Background:
Insulin and Insulin-like Growth Factors (IGF-I and II) are for development, metabolism, growth and maintenance of tissues, and their activity is dysregulated in type 2 diabetes, cancer and disorders with an inflammatory component. Despite the fundamental nature of the Insulin/IGF system, and extensive knowledge on its ligands, receptors (IR and IGF-1R), and canonical signalling pathway, the mechanisms underlying the different biological actions of Insulin and IGFs in normal physiology and disease are still poorly understood. It is still not well understood how cell, tissue and disease contexts or specific regions of each receptor their overall signalling output. These mechanisms have been challenging to uncover because the IGF-1R and IR are ubiquitously expressed and both receptors may be active in cells at the same time. Moreover, although insulin and related analogues are widely used to successfully control diabetes, drugs that inhibit IGF activity have been largely unsuccessful in different cancers. However, anti-IGF-1R antibodies that were originally developed for testing in cancer have recently been successfully repurposed for the treatment of Thyroid Eye Disease (TED). This highlights the potential to effectively inhibit IGF activity in this, and potentially other, inflammatory conditions.
Current research:
Our research programme is taking an innovative spatio-temporal approach (including in cell proteomics and advanced imaging) to determine how insulin and IGF-1 receptors emit specific signals in different tissues. We are using protein modelling and multiple receptor constructs to provide a structural basis for how these receptors are activated and regulated in different contexts. We are also aiming to establish a mechanistic basis for the success of IGF-1R inhibition in TED and provide a rationale for targeting the IGF-1R in other inflammatory conditions.
Separate areas of research and collaboration address the functions of key cellular proteins that were identified in the course of studying IGF-1 activity in cancers These include:
(1) Hrg-1/Slca48a1, an essential heme transporter, which interacts with and is required for cellular acidification by the Vacuolar ATPase in endosomal function.
(2) PDLIM2, a nuclear and cytoskeletal regulator of protein stability, including transcription factors and adhesion signalling proteins that control cell fate, particularly the differentiation of immune cells, transformation of epithelial cells, cell polarity, and metabolic status.
(3) PNCI/ SLC25A33, a highly conserved essential mitochondrial pyrimidine nucleotide carrier (UTP) that is necessary for mitochondria DNA and RNA synthesis.
(4) PBK/TOP kinase, which is highly active in mitogenic cancer cells
Biography
Rosemary O'Connor joined the Department of Biochemistry in 1997. She was appointed as Professor of Cell Biology in 2007, was Head of the Department of Biochemistry from 2008 to 2010, and Head of School from 2016-2021. Prior to this, she held appointments as Lecturer/Senior Lecturer and Associate Professor in Biochemistry. She holds a BSc. from University College Galway and a Ph.D. from NUI Maynooth. Research experience was gained in the USA and Germany in academia (the Institute of Pathology of the University of Wuerzburg, Germany and the Wistar Institute at U PENN, Philadelphia) and in Industry (Immunogen, Inc., Cambridge, Massachusetts) where her contributions led to new drug discovery and clinical trials. In UCC she established the Cell Biology Laboratory which focuses on Insulin-like Growth Factor actions particularly in cancer and neurodegeneration, although applications of this research extend to most branches of biology. She was a founding Investigator of the Biosciences Institute and was Director of the structured PhD program in Cancer Biology. She has supervised 24 PhD students to completion, co-supervised/mentored circa 20 others as well as >20 postdoctoral researchers and research assistants. Prof O’Connor has served on scientific boards and advisory committees for the European Union, Science Foundation Ireland, the Breast Cancer Campaign (UK), and Irish Cancer Society. She was awarded the Irish Area Section Medal by the Biochemical Society in 2007 and chaired the Gordon Research Conference on Insulin-like Growth Factors in Physiology and Disease in 2011. She received an award from the Irish Association for Cancer Research for "Outstanding contributions to cancer research on the Island of Ireland" in 2019 and is the current President of the International Society for Insulin-like Growth Factor research.Research Interests
Insulin and Insulin-like Growth Factors (IGF-I and II) are for development, metabolism, growth and maintenance of tissues, and their activity is dysregulated in type 2 diabetes, cancer and disorders with an inflammatory component. Despite the fundamental nature of the Insulin/IGF system, and extensive knowledge on its ligands, receptors (IR and IGF-1R), and canonical signalling pathway, the mechanisms underlying the different biological actions of Insulin and IGFs in normal physiology and disease are still poorly understood. It is still not well understood how cell, tissue and disease contexts or specific regions of each receptor their overall signalling output. These mechanisms have been challenging to uncover because the IGF-1R and IR are ubiquitously expressed and both receptors may be active in cells at the same time. Moreover, although insulin and related analogues are widely used to successfully control diabetes, drugs that inhibit IGF activity have been largely unsuccessful in different cancers. However, anti-IGF-1R antibodies that were originally developed for testing in cancer have recently been successfully repurposed for the treatment of Thyroid Eye Disease (TED). This highlights the potential to effectively inhibit IGF activity in this, and potentially other, inflammatory conditions.
Current research:
Our research programme is taking an innovative spatio-temporal approach (including in cell proteomics and advanced imaging) to determine how insulin and IGF-1 receptors emit specific signals in different tissues. We are using protein modelling and multiple receptor constructs to provide a structural basis for how these receptors are activated and regulated in different contexts. We are also aiming to establish a mechanistic basis for the success of IGF-1R inhibition in TED and provide a rationale for targeting the IGF-1R in other inflammatory conditions.
Separate areas of research and collaboration address the functions of key cellular proteins that were identified in the course of studying IGF-1 activity in cancers These include:
(1) Hrg-1/Slca48a1, an essential heme transporter, which interacts with and is required for cellular acidification by the Vacuolar ATPase in endosomal function.
(2) PDLIM2, a nuclear and cytoskeletal regulator of protein stability, including transcription factors and adhesion signalling proteins that control cell fate, particularly the differentiation of immune cells, transformation of epithelial cells, cell polarity, and metabolic status.
(3) PNCI/ SLC25A33, a highly conserved essential mitochondrial pyrimidine nucleotide carrier (UTP) that is necessary for mitochondria DNA and RNA synthesis.
(4) PBK/TOP kinase, which is highly active in mitogenic cancer cells
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2020) | 'IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr1250 and Tyr1251' Rieger L.;O'Shea S.;Godsmark G.;Stanicka J.;Kelly G.;O'Connor R. (2020) 'IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr1250 and Tyr1251'. Science Signaling, 13 (633) [DOI] [Details] | |
| (2020) | 'Controlled Signaling-Insulin-Like Growth Factor Receptor Endocytosis and Presence at Intracellular Compartments' Rieger L;O'Connor R; (2020) 'Controlled Signaling-Insulin-Like Growth Factor Receptor Endocytosis and Presence at Intracellular Compartments'. Frontiers In Endocrinology, 11 [DOI] [Details] | |
| (2020) | 'IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3 beta-Nrf2-BNIP3 Pathway' Riis, S;Murray, JB;O'Connor, R (2020) 'IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3 beta-Nrf2-BNIP3 Pathway'. Cells, 9 [DOI] [Details] | |
| (2019) | 'A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer' Wilkinson R.;Burden R.;McDowell S.;McArt D.;McQuaid S.;Bingham V.;Williams R.;Cox Ó.;O'Connor R.;McCabe N.;Kennedy R.;Buckley N.;Scott C. (2019) 'A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer'. Oncology, 2019 [DOI] [Details] | |
| (2019) | 'PDLIM2 is a marker of adhesion and ß-catenin activity in triple-negative breast cancer' Cox, Orla T.; Edmunds, Shelley J.; Simon-Keller, Katja; Li, Bo; Moran, Bruce; Buckley, Niamh E.; Bustamante-Garrido, Milan; Healy, Nollaig; O'Flanagan, Ciara H.; Gallagher, William M.; Kennedy, Richard D.; Bernards, René; Caldas, Carlos; Chin, Suet-Feung; Marx, Alexander; O'Connor, Rosemary (2019) 'PDLIM2 is a marker of adhesion and ß-catenin activity in triple-negative breast cancer'. Cancer Research, 79 (10):2619-2633 [DOI] [Full Text] [Details] | |
