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Research Profile

Thomas Cotter

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Biography

Prof. Cotter, graduated with a B.Sc. in Biochemistry from University College Cork before completing a Ph.D. at the University of Oxford where he was a Pirie-Reid Scholar. Following positions in the USA (Post-Doctoral & subsequently Fullbright visiting Professor) and Ireland, he has been Professor of Biochemistry at Cork since 1995. Prof. Cotter was the first recipient of the Gold Medal presented by The Irish Research Scientists Association in 1996. He was also awarded the Boyle Medal for his work in 1999, Royal Irish Academy Medal for Biochemistry in 2002 and was elected to membership of the Royal Irish Academy in 2005. His main research interests are in understanding cell death and survival mechanisms. Prof. Cotter is also co-founder of two start-up biotechnology companies. He has served on the Boards of Science Foundation Ireland, and The Health Research Board of Ireland.‍

Research Interests

The main research focus in the Cotter Laboratory is in understanding the role of cell signalling pathways, in particular those that are redox regulated and active, in tumour cell survival and in degenerative conditions of the retina.  The role of reactive oxygen species such as hydrogen peroxide has undergone a renaissance in the last decade with this molecule shown to be acting as both a driver of cell death (at high concentrations) but also more significantly as a specific activator of cell survival pathways at lower concentrations. 
In the case of several tumours both leukaemia and colon we see an increase in ROS production on oncogene activation.  From multiphoton microscopy this increase appears to be localised to the ER and is produced by activation of one member of the NADPH Oxidase (Nox) family of enzymes.  This in turn activates the Akt/PI3k pathway by the inhibition of one of several negatively regulating phosphatases.  The result is a stronger tumour cell survival signal which aids tumour development and hinder chemotherapeutic treatments.
In the retina our focus is also on the signalling role of ROS specifically how it contributes to post-mitotic cells cell survival either following short term stress or via growth factor signalling.  This is particularly important as we strive to understand what occurs at the biochemical level during degenerative retinal diseases.  We are also exploring new molecular therapies and the role played by cells such as glial cells which are not directly involved in the visual process itself, but which are none the less vital for the process.  


 
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Publications

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Edited Books

 YearPublication
(2003)Essays in Biochemistry Volume 39-43
Cotter, T.G (Ed.). (2003) Essays in Biochemistry Volume 39-43 Essays in Biochemistry Volume 39-43. [Details]
(1996)Apoptosis: A users Guide
Cotter, T.G, Martin, S (Ed.). (1996) Apoptosis: A users Guide Apoptosis: A users Guide. [Details]
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Peer Reviewed Journals

 YearPublication
(2013)'Less stress, more success? Oncological implications of surgery-induced oxidative stress'
O'Leary, DP,Wang, JH,Cotter, TG,Redmond, HP (2013) 'Less stress, more success? Oncological implications of surgery-induced oxidative stress'. Gut, 62 :461-470 [DOI] [Details]
(2013)'Oncogene driven Redox signalling in tumour cells'
Cotter, TG,Stanicka, J,Landry, W (2013) 'Oncogene driven Redox signalling in tumour cells'. International Journal of Molecular Medicine, 32 :35-35 [Details]
(2013)'Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox'
