Biography
Dmitri B. Papkovsky graduated Chemistry Department of Moscow State University in 1982 (MSc) and obtained his PhD degree in 1986 from the Institute of Biochemistry, Russian Academy of Sciences, Moscow. In 1996 he joined the University College Cork where he is currently Professor in the School of Biochemistry and Cell Biology, Head of Biophysics and Bioanalysis lab. Prof. D. Papkovsky is also a founding member and PI of the SFI funded Irish Photonics Integration Centre (www.ipic.ie) and the UCC (Analytical and Biological Chemistry Research Facility https://www.ucc.ie/en/abcrf/about/). He is also co-founder and Chief Scientific Officer of an Irish biotech company Luxcel Biosciences Ltd (www.luxcel.com). Current research interests of Prof. Papkovsky include investigation of the roles of oxygen in biological systems, cell metabolism and hypoxia research, development of phosphorescence based oxygen sensing probes and measurement methodologies, new applications of optical oxygen sensing and imaging. Prof. Papkovsky is author of 170+ publications in peer-reviewed journals and 15+ patents and patent applications. His H-index is 42 (as of November 2016).
Research Interests
Main Research Interests :- Molecular Oxygen (O2) in Biological Systems: Cell Metabolism, Bioenergetics, Mitochondrial Function, Hypoxia signalling.
- O2 as a Marker of Cellular (Dys)function and Toxicity. Application to Cancer, Neuroscience, Stem Cell Research and Disease Models. Imaging of O2 in Cells, Tissues, Animal Models.
- New Sensors, Probes and Bioanalytical Applications. BioImaging.
- Fluorescent Spectroscopy, Time-Resolved Fluorescence. Phosphorescent Porphyrins.
- Advanced (Bio)Materials, Bioconjugate Chemistry, Analytical Method Development.
We have a range of modern and unique spectroscopic and biochemical equipment including:
- Live-cell confocal FLIM-TCSPC imaging system with ns-ms time resolution (Becker& Hickl - Carl Zeiss)
- Wide-field camera based FLIM microscope for live cell imaging (Carl Zeiss - LaVision)
- Two Hypoxia Stations (Coy Scientific) for continuous cell culture and bioassays under low pO2. Standard tissue culture facility.
- Multi-label readers: FLUOstar Omega with O2/CO2 control (BMG), Victor (PerkinElmer) - 2.
- Handheld optical oxygen sensors: OpTech Platinum (Mocon) and Firesting (PyroScience).
- Precision gas mixing and calibration equipment for sensor and application development.
- UV-VIS and fluorescence specs, Agilent HP1100 Series HPLC system.
We also have access to centralised facilities such as tissue culture room, animal house, fluorescent confocal and two-photon microscopes (Olympus), core equipment within UCC and microfabrication facilities at the Tyndall National Institute. Collaborate with many academic labs and companies worldwide.
Current Members of the Lab:
- Alexander Zhdanov, PhD - Postdoctoral Researcher (EI CF grant)
- Ruslan Dmitriev, PhD - Postdoctoral Researcher (SFI TIDA grant)
- Swagata Banerjee, PhD - Postdoctoral Researcher (DAFM grant)
- Alina Kondrashina, MSc - PhD Fellow (EU FP7 ITN Project 'Chebana')
- Irina Okkelman, PhD - Research Assistant (EI CF grant)
- Alicia Waters, MSc - PhD Fellow (EU FP7 ITN Project 'Chebana')
- Caroline Kelly, BSc - MSc Student (DAFM grant)
- James Jenkins, BSc - PhD Student (SFI grant)
Research Grants
| Project | Funding Body | Start Date | End Date | Award | |
|---|---|---|---|---|---|
| DAFF - Manufacture, application & assessment of smart packaging concepts consisting of nanoparticle technology & gas sensor technologies in conventional food packaging systems. | Department of Agriculture Fisheries & Forestry (DAFF) | 01-NOV-08 | 31-MAY-13 | €380,878.00 | |
| SFI "Development & Biological Applications of Intracellular Oxygen Sensing Technology" | Science Foundation of Ireland | 30-AUG-08 | 28-FEB-13 | €1,176,301.00 | |
| Chemical Bioanalysis | European Union | 01-DEC-10 | 30-NOV-14 | €518,909.00 | |
| Smart Packagin systems containing novel optochemical O2 and CO2 sensors for the food industry. | Department of Agriculture Fisheries & Forestry (DAFF) | 01-NOV-12 | 01-OCT-16 | €335,293.00 | |
| Advanced optical oxygen imaging platform for in vivo use. | Enterprise Irl | 01-MAR-13 | 31-JUL-15 | €291,243.00 | |
| SFI 12/RC/2276 I-PIC UCC portion. | Science Foundation of Ireland | 20-MAY-13 | 31-MAY-19 | €736,556.00 | |
| Equipment Budget | Science Foundation of Ireland | 01-JAN-10 | 30-SEP-10 | €21,594.00 | |
| EI"Integrated Measurement Platform for Optical Oxygen Respirometry" | Enterprise Irl | 01-JAN-08 | 31-DEC-10 | €26,650.00 | |
| DAFF "New analytical systems for quality and safety assessment of packages foods based on optical" | Department of Agriculture Fisheries & Forestry (DAFF) | 01-SEP-06 | 30-SEP-10 | €280,127.00 | |
| Equipment | Science Foundation of Ireland | 01-JAN-11 | 11-SEP-12 | €31,795.00 | |
| EPA Advanced systems for biological assessment of toxictiy of industrial chemicals | Environment Protection Agency (EPA) | 01-OCT-06 | 30-SEP-09 | €90,000.00 |
Contract Researchers
| Researcher Name | Project | Role | Funding Body | |
|---|---|---|---|---|
| Dr. Alexander Zhdanov | In vivo oxygen imaging | Postdoctoral Researcher | Enterprise Ireland | |
| Dr. Irina Okkelman | In vivo oxygen imaging | Postdoctoral Researcher | Science Foundation Ireland | |
| Dr. Ruslan Dmitriev | SFI Industry Fellowship | Research Fellow | Science Foundation Ireland |
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2014) | 'Small molecule phosphorescent probes for O2 imaging in 3D tissue models' Dmitriev RI, Kondrashina AV, Koren K, Klimant I, Zhdanov AV, Pakan JMP, McDermott KW and Papkovsky DB (2014) 'Small molecule phosphorescent probes for O2 imaging in 3D tissue models'. Biomaterials Science, 2 :853-866 [Details] | |