| (2018) | 'FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion' Stanicka, J;Rieger, L;O'Shea, S;Cox, O;Coleman, M;O'Flanagan, C;Addario, B;McCabe, N;Kennedy, R;O'Connor, R (2018) 'FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion'. Oncogene, 37 :3131-3150 [DOI] [Full Text] [Details] | |
| (2017) | 'Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells' Lyons, Amy; Coleman, Michael; Riis, Sarah; Favre, Cedric; O'Flanagan, Ciara H.; Zhdanov, Alexander V.; Papkovsky, Dmitri B.; Hursting, Stephen D.; O'Connor, Rosemary (2017) 'Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells'. Journal of Biological Chemistry, 292 (41):16983-16998 [DOI] [Full Text] [Details] | |
| (2017) | 'Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation' Davies, SJ;Ryan, J;O'Connor, PBF;Kenny, E;Morris, D;Baranov, PV;O'Connor, R;McCarthy, TV (2017) 'Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation'. Adipocyte, 6 :259-276 [DOI] [Details] | |
| (2016) | 'IGF-1R inhibition sensitizes breast cancer cells to ATM-Related Kinase (ATR) inhibitor and cisplatin' O'Flanagan CH;O'Shea S;Lyons A;Fogarty FM;McCabe N;Kennedy RD;O'Connor R; (2016) 'IGF-1R inhibition sensitizes breast cancer cells to ATM-Related Kinase (ATR) inhibitor and cisplatin'. Oncotarget, [DOI] [Details] | |
| (2016) | 'Bile acids destabilise HIF-1alpha and promote anti-tumour phenotypes in cancer cell models' Phelan, J. P.,Reen, F. J.,Dunphy, N.,O'Connor, R.,O'Gara, F. (2016) 'Bile acids destabilise HIF-1alpha and promote anti-tumour phenotypes in cancer cell models'. BMC Cancer, 16 [DOI] [Details] | |
| (2016) | 'RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells' Kiely M;Adams DR;Hayes SL;O'Connor R;Baillie GS;Kiely PA; (2016) 'RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells'. Cellular Signalling, [DOI] [Details] | |
| (2015) | 'IGF-1 receptor and adhesion signaling: an important axis in determining cancer cell phenotype and therapy resistance' Cox, OT;O'Shea, S;Tresse, E;Bustamante-Garrido, M;Kiran-Deevi, R;O'Connor, R (2015) 'IGF-1 receptor and adhesion signaling: an important axis in determining cancer cell phenotype and therapy resistance'. Frontiers In Endocrinology, 6 [DOI] [Details] | |
| (2014) | 'RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK' Dwane, S,Durack, E,O'Connor, R,Kiely, PA (2014) 'RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK'. Cellular Signalling, 26 :9-18 [DOI] [Details] | |
| (2014) | 'PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome' Bowe RA, Cox OT, Ayllón V, Tresse E, Healy NC, Edmunds SJ, Huigsloot M, O'Connor R (2014) 'PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome'. Molecular biology of the cell, 25 (1):184-195 [DOI] [Details] | |
| (2014) | 'Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the β1-Integrin–RhoA signaling axis' Deevi, Ravi Kiran; Cox, Orla T.; O'Connor, Rosemary (2014) 'Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the β1-Integrin–RhoA signaling axis'. Neoplasia, 16 (5):422-431 [DOI] [Full Text] [Details] | |
| (2014) | 'PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D' Vanoirbeek, E;Eelen, G;Verlinden, L;Carmeliet, G;Mathieu, C;Bouillon, R;O'Connor, R;Xiao, G;Verstuyf, A (2014) 'PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D'. Oncogene, 33 :1904-1911 [DOI] [Details] | |
| (2014) | 'HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase' Fogarty FM, O'Keeffe J, Zhdanov A, Papkovsky D, Ayllon V and O'Connor R (2014) 'HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase'. Oncogene, 33 :4653-4663 [DOI] [Details] | |
| (2013) | 'HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase' Fogarty FM, O'Keeffe J, Zhadanov A, Papkovsky D, Ayllon V, O'Connor R (2013) 'HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase'. Oncogene, [DOI] [Details] | |
| (2013) | 'Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer' Eccles, SA;Aboagye, EO;Ali, S;Anderson, AS;Armes, J;Berditchevski, F;Blaydes, JP;Brennan, K;Brown, NJ;Bryant, HE;Bundred, NJ;Burchell, JM;Campbell, AM;Carroll, JS;Clarke, RB;Coles, CE;Cook, GJR;Cox, A;Curtin, NJ;Dekker, LV;Silva, ID;Duffy, SW;Easton, DF;Eccles, DM;Edwards, DR;Edwards, J;Evans, DG;Fenlon, DF;Flanagan, JM;Foster, C;Gallagher, WM;Garcia-Closas, M;Gee, JMW;Gescher, AJ;Goh, V;Groves, AM;Harvey, AJ;Harvie, M;Hennessy, BT;Hiscox, S;Holen, I;Howell, SJ;Howell, A;Hubbard, G;Hulbert-Williams, N;Hunter, MS;Jasani, B;Jones, LJ;Key, TJ;Kirwan, CC;Kong, A;Kunkler, IH;Langdon, SP;Leach, MO;Mann, DJ;Marshall, JF;Martin, LA;Martin, SG;Macdougall, JE;Miles, DW;Miller, WR;Morris, JR;Moss, SM;Mullan, P;Natrajan, R;O'Connor, JPB;O'Connor, R;Palmieri, C;Pharoah, PDP;Rakha, EA;Reed, E;Robinson, SP;Sahai, E;Saxton, JM;Schmid, P;Smalley, MJ;Speirs, V;Stein, R;Stingl, J;Streuli, CH;Tutt, ANJ;Velikova, G;Walker, RA;Watson, CJ;Williams, KJ;Young, LS;Thompson, AM (2013) 'Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer'. Breast Cancer Research, 15 [DOI] [Details] | |
| (2013) | 'Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1' Abreu CM, Kumar R, Hamilton D, Dawdy AW, Creavin K, Eivers S, Finn K, Balsbaugh JL, O'Connor R, Kiely PA, Shabanowitz J, Hunt DF, Grenon M, Lowndes NF (2013) 'Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1'. Plos Genetics, 9 (4) [DOI] [Details] | |
| (2013) | 'PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D' Vanoirbeek E, Eelen G, Verlinden L, Carmeliet G, Mathieu C, Bouillon R, O'Connor R, Xiao G, Verstuyf A (2013) 'PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D'. Oncogene, [DOI] [Details] | |
| (2012) | 'Serine Phosphorylation of the Insulin-like Growth Factor I (IGF-1) Receptor C-terminal Tail Restrains Kinase Activity and Cell Growth' Kelly, GM;Buckley, DA;Kiely, PA;Adams, DR;O'Connor, R (2012) 'Serine Phosphorylation of the Insulin-like Growth Factor I (IGF-1) Receptor C-terminal Tail Restrains Kinase Activity and Cell Growth'. Journal of Biological Chemistry, 287 :28180-28194 [DOI] [Details] | |
| (2012) | 'Direct interaction between the scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription' Neasta J, Kiely PA, He DY, Adams DR, O'Connor R, Ron D (2012) 'Direct interaction between the scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription'. The Journal of Biological Chemistry, [DOI] [Details] | |
| (2012) | 'Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis' Kerr, E,Holohan, C,McLaughlin, KM,Majkut, J,Dolan, S,Redmond, K,Riley, J,McLaughlin, K,Stasik, I,Crudden, M,Van Schaeybroeck, S,Fenning, C,O'Connor, R,Kiely, P,Sgobba, M,Haigh, D,Johnston, PG,Longley, DB (2012) 'Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis'. Cell Death and Differentiation, 19 :1317-1327 [DOI] [Details] | |
| (2011) | 'Comparative bioenergetic assessment of transformed cells using a cell energy budget platform' Zhdanov, AV;Favre, C;O'Flaherty, L;Adam, J;O'Connor, R;Pollard, PJ;Papkovsky, DB (2011) 'Comparative bioenergetic assessment of transformed cells using a cell energy budget platform'. Integrative Biology, 3 :1135-1142 [DOI] [Details] | |
| (2010) | 'Ribosomal 18 S RNA Processing by the IGF-I-responsive WDR3 Protein Is Integrated with p53 Function in Cancer Cell Proliferation' McMahon, M;Ayllon, V;Panov, KI;O'Connor, R (2010) 'Ribosomal 18 S RNA Processing by the IGF-I-responsive WDR3 Protein Is Integrated with p53 Function in Cancer Cell Proliferation'. Journal of Biological Chemistry, 285 :18309-18318 [DOI] [Details] | |
| (2008) | 'Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels' Navab, R;Pedraza, C;Fallavollita, L;Wang, N;Chevet, E;Auguste, P;Jenna, S;You, Z;Bikfalvi, A;Hu, J;O'Connor, R;Erickson, A;Mort, JS;Brodt, P (2008) 'Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels'. Oncogene, 27 :4973-4985 [DOI] [Details] | |
| (2010) | 'Heme-binding Protein HRG-1 Is Induced by Insulin-like Growth Factor I and Associates with the Vacuolar H+-ATPase to Control Endosomal pH and Receptor Trafficking' O'Callaghan, KM;Ayllon, V;O'Keeffe, J;Wang, YR;Cox, OT;Loughran, G;Forgac, M;O'Connor, R (2010) 'Heme-binding Protein HRG-1 Is Induced by Insulin-like Growth Factor I and Associates with the Vacuolar H+-ATPase to Control Endosomal pH and Receptor Trafficking'. Journal of Biological Chemistry, 285 :381-391 [DOI] [Details] | |
| (2008) | 'Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level' Macartney-Coxson, DP;Hood, KA;Shi, HJ;Ward, T;Wiles, A;O'Connor, R;Hall, DA;Lea, RA;Royds, JA;Stubbs, RS;Rooker, S (2008) 'Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level'. BMC Cancer, 8 [DOI] [Details] | |
| (2007) | 'TOPK promotes tumour cell proliferation through p38MAPK activity and regulation of the DNA damage response' Ayllon, V;O'Connor, R (2007) 'TOPK promotes tumour cell proliferation through p38MAPK activity and regulation of the DNA damage response'. Oncogene, 26 :3451-3461 [DOI] [Details] | |
| (2007) | 'Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR' O'Donovan, HC;Kiely, PA;O'Connor, R (2007) 'Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR'. Cellular Signalling, 19 :2588-2595 [DOI] [Details] | |