Landry, WD,Woolley, JF,Cotter, TG (2013) 'Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox'. Leukemia Research, 37 :183-189 [DOI] [Details]
(2013)'Redox Regulation of Protein Kinases'
Corcoran A, Cotter TG (2013) 'Redox Regulation of Protein Kinases'. The FEBS journal, [DOI] [Details]
(2013)'Detection of DNA fragmentation in retinal apoptosis by TUNEL'
Doonan F, Cotter TG (2013) 'Detection of DNA fragmentation in retinal apoptosis by TUNEL'. Methods in molecular biology (Clifton, N.J.), 935 :207-213 [DOI] [Details]
(2013)'Less stress, more success? Oncological implications of surgery-induced oxidative stress'
O'Leary DP, Wang JH, Cotter TG, Redmond HP (2013) 'Less stress, more success? Oncological implications of surgery-induced oxidative stress'. Gut, 62 (3):461-470 [DOI] [Details]
(2013)'Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox'
Landry WD, Woolley JF, Cotter TG (2013) 'Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox'. Leukemia Research, 37 (2):183-189 [DOI] [Details]
(2013)'FLT3-driven redox-modulation of Ezrin regulates leukaemic cell migration'
Corcoran, A,Cotter, TG (2013) 'FLT3-driven redox-modulation of Ezrin regulates leukaemic cell migration'. Free Radical Research, 47 :20-34 [DOI] [Details]
(2013)'Redox-Regulated Growth Factor Survival Signaling'
Woolley JF, Corcoran A, Groeger G, Landry WD, Cotter TG (2013) 'Redox-Regulated Growth Factor Survival Signaling'. Antioxidants & Redox Signaling, [DOI] [Details]
(2012)'Reactive oxygen species regulate prosurvival ERK1/2 signaling and bFGF expression in gliosis within the retina'
Groeger G, Doonan F, Cotter TG, Donovan M (2012) 'Reactive oxygen species regulate prosurvival ERK1/2 signaling and bFGF expression in gliosis within the retina'. Molecular Vision, 53 (10):6645-6654 [DOI] [Details]
(2012)'Reactive Oxygen Species Regulate Prosurvival ERK1/2 Signaling and bFGF Expression in Gliosis within the Retina'
Groeger, G,Doonan, F,Cotter, TG,Donovan, M (2012) 'Reactive Oxygen Species Regulate Prosurvival ERK1/2 Signaling and bFGF Expression in Gliosis within the Retina'. Investigative Ophthalmology & Visual Science, 53 :6645-6654 [DOI] [Details]
(2012)'H2O2 Production Downstream of FLT3 Is Mediated by p22phox in the Endoplasmic Reticulum and Is Required for STAT5 Signalling'
Woolley, JF,Naughton, R,Stanicka, J,Gough, DR,Bhatt, L,Dickinson, BC,Chang, CJ,Cotter, TG (2012) 'H2O2 Production Downstream of FLT3 Is Mediated by p22phox in the Endoplasmic Reticulum and Is Required for STAT5 Signalling'. Plos One, 7 [DOI] [Details]
(2012)'Norgestrel may be a potential therapy for retinal degenerations'
Doonan F, Cotter TG (2012) 'Norgestrel may be a potential therapy for retinal degenerations'. Expert Opinion On Investigational Drugs, 21 (5):579-581 [DOI] [Details]
(2012)'H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling'
Woolley JF, Naughton R, Stanicka J, Gough DR, Bhatt L, Dickinson BC, Chang CJ, Cotter TG (2012) 'H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling'. Plos One, 7 (7) [DOI] [Details]
(2012)'TLR-4 signalling accelerates colon cancer cell adhesion via NF-κB mediated transcriptional up-regulation of Nox-1'
O'Leary DP, Bhatt L, Woolley JF, Gough DR, Wang JH, Cotter TG, Redmond HP (2012) 'TLR-4 signalling accelerates colon cancer cell adhesion via NF-κB mediated transcriptional up-regulation of Nox-1'. Plos One, 7 (10) [DOI] [Details]
(2012)'DUOX enzyme activity promotes AKT signalling in prostate cancer cells'
Pettigrew CA, Clerkin JS, Cotter TG (2012) 'DUOX enzyme activity promotes AKT signalling in prostate cancer cells'. Cancer Research, 32 (12):5175-5181 [Details]
(2012)'Preventing retinal apoptosis--is there a common therapeutic theme?'