| (2014) | 'Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling' Zhdanov, AV,Waters, AHC,Golubeva, AV,Dmitriev, RI,Papkovsky, DB (2014) 'Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling'. Biochimica Et Biophysica Acta-Bioenergetics, 1837 :51-62 [DOI] [Details] | |
| (2014) | 'Oxygen-sensitive phosphorescent nanomaterials produced from high-density polyethylene films by local solvent-crazing' Toncelli C, Arzhakova OV, Dolgova A, Volynskii AL, Bakeev NF, Kerry JP, Papkovsky DB (2014) 'Oxygen-sensitive phosphorescent nanomaterials produced from high-density polyethylene films by local solvent-crazing'. Analytical chemistry, 86 (3):1917-1923 [DOI] [Details] | |
| (2013) | 'Biological detection by optical oxygen sensing' Papkovsky DB, Dmitriev RI (2013) 'Biological detection by optical oxygen sensing'. Chemical Society Reviews, 42 (22):8700-8732 [DOI] [Details] | |
| (2013) | 'In vivo imaging of brain metabolism activity using a phosphorescent oxygen-sensitive probe' Tsytsarev, V,Arakawa, H,Borisov, S,Pumbo, E,Erzurumlu, RS,Papkovsky, DB (2013) 'In vivo imaging of brain metabolism activity using a phosphorescent oxygen-sensitive probe'. Journal of Neuroscience Methods, 216 :146-151 [DOI] [Details] | |
| (2013) | 'Chronic Hypoxia Leads to a Glycolytic Phenotype and Suppressed HIF-2 Signaling in PC12 Cells' Zhdanov AV, Dmitriev RI, Golubeva AV, Gavrilova SA, Papkovsky DB (2013) 'Chronic Hypoxia Leads to a Glycolytic Phenotype and Suppressed HIF-2 Signaling in PC12 Cells'. Biochimica Et Biophysica Acta, [DOI] [Details] | |
| (2013) | 'A CO2 sensor based on Pt-porphyrin dye and FRET scheme for food packaging applications' Borchert, NB,Kerry, JP,Papkovsky, DB (2013) 'A CO2 sensor based on Pt-porphyrin dye and FRET scheme for food packaging applications'. Sensors and Actuators B-Chemical, 176 :157-165 [DOI] [Details] | |
| (2013) | 'HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase' Fogarty FM, O'Keeffe J, Zhadanov A, Papkovsky D, Ayllon V, O'Connor R (2013) 'HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase'. Oncogene, [DOI] [Details] | |
| (2013) | 'Rapid detection and respirometric profiling of aerobic bacteria on panels of selective media' Jasionek, G,Ogurtsov, V,Papkovsky, D (2013) 'Rapid detection and respirometric profiling of aerobic bacteria on panels of selective media'. Journal of Applied Microbiology, 114 :423-432 [DOI] [Details] | |
| (2012) | 'A Phosphorescent Nanoparticle-Based Probe for Sensing and Imaging of (Intra)Cellular Oxygen in Multiple Detection Modalities' Kondrashina, AV,Dmitriev, RI,Borisov, SM,Klimant, I,O'Brien, I,Nolan, YM,Zhdanov, AV,Papkovsky, DB (2012) 'A Phosphorescent Nanoparticle-Based Probe for Sensing and Imaging of (Intra)Cellular Oxygen in Multiple Detection Modalities'. Advanced Functional Materials, 22 :4931-4939 [DOI] [Details] | |
| (2012) | 'Optical probes and techniques for O-2 measurement in live cells and tissue' Dmitriev, RI,Papkovsky, DB (2012) 'Optical probes and techniques for O-2 measurement in live cells and tissue'. Cell and Molecular Life Science, :2025-2039 [DOI] [Details] | |
| (2012) | 'Assessment of Cellular Oxygen Gradients with a Panel of Phosphorescent Oxygen-Sensitive Probes' Dmitriev, RI,Zhdanov, AV,Jasionek, G,Papkovsky, DB (2012) 'Assessment of Cellular Oxygen Gradients with a Panel of Phosphorescent Oxygen-Sensitive Probes'. Analytical Chemistry, 84 :2930-2938 [DOI] [Details] | |
| (2012) | 'High throughput quality and safety assessment of packaged green produce using two optical oxygen sensor based systems' Borchert, N.,Hempel, A.,Walsh, H.,Kerry, J.P.,Papkovsky, D.B. (2012) 'High throughput quality and safety assessment of packaged green produce using two optical oxygen sensor based systems'. Food Control, 28 :87-9387 [Details] | |
| (2013) | 'Nondestructive and Continuous Monitoring of Oxygen Levels in Modified Atmosphere Packaged Ready-to-Eat Mixed Salad Products Using Optical Oxygen Sensors, and Its Effects on Sensory and Microbiological Counts during Storage' Hempel, A,O'Sullivan, MG,Papkovsky, DB,Kerry, JP (2013) 'Nondestructive and Continuous Monitoring of Oxygen Levels in Modified Atmosphere Packaged Ready-to-Eat Mixed Salad Products Using Optical Oxygen Sensors, and Its Effects on Sensory and Microbiological Counts during Storage'. Journal of Food Science, 78 :1057-1062 [DOI] [Details] | |
| (2012) | 'Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling' Zhdanov AV, Dmitriev RI, Papkovsky DB (2012) 'Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling'. Bioscience reports, 32 (6):587-595 [DOI] [Details] | |
| (2011) | 'Analysis of total aerobic viable counts in raw fish by high-throughput optical oxygen respirometry' Hempel A, Borchert N, Walsh H, Roy Choudhury K, Kerry JP, Papkovsky DB; (2011) 'Analysis of total aerobic viable counts in raw fish by high-throughput optical oxygen respirometry'. Journal of Food Protection, 74 (5):776-782 [DOI] [Details] | |
| (2011) | 'Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo' Wotzlaw C, Bernardini A, Berchner-Pfannschmidt U, Papkovsky D, Acker H, Fandrey J (2011) 'Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo'. The Journal of Physiology, 301 (2):1-71 [DOI] [Details] | |
| (2011) | 'Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival' Frezza C, Zheng L, Tennant DA, Papkovsky DB, Hedley BA, Kalna G, Watson DG, Gottlieb E (2011) 'Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival'. Plos One, 6 (9) [DOI] [Details] | |
| (2011) | 'O2/pH Multisensor Based on One Phosphorescent Dye' Borchert, NB,Ponomarev, GV,Kerry, JP,Papkovsky, DB; (2011) 'O2/pH Multisensor Based on One Phosphorescent Dye'. Analytical Chemistry, 83 :18-22 [DOI] [Details] | |
| (2011) | 'Comparative bioenergetic assessment of transformed cells using a cell energy budget platform' Zhdanov, AV,Favre, C,O'Flaherty, L,Adam, J,O'Connor, R,Pollard, PJ,Papkovsky, DB (2011) 'Comparative bioenergetic assessment of transformed cells using a cell energy budget platform'. Integrative Biology, 3 :1135-1142 [DOI] [Details] | |
