Research Profile

Cora O'Neill

Biography

Dr. Cora O’Neill is Vice-Head of the School of Biochemistry and Cell Biology, Director of the Cork Neuroscience Centre and principal investigator of a research team whose major focus is Alzheimer’s disease and related dementia disorders. She graduated with a BSc (Hons) in Biochemistry from University College Dublin and PhD in Biochemistry from Trinity College Dublin (1985). She conducted her post-doctoral training at the Swedish Brain Bank in Umea Sweden (1986-87), where she started to work on Alzheimer’s disease, and subsequently in the Department of Geriatric Medicine, Karolinska Institute Sweden (1987-93) where she became a group leader in Alzheimer’s disease research. She was appointed as a College Lecturer  (1993) and Senior Lecturer (2001) in University College Cork, where she established the Alzheimer's disease Research Group and has been at the forefront of research in neurodegeneration. As Chair of Graduate Studies in the School of Biochemistry and Cell Biology, she is a leader in research-led teaching and post-graduate education.  

Dr. O’Neill’s  major research interests are to understand the basic mechanisms that cause neurodegeneration with age in Alzheimer’s, Parkinson’s and related neurodegenerative diseases. Her research pinpointing defects in insulin signalling in the brain as an early cause of Alzheimer’s disease is highly cited and translating to new therapies and biomarkers for the disease. This feeds into the ultimate goal of her research which is to develop better drug therapies, diagnostic tools and lifestyle interventions to treat and prevent neurodegeneration. She is a major advocate for increased investment in Alzheimer’s and neurodegeneration research nationally, has organised several national and international conferences and served on a number of scientific and advisory boards including the Irish National Steering Committee on Neurodegenerative diseases, the Royal Irish Academy National Committee for Biochemistry, the Irish Bioindustries Association committee and as Chair of the Irish Area Section of the Biochemical Society.  

Research Interests

Research Interests
Age related neurodegenerative diseases, particularly Alzheimer’s and related dementia disorders, have been identified as one of the major grand challenges facing society in the next thirty years. The overall aim of our research is to understand the basic mechanisms that stop functioning correctly in the brain to cause neurodegeneration in Alzheimer’s disease and related neurodegenerative disorders, including Parkinson’s disease. The ultimate aim of our work is  to translate our research findings to develop better diagnostic tools, treatment strategies and lifestyle choices to stall or prevent Alzheimer’s and related neurodegenerative disease, an extremely urgent societal challenge.

The outcome of our research program has led to significant discoveries which have identified primary defective molecular and cell systems that underlie neurodegeneration in Alzheimer’s disease and related disorders. Specifically, our more recent work and current research focus is leading in research highlighting the role of defective insulin and IGF-1 signalling and the interlinked PI3-kinase/Akt/mTOR axis as an early cause of neurodegeneration in Alzheimer’s and also Parkinson’s disease. This work  integrates with highly significant attention on this pathway as a converging causative metabolic node of all major diseases of ageing, including neurodegeneration, type 2 diabetes, and cancer. Importantly, our discoveries in this area are translating to new treatments targeting this pathway in neurodegenerative disease and to new diagnostic biomarker platforms for Alzheimer’s and Parkinson’s disease.

Our research approach employs a diverse range of biochemical, cell and molecular approaches to discover the primary and earliest mechanisms of neurodegeneration in Alzheimer’s disease, dementia and related disorders including Parkinson’s disease. Our research employs patient material, transgenic animal and cellular models of neurodegenerative disease. Our approach is multidisciplinary and has developed excellent institutional, national and international collaborations integrated with patient advocacy groups in order to combine basic and clinical translational research with patient care in neurodegeneration.