| (2005) | 'Mystique is a new insulin-like growth factor-l-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage-independent growth' Loughran, G;Healy, NC;Kiely, PA;Huigsloot, M;Kedersha, NL;O'Connor, R (2005) 'Mystique is a new insulin-like growth factor-l-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage-independent growth'. Molecular biology of the cell, 16 :1811-1822 [DOI] [Details] | |
| (2005) | 'RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251' Kiely, PA;Leahy, M;O'Gorman, D;O'Connor, R (2005) 'RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251'. Journal of Biological Chemistry, 280 :7624-7633 [DOI] [Details] | |
| (2004) | 'EphA3 is induced by CD28 and 1GF-1 and regulates cell adhesion' Smith, LM;Walsh, PT;Rudiger, T;Cotter, TG;Mc Carthy, TV;Marx, A;O'Connor, R (2004) 'EphA3 is induced by CD28 and 1GF-1 and regulates cell adhesion'. Experimental Cell Research, 292 :295-303 [DOI] [Details] | |
| (2004) | 'Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251' Leahy, M;Lyons, A;Krause, D;O'Connor, R (2004) 'Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251'. Journal of Biological Chemistry, 279 :18306-18313 [DOI] [Details] | |
| (2002) | 'Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells' Buckley, DA;Loughran, G;Murphy, G;Fennelly, C;O'Connor, R (2002) 'Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells'. Journal Of Clinical Pathology-Molecular Pathology, 55 :46-54 [Details] | |
| (2013) | 'RACK1 to the future--a historical perspective' Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA (2013) 'RACK1 to the future--a historical perspective'. Cell communication and signaling : CCS, 11 [DOI] [Details] | |
| (2013) | 'Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer' Eccles, SA,Aboagye, EO,Ali, S,Anderson, AS,Armes, J,Berditchevski, F,Blaydes, JP,Brennan, K,Brown, NJ,Bryant, HE,Bundred, NJ,Burchell, JM,Campbell, AM,Carroll, JS,Clarke, RB,Coles, CE,Cook, GJR,Cox, A,Curtin, NJ,Dekker, LV,Silva, ID,Duffy, SW,Easton, DF,Eccles, DM,Edwards, DR,Edwards, J,Evans, DG,Fenlon, DF,Flanagan, JM,Foster, C,Gallagher, WM,Garcia-Closas, M,Gee, JMW,Gescher, AJ,Goh, V,Groves, AM,Harvey, AJ,Harvie, M,Hennessy, BT,Hiscox, S,Holen, I,Howell, SJ,Howell, A,Hubbard, G,Hulbert-Williams, N,Hunter, MS,Jasani, B,Jones, LJ,Key, TJ,Kirwan, CC,Kong, A,Kunkler, IH,Langdon, SP,Leach, MO,Mann, DJ,Marshall, JF,Martin, LA,Martin, SG,Macdougall, JE,Miles, DW,Miller, WR,Morris, JR,Moss, SM,Mullan, P,Natrajan, R,O'Connor, JPB,O'Connor, R,Palmieri, C,Pharoah, PDP,Rakha, EA,Reed, E,Robinson, (2013) 'Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer'. Breast Cancer Research, 15 [DOI] [Details] | |
| (2013) | 'RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK' Dwane S, Durack E, O'Connor R, Kiely PA. (2013) 'RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK'. Cellular Signalling, [Details] | |
| (2012) | 'Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris' Ryan, RP,McCarthy, Y,Kiely, PA,O'Connor, R,Farah, CS,Armitage, JP,Dow, JM (2012) 'Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris'. Molecular Microbiology, 86 :557-567 [DOI] [Details] | |
| (2012) | 'GSK-3Beta phosphorylation of the IGF-1 Receptor C terminal tail restrains kinase activity and cell growth' Kelly GM, Buckley DA, Kiely PA, Adams DR, O'Connor R (2012) 'GSK-3Beta phosphorylation of the IGF-1 Receptor C terminal tail restrains kinase activity and cell growth'. The Journal of Biological Chemistry, [DOI] [Details] | |
| (2011) | 'Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway' Cao W, Ryan M, Buckley D, O'Connor R, Clarkson MR (2011) 'Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway'. The Journal of Immunology, 133 (2):179-189 [DOI] [Details] | |
| (2011) | 'Comparative bioenergetic assessment of transformed cells using a cell energy budget platform' Zhdanov AV, Favre C, O'Flaherty L, Adam J, O'Connor R, Pollard PJ, Papkovsky DB (2011) 'Comparative bioenergetic assessment of transformed cells using a cell energy budget platform'. Integrative biology : quantitative biosciences from nano to macro, 3 (11):1135-1142 [DOI] [Details] | |
| (2011) | 'Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction' O'Sullivan JF, Leblond AL, Kelly G, Kumar AH, Metharom P, Büneker CK, Alizadeh-Vikali N, Hristova I, Hynes BG, O'Connor R, Caplice NM (2011) 'Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction'. Circulation. Cardiovascular interventions, 4 (4):327-335 [DOI] [Details] | |
| (2010) | 'A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome' Cao, W; McMahon, M; Wang, B; O'Connor, R; Clarkson, M; (2010) 'A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome'. Blood Cells Mol Dis, 44 :22-27 [DOI] [Details] | |
| (2010) | 'Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling' Moloney, AM; Griffin, RJ; Timmons, S; O'Connor, R; Ravid, R; O'Neill, C; (2010) 'Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling'. Neurobiology of Aging, 31 :224-243 [DOI] [Details] | |
| (2010) | 'Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells' Favre, C,Zhdanov, A,Leahy, M,Papkovsky, D,O'Connor, R; (2010) 'Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells'. Oncogene, 29 :3964-3976 [DOI] [Details] | |
| (2010) | 'Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation' McMahon, M; Ayllón, V; Panov, KI; O'Connor, R; (2010) 'Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation'. The Journal of Biological Chemistry, 285 (24):18309-18318 [DOI] [Details] | |
| (2009) | 'Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappa B' Healy, NC,O'Connor, R (2009) 'Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappa B'. Journal of Leukocyte Biology, 85 :481-490 [DOI] [Details] | |
| (2009) | 'Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB' Healy NC, O'Connor R; (2009) 'Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB'. Journal of Leukocyte Biology, 85 (3):481-490 [DOI] [Details] | |
| (2009) | 'Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase' Kiely, PA,Baillie, GS,Barrett, R,Buckley, DA,Adams, DR,Houslay, MD,O'Connor, R; (2009) 'Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase'. The Journal of Biological Chemistry, 284 :20263-20274 [DOI] [Details] | |
| (2009) | 'Periodontitis and type 2 diabetes: is oxidative stress the mechanistic link?' Allen, E. M.,Matthews, J. B.,O'Connor, R.,O'Halloran, D.,Chapple, I. L.; (2009) 'Periodontitis and type 2 diabetes: is oxidative stress the mechanistic link?'. Scott Med J, 54 (2):41-7 [Details] | |
| (2008) | 'The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration' Clifford, N.,Smith, L. M.,Powell, J.,Gattenlohner, S.,Marx, A.,O'Connor, R.; (2008) 'The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration'. J Cell Biochem, 105 (5):1250-9 [Details] | |
| (2008) | 'Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling' Moloney, A. M.,Griffin, R. J.,Timmons, S.,O'Connor, R.,Ravid, R.,O'Neill, C.; (2008) 'Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling'. Neurobiol Aging, [Details] | |
| (2008) | 'Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels' Navab, R.,Pedraza, C.,Fallavollita, L.,Wang, N.,Chevet, E.,Auguste, P.,Jenna, S.,You, Z.,Bikfalvi, A.,Hu, J.,O'Connor, R.,Erickson, A.,Mort, J. S.,Brodt, P.; (2008) 'Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels'. Oncogene, 27 (37):4973-85 [Details] | |
| (2008) | 'Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta 1 integrin and for tumor cell proliferation and migration' Kiely, PA,Baillie, GS,Lynch, MJ,Houslay, MD,O'Connor, R; (2008) 'Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta 1 integrin and for tumor cell proliferation and migration'. The Journal of Biological Chemistry, 283 :22952-22961 [DOI] [Details] | |
| (2008) | 'The EphA3 Receptor Is Expressed in a Subset of Rhabdomyosarcoma Cell Lines and Suppresses Cell Adhesion and Migration' Clifford, N,Smith, LM,Powell, J,Gattenlohner, S,Marx, A,O'Connor, R; (2008) 'The EphA3 Receptor Is Expressed in a Subset of Rhabdomyosarcoma Cell Lines and Suppresses Cell Adhesion and Migration'. Journal of Cellular Biochemistry, 105 :1250-1259 [DOI] [Details] | |
| (2007) | 'PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response' Ayllon, V.,O'Connor, R.; (2007) 'PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response'. Oncogene, 26 (24):3451-61 [Details] | |
| (2007) | 'The insulin-like growth Factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth' Floyd, S,Favre, C,Lasorsa, FM,Leahy, M,Trigiante, G,Stroebel, P,Marx, A,Loughran, G,O'Callaghan, K,Marobbio, CMT,Slotboom, DJ,Kunji, ERS,Palmieri, F,O'Connor, R; (2007) 'The insulin-like growth Factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth'. Molecular Biology of The Cell, 18 :3545-3555 [Details] | |
| (2007) | 'Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR' O'Donovan, H. C.,Kiely, P. A.,O'Connor, R.; (2007) 'Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR'. Cell Signal, 19 (12):2588-95 [Details] | |
| (2006) | 'IGF-I controls a mutually exclusive association of RACK1 with PP2A and beta 1 integrin to promote cell migration' Kiely, PA., O¡¦Gorman, D., Luong, K., Ron, D., and R. O¡¦Connor; (2006) 'IGF-I controls a mutually exclusive association of RACK1 with PP2A and beta 1 integrin to promote cell migration'. Molecular and Cellular Biology, 26 (*):4041-4051 [Details] | |