| (2010) | 'Imaging of cellular oxygen and analysis of metabolic responses of mammalian cells' Fercher, A; O'Riordan, TC; Zhdanov, AV; Dmitriev, RI; Papkovsky, DB; (2010) 'Imaging of cellular oxygen and analysis of metabolic responses of mammalian cells'. Methods In Molecular Biology, 591 :257-273 [DOI] [Details] | |
| (2010) | 'Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange' Zhdanov AV, Ward MW, Taylor CT, Souslova EA, Chudakov DM, Prehn JH, Papkovsky DB; (2010) 'Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange'. Biochimica Et Biophysica Acta, 1797 (9):1627-1637 [DOI] [Details] | |
| (2010) | 'Mitochondrial Toxicity of Microcystin-LR on Cultured Cells: Application to the Analysis of Contaminated Water Samples' Jasionek G, Zhdanov A, Davenport J, Bláha L and Papkovsky DB (2010) 'Mitochondrial Toxicity of Microcystin-LR on Cultured Cells: Application to the Analysis of Contaminated Water Samples'. Environmental Science & Technology, 44 (7):2535-2541 [DOI] [Details] | |
| (2010) | 'Phosphorescent oxygen sensors based on nanostructured polyolefin substrates' Gillanders, RN; Arzhakova, OV; Hempel, A; Dolgova, A; Kerry, JP; Yarysheva, LM; Bakeev, NF; Volynskii, AL; Papkovsky, DB; (2010) 'Phosphorescent oxygen sensors based on nanostructured polyolefin substrates'. Analytical Chemistry, 82 (2):466-468 [DOI] [Details] | |
| (2010) | 'Evaluation of the derivates of phosphorescent Pt-coproporphyrin as intracellular oxygen-sensitive probes' Fercher A, Ponomarev GV, Yashunski D, Papkovsky D (2010) 'Evaluation of the derivates of phosphorescent Pt-coproporphyrin as intracellular oxygen-sensitive probes'. Analytical and Bioanalytical Chemistry, 396 (5):1793-1803 [DOI] [Details] | |
| (2010) | 'Bactenecin 7 peptide fragment as a tool for intracellular delivery of a phosphorescent oxygen sensor' Dmitriev RI, Ropiak HM, Yashunsky DV, Ponomarev GV, Zhdanov AV, Papkovsky DB; (2010) 'Bactenecin 7 peptide fragment as a tool for intracellular delivery of a phosphorescent oxygen sensor'. Febs Journal, 277 (22):4651-4661 [DOI] [Details] | |
| (2010) | 'Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique' Zhdanov AV, Ogurtsov VI, Taylor CT, Papkovsky DB; (2010) 'Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique'. Integrative biology : quantitative biosciences from nano to macro, 2 (9):443-451 [DOI] [Details] | |
| (2009) | 'Toxicological profiling of chemical and environmental samples using panels of test organisms and optical oxygen respirometry' Zitova A, O'Mahony FC, Cross M, Davenport J, Papkovsky DB; (2009) 'Toxicological profiling of chemical and environmental samples using panels of test organisms and optical oxygen respirometry'. Environmental Toxicology, 24 (2):116-127 [DOI] [Details] | |
| (2009) | 'Photophysical Properties of The New Phosphorescent Platinum(Ii) and Palladium(Ii) Complexes of Benzoporphyrins and Chlorins' Borisov, SM, Papkovsky, DB, Ponomarev, GV, DeToma, AS, Saf, R, Klimant, I; (2009) 'Photophysical Properties of The New Phosphorescent Platinum(Ii) and Palladium(Ii) Complexes of Benzoporphyrins and Chlorins'. Journal of Photochemistry and Photobiology A-Chemistry, 206 (1):87-92 [DOI] [Details] | |
| (2009) | 'Respirometric acute toxicity screening assay using Daphnia magna' Zitova, A,Cross, M,Hernan, R,Davenport, J,Papkovsky, DB; (2009) 'Respirometric acute toxicity screening assay using Daphnia magna'. Ecology, 25 :217-227 [DOI] [Details] | |
| (2009) | 'Toxicological Assessment of Chemicals Using Caenorhabditis Elegans and Optical Oxygen Respirometry' Schouest, K, Zitova, A, Spillane, C, Papkovsky, DB; (2009) 'Toxicological Assessment of Chemicals Using Caenorhabditis Elegans and Optical Oxygen Respirometry'. Environmental Toxicology and Chemistry, 28 (4):791-799 [Details] | |
| (2009) | 'PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells' Tambuwala MM, Cummins EP, Monfared M, Agbor TA, Garvey JF, Papkovsky DB, Taylor CT, Allan BB, O'Hagan KA, Cocchiglia S, Zhdanov AV; (2009) 'PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells'. Proceedings of The National Academy of Sciences of The United States of America, 106 (7):2188-2193 [DOI] [Details] | |
| (2008) | 'Data Analysis Algorithm For High Throughput Enzymatic Oxygen Consumption Assays Based On Quenched-Fluorescence Detection' Ogurtsov, VI, Hynes, J, Will, Y, Papkovsky, DB; (2008) 'Data Analysis Algorithm For High Throughput Enzymatic Oxygen Consumption Assays Based On Quenched-Fluorescence Detection'. Sensors and Actuators B-Chemical, 129 (2):581-590 [DOI] [Details] | |
| (2008) | 'Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission' Zhdanov AV, Ward MW, Prehn JH, Papkovsky DB; (2008) 'Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission'. The Journal of biological chemistry, 283 (9):5650-5661 [DOI] [Details] | |
| (2008) | 'The use of oxygen and pH-sensitive fluorescent probes for the investigation of perturbed cell metabolism' Hynes, J.,O'Riordan, T.,Papkovsky, D.,Will, Y.; (2008) 'The use of oxygen and pH-sensitive fluorescent probes for the investigation of perturbed cell metabolism'. Biochimica Et Biophysica Acta-Bioenergetics, 1777 :S77-S77 [Details] | |
| (2011) | 'Cell-Penetrating Conjugates of Coproporphyrins with Oligoarginine Peptides: Rational Design and Application for Sensing Intracellular O-2' Dmitriev, RI,Ropiak, HM,Ponomarev, GV,Yashunsky, DV,Papkovsky, DB (2011) 'Cell-Penetrating Conjugates of Coproporphyrins with Oligoarginine Peptides: Rational Design and Application for Sensing Intracellular O-2'. Bioconjugate Chemistry, 22 :2507-2518 [DOI] [Details] | |