Publications

Peer Reviewed Journals

 YearPublication
(2015)'The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes'
O'Flanagan CH, Morais VA, Wurst W, De Strooper B, O'Neill C (2015) 'The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes'. Oncogene, 34 ((11)):1363-1374 [DOI] [Details]
(2014)'PINK1 signalling in cancer biology'
O'Flanagan CH, O'Neill C (2014) 'PINK1 signalling in cancer biology'. Biochem Biophys Acta, 1846 ((2)):590-598 [DOI] [Details]
(2013)'The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-beta Plaque and Glial Pathology in a Mouse Model of Alzheimer's Disease'
Long-Smith, CM,Manning, S,McClean, PL,Coakley, MF,O'Halloran, DJ,Holscher, C,O'Neill, C (2013) 'The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-beta Plaque and Glial Pathology in a Mouse Model of Alzheimer's Disease'. NeuroMolecular Medicine, 15 :102-114 [DOI] [Details]
(2013)'PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease'
O' Neill, C (2013) 'PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease'. Experimental Gerontology, 48 :647-653 [DOI] [Details]
(2012)'Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease'
O'Neill, C,Kiely, AP,Coakley, MF,Manning, S,Long-Smith, CM (2012) 'Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease'. Biochemical Society Transactions, 40 :721-727 [DOI] [Details]
(2010)'Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling'
Moloney, AM; Griffin, RJ; Timmons, S; O'Connor, R; Ravid, R; O'Neill, C; (2010) 'Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling'. Neurobiology of aging, 31 (2):224-243 [DOI] [Details]
(2009)'Akt signal transduction dysfunction in Parkinson's disease'
Timmons, S; Coakley, MF; Moloney, AM; O' Neill, C; (2009) 'Akt signal transduction dysfunction in Parkinson's disease'. Neuroscience Letters, 467 (1):30-35 [DOI] [Details]
(2008)'Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells'
Lordan S, O'Neill C, O'Brien NM; (2008) 'Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells'. British Journal of Nutrition, 100 (2):287-296 [DOI] [CORA Link] [Details]
(2008)'Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease'
Stockley JH, O'Neill C; (2008) 'Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease'. Cell and Molecular Life Science, 65 (20):3265-3289 [DOI] [Details]
(2007)'The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain'
Stockley JH, O'Neill C; (2007) 'The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain'. Biochemical Society Transactions, 35 (Pt 3):574-576 [DOI] [Details]
(2006)'Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain'
Stockley JH, Ravid R, O'Neill C; (2006) 'Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain'. Febs Letters, 580 (28-29):6550-6560 [DOI] [Details]
(2005)'Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology'
Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, O'Connor R, O'Neill C; (2005) 'Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology'. Journal of Neurochemistry, 93 (1):105-117 [DOI] [Details]
(2001)'FKBP12 associates tightly with the skeletal muscle type 1 ryanodine receptor, but not with other intracellular calcium release channels'
Carmody M, Mackrill JJ, Sorrentino V, O'Neill C; (2001) 'FKBP12 associates tightly with the skeletal muscle type 1 ryanodine receptor, but not with other intracellular calcium release channels'. Febs Letters, 505 (1):97-102 [Details]
(1997)'Amyloid Precursor Protein Heat Shock Response in Lymphoblastoid Cell Lines Bearing Presenilin-1 Mutations'
Johnston, J. A.; Lannfelt, L.; Wiehager, B.; O'Neill, C.; Cowburn, R. F.; (1997) 'Amyloid Precursor Protein Heat Shock Response in Lymphoblastoid Cell Lines Bearing Presenilin-1 Mutations'. Biochimica Et Biophysica Acta, 1362 :183-192 [Details]
(1999)'Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies'
Kelliher, M,Fastbom, J,Cowburn, RF,Bonkale, W,Ohm, TG,Ravid, R,Sorrentino, V,O'Neill, C; (1999) 'Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies'. Neuroscience, 92 :499-513 [Details]
(1997)'G Protein Subunit Levels in Fibroblasts From Familial Alzheimer's Disease Patients: Lower Levels of the High Molecular Weight Gs alpha Isoform in Patients With Decreased beta -Adrenergic Receptor Stimulated CAMP Formation [B2936]'
Shanahan, C.; Gibson, G. E.; Cowburn, R. F.; Johnston, J. A.; Wiehager, B.; Lannfelt, L.; O'Neill, C.; (1997) 'G Protein Subunit Levels in Fibroblasts From Familial Alzheimer's Disease Patients: Lower Levels of the High Molecular Weight Gs alpha Isoform in Patients With Decreased beta -Adrenergic Receptor Stimulated CAMP Formation [B2936]'. Neuroscience Letters, 232 :33-36 [Details]
(1997)'Amyloid precursor protein heat shock response in lymphoblastoid cell lines bearing presenilin-1 mutations'
Johnston, JA,Lannfelt, L,Wiehager, B,O'Neill, C,Cowburn, RF; (1997) 'Amyloid precursor protein heat shock response in lymphoblastoid cell lines bearing presenilin-1 mutations'. Biochem Biophys Acta, 1362 :183-192 [Details]
(1996)'Cholinergic Signal Transduction Mechanisms in Alzheimer's Disease [B2934]'
Cowburn, R. F.; Fowler, C. J.; O'Neill, C.; (1996) 'Cholinergic Signal Transduction Mechanisms in Alzheimer's Disease [B2934]'. Annals of Psychiatry, 6 :265-272 [Details]
(1996)'Oxidative Stress and Apoptosis in Neurodegeneration [B3068]'
O'Gorman, A. M.; McGowan, A. J.; O'Neill, C.; Cotter, T. G.; (1996) 'Oxidative Stress and Apoptosis in Neurodegeneration [B3068]'. Journal of The Neurological Sciences, 139 :45-52 [Details]
(1996)'Neurotransmitter Receptor/G-Protein Mediated Signal Transduction in Alzheimer's Disease Brain [B2933]'
Cowburn, R. F.; Fowler, C. J.; O'Neill, C.; (1996) 'Neurotransmitter Receptor/G-Protein Mediated Signal Transduction in Alzheimer's Disease Brain [B2933]'. Neurodegeneration, 5 :483-488 [Details]
(1996)'Receptor-effector coupling dysfunctions in Alzheimer's disease'
Fowler CJ, Garlind A, O'Neill C, Cowburn RF (1996) 'Receptor-effector coupling dysfunctions in Alzheimer's disease'. Annals of The New York Academy of Sciences, 786 :294-304 [Details]
(1996)'Neurotransmitters, signal transduction and second-messengers in Alzheimer's disease'
Cowburn RF, Fowler CJ, O'Neill C (1996) 'Neurotransmitters, signal transduction and second-messengers in Alzheimer's disease'. Acta neurologica Scandinavica. Supplementum, 165 :25-32 [Details]
(1995)'Membrane Alterations As Causes of Impaired Signal Transduction in Alzheimer's Disease and Aging [B2927]'
Cowburn, R. F.; O'Neill, C.; Fowler, C. J.; (1995) 'Membrane Alterations As Causes of Impaired Signal Transduction in Alzheimer's Disease and Aging [B2927]'. Trends In Pharmacological Sciences, 18 :483-484 [Details]
(1995)'Disturbances in Signal Transduction Mechanisms in Alzheimer's Disease [B2928]'
Fowler, C. J.; Cowburn, R. F.; Garlind, A.; Winblad, B.; O'Neill, C.; (1995) 'Disturbances in Signal Transduction Mechanisms in Alzheimer's Disease [B2928]'. Molecular and Cellular Biochemistry, 149/150 :287-292 [Details]
(1994)'G-Protein Linked Signal Transduction Systems in the Alzheimer's Disease Brain [B2922]'
O'Neill, C.; Fowler, C. J.; Winblad, B., Cowburn R.; (1994) 'G-Protein Linked Signal Transduction Systems in the Alzheimer's Disease Brain [B2922]'. Biochemical Society Transactions, 22 :167-171 [Details]
(1994)'Regionally Selective Alterations in G Protein Subunit Levels in the Alzheimer's Disease Brain [B2920]'
O'Neill, C.; Wiehager, B.; Fowler, C. J.; Ravid, R.; Winblad, B.; Cowburn, R. F.; (1994) 'Regionally Selective Alterations in G Protein Subunit Levels in the Alzheimer's Disease Brain [B2920]'. Brain Research, 636 :193-201 [Details]
(1994)'Adenylyl Cyclase Activity and G-Protein Subunit Levels in Postmortem Frontal Cortex of Suicide Victims [B2921]'
Cowburn, R. F.; Marcusson, J. O.; Eriksson, A.; Wiehager, B.; O'Neill, C.; (1994) 'Adenylyl Cyclase Activity and G-Protein Subunit Levels in Postmortem Frontal Cortex of Suicide Victims [B2921]'. Brain Research, 633 :297-304 [Details]
(1994)'The Significance of the Swedish APP670/671 Mutation in the Development of Alzheimer's Disease Amyloidosis [B2923]'