Doonan F, Groeger G, Cotter TG (2012) 'Preventing retinal apoptosis--is there a common therapeutic theme?'. Experimental Cell Research, 318 (11):1278-1284 [DOI] [Details]
(2011)'Differential roles of ERK1/2 and JNK in retinal development and degeneration'
Donovan, M,Doonan, F,Cotter, TG; (2011) 'Differential roles of ERK1/2 and JNK in retinal development and degeneration'. Journal of Neurochemistry, 116 :33-42 [DOI] [Details]
(2011)'bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells'
Farrell SM, Groeger G, Bhatt L, Finnegan S, O'Brien CJ, Cotter TG; (2011) 'bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells'. The European Journal of Neuroscience, 33 (4):632-641 [DOI] [Details]
(2011)'Hydrogen peroxide: a Jekyll and Hyde signalling molecule'
Gough DR, Cotter TG (2011) 'Hydrogen peroxide: a Jekyll and Hyde signalling molecule'. Cell Death & Disease, 2 [DOI] [Details]
(2011)'Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein'
Alvira D, Naughton R, Bhatt L, Tedesco S, Landry WD, Cotter TG (2011) 'Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein'. Biological chemistry, 286 (37):32313-32323 [DOI] [Details]
(2011)'Enhancing survival of photoreceptor cells in vivo using the synthetic progestin Norgestrel'
Doonan F, O'Driscoll C, Kenna P, Cotter TG (2011) 'Enhancing survival of photoreceptor cells in vivo using the synthetic progestin Norgestrel'. Journal of Neurochemistry, 118 (5):915-927 [DOI] [Details]
(2011)'Age-dependent rat retinal ganglion cell susceptibility to apoptotic stimuli: implications for glaucoma'
Guerin MB, Donovan M, McKernan DP, O'Brien CJ, Cotter TG (2011) 'Age-dependent rat retinal ganglion cell susceptibility to apoptotic stimuli: implications for glaucoma'. Clinical & experimental ophthalmology, 39 (3):243-251 [DOI] [Details]
(2011)'A novel free radical scavenger rescues retinal cells in vivo'
O'Driscoll C, Doonan F, Sanvicens N, Messeguer A, Cotter TG (2011) 'A novel free radical scavenger rescues retinal cells in vivo'. Eye, 93 (1):65-74 [DOI] [Details]
(2010)'Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system'
Bhatt, L; Groeger, G; McDermott, K; Cotter, TG; (2010) 'Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system'. Molecular Vision, 16 :283-293 [Details]
(2010)'Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system'
Bhatt, L; Groeger, G; McDermott, K; Cotter TG; (2010) 'Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system'. Molecular Vision, 23 (16):283-293 [Details]
(2010)'Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system'
Bhatt, L,Groeger, G,McDermott, K,Cotter, TG; (2010) 'Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system'. Molecular Vision, 16 :283-293 [Details]
(2010)'Surgical Injury enhances the expression of genes that mediate breast cancer metastasis to the lung'
Al Sahaf O, Wang JH, Browne TJ, Cotter TG, Redmond HP; (2010) 'Surgical Injury enhances the expression of genes that mediate breast cancer metastasis to the lung'. Annals of surgery, 252 (6):1037-1043 [Details]
(2010)'Surgical Injury Enhances the Expression of Genes That Mediate Breast Cancer Metastasis to the Lung'
Al-Sahaf, O,Wang, JH,Browne, TJ,Cotter, TG,Redmond, HP; (2010) 'Surgical Injury Enhances the Expression of Genes That Mediate Breast Cancer Metastasis to the Lung'. Annals of Surgery, 252 :1037-1043 [DOI] [Details]
(2010)'Surgical injury enhances the expression of genes that mediate breast cancer metastasis to the lung'
Al-Sahaf O, Wang JH, Browne TJ, Cotter TG, Redmond HP; (2010) 'Surgical injury enhances the expression of genes that mediate breast cancer metastasis to the lung'. Annals of Surgery, 252 (6):1037-1043 [DOI] [Details]
(2010)'A stress survival response in retinal cells mediated through inhibition of the serine/threonine phosphatase PP2A'
Finnegan S, Mackey AM, Cotter TG; (2010) 'A stress survival response in retinal cells mediated through inhibition of the serine/threonine phosphatase PP2A'. The European Journal of Neuroscience, 32 (3):322-334 [DOI] [Details]
(2009)'Stress-Induced Activation of Nox Contributes to Cell Survival Signalling Via Production of Hydrogen Peroxide'
Groeger, G, Mackey, AM, Pettigrew, CA, Bhatt, L, Cotter, TG; (2009) 'Stress-Induced Activation of Nox Contributes to Cell Survival Signalling Via Production of Hydrogen Peroxide'. Journal of Neurochemistry, 109 (5):1544-1554 [DOI] [Details]
(2009)'Histone Deacetylase Activity In Conjunction With E2f-1 and P53 Regulates Apaf-1 Expression In 661w Cells and The Retina'
Wallace, DM, Cotter, TG; (2009) 'Histone Deacetylase Activity In Conjunction With E2f-1 and P53 Regulates Apaf-1 Expression In 661w Cells and The Retina'. Journal of Neuroscience Research, 87 (4):887-905 [DOI] [Details]
(2009)'Stress-induced activation of Nox contributes to cell survival signalling via production of hydrogen peroxide'