| (2005) | 'Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology' Griffin, RJ,Moloney, A,Kelliher, M,Johnston, JA,Ravid, R,Dockery, P,O'Connor, R,O'Neill, C; (2005) 'Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology'. Journal of Neurochemistry, 93 :105-117 [DOI] [Details] | |
| (2005) | 'Gene expression profiles in cells transformed by overexpression of the IGF-I receptor' Loughran, G., Huigsloot, M, Kiely, P.A., Smith, L.M., Floyd, S., Ayllon, V., Meerovitch, K., and R. O’Connor; (2005) 'Gene expression profiles in cells transformed by overexpression of the IGF-I receptor'. Oncogene, 24 (*):6185-6193 [Details] | |
| (2005) | 'Eukaryotic membrane protein overproduction in Lactococcus lactis' Kunji, E. R.,Chan, K. W.,Slotboom, D. J.,Floyd, S.,O'Connor, R.,Monne, M.; (2005) 'Eukaryotic membrane protein overproduction in Lactococcus lactis'. Curr Opin Biotechnol, 16 (5):546-51 [Details] | |
| (2005) | 'Gene expression profiles in cells transformed by overexpression of the IGF-I receptor' Loughran G, Huigsloot M, Kiely PA, Smith LM, Floyd S, Ayllon V, O'Connor R; (2005) 'Gene expression profiles in cells transformed by overexpression of the IGF-I receptor'. Oncogene, 24 (40):6185-6193 [DOI] [Details] | |
| (2005) | 'RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251' Kiely. P.A., Leahy, M., O’Gorman, D., and R. O’Connor; (2005) 'RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251'. Journal of Biological Chemistry, 280 (9):7624-7633 [Details] | |
| (2005) | 'Mystique Is a new Insulin-like Growth Factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage-independent growth' Loughran, G., Healy, N., Kiely, P., Kedersha, N., and R. O’Connor; (2005) 'Mystique Is a new Insulin-like Growth Factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage-independent growth'. Molecular Biology of The Cell, 16 (4):1811-1822 [Details] | |
| (2004) | 'Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251' Leahy, M.,Lyons, A.,Krause, D.,O'Connor, R.; (2004) 'Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251'. Journal of Biological Chemistry, 279 (18):18306-18313 [Details] | |
| (2004) | 'EphA3 is induced by CD28 and 1GF-1 and regulates cell adhesion' Smith, L. M.,Walsh, P. T.,Rudiger, T.,Cotter, T. G.,Mc Carthy, T. V.,Marx, A.,O'Connor, R.; (2004) 'EphA3 is induced by CD28 and 1GF-1 and regulates cell adhesion'. Experimental Cell Research, 292 (2):295-303 [Details] | |
| (2004) | 'A low-volume platform for cell-respirometric screening based on quenched-luminescence oxygen sensing' Alderman, J.,Hynes, J.,Floyd, S. M.,Kruger, J.,O'Connor, R.,Papkovsky, D. B.; (2004) 'A low-volume platform for cell-respirometric screening based on quenched-luminescence oxygen sensing'. Biosensors & Bioelectronics, 19 (11):1529-1535 [Details] | |
| (2003) | 'Fluorescence-based cell viability screening assays using water-soluble oxygen probes' Hynes, J,Floyd, S,Soini, AE,O'Connor, R,Papkovsky, DB; (2003) 'Fluorescence-based cell viability screening assays using water-soluble oxygen probes'. Journal of Biomolecular Screening, 8 :264-272 [DOI] [Details] | |
| (2003) | 'Regulation of IGF-I receptor signaling in tumor cells' O'Connor, R.; (2003) 'Regulation of IGF-I receptor signaling in tumor cells'. Hormone and Metabolic Research, 35 (11-12):771-777 [Details] | |
| (2002) | 'Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X-L' Walsh, M.,Lutz, R. J.,Cotter, T. G.,O'Conner, R.; (2002) 'Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X-L'. Blood, 99 (9):3439-3448 [Details] | |
| (2002) | 'Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes' Walsh, PT,Smith, LM,O'Connor, R (2002) 'Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes'. The Journal of Immunology, 107 :461-471 [Details] | |
| (2002) | 'Structure-activity relationship of indomethacin analogues for MRP-1, COX-1 and COX-2 inhibition: identification of novel chemotherapeutic drug resistance modulators' Touhey, S,O'Connor, R,Plunkett, S,Maguire, A,Clynes, M; (2002) 'Structure-activity relationship of indomethacin analogues for MRP-1, COX-1 and COX-2 inhibition: identification of novel chemotherapeutic drug resistance modulators'. Cancer, 38 :1661-1670 [DOI] [Details] | |
| (2002) | 'Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts' Buckley, D. A.,Cheng, A.,Kiely, P. A.,Tremblay, M. L.,O'Connor, R.; (2002) 'Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts'. Molecular and Cellular Biology, 22 (7):1998-2010 [Details] | |
| (2002) | 'Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells' Buckley, D. A.,Loughran, G.,Murphy, G.,Fennelly, C.,O'Connor, R.; (2002) 'Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells'. Journal of Clinical Pathology-Molecular Pathology, 55 (1):46-54 [Details] | |
| (2002) | 'AKT signal transduction is impaired in the Alzheimer's disease brain' Griffin, R. J.,Fennelly, C.,O'Connor, R.,O'Neill, C.,Johnston, J. A.,Williams, C. H.,Ravid, R.; (2002) 'AKT signal transduction is impaired in the Alzheimer's disease brain'. Neurobiology of Aging, 23 (1) [Details] | |
| (2002) | 'Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes' Walsh, P. T.,Smith, L. M.,O'Connor, R.; (2002) 'Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes'. Immunology, 107 (4):461-471 [Details] | |
| (2001) | 'Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol' Krause, D.,Lyons, A.,Fennelly, C.,O'Connor, R.; (2001) 'Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol'. Journal of Biological Chemistry, 276 (22):19244-19252 [Details] | |
| (2000) | 'Regulation of survival signals from the insulin-like growth factor-I receptor' O'Connor, R.,Fennelly, C.,Krause, D.; (2000) 'Regulation of survival signals from the insulin-like growth factor-I receptor'. Biochemical Society Transactions, 28 :47-51 [Details] | |
| (2000) | 'The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis' Walsh, P. T.,O'Connor, R.; (2000) 'The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis'. European Journal of Immunology, 30 (4):1010-1018 [Details] | |
| (2000) | 'A cell viability assay based on monitoring respiration by optical oxygen sensing' O'Riordan, T. C.,Buckley, D.,Ogurtsov, V.,O'Connor, R.,Papkovsky, D. B.; (2000) 'A cell viability assay based on monitoring respiration by optical oxygen sensing'. Analytical Biochemistry, 278 (2):221-227 [Details] | |
| (1998) | 'Survival factors and apoptosis' O'Connor, R.; (1998) 'Survival factors and apoptosis'. Adv Biochem Eng Biotechnol, 62 :137-66 [Details] | |
| (1998) | 'Regulation of tumor cell survival by the IGF-I receptor C- terminus' O'Connor, R.,Resnicoff, M.,Baserga, R.,Dalton, E.,McDonagh, M.; (1998) 'Regulation of tumor cell survival by the IGF-I receptor C- terminus'. British Journal of Cancer, 78 [Details] | |
| (1998) | 'Expression of the insulin-like growth factor I receptor C terminus as a myristylated protein leads to induction of apoptosis in tumor cells' Liu, Y.,Lehar, S.,Corvi, C.,Payne, G.,O'Connor, R.; (1998) 'Expression of the insulin-like growth factor I receptor C terminus as a myristylated protein leads to induction of apoptosis in tumor cells'. Cancer Res, 58 (3):570-6 [Details] | |
| (1998) | 'Inhibition of tumorigenesis and induction of apoptosis in human tumor cells by the stable expression of a myristylated COOH terminus of the insulin-like growth factor I receptor' Hongo, A.,Yumet, G.,Resnicoff, M.,Romano, G.,O'Connor, R.,Baserga, R.; (1998) 'Inhibition of tumorigenesis and induction of apoptosis in human tumor cells by the stable expression of a myristylated COOH terminus of the insulin-like growth factor I receptor'. Cancer Research, 58 (11):2477-2484 [Details] | |
| (1997) | 'Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis' O'Connor, R.,Kauffmann-Zeh, A.,Liu, Y.,Lehar, S.,Evan, G. I.,Baserga, R.,Blattler, W. A.; (1997) 'Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis'. Mol Cell Biol, 17 (1):427-35 [Details] | |
| (1996) | 'Cure of multidrug-resistant human B-cell lymphoma xenografts by combinations of anti-B4-blocked ricin and chemotherapeutic drugs' Liu, C. N.,Lambert, J. M.,Teicher, B. A.,Blattler, W. A.,Oconnor, R.; (1996) 'Cure of multidrug-resistant human B-cell lymphoma xenografts by combinations of anti-B4-blocked ricin and chemotherapeutic drugs'. Blood, 87 (9):3892-3898 [Details] | |
| (1995) | 'Induction of Apoptosis by the Bcl-2 Homolog Bak' Chittenden, T.,Harrington, E. A.,O'Connor, R.,Flemington, C.,Lutz, R. J.,Evan, G. I.,Guild, B. C.; (1995) 'Induction of Apoptosis by the Bcl-2 Homolog Bak'. Nature, 374 (6524):733-736 [Details] | |
| (1995) | 'Anti-B4-Blocked Ricin Synergizes with Doxorubicin and Etoposide on Multidrug-Resistant and Drug-Sensitive Tumors' O'Connor, R.,Liu, C. N.,Ferris, C. A.,Guild, B. C.,Teicher, B. A.,Corvi, C.,Liu, Y. M.,Arceci, R. J.,Goldmacher, V. S.,Lambert, J. M.,Blattler, W. A.; (1995) 'Anti-B4-Blocked Ricin Synergizes with Doxorubicin and Etoposide on Multidrug-Resistant and Drug-Sensitive Tumors'. Blood, 86 (11):4286-4294 [Details] | |