Johnston, J.; O'Neill, C.; Lannfelt, L.; Winblad, B.; Cowburn, R. F.; (1994) 'The Significance of the Swedish APP670/671 Mutation in the Development of Alzheimer's Disease Amyloidosis [B2923]'. Neurochemistry International, 25 :73-78 [Details]
(1994)'Increased beta-Amyloid Release and Levels of the Amyloid Precursor Protein in Fibroblast Cell Lines From Family Members With the Swedish Alzheimer's Disease APP670/671 Mutation [B2924]'
Johnston, J.; Cowburn, R. F.;Norgen, S.; Wiehager, B.; Venizelous, N.;Winblad, B.; Vigo-Pelfrey, C.; Schenk, D.; Lannfelt, L.; O'Neill, C.; (1994) 'Increased beta-Amyloid Release and Levels of the Amyloid Precursor Protein in Fibroblast Cell Lines From Family Members With the Swedish Alzheimer's Disease APP670/671 Mutation [B2924]'. FEBS Letters, 354 :274-278 [Details]
(1993)'Biochemical Pathology and Treatment Strategys in Alzheimer's Disease Emphasis on the Cholinergic System [B2918]'
Winblad, B.; Messamore, E.; O'Neill, C.; Cowburn, R. F.; (1993) 'Biochemical Pathology and Treatment Strategys in Alzheimer's Disease Emphasis on the Cholinergic System [B2918]'. Acta Neurologica Scandinavica - Supplement, 88 :4-6 [Details]
(1993)'Disrupted beta -1 Adrenoceptor-G Protein Coupling in the Temporal Cortex of Patients With Alzheimer's Disease [B3136]'
Cowburn, R. F.; Vestling, M.; Fowler, C. J.; Ravid, R.; Winblad, B.; O'Neill, C.; (1993) 'Disrupted beta -1 Adrenoceptor-G Protein Coupling in the Temporal Cortex of Patients With Alzheimer's Disease [B3136]'. Neuroscience Letters, 155 :163-166 [Details]
(1992)'Neurotransmitter, Receptor and Signal Transduction Disturbances in Alzheimer's Disease [B3804]'
Fowler, C. J.; O'Neill, C.; Winblad, B.; Cowburn, R. F.; (1992) 'Neurotransmitter, Receptor and Signal Transduction Disturbances in Alzheimer's Disease [B3804]'. Acta Neurologica Scandinavica. Supplementum, 139 :59-62 [Details]
(1992)'Adenylyl Cylase Activity in Post-Mortem Human Brain: Evidence of Altered G-Protein Mediation in Alzheimer's Disease [B3130]'
Cowburn, R. F.; O'Neill, C.; Ravid, R.; Alafuzoff, I.; Winblad, B.; Fowler, C. J.; (1992) 'Adenylyl Cylase Activity in Post-Mortem Human Brain: Evidence of Altered G-Protein Mediation in Alzheimer's Disease [B3130]'. Journal of Neurochemistry, 58 :1409-1419 [Details]
(1992)'Preservation of Gi-Protein Inhibited Adenylyl Cylase Activity in the Brains of Patients With Alzheimer's Disease [B3129]'
Cowburn, R. F.; O'Neill, C.; Ravid, R.; Winblad, B.; Fowler, C. J.; (1992) 'Preservation of Gi-Protein Inhibited Adenylyl Cylase Activity in the Brains of Patients With Alzheimer's Disease [B3129]'. Neuroscience Letters, 141 :16-21 [Details]
(1992)'Brain Signal Transduction Disturbances in Neurodegenerative Disorders [B3131]'
Fowler, C. J.; Cowburn, R. F.; O'Neill, C.; (1992) 'Brain Signal Transduction Disturbances in Neurodegenerative Disorders [B3131]'. Cellular Signalling, 4 :1-9 [Details]
(1991)'Characterisation and regional distribution of guanine nucleotide mediated adenylyl cyclase from human brain'
Cowburn, R.F., Garlind, A., O'Neill, C., Alafuzoff, I., Winblad, B. and Fowler, C.J; (1991) 'Characterisation and regional distribution of guanine nucleotide mediated adenylyl cyclase from human brain'. Neurochemistry International, 18 :389-398 [Details]
(1991)'Antagonism by 8-hydroxy-2(Di-n-propylamino)tetraline of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human 1MR-32 and SK-N-MC neuroblastoma cells'
Fowler, C. J.,Ahlgren, P. C.,O'Neill, C.; (1991) 'Antagonism by 8-hydroxy-2(Di-n-propylamino)tetraline of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human 1MR-32 and SK-N-MC neuroblastoma cells'. Life Sciences, 48 (10):959-967   [Details]
(1991)'Preservation of 5-hydroxytryptamine 1A-receptor-G protein interactions in the cerebral cortex of patients with Alzheimer's disease'
O'Neill, C., Cowburn, R.F., Wiehager, B., Alafuzoff, I., Winblad, B. and Fowler, C.J; (1991) 'Preservation of 5-hydroxytryptamine 1A-receptor-G protein interactions in the cerebral cortex of patients with Alzheimer's disease'. Neuroscience Letters, 133 :15-19 [Details]
(1991)'Assay of a phosphatidylinositol bisphosphate phospholipase C activity in post-mortem human brain'
O'Neill, C., Fowler, C.J., Wiehager, B., Alafuzoff, I. and Winblad, B. ; (1991) 'Assay of a phosphatidylinositol bisphosphate phospholipase C activity in post-mortem human brain'. Brain Research, 543 :959-967 [Details]
(1991)'Coupling of human brain cerebral cortical alpha 2-adrenoceptors to GTP-binding proteins in Alzheimer's disease'
O'Neill C, Fowler CJ, Wiehager B, Cowburn RF, Alafuzoff I, Winblad B; (1991) 'Coupling of human brain cerebral cortical alpha 2-adrenoceptors to GTP-binding proteins in Alzheimer's disease'. Brain Research, 563 (1-2):39-43 [Details]
(1990)'Alzheimer's Disease: is there a problem beyond recognition?'
Fowler, C.J., O'Neill, C., Garlind, A. and Cowburn, R.F. ; (1990) 'Alzheimer's Disease: is there a problem beyond recognition?'. Trends in Pharmacological Sciences, 11 :183-184 [Details]
(1990)'Effect of monovalent ions upon G proteins coupling muscarinic receptors to phosphoinositide hydrolysis in the rat cerebral cortex'
Tiger, G.,Bjorklund, P. E.,Cowburn, R. F.,Garland, A.,O'Neill, C.,Wiehager, B.,Fowler, C. J.; (1990) 'Effect of monovalent ions upon G proteins coupling muscarinic receptors to phosphoinositide hydrolysis in the rat cerebral cortex'. European Journal of Pharmacology Molecular Pharmacology Section, 2 (1):51-62   [Details]
(1989)'Muscarinic receptors coupled to inositol phospholipid breakdown in human SH-SY5Y neuroblastoma cells: effect of retinoic acid-induced differentiation'
Fowler, C. J. and O'Neill, C. and Almqvist, P. and Nilsson, S. and Wiehager, B. and Winblad, B.; (1989) 'Muscarinic receptors coupled to inositol phospholipid breakdown in human SH-SY5Y neuroblastoma cells: effect of retinoic acid-induced differentiation'. Neurochemistry International, 15 (1):73-79 [Details]
(1989)'B-1 adrenergic receptor binding sites in post-mortal human cerebral microvessel preparations : preservation in multi-infarct dementia and dementia of Alzheimer type'
O'Neill, C.,Fowler, C. J.,Winblad, B.; (1989) 'B-1 adrenergic receptor binding sites in post-mortal human cerebral microvessel preparations : preservation in multi-infarct dementia and dementia of Alzheimer type'. Journal of Neural Transmission-Parkinsons Disease and Dementia Section, 1 (4):303-310   [Details]
(1988)'Adrenergic, serotoninergic, histaminergic, and imipramine binding sites in post-mortal human cerebral microvessel preparations'
O'Neill, C.,Fowler, C. J.,Marcusson, J. O.,Winblad, B.; (1988) 'Adrenergic, serotoninergic, histaminergic, and imipramine binding sites in post-mortal human cerebral microvessel preparations'. Journal of Neural Transmission, 73 (3):177-189   [Details]
(1988)'The effect of Triton X-100 on bovine brain synaptic membranes'
O'Neill, C.,Williams, D. C.; (1988) 'The effect of Triton X-100 on bovine brain synaptic membranes'. Neurochemical Research, 13 (9):871-877   [Details]
(1988)'Influence of age on effects induced by intermittent ethanol treatment on the ethanol drinking pattern and related neurochemical changes in the rat'
Wahlstrom, G.,Stenstrom, A.,Tiger, G.,O'Neill, C.,Fowler, C.,Magnusson, O.,Nordberg, A.; (1988) 'Influence of age on effects induced by intermittent ethanol treatment on the ethanol drinking pattern and related neurochemical changes in the rat'. Drug and Alcohol Dependence, 22 (1-2):117-128   [Details]
(1983)'Synergistic inhibition of [3H]muscimol binding to calf-brain synaptic membranes in the presence of L-homocysteine and pyridoxal 5'-phosphate. A possible mechanism for homocysteine-induced seizures'
Griffiths R, Williams DC, O'Neill C, Dewhurst IC, Ekuwem CE, Sinclair CD; (1983) 'Synergistic inhibition of [3H]muscimol binding to calf-brain synaptic membranes in the presence of L-homocysteine and pyridoxal 5'-phosphate. A possible mechanism for homocysteine-induced seizures'. European Journal of Biochemistry, 137 (3):467-478 [Details]