Groeger, G,Mackey, AM,Pettigrew, CA,Bhatt, L,Cotter, TG; (2009) 'Stress-induced activation of Nox contributes to cell survival signalling via production of hydrogen peroxide'. Journal of Neurochemistry, 109 :1544-1554 [DOI] [Details]
(2009)'Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway'
Naughton, R,Quiney, C,Turner, SD,Cotter, TG; (2009) 'Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway'. Official Journal of The Leukemia Society of America, 23 :1432-1440 [DOI] [Details]
(2009)'Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification'
Smith, MJ,Culhane, AC,Donovan, M,Coffey, JC,Barry, BD,Kelly, MA,Higgins, DG,Wang, JH,Kirwan, WO,Cotter, TG,Redmond, HP; (2009) 'Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification'. British Journal of Cancer, 100 :1452-1464 [DOI] [Details]
(2009)'Histone Deacetylase Activity in Conjunction With E2F-1 and p53 Regulates Apaf-1 Expression in 661W Cells and the Retina'
Wallace, DM,Cotter, TG; (2009) 'Histone Deacetylase Activity in Conjunction With E2F-1 and p53 Regulates Apaf-1 Expression in 661W Cells and the Retina'. The Journal of Neuroscience, 87 :887-905 [DOI] [Details]
(2009)'Apoptosis and cancer: the genesis of a research field'
Cotter TG; (2009) 'Apoptosis and cancer: the genesis of a research field'. Nature Reviews. Cancer, 9 (7):501-507 [DOI] [Details]
(2009)'Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway'
Naughton R, Quiney C, Turner SD, Cotter TG; (2009) 'Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway'. Official Journal of The Leukemia Society of America, 23 (8):1432-1440 [DOI] [Details]
(2009)'Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification'
Smith MJ, Culhane AC, Donovan M, Coffey JC, Barry BD, Kelly MA, Higgins DG, Wang JH, Kirwan WO, Cotter TG, Redmond HP; (2009) 'Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification'. British Journal of Cancer, 100 (9):1452-1464 [DOI] [Details]
(2009)'Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2'
Doonan F, Wallace DM, O'Driscoll C, Cotter TG; (2009) 'Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2'. Journal of Neurochemistry, 109 (2):631-643 [DOI] [Details]
(2009)'Hydrogen peroxide as a cell survival signaling molecule'
Groeger G, Quiney C, Cotter TG; (2009) 'Hydrogen peroxide as a cell survival signaling molecule'. Antioxidants & Redox Signaling, [DOI] [Details]
(2009)'IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death'
Arroba AI, Wallace D, Mackey A, de la Rosa EJ, Cotter TG; (2009) 'IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death'. The European Journal of Neuroscience, 30 (6):975-986 [DOI] [Details]
(2009)'Igf-I Maintains Calpastatin Expression and Attenuates Apoptosis In Several Models of Photoreceptor Cell Death'
Arroba, AI, Wallace, D, Mackey, A, de la Rosa, EJ, Cotter, TG; (2009) 'Igf-I Maintains Calpastatin Expression and Attenuates Apoptosis In Several Models of Photoreceptor Cell Death'. The European Journal of Neuroscience, 30 (6):975-986 [DOI] [Details]
(2009)'Rosiglitazone Acts As A Neuroprotectant In Retinal Cells Via Up-Regulation of Sestrin-1 and Sod-2'
Doonan, F, Wallace, DM, O'Driscoll, C, Cotter, TG; (2009) 'Rosiglitazone Acts As A Neuroprotectant In Retinal Cells Via Up-Regulation of Sestrin-1 and Sod-2'. Journal of Neurochemistry, 109 (2):631-643 [DOI] [Details]
(2009)'Analysis of Differential Gene Expression In Colorectal Cancer and Stroma Using Fluorescence-Activated Cell Sorting Purification'
Smith, MJ, Culhane, AC, Donovan, M, Coffey, JC, Barry, BD, Kelly, MA, Higgins, DG, Wang, JH, Kirwan, WO, Cotter, TG, Redmond, HP; (2009) 'Analysis of Differential Gene Expression In Colorectal Cancer and Stroma Using Fluorescence-Activated Cell Sorting Purification'. British Journal of Cancer, 100 (9):1452-1464 [DOI] [Details]
(2009)'Bcr-Abl-Mediated Redox Regulation of The Pi3k/Akt Pathway'
Naughton, R, Quiney, C, Turner, SD, Cotter, TG; (2009) 'Bcr-Abl-Mediated Redox Regulation of The Pi3k/Akt Pathway'. Official Journal of The Leukemia Society of America, 23 (8):1432-1440 [DOI] [Details]
(2009)'Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina'
Wallace DM, Cotter TG; (2009) 'Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina'. Journal of Neuroscience Research, 87 (4):887-905 [DOI] [Details]
(2009)'Deregulation of cell death (apoptosis): implications for tumor development'
Pettigrew CA, Cotter TG; (2009) 'Deregulation of cell death (apoptosis): implications for tumor development'. Discovery Medicine, 8 (41):61-63 [Details]
(2008)'A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell'
O'Connor, JC,Wallace, DM,O'Brien, CJ,Cotter, TG; (2008) 'A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell'. Investigative Ophthalmology & Visual Science, 49 :4237-4244 [DOI] [Details]
(2008)'Cell Death In Brain Development and Degeneration: Control of Caspase Expression May Be Key!'