| (1993) | 'Anti-B4 Blocked Ricin as a Candidate to Reverse Multidrug- Resistance in B-Cell Tumors' O'Connor, R.,Liu, C.,Teicher, B. A.,Shah, S. A.,Blattler, W. A.; (1993) 'Anti-B4 Blocked Ricin as a Candidate to Reverse Multidrug- Resistance in B-Cell Tumors'. Blood, 82 (10):A140-A140 [Details] | |
| (1993) | 'Potentiation of Chemotherapy by Anti-B4-Blocked Ricin against a Human B-Cell Lymphoma in-Vitro and in-Vivo' Liu, C.,Oconnor, R.,Derr, S. M.,Shah, S. A.,Blattler, W. A.; (1993) 'Potentiation of Chemotherapy by Anti-B4-Blocked Ricin against a Human B-Cell Lymphoma in-Vitro and in-Vivo'. Blood, 82 (10):A140-A140 [Details] | |
| (1993) | 'Establishment of a Karyotypically Normal Cytotoxic Leukemic T- Cell Line from a T-All Sample Engrafted in Scid Mice' Cesano, A.,Oconnor, R.,Nowell, P. C.,Lange, B.,Clark, S. C.,Santoli, D.; (1993) 'Establishment of a Karyotypically Normal Cytotoxic Leukemic T- Cell Line from a T-All Sample Engrafted in Scid Mice'. Blood, 81 (10):2714-2722 [Details] | |
| (1993) | 'Interactions of Anti-B4-Br with Chemotherapeutic-Agents on B- All Cells-Invitro' O'Connor, R.,Goldmacher, V. S.,Teicher, B. A.,Blattler, W. A.; (1993) 'Interactions of Anti-B4-Br with Chemotherapeutic-Agents on B- All Cells-Invitro'. Journal of Cellular Biochemistry, :270-270 [Details] | |
| (1992) | 'Pediatric Leukemia Lymphoma with T(8 14)(Q24 Q11)' Lange, B. J.,Raimondi, S. C.,Heerema, N.,Nowell, P. C.,Minowada, J.,Steinherz, P. E.,Arenson, E. B.,O'Connor, R.,Santoli, D.; (1992) 'Pediatric Leukemia Lymphoma with T(8 14)(Q24 Q11)'. Leukemia, 6 (7):613-618 [Details] | |
| (1992) | 'Phenotypic Changes Induced by Interleukin-2 (IL-2) and IL-3 in an Immature T-Lymphocytic Leukemia Are Associated with Regulated Expression of Il-2 Receptor-Beta Chain and of Protein Tyrosine Kinases Lck and Lyn' O'Connor, R.,Torigoe, T.,Reed, J. C.,Santoli, D.; (1992) 'Phenotypic Changes Induced by Interleukin-2 (IL-2) and IL-3 in an Immature T-Lymphocytic Leukemia Are Associated with Regulated Expression of Il-2 Receptor-Beta Chain and of Protein Tyrosine Kinases Lck and Lyn'. Blood, 80 (4):1017-1025 [Details] | |
| (1992) | 'Interleukin-3 Regulates the Activity of the Lyn Protein- Tyrosine Kinase in Myeloid-Committed Leukemic-Cell Lines' Torigoe, T.,O'Connor, R.,Santoli, D.,Reed, J. C.; (1992) 'Interleukin-3 Regulates the Activity of the Lyn Protein- Tyrosine Kinase in Myeloid-Committed Leukemic-Cell Lines'. Blood, 80 (3):617-624 [Details] | |
| (1992) | 'Regulation of Src-Family Protein Tyrosine Kinases by Interleukins, IL-2, and IL-3' Torigoe, T.,Oconnor, R.,Fagard, R.,Fischer, S.,Santoli, D.,Reed, J. C.; (1992) 'Regulation of Src-Family Protein Tyrosine Kinases by Interleukins, IL-2, and IL-3'. Leukemia, 6 :S94-S97 [Details] | |
| (1992) | 'Interleukin-4 Inhibits Il-2-Induced Proliferation of a Human T- Leukemia Cell-Line without Interfering with P56-Lck Kinase Activation' Torigoe, T.,Oconnor, R.,Fagard, R.,Fischer, S.,Santoli, D.,Reed, J. C.; (1992) 'Interleukin-4 Inhibits Il-2-Induced Proliferation of a Human T- Leukemia Cell-Line without Interfering with P56-Lck Kinase Activation'. Cytokine, 4 (5):369-376 [Details] | |
| (1991) | 'Homing and Progression Patterns of Childhood Acute Lymphoblastic Leukemias in Severe Combined Immunodeficiency Mice' Cesano, A.,Oconnor, R.,Lange, B.,Finan, J.,Rovera, G.,Santoli, D.; (1991) 'Homing and Progression Patterns of Childhood Acute Lymphoblastic Leukemias in Severe Combined Immunodeficiency Mice'. Blood, 77 (11):2463-2474 [Details] | |
| (1991) | 'Growth-Factor Requirements of Childhood Acute T-Lymphoblastic Leukemia - Correlation between Presence of Chromosomal- Abnormalities and Ability to Grow Permanently Invitro' O'Connor, R.,Cesano, A.,Lange, B.,Finan, J.,Nowell, P. C.,Clark, S. C.,Raimondi, S. C.,Rovera, G.,Santoli, D.; (1991) 'Growth-Factor Requirements of Childhood Acute T-Lymphoblastic Leukemia - Correlation between Presence of Chromosomal- Abnormalities and Ability to Grow Permanently Invitro'. Blood, 77 (7):1534-1545 [Details] | |
| (1990) | 'Characterization of a Protein with an Acetylcholine-Receptor Epitope from Myasthenia Gravis-Associated Thymomas' Marx, A.,O'Connor, R.,Geuder, K. I.,Hoppe, F.,Schalke, B.,Tzartos, S.,Kalies, I.,Kirchner, T.,Mullerhermelink, H. K.; (1990) 'Characterization of a Protein with an Acetylcholine-Receptor Epitope from Myasthenia Gravis-Associated Thymomas'. Laboratory Investigation, 62 (3):279-286 [Details] | |
| (1990) | 'Synergistic and Antagonistic Effects of Il-1-Alpha and Il-4, Respectively, on the Il-2-Dependent Growth of a T-Cell Receptor-Gamma,Delta+ Human-T Leukemia-Cell Line' Santoli, D.,O'Connor, R.,Cesano, A.,Phillips, P.,Colt, T. L.,Lange, B.,Clark, S. C.,Rovera, G.; (1990) 'Synergistic and Antagonistic Effects of Il-1-Alpha and Il-4, Respectively, on the Il-2-Dependent Growth of a T-Cell Receptor-Gamma,Delta+ Human-T Leukemia-Cell Line'. Journal of Immunology, 144 (12):4703-4711 [Details] | |
| (1990) | 'Human Monoclonal-Antibody against a Tissue Polypeptide Antigen- Related Protein from a Patient with a Signet-Ring Cell- Carcinoma of the Stomach' Pfaff, M.,Oconnor, R.,Vollmers, H. P.,Mullerhermelink, H. K.; (1990) 'Human Monoclonal-Antibody against a Tissue Polypeptide Antigen- Related Protein from a Patient with a Signet-Ring Cell- Carcinoma of the Stomach'. Cancer Research, 50 (16):5192-5198 [Details] | |
| (1990) | 'Growth Factor-Dependent Differentiation Along the Myeloid and Lymphoid Lineages in an Immature Acute Lymphocytic-T Leukemia' O'Connor, R.,Cesano, A.,Kreider, B. L.,Lange, B.,Clark, S. C.,Nowell, P. C.,Finan, J.,Rovera, G.,Santoli, D.; (1990) 'Growth Factor-Dependent Differentiation Along the Myeloid and Lymphoid Lineages in an Immature Acute Lymphocytic-T Leukemia'. Journal of Immunology, 145 (11):3779-3787 [Details] | |
| (1989) | 'Sc-1, a Functional Human Monoclonal-Antibody against Autologous Stomach Carcinoma-Cells' Vollmers, H. P.,O'Connor, R.,Muller, J.,Kirchner, T.,Mullerhermelink, H. K.; (1989) 'Sc-1, a Functional Human Monoclonal-Antibody against Autologous Stomach Carcinoma-Cells'. Cancer Research, 49 (9):2471-2476 [Details] | |
| (1989) | 'Identification of a Leukocyte Alloantigen with a High-Frequency Expression in Leukemia Patients' O'Connor, R.,Bradley, J. G.,Omeara, A.,Cotter, T. G.; (1989) 'Identification of a Leukocyte Alloantigen with a High-Frequency Expression in Leukemia Patients'. Blood, 73 (2):553-558 [Details] | |
| (1989) | 'Proteins with Epitopes of the Acetylcholine-Receptor in Epithelial-Cell Cultures of Thymomas in Myasthenia-Gravis' Marx, A.,Kirchner, T.,Hoppe, F.,O'Connor, R.,Schalke, B.,Tzartos, S.,Mullerhermelink, H. K.; (1989) 'Proteins with Epitopes of the Acetylcholine-Receptor in Epithelial-Cell Cultures of Thymomas in Myasthenia-Gravis'. American Journal of Pathology, 134 (4):865-877 [Details] | |
| (1989) | 'Charakterisierung von Zellen Menschlicher Magenkarzinoma' Müller, J., O¿Connor, R., Vollmers, H.P. and H.K. Müller-Hermelink ; (1989) 'Charakterisierung von Zellen Menschlicher Magenkarzinoma'. Ver. Dtsch. Ges. Pathol, 72 (7):214-220 [Details] | |
| (1987) | 'Production and Characterization of a Monoclonal-Antibody to a Myeloid Specific Differentiation Antigen' O'Connor, R.,Bradley, J. G.,Lawlor, E.,Cotter, T. G.; (1987) 'Production and Characterization of a Monoclonal-Antibody to a Myeloid Specific Differentiation Antigen'. Leukemia Research, 11 (5):481-488 [Details] | |
| (1987) | 'Identification of a Leukocyte Antigen with a High-Frequency Expression in Leukemia Patients' Cotter, T.,Bradley, J.,O'Connor, R.; (1987) 'Identification of a Leukocyte Antigen with a High-Frequency Expression in Leukemia Patients'. European Journal of Cancer & Clinical Oncology, 23 (11):1741-1741 [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2004) | 'The IGF-I Receptor in Cell Survival: Signalling and Regulation' Kiely, PA, Lyons, A., O¿Gorman, D, and R. O¿Connor; (2004) 'The IGF-I Receptor in Cell Survival: Signalling and Regulation' In: Cell Engineering: Apoptosis. U.K: Kluwer. [Details] | |
| (1997) | 'Modulating Cytokine-Dependent Survival by Targeting the IGF-IR [B3036]' O'Connor, R.; (1997) 'Modulating Cytokine-Dependent Survival by Targeting the IGF-IR [B3036]' In: IBC Library Series: Apoptosis: Practical Applications and Novel Therapeutics. [Details] | |
| (1997) | 'Modulation of Apoptosis for Treatment of Disease [B3035]' Lutz, R. J.; O'Connor, R.; Chittenden, T.; (1997) 'Modulation of Apoptosis for Treatment of Disease [B3035]' In: New Development in Drug Discovery. [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2008) | Alzheimer's and Dementia 4 (4) O'Neill, C., Moloney, A.M., Griffin, R.J., Coakley, M.F., Timmons, S., O'Connor, R., Ravid, R. ; (2008) Defects in IGF-1 receptor, insulin receptor, and insulin receptor substrate proteins in Alzheimer's disease neurons indicate resistance to insulin and IGF-1 signalling Alzheimer's and Dementia 4 (4) 11th International Conference of Alzheimer's disease and related disorders, Chicago, USA, [Details] | |