Book Chapters

 YearPublication
(2001)'Dysfunctional ryanodine receptor calcium release and calcium homeostatsis in Alzheimer's disease'
O'Neill, C; Cowburn, R; Bonkale, W; Ohm, TG; Fastbom, J; Carmody, M; Kelliher, M.; (2001) 'Dysfunctional ryanodine receptor calcium release and calcium homeostatsis in Alzheimer's disease' In: Biochemical Society Symposium 67 Neuronal Signal Transduction and Alzheimer's disease. UK: Portland Press. [Details]
(2001)'Receptor G- Protein signalling in Alzheimer's disease'
Cowburn, RF; O'Neill, C; Bonkale, WL; Ohm, TG; Fastbom, J.; (2001) 'Receptor G- Protein signalling in Alzheimer's disease' In: Biochemical Society Symposium 67 Neuronal Signal Transduction and Alzheimer's disease. UK: Portland Press. [Details]
(1996)'Receptor-Effector Coupling Dysfunctions in Alzheimer's Disease [B2930]'
Fowler, C. J.; Garlind, A.; O'Neill, C.; Cowburn, R. F.; (1996) 'Receptor-Effector Coupling Dysfunctions in Alzheimer's Disease [B2930]' In: Pharmacological Intervention in Aging and Age-Associated Disorders. Vol 786: Annals of the New York Academy of Sciences. [Details]
(1995)'Adenylyl Cyclase Signal Transduction in the Alzheimer's Disease Brain [B2926]'
Cowburn, R. F.; Fowler, C. J.; Winblad, B.; O'Neill, C.; (1995) 'Adenylyl Cyclase Signal Transduction in the Alzheimer's Disease Brain [B2926]' In: Aging, Health and Healing. New York: Publishing. [Details]
(1993)'Integrity of the Adenylyl Cyclase Signal Transduction Complex in Alzheimer's Disease Brain'
Cowburn, R. F.; Fowler, C. J.; Garlind, A.; Winblad, B.; O'Neill, C.; (1993) 'Integrity of the Adenylyl Cyclase Signal Transduction Complex in Alzheimer's Disease Brain' In: Alzheimer's Disease: Advances in Clinical and Basic Research. New York: John Wiley. [Details]
(1992)'Is Alzheimer's Dementia a Treatable Disease? [B2917]'
Winblad, B.; Cowburn, R. F.; O'Neill, C.; Fowler, C. J.; (1992) 'Is Alzheimer's Dementia a Treatable Disease? [B2917]' In: Neurodevelopment, Aging and Cognition. New York: Birkhauser. [Details]
(1987)'The influence of age on neurotransmitters in the human brain'
O'Neill, C., Marcusson, J., Nordberg, A. and Winblad, B. ; (1987) 'The influence of age on neurotransmitters in the human brain' In: NATO ASI series. Berlin Heidelberg: Springer-Verlag. [Details]