Madden, SD, Cotter, TG; (2008) 'Cell Death In Brain Development and Degeneration: Control of Caspase Expression May Be Key!'. Molecular Neurobiology, 37 (1):1-6 [DOI] [Details]
(2008)'A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell'
O'Connor JC, Wallace DM, O'Brien CJ, Cotter TG; (2008) 'A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell'. Investigative Ophthalmology & Visual Science, 49 (10):4237-4244 [DOI] [Details]
(2008)'Redox survival signalling in retina-derived 661W cells'
Mackey AM, Sanvicens N, Groeger G, Doonan F, Wallace D, Cotter TG; (2008) 'Redox survival signalling in retina-derived 661W cells'. Cell Death and Differentiation, 15 (8):1291-1303 [DOI] [Details]
(2008)'Basic Fibroblast Growth Factor-Induced Protection From Light Damage In The Mouse Retina In Vivo'
O'Driscoll, C, O'Connor, J, O'Brien, CJ, Cotter, TG; (2008) 'Basic Fibroblast Growth Factor-Induced Protection From Light Damage In The Mouse Retina In Vivo'. Journal of Neurochemistry, 105 (2):524-536 [DOI] [Details]
(2008)'Mechanisms Driving Local Breast Cancer Recurrence In A Model of Breast-Conserving Surgery'
Smith, MJ, Culhane, AC, Killeen, S, Kelly, MA, Wang, JH, Cotter, TG, Redmond, HP; (2008) 'Mechanisms Driving Local Breast Cancer Recurrence In A Model of Breast-Conserving Surgery'. Annals of Surgical Oncology, 15 (10):2954-2964 [DOI] [Details]
(2008)'Mechanisms of ROS modulated cell survival during carcinogenesis'
Clerkin JS, Naughton R, Quiney C, Cotter TG; (2008) 'Mechanisms of ROS modulated cell survival during carcinogenesis'. Cancer Letters, 266 (1):30-36 [DOI] [Details]
(2008)'Redox survival signalling in retina-derived 661W cells'
Mackey, AM,Sanvicens, N,Groeger, G,Doonan, F,Wallace, D,Cotter, TG; (2008) 'Redox survival signalling in retina-derived 661W cells'. Cell, 15 :1291-1303 [DOI] [Details]
(2008)'Morphological Assessment of Apoptosis'
Doonan, F, Cotter, TG; (2008) 'Morphological Assessment of Apoptosis'. Methods, 44 (3):200-204 [DOI] [Details]
(2007)'bFGF promotes photoreceptor cell survival in vitro by PKA-mediated inactivation of glycogen synthase kinase 3 beta and CREB-dependent Bcl-2 up-regulation'
O'Driscoll, C,Wallace, D,Cotter, TG; (2007) 'bFGF promotes photoreceptor cell survival in vitro by PKA-mediated inactivation of glycogen synthase kinase 3 beta and CREB-dependent Bcl-2 up-regulation'. Journal of Neurochemistry, 103 :860-870 [DOI] [Details]
(2007)'Bim expression indicates the pathway to retinal cell death in development and degeneration'
Doonan F, Donovan M, Gomez-Vicente V, Bouillet P, Cotter TG; (2007) 'Bim expression indicates the pathway to retinal cell death in development and degeneration'. The Journal of Neuroscience, 27 (40):10887-10894 [DOI] [Details]
(2007)'A key role for calpains in retinal ganglion cell death'
McKernan DP, Guerin MB, O'Brien CJ, Cotter TG; (2007) 'A key role for calpains in retinal ganglion cell death'. Investigative Ophthalmology & Visual Science, 48 (12):5420-5430 [DOI] [Details]
(2007)'Key apoptosis regulating proteins are down-regulated during postnatal tissue development'
Madden SD, Donovan M, Cotter TG; (2007) 'Key apoptosis regulating proteins are down-regulated during postnatal tissue development'. The International Journal of Developmental Biology, 51 (5):415-423 [DOI] [Details]
(2007)'A Critical role for Bim in retinal ganglion cell death'
McKernan DP, Cotter TG; (2007) 'A Critical role for Bim in retinal ganglion cell death'. Journal of Neurochemistry, 102 (3):922-930 [DOI] [Details]
(2007)'Bfgf Promotes Photoreceptor Cell Survival In Vitro By Pka-Mediated Inactivation of Glycogen Synthase Kinase 3 Beta and Creb-Dependent Bcl-2 Up-Regulation'
O'Driscoll, C, Wallace, D, Cotter, TG; (2007) 'Bfgf Promotes Photoreceptor Cell Survival In Vitro By Pka-Mediated Inactivation of Glycogen Synthase Kinase 3 Beta and Creb-Dependent Bcl-2 Up-Regulation'. Journal of Neurochemistry, 103 (3):860-870 [DOI] [Details]