| (2006) | Alzheimer's and Dementia 2, (3) Moloney, A., Griffin, R.J., Timmons, S., Ravid, R., O' Connor, R. and O' Neill, C; (2006) Impaired IGF-1 receptor signal transduction in Alzheimer's disease Alzheimer's and Dementia 2, (3) 10th International Conference of Alzheimer's disease and related disorders, Madrid, Spain, July 2006, [Details] | |
| (2006) | Alzheimer's and Dementia 2: (3) O' Neill, C., Moloney, A., Timmons, S., Kelliher, M., Dockery, P., O' Connor, R., Johnston, J.A, Ravid, R., and Griffin R.J.; (2006) Excessive activation of Akt signalling links to neuronal cell death in Alzheimer's disease Alzheimer's and Dementia 2: (3) 10th International Conference of Alzheimer's disease and related disorders, Madrid, Spain, July 2006, [Details] | |
| (2002) | 6th Eur. Conf. Optical Chemical Sensors and Biosensors Hynes, J; Floyd, S; O'Connor, R; Papkovsky, DB; (2002) Monitoring of cellular respiration using phosphorescent oxygen probes and its potential applicatins . In: * eds. 6th Eur. Conf. Optical Chemical Sensors and Biosensors Manchester, UK, , 07-APR-02 - 11-APR-02 , pp.237-237 [Details] | |
| (2002) | Neurobiology of Aging, 23. (1) Griffin, R. J.,Fennelly, C.,O'Connor, R.,O'Neill, C.,Johnston, J. A.,Williams, C. H.,Ravid, R.; (2002) AKT signal transduction is impaired in the Alzheimer's disease brain Neurobiology of Aging, 23. (1) 8th International Conference of Alzheimer's disease and related disorders, Stockholm, Sweden, , pp.1365-1365 [Details] | |
| (2001) | 5th Euroconference on Environmental Analytical Chemistry The impact of (Bio)Sensors and bioanalytical techniques on environmental monitoring Hynes, J; Floyd, S; O'Connor, R; Papkovsky, DB.; (2001) Monitoring of respiration of mammalian cells using quenched fluorescene oxygen sensing . In: * eds. 5th Euroconference on Environmental Analytical Chemistry The impact of (Bio)Sensors and bioanalytical techniques on environmental monitoring Blarney, Ireland, , 08-SEP-01 - 12-SEP-01 , pp.61-61 [Details] | |
| (2000) | 5th Eur. Conf. Optical Chemical Sensors and Biosensors O'Riordan, T; O'Connor, R; Papkovsky, DP; (2000) Cell metabolic profile determination using an optical oxygen sensor, Abst . In: * eds. 5th Eur. Conf. Optical Chemical Sensors and Biosensors Lyon, , 16-APR-00 - 19-APR-00 , pp.223-223 [Details] | |
| (2000) | Society for Neuroscience 762.19 Griffin, RJ; Kelliher, M; Johnston, JA; Williams, CH; Ravid, R; Fennelly, C; O'Connor, R; O'Neill, C.; (2000) Dysfunctional insulin-like growth factor-1-Akt signal transduction in Alzheimer's disease brain Society for Neuroscience 762.19 30th Annual Meeting New Orleans, USA, November 4-9 2000, , 04-NOV-00 - 09-NOV-00 [Details] | |
| (2000) | Eur. Conf. Optical Chemical Sensors and Biosensors O'Riordan, T; O'Connor, R; Papkovsky, DP.; (2000) Cell metabolic profile determination using an optical oxygen sensor, Abst . In: * eds. Eur. Conf. Optical Chemical Sensors and Biosensors Lyon, , 16-APR-00 - 19-APR-00 , pp.223-223 [Details] | |
| (1999) | 670th Biochemical Society Meeting O'Riordan, T; Buckley, D; O'Connor, R; Papkovsky, DB; (1999) Cell Viability screening method using optical oxygen sensor, Abst . In: * eds. 670th Biochemical Society Meeting Cork, , 07-SEP-99 - 09-SEP-99 , pp.A23-A23 [Details] | |
| (2002) | AKT signal transduction is impaired in the Alzheimer's disease brain Griffin, RJ,Fennelly, C,O'Connor, R,O'Neill, C,Johnston, JA,Williams, CH,Ravid, R (2002) NEUROBIOLOGY OF AGING AKT signal transduction is impaired in the Alzheimer's disease brain , pp.372-372 [Details] | |
| (2006) | 10th Annual Conference on Alzheimer's Disease and Related Disorders Moloney A, Griffin R, Timmons S, Ravid R, O’Connor R, O’Neill C. (2006) Impaired IGF-I receptor and insulin receptor signal transduction in Alzheimer’s disease 10th Annual Conference on Alzheimer's Disease and Related Disorders [Details] | |
| (2008) | 12th International Conference on Alzheimer's Disease and Related Disorders O'Neill, C, Moloney, A, Griffin, R, Coakley, M, Timmons, S, O'Connor, R, Ravid, R (2008) Defects in IGF-1 receptor, insulin receptor, and insulin receptor substrate proteins in Alzheimer's disease neurons indicate resistance to insulin and IGF-1 signalling 12th International Conference on Alzheimer's Disease and Related Disorders [Details] | |
| (2006) | 10th Annual Conference on Alzheimer's Disease and Related Disorders O’ Neill C, Moloney A, Timmons S, Kelliher M, Dockery P, O’ Connor R, Johnston J, Ravid R, Griffin R. (2006) Excessive activation of Akt signalling links to neuronal cell death in Alzheimer’s disease 10th Annual Conference on Alzheimer's Disease and Related Disorders [Details] |
Abstract
| Year | Publication | |
|---|---|---|
| (2012) | Potent long-term cardioprotective effects of single low dose insulin-like growth factor-1 (LD-IGF-1) treatment post myocardial infarction. O'sullivan, JF,Leblond, AL,Kelly, G,Kumar, AHS,Metharom, P,Buneker, CK,Alizadeh-Vikali, N,Hynes, BG,O'connor, R,Caplice, NM (2012) Potent long-term cardioprotective effects of single low dose insulin-like growth factor-1 (LD-IGF-1) treatment post myocardial infarction. Abstract [Details] | |
| (2011) | POTENT CARDIOPROTECTIVE EFFECTS OF LOW DOSE INSULIN-LIKE GROWTH FACTOR-1 (LD-IGF-1) TREATMENT POST MYOCARDIAL INFARCTION ARE MEDIATED THROUGH PHOSPHORYLATION OF THE IGF-1 RECEPTOR, GSK-3BETA INHIBITION AND SURVIVAL KINASE UPREGULATION. O'Sullivan, JF,Leblond, AL,Metharom, P,Kumar, AHS,Kelly, G,Hristova, E,Hynes, B,O'Connor, R,Caplice, NM (2011) POTENT CARDIOPROTECTIVE EFFECTS OF LOW DOSE INSULIN-LIKE GROWTH FACTOR-1 (LD-IGF-1) TREATMENT POST MYOCARDIAL INFARCTION ARE MEDIATED THROUGH PHOSPHORYLATION OF THE IGF-1 RECEPTOR, GSK-3BETA INHIBITION AND SURVIVAL KINASE UPREGULATION. Abstract [Details] | |
| (2010) | Dunnigan Type Lipodystrophy - Altered Adipocyte Distribution in Patients & Altered Adipocyte Differentiation in Cell Models. Ryan, JO,O'Callaghan, CM,Buckley, D,Crowley, V,O'Connor, R,McCarthy, T,O'Halloran, DJ (2010) Dunnigan Type Lipodystrophy - Altered Adipocyte Distribution in Patients & Altered Adipocyte Differentiation in Cell Models. Abstract [Details] | |
| (2010) | Tim-4 Ig Inhibits CD4(+) T Cell Responses by a Tim-1 Independent Pathway In Vitro. Cao, W,Ryan, M,O'Connor, R,Clarkson, M (2010) Tim-4 Ig Inhibits CD4(+) T Cell Responses by a Tim-1 Independent Pathway In Vitro. Abstract [Details] | |
| (1998) | Regulation of tumor cell survival by the IGF-I receptor C-terminus. O'Connor, R,Resnicoff, M,Baserga, R,Dalton, E,McDonagh, M (1998) Regulation of tumor cell survival by the IGF-I receptor C-terminus. Abstract [Details] | |
| (2004) | Regulation of IGF-I signalling in cardiomyocytes in adhesion. O'Donovan, HC,O'Connor, R (2004) Regulation of IGF-I signalling in cardiomyocytes in adhesion. Abstract [Details] | |
| (2011) | Potent Long-term Cardioprotective Effects of Single Low Dose Insulin-like Growth Factor-1 (LD-IGF-1) Treatment Post Myocardial Infarction. O'Sullivan, JF,Leblond, AL,Kelly, G,Kumar, AHS,Metharom, P,Buneker, CK,Alizadeh-Vikali, N,Hristova, I,Hynes, BG,O'Connor, R,Caplice, NM (2011) Potent Long-term Cardioprotective Effects of Single Low Dose Insulin-like Growth Factor-1 (LD-IGF-1) Treatment Post Myocardial Infarction. Abstract [Details] | |
| (2004) | Characterisation of an IGF-I responsive gene that encodes a new endosomal protein. O'Callaghan, KM,O'Connor, R (2004) Characterisation of an IGF-I responsive gene that encodes a new endosomal protein. Abstract [Details] | |
| (2004) | Regulation of IGF-I-mediated cell migration by adhesion and the scaffolding protein RACK1. O'Connor, R,Leahy, M,Kiely, P (2004) Regulation of IGF-I-mediated cell migration by adhesion and the scaffolding protein RACK1. Abstract [Details] |
Book Reviews
| Year | Publication | |
|---|---|---|
| (2009) | Periodontitis and Type 2 Diabetes: Is Oxidative Stress the Mechanistic Link?. Allen, EM,Matthews, JB,O'Connor, R,O'Halloran, D,Chapple, ILC (2009) Periodontitis and Type 2 Diabetes: Is Oxidative Stress the Mechanistic Link?. Book Reviews [Details] |
Review Articles
| Year | Publication | |
|---|---|---|
| (2000) | Regulation of survival signals from the insulin-like growth factor-I receptor. O'Connor, R,Fennelly, C,Krause, D (2000) Regulation of survival signals from the insulin-like growth factor-I receptor. Review Articles [Details] | |
| (2003) | Regulation of IGF-I receptor signaling in tumor cells. O'Connor, R (2003) Regulation of IGF-I receptor signaling in tumor cells. Review Articles [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2019 | Award for outstanding contribution to Cancer Research on the Island of Ireland | Irish Association for Cancer Research | |
| 2007 | Biochemical Society Medal | The Biochemical Society Irish Area |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| Irish Association for Cancer Research | * | 01-SEP-02 / 30-DEC-99 | |
| American Association for Cancer Research | * | 30-DEC-99 / 30-DEC-99 | |
| American Society for Biochemistry & Molecular Biology | * | 30-DEC-99 / 30-DEC-99 | |
| American Society for Microbiology | * | 30-DEC-99 / 30-DEC-99 | |
| The Biochemical Society | * | 30-DEC-99 / 30-DEC-99 | |