Edited Books

 YearPublication
(2001)
O'Neill, C and Anderton, B (Ed.). (2001) Neuronal Signal transduction and Alzheimer's disease. UK: Portland Press. [Details]

Conference Publications

 YearPublication
(2013)11th International Alzheimer's and Parkinson's Conference AD/PD Neurodegenerative disease suppl
O'Neill, C., Coakley, M., Long-Smith, C., LaFerla F,. Kiely A (2013) Overactivation of the PI3-kinase/Akt signalling axis: an ealry event in AD linking Abeta to emerging tau pathogenesis and insulin resistance 11th International Alzheimer's and Parkinson's Conference AD/PD Neurodegenerative disease suppl [Details]
(2013)The 11th Internaional conference on Alzheimer's and Parkinson's diseas (AD/PD).Neurodegen. Disease
Long-Smith C, Manning S., Coakley, M. McClean P., O'Halloran D. Holscher, C and O'Neill C (2013) The diabetic drug liraglutide: a potential therapeutic for amelioration of insulin resistance, Abeta pathology, inflammation and cognitive decline The 11th Internaional conference on Alzheimer's and Parkinson's diseas (AD/PD).Neurodegen. Disease [Details]
(2012)16th International congress of Parkinson's and movement disorders
Kiely, AP., Moloney AM., O'Flanagan C., Coakley, MF, O'Neill, C (2012) Defects in PINK1 are part of Alzheimer's disease pathogenesis and associate with alterations in the mitochondrial fission protein Drp1 16th International congress of Parkinson's and movement disorders Movement Disorders 27 S493-4, [Details]
(2011)Irish J. Med Sci, 6th Annual Neuroscience Ireland Conference
Coakley, MF,O'Neill, C (2011) A beta pathology causes increased activation of Akt and a polarizaton of pathological phosphorlyated tau within neurons in the 3xTg-AD mouse model of Alzheimer's disease Irish J. Med Sci, 6th Annual Neuroscience Ireland Conference , pp.27-27 [Details]
(2011)Irish J. Med. Sci. 6th Annual Neuroscience Ireland Conference
Kiely, AP,Moloney, AM,Coakley, MF,O'Neill, C (2011) Liraglutide ameliorates insulin receptor pathology in a mouse model of Alzheimer's disease Irish J. Med. Sci. 6th Annual Neuroscience Ireland Conference , pp.31-32 [Details]
(2011)Irish J. Med Sci 6th Annual Neuroscience Ireland Conference
Long-Smith, CM,Coakley, MF,O'Neill, C (2011) The effect of amyloid-beta derived diffusible ligands on insulin related signal transduction in aged E18 rat hippocampal neurons in vitro Irish J. Med Sci 6th Annual Neuroscience Ireland Conference , pp.26-27 [Details]
(2010)Irish J. Med. Sci
Manning, SB,Coakley, MF,O'Halloran, DJ,O'Neill, C (2010) Investigation of the lipogenic enzyme regulator SREBP-1 in Alzheimer's disease Irish J. Med. Sci , pp.506-506 [Details]
(2010)Irish J. Med. Sci
Coakley, MF,Moloney, AM,O'Neill, C (2010) Hyperactivation of Akt assocates with the accumulation of Abeta in the 3xTg-AD model of Alzheimer's disease with associated defects in insulin receptor status Irish J. Med. Sci , pp.100-101 [Details]
(2008)Irish J. Med. Science
Kiely A.P., Moloney A.M., Timmons S., Coakley M.F., Ravid R., O'Neill C; (2008) Defects in PINK1 occur in Alzheimer's disease and associate with PTEN dysfunction in the disease Irish J. Med. Science [Details]
(2008)Irish J. Med Science
Coakley, M.F., Moloney, A.M., Oddo, S., La Ferla, F., O'Neill, C. ; (2008) Changes in Akt and IGF-1R receptor signalling relate to developing Aβ and tangle pathology in the triple transgenic mouse model of Alzheimer's disease Irish J. Med Science [Details]
(2008)Alzheimer's and Dementia 4 (4)
O'Neill, C., Moloney, A.M., Griffin, R.J., Coakley, M.F., Timmons, S., O'Connor, R., Ravid, R. ; (2008) Defects in IGF-1 receptor, insulin receptor, and insulin receptor substrate proteins in Alzheimer's disease neurons indicate resistance to insulin and IGF-1 signalling Alzheimer's and Dementia 4 (4) 11th International Conference of Alzheimer's disease and related disorders, Chicago, USA, [Details]
(2008)Alzheimer's and Dementia 4, (4)
Coakley, M.F., Moloney, A.M., Oddo, S., La Ferla, F., O'Neill, C; (2008) Changes in Akt and IGF-1R receptor signalling relate to developing Aβ and tangle pathology in the triple transgenic mouse model of Alzheimer's disease Alzheimer's and Dementia 4, (4) 11th International Conference of Alzheimer's disease and related disorders,Chicago, USA, July 2008, [Details]
(2008)Alzheimer's and Dementia, 4, (4)
O'Neill C., Stockley, J.H. and Walsh L. ; (2008) Defective protein kinase C activation in Alzheimer's disease: Possible relationship to altered cholesterol homeostasis and ineffective lipid raft formation Alzheimer's and Dementia, 4, (4) 11th International Conference of Alzheimer's disease and related disorders, Chicago, USA, July 2008, , pp.T742-T743 [Details]
(2008)Irish Journal of Medical Science
Stockley, J.H., Mattioli, F., O'Neill C ; (2008) Altered BACE1 (beta-secretase) levels and activity associate with synaptic formation in the developing mouse cortex Irish Journal of Medical Science [Details]
(2006)Irish Journal of Medical Science, 175:(3)
Stockley, J.H., Ravid, R. and O'Neill C; (2006) The relationship between Alzheimer's disease pathology, β-secretase activity, and the levels and localisation of BACE1 Irish Journal of Medical Science, 175:(3) [Details]
(2006)10th International Conference of Alzheimer's disease and related disorders, Madrid, Spain, July 2006
Stockley, J.H., Ravid, R., and O'Neill, C. ; (2006) Analysis of the relationship between AD pathology and the levels and localization of BACE1 and BACE2 with respect to understanding increased β-secretase activity in AD. Alzheimer's and Dementia 10th International Conference of Alzheimer's disease and related disorders, Madrid, Spain, July 2006 [Details]
(2006)Alzheimer's and Dementia 2: (3)
O' Neill, C., Moloney, A., Timmons, S., Kelliher, M., Dockery, P., O' Connor, R., Johnston, J.A, Ravid, R., and Griffin R.J.; (2006) Excessive activation of Akt signalling links to neuronal cell death in Alzheimer's disease Alzheimer's and Dementia 2: (3) 10th International Conference of Alzheimer's disease and related disorders, Madrid, Spain, July 2006, [Details]
(2006)Alzheimer's and Dementia 2, (3)
Moloney, A., Griffin, R.J., Timmons, S., Ravid, R., O' Connor, R. and O' Neill, C; (2006) Impaired IGF-1 receptor signal transduction in Alzheimer's disease Alzheimer's and Dementia 2, (3) 10th International Conference of Alzheimer's disease and related disorders, Madrid, Spain, July 2006, [Details]
(2006)Alzheimer's and Dementia, 2, (3)
Matthews, E., Lindsay, A., Stockley, J.H., Ravid, R., McCaffrey, M.W., O'Neill, C. and Moore, T.; (2006) The Jerky protein in Alzheimer's disease Alzheimer's and Dementia, 2, (3) 10th International Conference of Alzheimer's disease and related disorders, Madrid, Spain, July 2006, , pp.S214-S214 [Details]
(2004)Dying to survive: Enhanced activation of Akt in AD temporal cortex, results in hyperphosphorylation of many Akt substrates including tau
Griffin, RJ,Timmons, S,Ravid, R,O'Neill, C (2004) NEUROBIOLOGY OF AGING Dying to survive: Enhanced activation of Akt in AD temporal cortex, results in hyperphosphorylation of many Akt substrates including tau , pp.175-175 [Details]
(2004)Neurobiology of Aging 25
Griffin, R. J.,Timmons, S.,Ravid, R.,O'Neill, C.; (2004) Dying to survive: Enhanced activation of Akt in AD temporal cortex, results in hyperphosphorylation of many Akt substrates including tau Neurobiology of Aging 25 9th International Conference of Alzheimer's disease and related disorders,Philadelphia,US, July 2004, , pp.S175-S175   [Details]
(2004)Alterations in BACE1 and BACE2 expression and in the kinetics of beta-secretase activity in the Alzheimer's disease temporal cortex
Stockley, J,Ravid, R,O'Neill, C (2004) NEUROBIOLOGY OF AGING Alterations in BACE1 and BACE2 expression and in the kinetics of beta-secretase activity in the Alzheimer's disease temporal cortex , pp.140-140 [Details]
(2004)Neurobiology of Aging
Stockley, J.,Ravid, R.,O'Neill, C.; (2004) Alterations in BACE1 and BACE2 expression and in the kinetics of beta-secretase activity in the Alzheimer's disease temporal cortex Neurobiology of Aging International Conference of Alzheimer's disease and related disorders, Philadelphia, US, July 2004, , pp.S140-S140   [Details]
(2004)Loss and altered subcellular distribution of the phosphatase PTEN links to the development of Alzheimer's disease neurofibrillary pathology
Moloney, AM,Griffin, RJ,Ravid, R,O'Neill, C (2004) NEUROBIOLOGY OF AGING Loss and altered subcellular distribution of the phosphatase PTEN links to the development of Alzheimer's disease neurofibrillary pathology , pp.167-167 [Details]
(2004)Neurology of Aging 25
Moloney, A. M.,Griffin, R. J.,Ravid, R.,O'Neill, C.; (2004) Loss and altered subcellular distribution of the phosphatase PTEN links to the development of Alzheimer's disease neurofibrillary pathology Neurology of Aging 25 9th International Conference of Alzheimer's disease and related disorders,Philadelphia,US, July 2004, , pp.S167-S167   [Details]
(2002)Neurobiology of Aging, 23. (1)
Griffin, R. J.,Fennelly, C.,O'Connor, R.,O'Neill, C.,Johnston, J. A.,Williams, C. H.,Ravid, R.; (2002) AKT signal transduction is impaired in the Alzheimer's disease brain Neurobiology of Aging, 23. (1) 8th International Conference of Alzheimer's disease and related disorders, Stockholm, Sweden, , pp.1365-1365   [Details]
(2002)AKT signal transduction is impaired in the Alzheimer's disease brain
Griffin, RJ,Fennelly, C,O'Connor, R,O'Neill, C,Johnston, JA,Williams, CH,Ravid, R (2002) NEUROBIOLOGY OF AGING AKT signal transduction is impaired in the Alzheimer's disease brain , pp.372-372 [Details]
(2002)Neurobiology of Aging 23 (1)
Carmody, M.,Kelliher, M.,O'Neill, C.,Ravid, R.; (2002) Intracellular calcium release channels, FKBP12 and calcineurin contribute to altered calcium homeostasis in Alzheimer's disease Neurobiology of Aging 23 (1) 8th International Conference of Alzheimer's disease and related disorders, Stockholm, Sweden, , pp.1926-1926   [Details]
(2002)Intracellular calcium release channels, FKBP12 and calcineurin contribute to altered calcium homeostasis in Alzheimer's disease
Carmody, M,Kelliher, M,O'Neill, C,Ravid, R (2002) NEUROBIOLOGY OF AGING Intracellular calcium release channels, FKBP12 and calcineurin contribute to altered calcium homeostasis in Alzheimer's disease , pp.526-527 [Details]
(2000)Biochemical Soc. Trans, 28, A37, 46