(2007)'Key apoptosis regulating proteins are down-regulated during postnatal tissue development'
Madden, SD,Donovan, M,Cotter, TG (2007) 'Key apoptosis regulating proteins are down-regulated during postnatal tissue development'. The International Journal of Developmental Biology, 51 :415-423 [DOI] [Details]
(2007)'A key role for calpains in retinal ganglion cell death'
McKernan, DP,Guerin, MB,O'Brien, CJ,Cotter, TG (2007) 'A key role for calpains in retinal ganglion cell death'. Investigative Ophthalmology & Visual Science, 48 :5420-5430 [DOI] [Details]
(2007)'A Critical role for Bim in retinal ganglion cell death'
McKernan, DP,Cotter, TG; (2007) 'A Critical role for Bim in retinal ganglion cell death'. Journal of Neurochemistry, 102 :922-930 [DOI] [Details]
(2007)'Bim expression indicates the pathway to retinal cell death in development and degeneration'
Doonan, F,Donovan, M,Gomez-Vicente, V,Bouillet, P,Cotter, TG; (2007) 'Bim expression indicates the pathway to retinal cell death in development and degeneration'. The Journal of Neuroscience, 27 :10887-10894 [DOI] [Details]
(2006)'Induction of BIMEL following growth factor withdrawal is a key event in caspase-dependent apoptosis of 661W photoreceptor cells'
Gomez-Vicente, V,Doonan, F,Donovan, M,Cotter, TG; (2006) 'Induction of BIMEL following growth factor withdrawal is a key event in caspase-dependent apoptosis of 661W photoreceptor cells'. The European Journal of Neuroscience, 24 :981-990 [DOI] [Details]
(2006)'Analysis of apoptotic and survival mediators in the early post-natal and mature retina'
O'Driscoll, C,Donovan, M,Cotter, TG; (2006) 'Analysis of apoptotic and survival mediators in the early post-natal and mature retina'. Experimental Eye Research, 83 :1482-1492 [DOI] [Details]
(2006)'Analysis of Apoptotic and Survival Mediators In The Early Post-Natal and Mature Retina'
O'Driscoll, C, Donovan, M, Cotter, TG; (2006) 'Analysis of Apoptotic and Survival Mediators In The Early Post-Natal and Mature Retina'. Experimental Eye Research, 83 (6):1482-1492 [DOI] [Details]
(2006)'Decreased expression of pro-apoptotic Bcl-2 family members during retinal development and differential sensitivity to cell death'
Donovan M, Doonan F, Cotter TG; (2006) 'Decreased expression of pro-apoptotic Bcl-2 family members during retinal development and differential sensitivity to cell death'. Developmental Biology, 291 (1):154-169 [DOI] [Details]
(2006)'The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy'
Coffey JC, Wang JH, Bouchier-Hayes D, Cotter TG, Redmond HP; (2006) 'The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy'. Annals of Surgery, 243 (2):250-256 [DOI] [Details]
(2006)'Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling'
Piwocka K, Vejda S, Cotter TG, O'Sullivan GC, McKenna SL; (2006) 'Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling'. Blood, 107 (10):4003-4010 [DOI] [Details]
(2006)'Identification of transcriptional targets associated with the expression of p210 Bcr-Abl'
Hickey FB, Cotter TG; (2006) 'Identification of transcriptional targets associated with the expression of p210 Bcr-Abl'. European Journal of Haematology, 76 (5):369-383 [DOI] [Details]
(2006)'Age-dependent susceptibility of the retinal ganglion cell layer to cell death'
McKernan DP, Caplis C, Donovan M, O'brien CJ, Cotter TG; (2006) 'Age-dependent susceptibility of the retinal ganglion cell layer to cell death'. Investigative Ophthalmology & Visual Science, 47 (3):807-814 [DOI] [Details]
(2006)'Cancer surgery: risks and opportunities'
Coffey JC, Smith MJ, Wang JH, Bouchier-Hayes D, Cotter TG, Redmond HP; (2006) 'Cancer surgery: risks and opportunities'. News and Reviews In Molecular, Cellular and Developmental Biology, 28 (4):433-437 [DOI] [Details]
(2006)'The radical scavenger CR-6 protects SH-SY5Y neuroblastoma cells from oxidative stress-induced apoptosis: effect on survival pathways'