| British Society for Immunology | * | 30-DEC-99 / 30-DEC-99 | |
| The IGF Society | * | 30-DEC-99 / 30-DEC-99 | |
| American Association for Microbiology | * | 30-DEC-99 / 30-DEC-99 | |
| SFI Research Frontiers Directorate FES Advisory Committee | Member | 01-JAN-04 / 01-JAN-07 |
Patents
| Patent Number | Title | Granted | |
|---|---|---|---|
| 2003/0759 | IGF-responsive gene and use thereof | 01-APR-06 | |
| unknown | of Disease (CF5) PCT | 01-JAN-99 | |
| unknown | Treatment of Disease (MITOR) PCT | 01-JAN-99 | |
| 5,958,872 | Active Survival domains of IGF-IR and methods of use | 28-SEP-99 | |
| 2002/0025 | A Device, | 17-JAN-02 | |
| * | A Novel Protein | 01-OCT-03 |
Conference Contributions
| Year | Publication | |
|---|---|---|
| (2008) | Harvard Medical School (Brigham and Womens Hospital Division of Immunology), Rosemary O'Connor; (2008) Harvard Medical School (Brigham and Womens Hospital Division of Immunology). [Oral Presentation], Harvard Medical School (Brigham and Womens Hospital Division of Immunology), Boston, USA , 11-MAY-08 - 11-MAY-08. [Details] | |
| (2007) | Biochemical Society Irish Area Section Medal Lecture, RCSI, Rosemary O'Connor; (2007) Biochemical Society Irish Area Section Medal Lecture, RCSI. [Oral Presentation], Biochemical Society Irish Area Section Medal Lecture, RCSI, Dublin, Ireland , 22-NOV-07 - 22-NOV-07. [Details] | |
| (2007) | Seminar, German Cancer Centre, Rosemary O'Connor; (2007) German Cancer Centre Seminar. [Oral Presentation], Seminar, German Cancer Centre, University of Heidelberg, Germany , 17-DEC-07 - 17-DEC-07. [Details] | |
| (2007) | Science Foundation Ireland Science Summit, Rosemary O'Connor; (2007) Science Foundation Ireland Science Summit. [Oral Presentation], Science Foundation Ireland Science Summit, Unkown , 26-NOV-07 - 26-NOV-07. [Details] | |
| (2007) | Seminar Institute Queensland University of Technology, Rosemary O'Connor; (2007) Seminar Institute Queensland University of Technology. [Oral Presentation], Seminar Institute Queensland University of Technology, Brisbane, Australia , 02-NOV-07 - 01-NOV-07. [Details] | |
| (2007) | Tufts University School of Medicine, Department of Physiology, Rosemary O'Connor; (2007) Tufts University School of Medicine, Department of Physiology. [Oral Presentation], Tufts University School of Medicine, Department of Physiology, Boston, USA , 28-MAR-07 - 28-MAR-07. [Details] | |
| (2007) | American Association for Cancer Research Annual Meeting, Rosemary O'Connor; (2007) Oral presentation selected from proffered abstracts: P. Kiely. [Oral Presentation], American Association for Cancer Research Annual Meeting, San Francisco, USA , 01-APR-07 - 01-APR-07. [Details] | |
| (2007) | Symposium to mark opening of Centre for Cancer Research and Cell Biology, Queens University Belfast, Rosemary O'Connor; (2007) Symposium to mark opening of Centre for Cancer Research and Cell Biology, Queens University Belfast. [Oral Presentation], Symposium to mark opening of Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Ireland , 28-NOV-07 - 29-NOV-07. [Details] | |
| (2007) | Conference on Signalling Systems, Rosemary O'Connor; (2007) Conference on Signalling Systems (Science Among The Vines Barossa Meetings). [Oral Presentation], Conference on Signalling Systems, Adelaide, Australia, , 14-NOV-07 - 17-NOV-07. [Details] | |
| (2007) | Gordon Conference on IGFs in Physiology and Disease, Rosemary O'Connor; (2007) IGF-IR Signalling. [Oral Presentation], Gordon Conference on IGFs in Physiology and Disease, Ventura California, USA , 01-MAR-07 - 01-MAR-07. [Details] | |
| (2006) | All Ireland Cancer Conference, Rosemary O'Connor; (2006) All Ireland Cancer Conference. [Oral Presentation], All Ireland Cancer Conference, Belfast, Ireland , 12-NOV-06 - 14-NOV-06. [Details] | |
| (2006) | Division of Biochemistry and Molecular Biology, University of Glasgow: Seminar, Rosemary O'Connor; (2006) IGF System in Cancer. [Oral Presentation], Division of Biochemistry and Molecular Biology, University of Glasgow: Seminar, University of Glasgow, Scotland , 13-FEB-06 - 13-FEB-06. [Details] | |
| (2006) | All Ireland Cancer Conference, Rosemary O'Connor; (2006) Targeting the IGF-I Signalling Pathway in Cancer. [Oral Presentation], All Ireland Cancer Conference, Belfast, Ireland , 12-NOV-06 - 14-NOV-06. [Details] | |
| (2006) | Weatherall Institute of Molecular Medicine, Rosemary O'Connor; (2006) IGF-I Signalling in Tumour cell Migration. [Oral Presentation], Weatherall Institute of Molecular Medicine, University of Oxford, UK , 26-JUL-06 - 26-JUL-06. [Details] | |
| (2005) | Symposium on Common Molecular Mechanisms in Inflammation and Malignancy, St. Vincent¿s Education and Research Centre and Conway Institute UCD, Rosemary O'Connor; (2005) New pathways in IGF-I Survival Signaling. [Oral Presentation], Symposium on Common Molecular Mechanisms in Inflammation and Malignancy, St. Vincent¿s Education and Research Centre and Conway Institute UCD, Dublin, Ireland , 12-NOV-05 - 12-NOV-05. [Details] | |
| (2005) | Irish Association for Cancer Research annual meeting, Rosemary O'Connor; (2005) Irish Association for Cancer Research annual meeting. [Oral Presentation], Irish Association for Cancer Research annual meeting, Kilkenny, Ireland , 11-MAR-05 - 13-MAR-05. [Details] | |
| (2005) | China-Ireland Workshop on Biotechnology (SFI), Rosemary O'Connor; (2005) Regulation of IGF-IR signalling. [Oral Presentation], China-Ireland Workshop on Biotechnology (SFI), Beijing, China , 09-MAY-05 - 13-MAY-05. [Details] | |
| (2005) | Role of IGFs in Cancer, Rosemary O'Connor; (2005) New mediators and regulators of IGF-IR signalling. [Oral Presentation], Role of IGFs in Cancer, Taormina, Italy , 10-NOV-05 - 12-NOV-05. [Details] | |
| (2005) | University of California at San Francisco Gallo Research Center Seminar, Rosemary O'Connor; (2005) IGF-IR and RACK1 Signalling. [Oral Presentation], University of California at San Francisco Gallo Research Center Seminar, San Francisco, USA , 25-MAR-05 - 25-MAR-05. [Details] | |
| (2005) | International Conference on Mechanisms of Cell Death, Rosemary O'Connor; (2005) IGF Survival Signalling. [Oral Presentation], International Conference on Mechanisms of Cell Death, Maynooth, Ireland , 24-JUN-05 - 28-JUN-04. [Details] | |
| (2004) | UCD Conway Institute Seminar, Rosemary O'Connor; (2004) The IGF System: A Key to Survival. [Oral Presentation], UCD Conway Institute Seminar, UCD, Dublin, Ireland , 14-OCT-04 - 14-OCT-04. [Details] | |
| (2004) | Committee member of Irish Association for Cancer Research Annual Meeting, Rosemary O'Connor; (2004) Irish Association for Cancer Research Annual Meeting. [Conference Organising Committee Member], Committee member of Irish Association for Cancer Research Annual Meeting, Galway, Cork and Down, Ireland , 01-JAN-04 - 01-JAN-07. [Details] | |
| (2004) | International GH-IGF Symposium, Rosemary O'Connor; (2004) Anchor Talk in Signalling plenary session, Regulation of IGF-IR Signalling in Tumor Cells. [Oral Presentation], International GH-IGF Symposium, Cairns Australia , 18-APR-04 - 22-APR-04. [Details] | |
| (2003) | Gordon Research Conference on Insulin like Growth factors in Physiology and Disease, Rosemary O'Connor; (2003) IGF-1 Receptor signalling and regulation. [Oral Presentation], Gordon Research Conference on Insulin like Growth factors in Physiology and Disease, Ventura, California, USA , 09-MAR-03 - 14-MAR-03. [Details] | |
| (2003) | Endocrine Society Annual Meeting, Rosemary O'Connor; (2003) Plenary session on IGF-IR Function , Insulin-Like Growth Factor Receptor Regulation. [Oral Presentation], Endocrine Society Annual Meeting, Philadelphia, USA , 19-JUN-03 - 22-JUN-03. [Details] | |
| (2003) | Biotechnology, Cancer and Drug Resistance, Rosemary O'Connor; (2003) The IGF-I Receptor and Its Signalling Pathway as a target in Oncology. [Oral Presentation], Biotechnology, Cancer and Drug Resistance, Dublin, Ireland , 07-JUL-03 - 08-JUL-03. [Details] | |
| (2003) | MRC/Wellcome Research Center, Cambridge University, England, Rosemary O'Connor; (2003) Signalling from the IGF-I Receptor. [Oral Presentation], MRC/Wellcome Research Center, Cambridge University, England, Cambridge University, England , 01-DEC-03 - 01-DEC-03. [Details] | |
| (2003) | McGill Cancer Center, Montreal, Canada, Rosemary O'Connor; (2003) Signalling from the IGF-IR in Cancer. [Oral Presentation], McGill Cancer Center, Montreal, Canada, Montreal, Canada , 17-JUN-03 - 17-JUN-03. [Details] | |
| (2003) | Harvard Medical School, Boston, Rosemary O'Connor; (2003) The IGF-IR in Cancer. [Oral Presentation], Harvard Medical School, Boston, Boston, USA , 13-JUN-03 - 13-JUN-03. [Details] | |
| (2003) | Serono Research Institute, Geneva, Switzerland, Rosemary O'Connor; (2003) Regulation of IGF-IR Signalling in Cancer. [Oral Presentation], Serono Research Institute, Geneva, Switzerland, Geneva, Switzerland , 23-OCT-03 - 23-OCT-03. [Details] | |
| (2003) | Department of Biochemistry, NUI Galway, Rosemary O'Connor; (2003) IGF-IR Signalling in Cancer. [Oral Presentation], Department of Biochemistry, NUI Galway, Galway, Ireland , 07-NOV-03 - 07-NOV-03. [Details] | |