Shanahan, C; Kelliher, M; O'Neill, C.; (2000) Assessment of the integrity of metabotropic glutamate receptor binding and its function coupling to G Proteins in human brain an din Alzheimer's Disease Biochemical Soc. Trans, 28, A37, 46 670th Meeting of the Biochemical Society, University College Cork, Ireland, September 1999, , 01-SEP-99 - 30-DEC-99 [Details]
(2000)Biochemical Soc. Trans. 28, A36, 48
Kenny, M; O'Neill, C; (2000) Selective impairment of the soluble neuronal nitric oxide synthase enzyme in Alzheimer's disease brain Biochemical Soc. Trans. 28, A36, 48 670th Meeting of the Biochemical Society, University College Cork, Ireland, September 1999, , 01-SEP-99 - 30-DEC-99 [Details]
(2000)Biochemical Soc. Trans 28
Carmody, Mark and Kelliher, Mary and O'Neill, Cora; (2000) Investigating the involvement of the immunophilin FKBP12 in the neurochemical pathology of Alzheimer's disease brain Biochemical Soc. Trans 28 670th Meeting of the Biochemical Society, University College Cork, Ireland, September 1999, [Details]
(2000)Biochemical Soc. Trans. 28, A37, 45
Kelliher, M; O'Neill, C.; (2000) Enrichment of full length presenilin (PS) proteins in human brain soluble fractions: reduced levels of PS-2 in these fractions in Alzheimer's disease brain Biochemical Soc. Trans. 28, A37, 45 670th Meeting of the Biochemical Society, University College Cork, Ireland, September, 1999, , 01-SEP-99 - 30-DEC-99 [Details]
(2000)Biochemical Soc.Trans. 28
O'Neill, C; Kelliher, M; Cowburn, R; Bonkale, W; Ohm, TG; Fastbom, J.; (2000) Dysfunctional ryanodine receptor calcium release and calcium homeostasis in Alzheimer's disease Biochemical Soc.Trans. 28 670th Meeting of the Biochemical Society, University College Cork, Ireland, September 1999, , 01-SEP-99 - 30-DEC-99 [Details]
(2000)Biochemical Soc. Trans. 28, A35, 47
Jennings, R; Kelliher, M; O'Neill, C; (2000) Markedly reduced levels of soluble - catenin in Alzheimer's disease brain Biochemical Soc. Trans. 28, A35, 47 670th Meeting of the Biochemical Society, University College Cork, Ireland, September 1999, , 01-SEP-99 - 30-DEC-99 [Details]
(2000)Society for Neuroscience 762.19
Griffin, RJ; Kelliher, M; Johnston, JA; Williams, CH; Ravid, R; Fennelly, C; O'Connor, R; O'Neill, C.; (2000) Dysfunctional insulin-like growth factor-1-Akt signal transduction in Alzheimer's disease brain Society for Neuroscience 762.19 30th Annual Meeting New Orleans, USA, November 4-9 2000, , 04-NOV-00 - 09-NOV-00 [Details]
(1999)Biochemical Soc. Trans. 28, A17, F16
Cowburn, RF; O'Neill, C; Bonkale, WL, Ohm, TG; Fastbom, J.; (1999) J Receptor G-protein signalling in Alzheimer's disease Biochemical Soc. Trans. 28, A17, F16 670th Meeting of the Biochemical Society, University College Cork, Ireland, , 01-SEP-99 - 30-DEC-99 [Details]
(1999)Society for Neuroscience, 134.6
O'Neill, C; Fastbom; J; Cowburn, RF; Bonkale, W; Ravid, R; Ohm, TG; Carmody, M; Kelliher, M; (1999) Alterations in ryanodine receptor function: and early feature of Alzheimer's disease that correlates with neurofibrillary and -amyloid pathologies Society for Neuroscience, 134.6 29th Annual Meeting Society for Neuroscience, Miami Beach, Fla, USA, October 23-28 1999, , 23-OCT-99 - 28-OCT-99 [Details]
(1998)Neurobiology of Aging Vol 19 No 4s. s51
Kelliher, M., Fastbom. J., Cowburn, J., Ohm, T. and O' Neill, C.; (1998) Loss of functional ryanodine receptors in the Alzheimer's disease brain: Examination of relationship of loss to neuropathological staging of the disease Neurobiology of Aging Vol 19 No 4s. s51 6th International Conference on Alzheimer's disease and related disorders, Amsterdam, July 1998, [Details]
(1998)Neurology of Aging Vol 19 No4s. s51
Kenny, M., Walsh, R. Ravid, R. and O' Neill, C; (1998) Deficiencies in the Nitric oxide synthase enzyme in Alzheimer's disease brain Neurology of Aging Vol 19 No4s. s51 6th International Conference on Alzheimer's disease and related disorders, Amsterdam, July 1998, [Details]
(1998)Neurology of Aging Vol 19 No 4s. s51
Carmody, M., Kelliher, M., Ravid, R. and O¿ Neill, C ; (1998) Reduction of the levels of the immunophilin FKBP12 in Alzheimer's disease brain in the presence of similar kinetics for 3HFK506 binding Neurology of Aging Vol 19 No 4s. s51 6th International Conference on Alzheimer's disease and related disorders, Amsterdam, the Netherland, [Details]
(1997)Proceedings of the FEBS Special Meeting on Cell-Signalling Mechanisms, (29 June-3 July)
Kelliher, M.; Ravid, R.; O'Neill, C.; (1997) Loss of Ryanodine Receptor Calcium Release Channels in Alzheimer's Disease Brain [B2940] Proceedings of the FEBS Special Meeting on Cell-Signalling Mechanisms, (29 June-3 July) Amsterdam, The Netherlands, , 29-JUN-97 - 03-JUL-97 [Details]
(1997)Proceedings of 27th Annual Meeting of The American Society for Neuroscience 736.19
O' Neill, C., Kenny, M., Walsh, R., Ravid, R., and Kelliher, M. ; (1997) Nitric oxide synthase activity and [3H]-L-N-nitroarginine binding in control and Alzheimer's disease brain Proceedings of 27th Annual Meeting of The American Society for Neuroscience 736.19 New Orleans, USA, October 25-30 1997, [Details]
(1997)Proceedings of the FEBS Special Meeting on Cell-Signalling Mechanisms
Kenny, M.; Ravid, R.; O'Neill, C.; (1997) Nitric Oxide Synthase Activity in Control and Alzheimer's Disease Brain Proceedings of the FEBS Special Meeting on Cell-Signalling Mechanisms Amsterdam, The Netherlands, June 29-July 3, 1997, , 29-JUN-97 - 03-JUL-97 [Details]
(1997)Proceedings of the FEBS Special Meeting on Cell-Signalling Mechanisms
Shanahan, C.; Gibson, G. E.; Cowburn, R. F.; Johnston, J.; Wiehager, B.; Lannfelt, L.; O'Neill, C.; (1997) Heterotrimeric G Protein Subunit Levels in Fibroblasts From Familial Alzheimer's Disease and Matched Proceedings of the FEBS Special Meeting on Cell-Signalling Mechanisms Amsterdam, The Netherlands, June 290July 3, 1997, , 29-JUN-97 - 03-JUL-97 [Details]
(1996)Proceedings of the FEBS Special Meeting on Cell-Signalling Mechanisms, Amsterdam
O'Neill, C. and Kelliher, M. and Ravid, R.; (1996) Loss of ryanodine receptor calcium release channels in Alzheimer's disease brain Proceedings of the FEBS Special Meeting on Cell-Signalling Mechanisms, Amsterdam [Details]
(1996)Neurobiology of Aging Vol 17, Suppl,, 708
O'Neill, C.,Kelliher, M.,Ravid, R.; (1996) Loss of ryanodine receptor calcium release channels in Alzheimer's disease brain Neurobiology of Aging Vol 17, Suppl,, 708 5th International Conference on Alzheimer's disease and related disorders, Osaka, Japan, July 1996,   [Details]
(1995)Biochemical Society Transactions, 23
Shanahan, C.; Deasy, M.; Ravid, R.; O'Neill, C.; (1995) Comparative Immunoblot Analysis of the Guanine Nucleotide Binding Protein Gq alpha in Control and Alzheimer's Disease Brain Biochemical Society Transactions, 23 Biochemical Society Meeting, UCC, Cork, Ireland, September 1994, [Details]
(1994)Neurology of Aging, 15, Suppl 1
Johnston, J.; Cowburn, R.; Wiehager, B.; Norgren, S.; Lannfelt, C.; Vigo-Pelfrey, D.; Schenk, D.; Citron, M.; Selkoe, D.; O'Neill, C.; (1994) Amyloid Precursor Protein Expression and beta Amyloid Release in Fibroblast Cell Lines Obtained From Family Members With the Swedish APP670/671 Mutation Neurology of Aging, 15, Suppl 1 4th International Conference on Alzheimer's disease and related disorders,Minneapolis,USA,July 1994, [Details]
(1992)Neurobiology of Aging 13, Suppl. 1
Cowburn, R. F.; O'Neill, C.; Fowler, C. J.; Ravid, R.; Winblad, B.; (1992) Selective Impairment of Gs-Protein Stimulated Adenylyl Cyclase Activity in Alzheimer's Disease Brain Neurobiology of Aging 13, Suppl. 1 3rd International Conference on Alzheimer's disease and related disorders, Padua, Italy, July 1992, [Details]
(1992)Neurochem. Int. 21, Suppl
O' Neill, C., Cowburn, R.F., Fowler, C.J., Alafuzoff, I and Winblad, B. ; (1992) G protein receptor coupling in Alzheimer's disease brain Neurochem. Int. 21, Suppl [Details]
(1992)Neurobiology of Aging 13, Suppl. 1
O'Neill, C.,Cowburn, R. F.,Fowler, C. J.,Wiehager, B.,Alafuzoff, I.,Winblad, B.; (1992) Coupling of Human Brain Cerebral Cortical alpha 2-Adrenoceptors and 5-Hydroxy-Tryptamine1A Receptors to G Proteins in Alzheimer's Disease Neurobiology of Aging 13, Suppl. 1 3rd International Conference on Alzheimer's disease and related disorders, Padua, Italy, July 1992, , pp.235, S61-S61   [Details]
(1990)European Journal of Neuroscience, Suppl. 3
Fowler, C.J., O'Neill, C., and Tiger, G. ; (1990) Anomalous interaction of fluoride ions with G-proteins coupled to phosphatidylinositol specific phospholipase C in the rat brain European Journal of Neuroscience, Suppl. 3 [Details]
(1989)Biology of Cell Transduction signalling
Fowler, C. J.,O'Neill, C.,Almqvist, P.,Nilsson, S.,Wiehager, B.,Winblad, B.; (1989) Muscarinic receptors coupled to inositol phospholipid breakdown in human neuroblastoma cells : effect of retinoic acid induced differentiation Biology of Cell Transduction signalling 9th Int. Washington Spring Symposium,   [Details]
(1989)Journal of Neurochemistry 52, Suppl
Fowler, C.J., Tiger, G., Bjsrklund, P.E., Almqvist, P., O'Neill, C., ; (1989) Enhancement by K+ of carbachol-stimulated inositol phospholipid breakdown: Regional and species variation Journal of Neurochemistry 52, Suppl [Details]
(1987)Neuroscience, 22, Suppl
O'Neill, C., Fowler, C., Marcusson, J. and Winblad, B; (1987) Morphological and neurotransmitter receptor binding characterisation of human brain microvessels Neuroscience, 22, Suppl [Details]
(1987)Neuroscience, 22, Suppl
Wester, P., Fowler, C.J., Hardy, J., O'Neill, C. and Winblad, B; (1987) Ventricular CSF monoamine transmitter and metabolite concentrations reflect human brain neurochemistry in autopsy samples Neuroscience, 22, Suppl [Details]
(1984)Biochemical Society Transactions, 12
Williams, D.C., O'Riordan, C., Beattie, R.E. and O'Neill C; (1984) Multiple forms of calmodulin on SDS-polyacrylamide gel electrophoresis Biochemical Society Transactions, 12 , pp.472-474 [Details]
(1983)J Neurochem. 41, Suppl. S-26B
Griffiths, R. and Williams, D. C. and O'Neill, C. and Dewhurst, I. C. and Ekuwem, C. E. and Sinclair, C. D.; (1983) Synergistic inhibition of 3H-Muscimol binding to calf brain synaptic membranes by L-homocysteine and pyridoxal 5-phosphate J Neurochem. 41, Suppl. S-26B , pp.467-478 [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
1992KABI-Pharmacia Award
1993KABI-Pharmacia Award