| (2012) | 'Complexes of IrIII-Octaethylporphyrin with Peptides as Probes for Sensing Cellular O2' Koren, K,Dmitriev, RI,Borisov, SM,Papkovsky, DB,Klimant, I (2012) 'Complexes of IrIII-Octaethylporphyrin with Peptides as Probes for Sensing Cellular O2'. Chembiochem, 13 :1184-1190 [DOI] [Details] | |
| (2011) | 'Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival' Frezza, C,Zheng, L,Tennant, DA,Papkovsky, DB,Hedley, BA,Kalna, G,Watson, DG,Gottlieb, E; (2011) 'Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival'. Plos One, 6 [DOI] [Details] | |
| (2011) | 'Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo' Wotzlaw, C,Bernardini, A,Berchner-Pfannschmidt, U,Papkovsky, D,Acker, H,Fandrey, J; (2011) 'Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo'. The American Journal of Physiology, 301 :266-271 [DOI] [Details] | |
| (2010) | 'Evaluation of the derivates of phosphorescent Pt-coproporphyrin as intracellular oxygen-sensitive probes' Fercher, A,Ponomarev, GV,Yashunski, D,Papkovsky, D; (2010) 'Evaluation of the derivates of phosphorescent Pt-coproporphyrin as intracellular oxygen-sensitive probes'. Analytical and Bioanalytical Chemistry, 396 :1793-1803 [DOI] [Details] | |
| (2010) | 'Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells' Favre, C,Zhdanov, A,Leahy, M,Papkovsky, D,O'Connor, R; (2010) 'Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells'. Oncogene, 29 :3964-3976 [DOI] [Details] | |
| (2010) | 'Intracellular oxygen-sensitive phosphorescent probes based on cell-penetrating peptides. Anal Biochem' Dmitriev, R. I.,Zhdanov, A. V.,Ponomarev, G. V.,Yashunski, D. V.,Papkovsky, D. B.; (2010) 'Intracellular oxygen-sensitive phosphorescent probes based on cell-penetrating peptides. Anal Biochem'. Anal Biochem, 398 (1):24-33 [Details] | |
| (2013) | 'GreenLight Model 960' Fernandes R, Carey C, Hynes J, Papkovsky D (2013) 'GreenLight Model 960'. Journal of AOAC International, 96 (2):369-385 [Details] | |
| (2014) | 'Oxygen-sensitive phosphorescent nanomaterials produced from high-density polyethylene films by local solvent-crazing' Toncelli, C., Arzhakova, O.V., Dolgova, A., Volynskii, A.L., Bakeev, N.F., Kerry, J.P. and Papkovsky, D.B. (2014) 'Oxygen-sensitive phosphorescent nanomaterials produced from high-density polyethylene films by local solvent-crazing'. Analytical Chemistry, 86 :1917-1923 [Details] | |
| (2014) | 'Phosphorescent O2 sensors based on polyolefin fabric materials' Kelly, C.A., Toncelli, C., Kerry, J.P. and Papkovsky, D.B (2014) 'Phosphorescent O2 sensors based on polyolefin fabric materials'. Journal of Materials Chemistry, 2 :2169-2174 [Details] | |
| (2014) | 'Phosphorescent O-2 sensors based on polyolefin fabric materials' Kelly, CA,Toncelli, C,Kerry, JP,Papkovsky, DB (2014) 'Phosphorescent O-2 sensors based on polyolefin fabric materials'. Journal of Materials Chemistry C, 2 :2169-2174 [DOI] [Details] | |
| (2013) | 'Imaging of neurosphere oxygenation with phosphorescent probes' Dmitriev RI, Zhdanov AV, Nolan YM and Papkovsky DB (2013) 'Imaging of neurosphere oxygenation with phosphorescent probes'. Biomaterials, 34 :9307-9317 [Details] | |
| (2014) | 'Oxygen-Sensitive Phosphorescent Nanomaterials Produced from High-Density Polyethylene Films by Local Solvent-Crazing' Toncelli, C,Arzhakova, OV,Dolgova, A,Volynskii, AL,Bakeev, NF,Kerry, JP,Papkovsky, DB (2014) 'Oxygen-Sensitive Phosphorescent Nanomaterials Produced from High-Density Polyethylene Films by Local Solvent-Crazing'. Analytical chemistry, 86 :1917-1923 [DOI] [Details] | |
| (2014) | 'Small molecule phosphorescent probes for O-2 imaging in 3D tissue models' Dmitriev, RI,Kondrashina, AV,Koren, K,Klimant, I,Zhdanov, AV,Pakan, JMP,McDermott, KW,Papkovsky, DB (2014) 'Small molecule phosphorescent probes for O-2 imaging in 3D tissue models'. Biomaterials Science, 2 :853-866 [DOI] [Details] | |
| (2013) | 'Nondestructive and continuous monitoring of oxygen levels in modified atmosphere packaged ready-to-eat mixed salad products using optical oxygen sensors, and its effects on sensory and microbiological counts during storage' Hempel, A., O’Sullivan, M.G., Papkovsky, D.B. and Kerry, J.P. (2013) 'Nondestructive and continuous monitoring of oxygen levels in modified atmosphere packaged ready-to-eat mixed salad products using optical oxygen sensors, and its effects on sensory and microbiological counts during storage'. Journal of Food Science, 79 :1057-1062 [Details] | |
| (2014) | 'pH-sensitive perylene bisimide probes for live cell fluorescence lifetime imaging' Aigner, D,Dmitriev, RI,Borisov, SM,Papkovsky, DB,Klimant, I (2014) 'pH-sensitive perylene bisimide probes for live cell fluorescence lifetime imaging'. Journal of Materials Chemistry B, 2 :6792-6801 [DOI] [Details] | |
| (2014) | 'Discrete O-2 sensors produced by a spotting method on polyolefin fabric substrates' Kelly, CA,Toncelli, C,Kerry, JP,Papkovsky, DB (2014) 'Discrete O-2 sensors produced by a spotting method on polyolefin fabric substrates'. Sensors and Actuators B-Chemical, 203 :935-940 [DOI] [Details] | |
| (2011) | 'Analysis of total aerobic viable counts in raw fish by high throughput optical oxygen respirometry' Hempel, A., Borchert, N., Walsh, H., Choudhury, K.R., Kerry, J.P. and Papkovsky, D.B. (2011) 'Analysis of total aerobic viable counts in raw fish by high throughput optical oxygen respirometry'. Journal of Food Protection, 74 :776-782 [Details] | |
| (2014) | 'Application of gas sensing technologies for non-destructive monitoring of headspace gases (O2 and CO2) during chilled storage of packaged mushrooms (Agaricus bisporus) and their correlation with product quality parameters' Borchert, N.B., Cruz-Romero, M.C., Mahajan, P.V., Ren. M., Papkovsky, D.B. and Kerry, J.P. (2014) 'Application of gas sensing technologies for non-destructive monitoring of headspace gases (O2 and CO2) during chilled storage of packaged mushrooms (Agaricus bisporus) and their correlation with product quality parameters'. Food Packaging and Shelf Life, 2 :17-29 [DOI] [Details] | |