Sanvicens N, Gómez-Vicente V, Messeguer A, Cotter TG; (2006) 'The radical scavenger CR-6 protects SH-SY5Y neuroblastoma cells from oxidative stress-induced apoptosis: effect on survival pathways'. Journal of neurochemistry, 98 (3):735-747 [DOI] [Details]
(2006)'Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina'
Wallace DM, Donovan M, Cotter TG; (2006) 'Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina'. Investigative Ophthalmology & Visual Science, 47 (7):2765-2772 [DOI] [Details]
(2006)'Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells'
Sanvicens N, Cotter TG; (2006) 'Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells'. Journal of Neurochemistry, 98 (5):1432-1444 [DOI] [Details]
(2006)'Induction of BIM(EL) following growth factor withdrawal is a key event in caspase-dependent apoptosis of 661W photoreceptor cells'
Gómez-Vicente V, Doonan F, Donovan M, Cotter TG; (2006) 'Induction of BIM(EL) following growth factor withdrawal is a key event in caspase-dependent apoptosis of 661W photoreceptor cells'. The European journal of neuroscience, 24 (4):981-990 [DOI] [Details]
(2006)'ROS and protein oxidation in early stages of cytotoxic drug induced apoptosis'
England K, Driscoll CO, Cotter TG; (2006) 'ROS and protein oxidation in early stages of cytotoxic drug induced apoptosis'. Free Radical Research, 40 (11):1124-1137 [DOI] [Details]
(2006)'BCR-ABL regulates phosphatidylinositol 3-kinase-p110 gamma transcription and activation and is required for proliferation and drug resistance'
Hickey, FB,Cotter, TG; (2006) 'BCR-ABL regulates phosphatidylinositol 3-kinase-p110 gamma transcription and activation and is required for proliferation and drug resistance'. The Journal of Biological Chemistry, 281 :2441-2450 [DOI] [Details]
(2006)'Identification of transcriptional targets associated with the expression of p210 Bcr-Abl'
Hickey, FB,Cotter, TG; (2006) 'Identification of transcriptional targets associated with the expression of p210 Bcr-Abl'. European Journal of Haematology, 76 :369-383 [DOI] [Details]
(2006)'Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling'
Piwocka, K,Vejda, S,Cotter, TG,O'Sullivan, GC,McKenna, SL; (2006) 'Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling'. Blood, 107 :4003-4010 [Details]
(2006)'ROS and protein oxidation in early stages of cytotoxic drug induced apoptosis'
England, K,Driscoll, CO,Cotter, TG; (2006) 'ROS and protein oxidation in early stages of cytotoxic drug induced apoptosis'. Free Radical Research, 40 :1124-1137 [DOI] [Details]
(2006)'Histone deacetylase activity regulates Apaf-1 and caspase 3 expression in the developing mouse retina'
Wallace, DM,Donovan, M,Cotter, TG; (2006) 'Histone deacetylase activity regulates Apaf-1 and caspase 3 expression in the developing mouse retina'. Investigative Ophthalmology & Visual Science, 47 :2765-2772 [DOI] [Details]
(2006)'Age-dependent susceptibility of the retinal ganglion cell layer to cell death'
McKernan, DP,Caplis, C,Donovan, M,O'Brien, CJ,Cotter, TG; (2006) 'Age-dependent susceptibility of the retinal ganglion cell layer to cell death'. Investigative Ophthalmology & Visual Science, 47 :807-814 [DOI] [Details]
(2006)'The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy'
Coffey, JC,Wang, JH,Bouchier-Hayes, D,Cotter, TG,Redmond, HP; (2006) 'The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy'. Annals of Surgery, 243 :250-256 [DOI] [Details]
(2006)'Multiplex analysis with peptide-encoded beads'
Sanvicens, N,Galvin, P,Cotter, TG; (2006) 'Multiplex analysis with peptide-encoded beads'. Bioconjugate Chemistry, 17 :1607-1611 [DOI] [Details]
(2006)'Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells'
Sanvicens, N,Cotter, TG; (2006) 'Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells'. Journal of Neurochemistry, 98 :1432-1444 [DOI] [Details]