Professional Associations

 AssociationFunctionFrom / To
The Biochemical Society Member and Chair IAS 2000-2003/
The American Society of Neuroscience Member/
The International Brain Research Organisation Member/
Neuroscience Ireland Member/
The American Association for the Advancement of Science Member/
The Alzheimer Society of Ireland Member/

Conference Contributions

 YearPublication
(2014)INBIND Biomarkers in Neurodegenerative disease,
Cora O'Neill (2014) Translating brain biomakers to blood biomarkers for Parkinson's diagnosis and treatment: focus on the Akt system. [Invited Lectures (Conference)], INBIND Biomarkers in Neurodegenerative disease, UCC, Ireland . [Details]
(2011)Galway Neuroscience Seminar Series,
Cora O'Neill (2011) Defective insulin and IGF-1 signalling is central to neurodegeneration in Alzheimer's disease. [Invited Seminars/Guest Lectures], Galway Neuroscience Seminar Series, UCG, Galway . [Details]
(2014)Trinity College Institute of Neuroscience (TCIN) Seminar Series,
Cora O'Neill (2014) Insulin signalling resistance: a coverging mechanism and treament target for Alzheimer's and diabetes. [Invited Seminars/Guest Lectures], Trinity College Institute of Neuroscience (TCIN) Seminar Series, TCD, Dublin . [Details]
(2013)International Conference on Alzheimer's and Parkinson's disease ADPD,
Cora O'Neill (2013) Overactivation of the PI3-kinase-Akt signalling axis: An early event in Alzheimer's disease linking Abeta to emerging tau pathology. [Invited Oral Presentation], International Conference on Alzheimer's and Parkinson's disease ADPD, Florence Italy . [Details]
(2013)Nottingham University Seminar Series,
Cora O'Neill (2013) Understanding and targeting neuronal insulin resistance in Alzheimer's disease. [Invited Seminars/Guest Lectures], Nottingham University Seminar Series, Nottingham, UK . [Details]
(2013)Dublin City University Biotechnology Seminar Series,
Cora O'Neill (2013) Neuronal insulin resisitance in Alzheimer's disease understanding and targeting signals of neurodegeneration. [Invited Seminars/Guest Lectures], Dublin City University Biotechnology Seminar Series, Dublin, Ireland . [Details]
(2012)The 11th International Symposium on Neurobiology and Neuroendocrinology of Aging,
Cora O'Neill (2012) PI3-kinase/Akt mTOR signalling impaired on/off switches in aging cognitive decline and Alzheimer's disease. [Invited Lectures (Conference)], The 11th International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz Austria . [Details]
(2012)Neurons Under Stress,
Caitriona Long-Smith, Cora O'Neill (2012) Alterations in the localisation and distribution of insulin receptors in an animal model of Alzheimer's disease: liraglutide as a potential therapeutic for aberrant insulin receptor signalling. [Invited Oral Presentation], Neurons Under Stress, RCSI, Dublin . [Details]
(2011)Gordon Research Conference: Insulin like growth factors in physiology and disease,
Cora O'Neill (2011) Defective insulin and IGF-1 signalling is central to neurodegeneration in Alzheimer's disease. [Invited Oral Presentation], Gordon Research Conference: Insulin like growth factors in physiology and disease, Ventura USA . [Details]
(2011)Biochemical Society Protein Folding and misfolding mechanisms and consequences,
Cora O'Neill (2011) Insulin and IGF-1 signalling: longevity, protein homeostasis and Alzheimer's disease. [Invited Lectures (Conference)], Biochemical Society Protein Folding and misfolding mechanisms and consequences, Maynooth, Ireland . [Details]
(2011)CLASS Conway Lecture and Seminar Series,
Cora O'Neill (2011) Understanding and targeting signals of neurodegeneration in Alzheimer's disease: focus on insulin and IGF-1 signalling pathways. [Invited Seminars/Guest Lectures], CLASS Conway Lecture and Seminar Series, UCD, Dublin . [Details]
(2010)Alzheimer's Research Trust local colloqium Northern Ireland,
Cora O'Neill (2010) Defective insulin and IGF-1 signalling and the development of Alzheimer's disease. [Invited Seminars/Guest Lectures], Alzheimer's Research Trust local colloqium Northern Ireland, QUB, Belfast, Northern Ireland . [Details]
(2009)9th International Conference on Alzheimer's and Parkinson's (ADPD),
John Stockley, Cora O'Neill (2009) BACE1 levels and activity associate with post-natal synaptic maturation: implications for Alzheimer's disease. [Invited Lectures (Conference)], 9th International Conference on Alzheimer's and Parkinson's (ADPD), Prague, Czech Republic . [Details]
(2008)UCC College of Science, Engineering and Food Science Annual Public Lecture Series,
Cora O' Neill; (2008) Alzheimer's disease: progress in understanding a complex brain disorder. [Oral Presentation], UCC College of Science, Engineering and Food Science Annual Public Lecture Series, University College Cork , 01-JAN-08 - 01-JAN-08. [Details]
(2007)Biochemical Society New opportunities for elucidating protease biology and therapeutic strategies,
John Stockley, Cora O'Neill (2007) Analysis of beta secretase kinetics and protein levels of BACE1 and BACE2 in human control and Alzheimer's brain. [Invited Oral Presentation], Biochemical Society New opportunities for elucidating protease biology and therapeutic strategies, Chicherster, England, UK . [Details]
(2006)Inaugural meeting of Neuroscience Ireland, incorporating a Biochemical Society Independent meeting,
Cora O'Neill; (2006) Neurological disorders, molecules, mechanisms and therapeutics. [Conference Organising Committee Member], Inaugural meeting of Neuroscience Ireland, incorporating a Biochemical Society Independent meeting, University College Cork , 21-SEP-06 - 22-SEP-06. [Details]
(2005)Department of Geriatric Medicine, Karolinska Institute Stockholm,
Cora O' Neill; (2005) Dying to survive: The IGF-1 receptor - Akt pathway in Alzheimer's disease. [Invited Oral Presentation], Department of Geriatric Medicine, Karolinska Institute Stockholm, Karolinska Institute Stockholm , 01-JAN-05 - 01-JAN-05. [Details]
(2005)International conference on Alzheimer's disease and related disorders,
Cora O' Neill; (2005) Excessive activation of Akt signalling links to neuronal cell death in Alzheimer's disease. [Oral Presentation], International conference on Alzheimer's disease and related disorders, Madrid, Spain , 01-JAN-05 - 01-JAN-05. [Details]
(2005)Neurodegeneration Ireland,
Cora O'Neill; (2005) Molecular mechanisms of Neurodegeneration. [Conference Organising Committee Member], Neurodegeneration Ireland, University College Dublin , 14-MAR-05 - 15-MAR-05. [Details]
(2003)National Neuroscience Network,
Cora O'Neill; (2003) Understanding signal transduction in Alzheimer's disease. [Oral Presentation], National Neuroscience Network, Trinity College Dublin , 01-JAN-03 - 01-JAN-03. [Details]
(2003)Department of Biochemistry National University of Ireland, Galway,
Cora O' Neill; (2003) Alzheimer's disease defining molecular signals of neurodegeneration. [Oral Presentation], Department of Biochemistry National University of Ireland, Galway, National University of Ireland, Galway , 01-JAN-03 - 01-JAN-03. [Details]
(2003)Department of Biochemistry, Trinity College Dublin,
O' Neill, Cora; (2003) Signal Transduction Dysfunction in Alzheimer's disease: focus on the IGF-1 receptor-Akt pathway. [Oral Presentation], Department of Biochemistry, Trinity College Dublin, Trinity College Dublin , 01-JAN-03 - 01-JAN-03. [Details]
(2003)BioSciences Institute, UCC,
Cora O' Neill; (2003) Neuronal signal transduction in Alzheimer's disease. [Oral Presentation], BioSciences Institute, UCC, University College Cork , 01-JAN-03 - 01-JAN-03. [Details]
(2003)Graduate Medical Education Programme, University College Dublin,
Cora O' Neill; (2003) Molecular pathology of Alzheimer's disease. [Oral Presentation], Graduate Medical Education Programme, University College Dublin, University College Dublin , 01-JAN-03 - 01-JAN-03. [Details]
(2001)School of Biology and Biochemistry, Queens University Belfast,
Cora O' Neill; (2001) Calcium signal transduction in Alzheimer's disease. [Oral Presentation], School of Biology and Biochemistry, Queens University Belfast, Queens University Belfast , 01-JAN-01 - 01-JAN-01. [Details]
(2001)University College Dublin,
Cora O' Neill; (2001) Identifying neuronal signal transduction events that cause Alzheimer's disease. [Oral Presentation], University College Dublin, University College Dublin , 01-JAN-01 - 01-JAN-01. [Details]
(1999)Annual Symposium of the Biochemical Society,
Cora O'Neill; (1999) Neuronal Signal Transduction and Alzheimer's disease. [Conference Organising Committee Member], Annual Symposium of the Biochemical Society, University College Cork , 01-JAN-99 - 01-JAN-99. [Details]
(1999)670th Biochemical Society Meeting,
Cora O'Neill; (1999) Joint co-organiser. [Conference Organising Committee Member], 670th Biochemical Society Meeting, University College Cork , 01-JAN-99 - 01-JAN-99. [Details]
(1997)Biochemical Society Irish Area Sections meetings,
Cora O'Neill; (1997) Predoctoral Meeting Organiser. [Conference Organising Committee Member], Biochemical Society Irish Area Sections meetings, Unknown , 01-JAN-97 - 01-JAN-03. [Details]
(1997)Biochemical Society Lecture Tour,
Cora O'Neill; (1997) Yearly organisation of the Biochemical Society Lecture Tour. [Conference Organising Committee Member], Biochemical Society Lecture Tour, Unknown , 01-JAN-97 - 01-JAN-00. [Details]