| (2014) | 'HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase' Fogarty FM, O'Keeffe J, Zhdanov A, Papkovsky D, Ayllon V and O'Connor R (2014) 'HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase'. Oncogene, 33 :4653-4663 [DOI] [Details] | |
| (2014) | 'Phosphorescent oxygen sensors produced by spot-crazing of polyphenylenesulfide films' Toncelli, C,Arzhakova, OV,Dolgova, A,Volynskii, AL,Kerry, JP,Papkovsky, DB (2014) 'Phosphorescent oxygen sensors produced by spot-crazing of polyphenylenesulfide films'. Journal of Materials Chemistry C, 2 :8035-8041 [DOI] [Details] | |
| (2012) | 'Detection of cheese packaging containment failures using reversible optical oxygen sesnors' Hempel, A., Gillanders, R.N., Papkovsky, D.B. and Kerry, J.P. (2012) 'Detection of cheese packaging containment failures using reversible optical oxygen sesnors'. International Journal of Dairy Technology, 65 :456-460 [Details] | |
| (2013) | 'Use of optical oxygen sensors to monitor residual oxygen in pre- and post-pasteurised bottled beer and its effect on sensory attributes and product acceptability during simulated commercial storage' Hempel, A., O’Sullivan, M.G., Papkovsky, D.B. and Kerry, J.P. (2013) 'Use of optical oxygen sensors to monitor residual oxygen in pre- and post-pasteurised bottled beer and its effect on sensory attributes and product acceptability during simulated commercial storage'. LWT - Food Science and Technology, 50 :226-231 [Details] | |
| (2013) | 'A CO2 sensor based on Pt-porphyrin dye and FRET scheme for food packaging applications' Borchert, N., Kerry, J.P. and Papkovsky, D.B. (2013) 'A CO2 sensor based on Pt-porphyrin dye and FRET scheme for food packaging applications'. Sensors and Actuators, 8 :112-118 [Details] | |
| (2013) | 'Use of smart packaging technologies for monitoring and extending the shelf-life quality of modified atmosphere packaged (MAP) bread: application of intelligent oxygen sensors and active ethanol emitters' Hempel, A., O’Sullivan, M.G., Papkovsky, D.B. and Kerry, J.P. (2013) 'Use of smart packaging technologies for monitoring and extending the shelf-life quality of modified atmosphere packaged (MAP) bread: application of intelligent oxygen sensors and active ethanol emitters'. European Food Reseach and Technology, 237 :117-124 [Details] | |
| (2012) | 'Modular microfluidic system as a model of cystic fibrosis airways' Skolimowski, M,Nielsen, MW,Abeille, F,Skafte-Pedersen, P,Sabourin, D,Fercher, A,Papkovsky, D,Molin, S,Taboryski, R,Sternberg, C,Dufva, M,Geschke, O,Emneus, J (2012) 'Modular microfluidic system as a model of cystic fibrosis airways'. Biomicrofluidics, 6 [DOI] [Details] | |
| (2013) | 'Use of optical oxygen sensors to monitor residual oxygen in pre- and post-pasteurised bottled beer and its effect on sensory attributes and product acceptability during simulated commercial storage' Hempel, A,O'Sullivan, MG,Papkovsky, DB,Kerry, JP (2013) 'Use of optical oxygen sensors to monitor residual oxygen in pre- and post-pasteurised bottled beer and its effect on sensory attributes and product acceptability during simulated commercial storage'. LWT - Food Science and Technology, 50 :226-231 [DOI] [Details] | |
| (2011) | 'Intracellular O-2 Sensing Probe Based on Cell-Penetrating Phosphorescent Nanoparticles' Fercher, A,Borisov, SM,Zhdanov, AV,Klimant, I,Papkovsky, DB; (2011) 'Intracellular O-2 Sensing Probe Based on Cell-Penetrating Phosphorescent Nanoparticles'. ACS Nano, 5 :5499-5508 [DOI] [Details] | |
| (2009) | 'Toxicological assessment of chemicals using Caenorhabditis elegans and optical oxygen respirometry' Schouest K, Zitova A, Spillane C, Papkovsky D; (2009) 'Toxicological assessment of chemicals using Caenorhabditis elegans and optical oxygen respirometry'. Environmental Toxicology, 28 (4):791-799 [DOI] [Details] | |
| (2015) | 'Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling' Zhdanov AV, Waters AH, Golubeva AV, Papkovsky DB (2015) 'Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling'. Experimental Cell Research, 330 (1):13-28 [DOI] [Details] | |
| (2013) | 'Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells' Zhdanov, AV,Dmitriev, RI,Golubeva, AV,Gavrilova, SA,Papkovsky, DB (2013) 'Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells'. Biochimica Et Biophysica Acta-General Subjects, 1830 :3553-3569 [DOI] [Details] |
Books
| Year | Publication | |
|---|---|---|
| (2012) | Phosphorescent Oxygen-Sensitive Probes. Papkovsky DB, Zhdanov AV, Fercher A, Dmitriev RI, Hynes J (2012) Phosphorescent Oxygen-Sensitive Probes. Basel: Springer. [DOI] [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2012) | 'O2 Imaging in Biological Specimens. Phosphorescent Oxygen-Sensitive Probes' Fercher, Andreas,Zhdanov, AlexanderV,Papkovsky, DmitriB (2012) 'O2 Imaging in Biological Specimens. Phosphorescent Oxygen-Sensitive Probes' In: Phosphorescent Oxygen-sensitive probes. Basel: Springer. [Details] | |
| (2010) | 'Imaging of cellular oxygen and analysis of metabolic responses of mammalian cells' Fercher A, O'Riordan TC, Zhdanov AV, Dmitriev RI, Papkovsky DB; (2010) 'Imaging of cellular oxygen and analysis of metabolic responses of mammalian cells' In: Live cell imaging. Methods and protocols. New York: Humana Press. [Details] | |
| (2014) | 'Kinetic analysis of local oxygenation and respiratory responses of Mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry' Zhdanov AV, Dmitriev RI, Hynes J, Papkovsky DB (2014) 'Kinetic analysis of local oxygenation and respiratory responses of Mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry' In: Methods in Enzymology, V. 542. Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism. USA: Academic Press. [DOI] [Details] | |
