemistry for Food and Nutritional Scientists

CM3022 - Synthesis, Structure and Reactivity of Organic Compounds

CM3028 - Scientific Communication and Information Literacy Skills

CM4022 - Advanced Organic Synthesis, Biosynthesis and Reactivity

CM7005 - Theory and Application of Computational Chemistry 

Previously

CM1100 - History of Chemistry

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2016Michael Reen NUI (UCC)PHDThe development of novel chiral tethers for controlling intramolecular aryl-aryl coupling and their application in the synthesis of Gomisin M1 and analogues
2014Kate O'Reilly NUI (UCC)PHDTowards the enantioselective synthesis of Plakortide P and its application to the development of drugs for the treatment of Chagas Disease

Current Postgraduate Students

 StudentDegree Type
Gandhi Hirenkumar Doctoral Degree
Jones David James Doctoral Degree
Lyons Therese Anne Doctoral Degree
O Donovan Fiona Patricia Doctoral Degree

Internal Collaborators

 NameInstituteCountry
Dr Eileen O'Leary School of Pharmacy, UCCIRELAND

External Collaborators

 NameOrganisation / InstituteCountry
Maurilio José Soares Instituto Carlos ChagasBRAZIL