Committees

 CommitteeFunctionFrom / To
Health Research Board Post-doctoral Fellowship grant review panel committee member2004 / 2007
Alzheimer's Association of Ireland Medical and Scientific Advisory Panel member2013 /
Biochemical Society Development and Disease Committee member2003 / 2008
Graduate Studies Committee School of Biochemistry and Cell Biology Chair2010 /
Ethics University Committee University College Cork member SEFs representative2012 /
Strategic Research Agenda in Neurodegenerative Disease Steering Committee member2010 / 2013
Irish Bioindustries Association (IBIA) Committee member2000 / 2003
Royal Irish Academy (RIA) National Committee for Biochemistry member2000 / 2003
Biochemical Society Education Committee member2003 / 2008
Health Research Board Endocrinology Grant Review Committee member2002 /
Health Research Board Neuroscience grant review committee member2002 / 2004
Irish Research Scientists Association Committee member2003 / 2006
Graduates Studies Commiitee SEFS UCC member2011 /
Irish Research Network in Neurodegenerative Disease Steering Committee member2013 /
Executive Managment Committee (EMT) Science Faculty SEFs Member2003 / 2009
Biochemical Society Irish Area Section Committee Chair2000 / 2003

Employment

 EmployerPositionFrom / To
Karolinska Institute, Sweden Post-Doctoral Fellow, Research Scientist and Group Leader01-JAN-87 / 31-DEC-93
University of Umea, Sweden Post-Doctoral Research Fellow01-JAN-86 / 31-DEC-87
National University of Ireland, Dublin Post-Doctoral Research Fellow01-JAN-85 / 31-DEC-86
University College Cork Senior Lecturer, Biochemistry, BioSciences Institute01-SEP-93 /
St. Vincent's Hospital Dublin Biochemist02-JAN-80 / 01-OCT-80

Education

 YearInstitutionQualificationSubject
1979University College Dublin BScBiochemistry
1985Trinity College, University of Dublin PhDBiochemistry

Languages

 LanguageReadingWritingSpeaking
Irish FunctionalFunctionalFunctional
French FunctionalFunctionalFunctional
Swedish FluentFunctionalFunctional

Outreach Activities

 Description

I am active in public awareness and outreach activities for Alzheimer’s disease, neurodegeneration and education in biochemistry, cell biology and neuroscience. This involves interaction with: patients and advocacy groups for Alzheimer’s and neurodegenerative research; undergraduate and post-graduate bodies; schools; industry, and national and international committees and organisations that inform policy. I am active in both public outreach; conference organisation, media interaction and several national and international committees to maximise outreach in these areas.

Journal Activities

 JournalRoleTo / From
Journal Of Biological Chemistry Referee-
Acta Neuropathologica Referee-
Journal Of Neuroscience Referee-
Neurobiology Of Disease Referee-
Cell Death And Differentiation Referee-
Biological Psychiatry Referee-
Experimental Gerontology Referee-
Cell And Molecular Life Science Referee-
Neuromolecular Medicine Referee-
Biochemical Journal Referee-
The Journal Of Alzheimer’S Disease & Parkinsonism Referee-
Febs Letters Referee-
Neuroscience Letters Referee-
Neuroreport Referee-
Neuroscience Referee-
Neurobiology Of Aging Referee-
European Journal Of Neuroscience Referee-
Journal Of Neurochemistry Referee-
Aging Cell Referee-

Teaching Activities

Teaching Interests

As Vice-Head of the School of Biochemistry and Cell Biology and Chair of Graduate Studies in the School of Biochemistry and Cell Biology, I hold a number of undergraduate and post-graduate education responsibilities.

Currently I lecture and integrate research-led teaching to all undergraduate levels from second year right through to fourth year, MSc and PhD post-graduate programmes. My specialisation is metabolism and cell signalling in the broadest sense in Biochemistry and Cell Biology and specifically how this integrates with brain function in health and disease. At second year level I teach a basic cell metabolism module covering how molecules enable life and energy transformation in cells in health and how these systems can go awry in disease. At third and fourth year level I teach a basic brain neurochemistry module (third year) and a research level module covering the molecular / cellular basis of neurodegenerative disease with a specific focus on Alzheimer’s and Parkinson’s disease (fourth year).

My teaching contributes to eight degree outlets in the College of Science Engineering and Food Science SEFS), to the Biomedical Science Degree (UCC/CIT) and is a major component of the interdisciplinary Neuroscience degree at UCC. At all levels I am passionate about research-led teaching with best integration of practical aspects, discovery and innovation with scientific theory.  I have received several teaching awards, including from NAIRTL and supervised over a 100 final year and visiting student research projects. As Chair of Graduate Studies in the School of Biochemistry and Cell Biology, I oversee our extensive taught MSc and research MSc and PhD programmes. Eleven PhD students, 2 MD and a number of MSc students have successfully graduated from my own research team.   

I currently teach introductory biochemistry, with a focus on cellular metabolism, to second year undergraduate Science students, and Molecular Neuroscience to 3rd and 4th year undergraduate Science students. An outline of my courses and all courses taught by staff in the Department of Biochemistry are available in UCC's Book of Modules.

Current Postgraduate Students

 StudentDegree Type
Yeomans Sandra Ellen Masters Degree by Research

Modules Taught

 Term (ID))TitleLinkSubject
2015Molecular Basis of Brain Disorders BC4011Molecular Basis of Brain Disorders
2015Biochemistry of the Central Nervous System BC3008Biochemistry of the Central Nervous System
2015Principles of Metabolic Pathways BC2002Principles of Metabolic Pathways

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School of Biochemistry and Cell Biology

Scoil na Bithcheimice agus na Cillbhitheolaíochta

University College Cork, Western Road, Cork.

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