| (2014) | 'Kinetic Analysis of Local Oxygenation and Respiratory Responses of Mammalian Cells Using Intracellular Oxygen-Sensitive Probes and Time-Resolved Fluorometry' Zhdanov, AV,Dmitriev, RI,Hynes, J,Papkovsky, DB,Galluzzi, L,Kroemer, G (2014) 'Kinetic Analysis of Local Oxygenation and Respiratory Responses of Mammalian Cells Using Intracellular Oxygen-Sensitive Probes and Time-Resolved Fluorometry' In: L. Galluzzi, G. Kroemer (eds). Bioenergetic/Mitochondrial Aspects od Oncometabolism. Elsevier: Methods in Enzymology. [DOI] [Details] | |
| (2011) | 'Water toxicity monitoring using optical oxygen sensing and respirometry' Alice Zitova, Greg Jasionek, Dmitri B. Papkovsky; (2011) 'Water toxicity monitoring using optical oxygen sensing and respirometry' In: Waste Water - EVALUATION AND MANAGEMENT. www.intechopen.com: InTech Open Access Publisher. [Details] | |
| (2010) | 'Live Cell Imaging: Methods and Protocols' Papkovksy, Dmitri B; (2010) 'Live Cell Imaging: Methods and Protocols' In: Methods in Molecular Biology. USA: Humana Press. [DOI] [Details] | |
| (2008) | 'The use of oxygen-sensitive fluorescent probes for the assessment of mitochondrial function' Hynes J, O¿Riordan TC, Papkovsky DB ; (2008) 'The use of oxygen-sensitive fluorescent probes for the assessment of mitochondrial function' In: Mitochondrial Dysfunction in Drug-induced Toxicity. New York: John Wiley & Sons. [Details] | |
| (2006) | 'Sensors for Food Safety and Security' Papkovsky, Dmitri B.; (2006) 'Sensors for Food Safety and Security' In: Optical Chemical Sensors. Italy: Springer Netherlands. [DOI] [Details] | |
| (2004) | 'Methods in optical oxygen sensing: protocols and critical analyses' Papkovsky DB; (2004) 'Methods in optical oxygen sensing: protocols and critical analyses' In: Oxygen Sensing. N-Y: Methods in Enzymololy, v.383. [Details] |
Edited Books
| Year | Publication | |
|---|---|---|
| (2010) | Live Cell Imaging: Methods and Protocols Papkovsky DB (Ed.). (2010) Live Cell Imaging: Methods and Protocols Live Cell Imaging: Methods and Protocols. NY: Humana Press. [Details] |
Other Journals
| Year | Publication | |
|---|---|---|
| (2013) | 'Kinetic analysis of local oxygenation and respiratory responses of Mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry' Zhdanov, AV and Dmitriev, RI and Hynes, J and Papkovsky, DB (2013) 'Kinetic analysis of local oxygenation and respiratory responses of Mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry' Methods In Enzymology, 542 :183-207. [Details] | |
| (2013) | 'Insight into oxygenation levels within 3D cell models and its impact on cell metabolism' Papkovsky, DB,Carey, C,Morten, K,Dmitriev, RI,Hynes, J (2013) 'Insight into oxygenation levels within 3D cell models and its impact on cell metabolism' The Faseb Journal, . [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2002) | 2nd SENSPOL Workshop Papkovsky, DB; O'Mahony, FC; Ogurtsov, VI; Hill, M.; (2002) Monitorin gof soil bioremediation process by optical oxygen sensing and micro-respirometry . In: * eds. 2nd SENSPOL Workshop London, , 04-JUN-02 - 07-JUN-02 , pp.*-* [Details] | |
| (2011) | MOLECULAR BIOLOGY OF THE CELL Dmitriev, RI and Fercher, A and Zhdanov, AV and Papkovsky, DB (2011) Oxygen microscopy and high-throughput analysis of icO (2) by means of cell-penetrating phosphorescent dyes MOLECULAR BIOLOGY OF THE CELL [Details] | |
| (2014) | Experimental Biology 2014 Dmitriev RI, Kondrashina AV, Foley T, Papkovsky DB (2014) Imaging of molecular oxygen at subcellular resolution in mammalian cell culture: from 2D to 3D models Experimental Biology 2014 [Details] | |
| (2013) | 3D O-2 imaging in the neuronal spheroids Dmitriev, RI,Zhdanov, AV,Nolan, YM,Papkovsky, DB (2013) FASEB JOURNAL 3D O-2 imaging in the neuronal spheroids [Details] | |
| (2013) | 8th Annual Neuroscience Ireland conference Dmitriev RI, Zhdanov AV, Nolan YM, Papkovsky DB (2013) An imaging method to analyse o2 distribution in live neurospheres 8th Annual Neuroscience Ireland conference University College Cork, [Details] | |
| (2011) | Sensors, 2011 IEEE Twomey K., Stephens M., Jasionek G., Papkovsky D., Ogurtsov V. (2011) A portable sensing system for water quality monitoring Sensors, 2011 IEEE , pp.1878-1880 [Details] |
Published Reports
| Year | Publication | |
|---|---|---|
| (2009) | Development of a novel environmental monitoring system based on optical oxygen sensing and respirometry. Papkovsky DB et al.; (2009) Development of a novel environmental monitoring system based on optical oxygen sensing and respirometry. EPA Ireland, www.epa.ie. [Details] |
Abstract
| Year | Publication | |
|---|---|---|
| (2012) | Assessment of intracellular O-2 gradient on a microplate reader. Dmitriev, RI,Zhdanov, AV,Jasionek, G,Papkovsky, DB (2012) Assessment of intracellular O-2 gradient on a microplate reader. Abstract [Details] | |
| (2012) | Histone H4 acetylation at K16 residue and mitochondrial activity in neuronal cells. Dmitriev, RI,Zhdanov, AV,Papkovsky, DB (2012) Histone H4 acetylation at K16 residue and mitochondrial activity in neuronal cells. Abstract [Details] | |
| (2012) | Availability of key metabolic substrates determines metabolic responses, local oxygenation and HIF-2a stabilization in pheochromocytoma PC12 cells. Zhdanov, A,Waters, A,Golubeva, A,Dmitriev, R,Papkovsky, D (2012) Availability of key metabolic substrates determines metabolic responses, local oxygenation and HIF-2a stabilization in pheochromocytoma PC12 cells. Abstract [DOI] [Details] | |
| (2012) | Control of oxygenation and bioenergetic assessment of respiring objects with the intracellular oxygen-sensing probes. Papkovsky, DB (2012) Control of oxygenation and bioenergetic assessment of respiring objects with the intracellular oxygen-sensing probes. Abstract [DOI] [Details] | |