| (2003) | Department of Biology, NUI, Maynooth, Rosemary O'Connor; (2003) Genes in Cancer. [Oral Presentation], Department of Biology, NUI, Maynooth, NUI Maynooth, Ireland , 04-NOV-03 - 04-NOV-03. [Details] | |
| (2002) | Harvard Medical School, *; (2002) IGF-1 Receptor Signalling in Cancer Cells. [Invited Oral Presentation], Harvard Medical School, Harvard , 10-OCT-02 - 10-OCT-02. [Details] | |
| (2002) | Laboratory Workshop on Molecular Biology run by UK Physiology Society, *; (2002) DNA Array Technology. [Invited Oral Presentation], Laboratory Workshop on Molecular Biology run by UK Physiology Society, Cork , 10-MAY-02 - 10-MAY-02. [Details] | |
| (2002) | Wellcome Trust MRC Nutrition Unit, *; (2002) *. [N/A], Wellcome Trust MRC Nutrition Unit, Cambridge University, UK , 01-DEC-02 - 01-DEC-02. [Details] | |
| (2002) | Joint Symposium of The Growth Hormone Research Society and the International Society for Insulin-like Growth Factor Research, Leahy,M; Lyon, A; Krause, D; O'Connor, R.; (2002) Role of Tyrosines 1250/1251 in signalling from the IGF-1R. [Oral Presentation], Joint Symposium of The Growth Hormone Research Society and the International Society for Insulin-like Growth Factor Research, USA , 05-OCT-02 - 09-OCT-02. [Details] | |
| (2002) | Joint Symposium of the Growth Hormone Research Society, Kiely, P; Buckley, DA; O'Connor, R.; (2002) Regulation of IGF-1-activated Signalling Pathways by RACK1 and Phosphates. [Oral Presentation], Joint Symposium of the Growth Hormone Research Society, Boston, USA , 05-OCT-02 - 09-OCT-02. [Details] | |
| (2002) | FASEB Summer Research Conference on Receptors and Signal Transduction, Leahy, M; Lyons, A; Krause, D; Kiely, PA; O'Connor, R.; (2002) Differential regulation of IFG-1-activated signalling pathways by the IFG-1 receptor C terminus. [N/A], FASEB Summer Research Conference on Receptors and Signal Transduction, Utah, USA , 29-JUN-02 - 03-JUL-02. [Details] | |
| (2002) | FASEB Summer Research Conference on Protein Phosphatases, Cheng, A; Buckley, DA; Kiely, P; Bal, GS; Kennedy, BP; Tremblay, ML; O'Connor, R.; (2002) Cellular Signaling in primary and immortalized fibroblasts deficient in PTP1B. [N/A], FASEB Summer Research Conference on Protein Phosphatases, Colorado, USA , 13-JUL-02 - 18-JUL-02. [Details] | |
| (2002) | Oncogenomics, Loughran, G; Kiely, PA; Smith, LM; Meerovitch, K; O'Connor, R.; (2002) The IGF-1 receptor regulates expression of genes associated with transformation, turmor cell growth, and metastasis. [N/A], Oncogenomics, Dublin , 01-MAY-02 - 05-MAY-02. [Details] | |
| (2002) | BioChem Pharma, *; (2002) Novel targets in the IGF-IR singalling pathway. [N/A], BioChem Pharma, Montreal , 07-NOV-02 - 07-NOV-02. [Details] | |
| (2002) | New Proteins as Mediators of IGF-1 Receptor Function in Tumours, *; (2002) *. [N/A], New Proteins as Mediators of IGF-1 Receptor Function in Tumours, * , 11-OCT-02 - 11-OCT-02. [Details] | |
| (2002) | International meeting/workshop on Quality Aspects of Biopharmaceutical Products, *; (2002) Introduction to Cell Biology. [Invited Oral Presentation], International meeting/workshop on Quality Aspects of Biopharmaceutical Products, Kinsale, Cork , 08-MAY-02 - 10-MAY-02. [Details] | |
| (2000) | Targeting the IGF-I receptor in Cancer, *; (2000) *. [N/A], Targeting the IGF-I receptor in Cancer, Manchester , 15-DEC-00 - 15-DEC-02. [Details] | |
| (2000) | Science Week, *; (2000) Biotechnology and the Quest for New Anti-Cancer drugs. [N/A], Science Week, cORK , 16-NOV-00 - 16-NOV-00. [Details] | |
| (2000) | First International Symposium on IGFs and Cancer, *; (2000) IGF-IR anti-apoptotic signalling and Jun kinases. [N/A], First International Symposium on IGFs and Cancer, Halle, Germany , 15-SEP-00 - 15-SEP-00. [Details] | |
| (1999) | Seventh Euroconference on Apoptosis, *; (1999) Regulation of anti-apoptotic signals from the IGF-IR. [N/A], Seventh Euroconference on Apoptosis, Israel , 01-SEP-99 - 01-SEP-99. [Details] | |
| (1999) | Biochemical Society Meeting, *; (1999) Survial Signal and the IGF-IR. [N/A], Biochemical Society Meeting, Cork , 08-SEP-99 - 08-SEP-99. [Details] | |
| (1999) | ADLAB 97, *; (1999) Developments in Molecular Methods for Cancer Treatment. [N/A], ADLAB 97, Dublin , 30-DEC-99 - 30-DEC-99. [Details] | |
| (1999) | Pfizer Central Research, *; (1999) Regulation of IGF-IR anti-apoptotic activity. [N/A], Pfizer Central Research, Connecticut, USA , 21-SEP-99 - 21-SEP-99. [Details] | |
| (1999) | IGF's BI-Annual International Conference, *; (1999) The IGF-IR is necessary for T lymphocyte survival. [N/A], IGF's BI-Annual International Conference, Brighton, UK , 01-OCT-99 - 01-OCT-99. [Details] | |
| (1998) | Signals for Cell Survival, *; (1998) *. [N/A], Signals for Cell Survival, Pharmacology Dept, UCD , 01-DEC-98 - 01-DEC-98. [Details] | |
| (1998) | Symposium: Mechanisms of innate and adaptive immuno-regulation, *; (1998) Suppression of apoptosis by IGF-I: a role in cell survival and transformation. [N/A], Symposium: Mechanisms of innate and adaptive immuno-regulation, St. Vincents ECR, Dublin , 15-MAY-98 - 15-MAY-98. [Details] | |
| (1998) | Symposium Apoptosis and Clinical Medicine, *; (1998) Role of IGF-IR-mediated suppression of apoptosis in tumours. [N/A], Symposium Apoptosis and Clinical Medicine, Lecce, Italy , 27-JUN-98 - 27-JUN-98. [Details] | |
| (1997) | European Workshop on Cell and Tissue Engineering, *; (1997) Role of the IGF-I Receptor C-Terminus in survival of tumor cells. [N/A], European Workshop on Cell and Tissue Engineering, Barcelona, Spain , 01-OCT-97 - 01-OCT-97. [Details] |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| Director of PhD Scholars Programme in Cancer Biology | 2008 / 2015 | ||
| Gordon Research Conference on Insulin-Like Growth Factors in Physiology and Disease | Conference Chair in 2011 | / | |
| Department of Biochemistry Graduate Studies Committee | 2005 / | ||
| UCC Science Faculty Standing Committee on Research and Postgraduate Studies | * | 2000 / 1899 | |
| SFI Frontiers in Engineering and Science Directorate | Advisory Committee Member | 2004 / 2007 | |
| Scientific Advisory Board Member for UK charity Breast Cancer Campaign | 2008 / | ||
| Irish Association for Cancer Research | Honorary Treasurer, Council Member, and organizer | 2002 / 2009 | |
| Irish Medicines Board advisory sub committees on biologicals and medical devices. | Member | / | |
| Health Research Board Cell and Molecular Medicine Panel | Member. Chair in 2006 | 2005 / 2009 | |
| NSF-funded South Texas Undergraduate Curriculum Consortium for Environmental and Biological Sciences Students | External advisor for | 2005 / | |
| UCC Science Faculty Research Committee, College of Medicine Research Committee | Member | 2000 / | |
| Management advisory committee UCC BioTransfer Unit | Member | / | |
| HRB, SFI, EI, EU FP4-6 programmes, Wellcome Trust, Charities | Panel Chair or reviewer | / | |
| Life Sciences panel Marie Curie International Training Networks | Vice chair | 2008 / | |
| SFI advisory committee for Cancer (2004) and the Cancer Centre Director Search Committee (2005) | SFI advisory committee | / | |
| Academic appointment panels UCC, NUI Maynooth, NUI Galway, TCD, and UL. | Chair or member | / | |
| Socrates International Student exchange coordinator for UCC Biochemistry Department | coordinato | 1999 / 2003 | |
| Biochemistry Department Disability Support Officer | Disability Support Officer | 1999 / 2003 | |
| PhD and MSc thesis examiner in Ireland, UK, and Australia | PhD and MSc thesis examiner | / | |
| Journal reviewer for JBC, EMBO, Cancer Res., Blood, J. Immunology, Oncogene, and others. | Journal reviewer | / | |
| Editorial Board Molecular Endocrinology | 2007 / |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| University College Cork | Professor of Cell Biology | 01-JAN-07 / 01-JAN-07 | |
| University College Cork | Head of Department of Biochemistry | 01-JAN-08 / 01-JAN-08 | |
| Apoptosis Technology Inc | Project Director & Research Scientist | 01-SEP-93 / 30-SEP-96 | |
| ImmunoGen, Inc | Group Leader and Research Scientist | 01-SEP-91 / 30-SEP-97 | |
| Wistar Institute, University of Pennsylvania | Research Fellow | 01-SEP-88 / 30-SEP-91 | |
| University of Wurzburg, Institute of Pathology, Germany | Post-Doctoral Fellow | 01-SEP-87 / 30-SEP-88 |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1983 | National University of Ireland Galway | BSc | Biochemistry | |
| 1987 | National University of Ireland Maynooth | PhD | Biology |
Languages
| Language | Reading | Writing | Speaking | |
|---|---|---|---|---|
| German | Basic | Basic | Basic |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Molecular Endocrinology | Editor | 01-JAN-08 - 01-JAN-12 |
Teaching Activities
Teaching Interests
Second Year Science Introductory Molecular Biology (ML2001)
Fourth Year Biochemistry Cell and Developmental Biology (BC4001)
PhD Scholars Programme in Cancer Biology
PhD Programme Molecular and Cell Biology
MSc. Biotechnology: Molecular Biology (BC6001)
MSc. Molecular and Cell Biology with Bioinnovation