| (2011) | Oxygen microscopy and high-throughput analysis of icO(2) by means of cell-penetrating phosphorescent dyes. Dmitriev, RI,Fercher, A,Zhdanov, AV,Papkovsky, DB (2011) Oxygen microscopy and high-throughput analysis of icO(2) by means of cell-penetrating phosphorescent dyes. Abstract [Details] | |
| (2011) | Uncoupling effect of bafilomycin A1 on HIF and cell bioenergetics. Dmitriev, RI,Zhdanov, AV,Papkovsky, DB (2011) Uncoupling effect of bafilomycin A1 on HIF and cell bioenergetics. Abstract [Details] | |
| (2011) | Rational design and experimental assessment of the new family of intracellular O-2-sensitive probes. Dmitriev, RI,Yashunsky, DV,Ropiak, HM,Zhdanov, AV,Ponomarev, GV,Papkovsky, DB (2011) Rational design and experimental assessment of the new family of intracellular O-2-sensitive probes. Abstract [Details] | |
| (2010) | Assessment of intracellular O-2 gradient on a microplate reader. Dmitriev, RI,Zhdanov, AV,Jasionek, G,Papkovsky, DB (2010) Assessment of intracellular O-2 gradient on a microplate reader. Abstract [Details] | |
| (2010) | Analysis of cellular function by use of cell-penetrating oxygen sensing probes. Ropiak, HM,Dmitriev, RI,Yashunski, DV,Ponomarev, GV,Zhdanov, AV,Papkovsky, DB (2010) Analysis of cellular function by use of cell-penetrating oxygen sensing probes. Abstract [DOI] [Details] | |
| (2010) | Histone H4 acetylation at K16 residue and mitochondrial activity in neuronal cells. Dmitriev, RI,Zhdanov, AV,Papkovsky, DB (2010) Histone H4 acetylation at K16 residue and mitochondrial activity in neuronal cells. Abstract [Details] | |
| (2008) | Analysis of respiratory responses of neuronal cells to the decrease of extracellular calcium. Zhdanov, AV,Papkovsky, DB (2008) Analysis of respiratory responses of neuronal cells to the decrease of extracellular calcium. Abstract [DOI] [Details] |
Book Reviews
| Year | Publication | |
|---|---|---|
| (2004) | Methods in optical oxygen sensing: Protocols and critical analyses. Papkovsky, DB (2004) Methods in optical oxygen sensing: Protocols and critical analyses. Book Reviews [Details] |
Generic
| Year | Publication | |
|---|---|---|
| (2003) | Focus on Packaging, In: Food Ireland, Yearbook and Directory. Dmitri Papkovsky; (2003) Focus on Packaging, In: Food Ireland, Yearbook and Directory. Generic [Details] |
Other
| Year | Publication | |
|---|---|---|
| (2008) | Analysis of Respiratory Responses of Neuronal Cells to The Decrease of Extracellular Calcium. Zhdanov, AV, Papkovsky, DB; (2008) Analysis of Respiratory Responses of Neuronal Cells to The Decrease of Extracellular Calcium. Other [DOI] [Details] | |
| (2008) | Biological Toxicity Testing of Heavy Metals and Environmental Samples Using Fluorescence-Based Oxygen Sensing and Respirometry. Zitova, A, O'Mahony, FC, Cross, M, Davenport, J, Papkovsky, DB; (2008) Biological Toxicity Testing of Heavy Metals and Environmental Samples Using Fluorescence-Based Oxygen Sensing and Respirometry. Other [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2003 | All-Island Seedcorn competition award - best start-up company of the year (Luxcel Biosciences Ltd.) | Intertrade Ireland | |
| 1995 | Lisa-Meitner Research Fellowship Award | Austrian Science Foundation (FWF) |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| The Royal Siciety of Chemistry | Member | 25-NOV-99 / | |
| The American Association for the Advancement of Science, AAAS | member | 11-AUG-99 / | |
| European Conference on Optical Chemical Sensors and Biosensors, Europtrode | Permanent Steering Committee member | 02-JUN-97 / | |
| Microscopy Society of Ireland | Committee member | 01-JAN-11 / |
Patents
| Patent Number | Title | Granted | |
|---|---|---|---|
| WO 2008012785 | A Probe for Cellular Oxygen | 31-JAN-08 | |
| US2009029402 | Assessment of Biological or Chemical Samples | 29-JAN-09 | |
| WO 2009156976 | Method of Toxicological Assessment | 30-DEC-09 | |
| US2008051646 | Probe for cellular oxygen | 28-FEB-08 | |
| IE20070532 | A probe for cellular oxygen | 06-FEB-08 | |
| IE20030021 | An assay device and method for chemical or biological screening | 06-AUG-03 | |
| WO03059518 | An assay device and method for chemical or biological screening | 24-JUL-03 | |
| US2004241783 | Assay device and method for chemical or biological screening | 02-DEC-04 | |
| IE20050095 | Detection of biologically active compounds | 21-SEP-95 | |
| IE2006002822 | Oxygen sensitive probe | 05-JAN-06 | |
| IE20060272 | Assessment of biological or chemical samples | 29-NOV-06 | |
| US2007042412 | Detection of biologically active compounds | 22-FEB-07 | |
| EP1869433 | Assessment of biological or chemical samples | 26-DEC-07 |
Conference Contributions
| Year | Publication | |
|---|---|---|
| (2008) | 5th International Conference on Porphyrins and Phthallocyanines, Dmitri Papkovsky; (2008) Sensing and imaging of (intra)cellular oxygen by means of the phosphorescent porphyrin probes. [Oral Presentation], 5th International Conference on Porphyrins and Phthallocyanines, Moscow , 01-JUL-08 - 01-JUL-08. [Details] | |
| (2008) | Eur. Conf. Optical Chemical Sensors and Biosensors, Dmitri Papkovsky; (2008) Sensing and imaging of intracellular oxygen and monitoring of metabolic responses of mammalian cells. [Oral Presentation], Eur. Conf. Optical Chemical Sensors and Biosensors, Dublin, Ireland , 01-APR-08 - 01-APR-08. [Details] | |
| (2008) | NATO Advanced Study Course in Optical Sensors, Dmitri Papkovsky; (2008) Micro-respirometry. [Oral Presentation], NATO Advanced Study Course in Optical Sensors, Seggau, Austria , 01-SEP-08 - 01-SEP-08. [Details] | |
| (2014) | Experimental Biology 2014, Dmitriev RI, Borisov SM, Kondrashina AV, Pakan JMP, Papkovsky DB (2014) Real-time monitoring of oxygenation in cultured organotypic brain slices,. [Oral Presentation], Experimental Biology 2014, San Diego, USA , 26-APR-14. [Details] | |
| (2014) | European Conference on Optical Chemical Sensors and Biosensors, Papkovsky DB (2014) Imaging of tissue oxygenation with phosphorescent oxygen (nano)sensors. [Poster Presentation], European Conference on Optical Chemical Sensors and Biosensors, Athens , 12-APR-14. [Details] | |
| (2014) | Imaging of oxygenation in 3D tissue models by means of cell-penetrating phosphorescent nanosensors, Papkovsky DB, Dmitriev RI (2014) International Microscopy Congress. [Oral Presentation], Imaging of oxygenation in 3D tissue models by means of cell-penetrating phosphorescent nanosensors, Prague, Czech Republic , 07-SEP-14 - 10-SEP-14. [Details] | |
| (2014) | HIF-independent inhibition of mitochondrial function by DMOG: an immediate-early effect and long-term consequences, Zhdanov AV, Collins F, Okkelman IA, Papkovsky DB (2014) 18th European Bioenergetics Congress. [Poster Presentation], HIF-independent inhibition of mitochondrial function by DMOG: an immediate-early effect and long-term consequences, Lisbon, Portugal , 12-JUL-14 - 16-JUL-14. [Details] | |
| (2014) | Optical imaging of cell and tissue oxygenation by means of cell-penetrating phosphorescent probes, Papkovsky DB (2014) 42nd Meeting of the International Society on Oxygen Transport to Tissue. [Oral Presentation], Optical imaging of cell and tissue oxygenation by means of cell-penetrating phosphorescent probes, London, UK , 28-JUN-14 - 30-JUN-14. [Details] | |
| (2014) | Phosphorescent porphyrin based oxygen (nano)sensors, Papkovsky DB (2014) International Conference on Porphyrins and Phthallocyanines, ICPP-2014. [Invited Oral Presentation], Phosphorescent porphyrin based oxygen (nano)sensors, Istanbul, Turkey , 22-JUN-14 - 26-JUN-14. [Details] | |
| (2013) | MitOX-2013 Symposium, Papkovsky DB (2013) Papkovsky DB, ‘New phosphorescent probes for imaging tissue oxygen’. [Oral Presentation], MitOX-2013 Symposium, December 4th, Oxford, UK , 04-DEC-13. [Details] | |
| (2014) | 3D mapping of tissue oxygen in chronically inflamed mouse bladder, Zhdanov AV, Golubeva AV, Cryan JF, Papkovsky DB (2014) International Microscopy Congress. [Poster Presentation], 3D mapping of tissue oxygen in chronically inflamed mouse bladder, Prague, Czech Republic , 07-SEP-14 - 12-SEP-14. [Details] | |
| (2014) | Experimental Biology 2014, Kondrashina AV, Ogirtsov VI, Dmitriev RI, Papkovsky DB (2014) Comparison of the different techniques of monitoring mammalian cell respiration. [Poster Presentation], Experimental Biology 2014, San Diego, USA , 26-APR-14. [Details] | |
| (2014) | Experimental Biology 2014, Waters AH, Zhdanov AV, Papkovsky DB (2014) Regulation of pyruvate dehydrogenase phosphorylation by hypoxia. [Poster Presentation], Experimental Biology 2014, San Diego, USA , 26-APR-14. [Details] | |
| (2013) | ASCB Annual Meeting, Dmitriev RI, Kondrashina AV, Zhdanov AV, Papkovsky DB (2013) Phosphorescent O2 imaging probes for use in 3D tissue models. [Oral Presentation], ASCB Annual Meeting, New Orleans, USA , 14-DEC-13. [Details] |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| Medical Research Council, UK | Reviewer | 2013 / | |
| European Research Council | Reviewer | 2013 / | |
| Hong Kong Research Grants Council Reviewer | Reviewer | 2005 / | |
| Austrian Science Foundation Grant Review Panel | Reviewer | 2006 / |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| University College Cork | Professor in Biochemistry | 01-OCT-06 / | |
| University College Cork | Statutory Lecturer in Biochemistry | 01-FEB-03 / 01-SEP-06 | |
| University College Cork | Lecturer in Biochemistry | 01-OCT-97 / 01-JAN-03 | |
| University College Cork | Research Scientist | 01-SEP-96 / 01-SEP-97 | |
| Karl-Franzens University | Research Fellow | 01-SEP-95 / 31-AUG-96 |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1982 | Moscow State University, Chemistry Department, Russia | MSc | Chemistry | |
| 1985 | Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia | PhD | Biochemistry |
Languages
| Language | Reading | Writing | Speaking | |
|---|---|---|---|---|
| Russian | Fluent | Fluent | Fluent |
Consultancy
| Client | Description | |
|---|---|---|
| Agilent Inc. |
Outreach Activities
| Description | |
|---|---|
Invited tutorial: 'Imaging of tissue oxygen by means of cell-penetrating phosphorescent probes and TCSPC-FLIM' 9th Workshop on Advanced Multiphoton and Fluorescence Lifetime Imaging Techniques, Saarbruecken, Germany, May 27-28, 2014. | |
Invited presentation: 'A new family of phosphorescent probes for imaging tissue oxygen' Clinical Research Priority Program "Tumor oxygen", University of Zurich, Switzerland, October 17, 2013 | |
Invited tutorial: ‘Phosphorescence based nanosensors for imaging tissue oxygen’ at the special postgraduate course ‘Luminescent Probes and Materials for Optical Chemical Sensors’, December 2, 2013, University of Turku, Finland | |
Committee member of the bi-annual summer school series 'Advanced Study Course in Optical Sensors', ASCOS (www.ascos.org) | |
Invited Tutorial ' O2 imaging in 3D tissue models with phosphorescent probes and FLIM' Workshop on Advanced Fluorescence Lifetime Imaging Techniques, Bethesda, USA, October 20-21, 2014. |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Open Analytical Journal | Editor | 01-JAN-07 - | |
| Sensors And Actuators B-Chemical | Editor | 01-JUN-13 - | |
| Advanced Functional Materials | Referee | 08-DEC-10 - | |
| Analytical Chemistry | Referee | 01-OCT-98 - |
Other Activities
| Description | |
|---|---|
PI and Member of Executive Management commity of the Irish Photonics Integration Centre | |
Reviewer for many journals: Adv Mater, Biomater, Chem Rev, Angew Chemie, Analyst, BBA Bioenergetics, Integr Biol, |
Teaching Activities
Modules Taught
| Term (ID)) | Title | Link | Subject | |
|---|---|---|---|---|
| 2020 | Biochemistry | BC1443 | Biochemistry | |
| 2020 | Introduction to Biomolecules and Metabolic Pathways | BC1024 | Introduction to Biomolecules and Metabolic Pathways |