(2006)'Cancer surgery: risks and opportunities'
Coffey, JC,Smith, MJF,Wang, JH,Bouchier-Hayes, D,Cotter, TG,Redmond, HP (2006) 'Cancer surgery: risks and opportunities'. Bioessays, 28 :433-437 [DOI] [Details]
(2006)'BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance'
Hickey FB, Cotter TG; (2006) 'BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance'. The Journal of Biological Chemistry, 281 (5):2441-2450 [DOI] [Details]
(2006)'Multiplex analysis with peptide-encoded beads'
Sanvicens N, Galvin P, Cotter TG; (2006) 'Multiplex analysis with peptide-encoded beads'. Bioconjugate Chemistry, 17 (6):1607-1611 [DOI] [Details]
(2006)'Retinal ganglion cells: dying to survive'
Guerin MB, McKernan DP, O'Brien CJ, Cotter TG; (2006) 'Retinal ganglion cells: dying to survive'. The International Journal of Developmental Biology, 50 (8):665-674 [DOI] [Details]
(2005)'Autocrine secretion of osteopontin results in degradation of I kappa B in Bcr-Abl-expressing cells'
Vejda S, Piwocka K, McKenna SL, Cotter TG; (2005) 'Autocrine secretion of osteopontin results in degradation of I kappa B in Bcr-Abl-expressing cells'. British Journal of Haematology, 128 (5):711-721 [DOI] [Details]
(2005)'Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis'
England K, Cotter TG; (2005) 'Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis'. Redox Report : Communications In Free Radical Research, 10 (5):237-245 [DOI] [Details]
(2005)'Fluorescence based oxygen uptake analysis in the study of metabolic responses to apoptosis induction'
Hynes J, O'Riordan TC, Curtin J, Cotter TG, Papkovsky DB; (2005) 'Fluorescence based oxygen uptake analysis in the study of metabolic responses to apoptosis induction'. Methods, 306 (1-2):193-201 [DOI] [Details]
(2005)'Activation of multiple pathways during photoreceptor apoptosis in the rd mouse'
Doonan F, Donovan M, Cotter TG; (2005) 'Activation of multiple pathways during photoreceptor apoptosis in the rd mouse'. Investigative Ophthalmology & Visual Science, 46 (10):3530-3538 [DOI] [Details]
(2005)'Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1, and MEK'
Hickey FB, England K, Cotter TG; (2005) 'Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1, and MEK'. Journal of Leukocyte Biology, 78 (1):289-300 [DOI] [Details]
(2005)'Multiple death pathways in retina-derived 661W cells following growth factor deprivation: crosstalk between caspases and calpains'
Gómez-Vicente V, Donovan M, Cotter TG; (2005) 'Multiple death pathways in retina-derived 661W cells following growth factor deprivation: crosstalk between caspases and calpains'. Cell death and differentiation, 12 (7):796-804 [DOI] [Details]
(2005)'Phosphoinositide 3-kinase accelerates postoperaive tumor growth by inhibiting apoptosis and enchancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy'
Coffey JC, Wang JH, Smith MJ, Laing A, Bouchier-Hayes D, Cotter TG, Redmond HP; (2005) 'Phosphoinositide 3-kinase accelerates postoperaive tumor growth by inhibiting apoptosis and enchancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy'. Journal of Biological Chemistry, 280 (22):20968-20977 [Details]
(2005)'Fluorescence based oxygen uptake analysis in the study of metabolic responses to apoptosis induction'
Hynes, J,O'Riordan, TC,Curtin, J,Cotter, TG,Papkovsky, DB; (2005) 'Fluorescence based oxygen uptake analysis in the study of metabolic responses to apoptosis induction'. Journal of Immunology, 306 :193-201 [DOI] [Details]
(2005)'Bcr-abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1, and MEK'
Hickey, FB,England, K,Cotter, TG; (2005) 'Bcr-abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1, and MEK'. Journal of Leukocyte Biology, 78 :289-300 [DOI] [Details]
(2005)'Activation of multiple pathways during photoreceptor apoptosis in the rd mouse'
Doonan, F,Donovan, M,Cotter, TG; (2005) 'Activation of multiple pathways during photoreceptor apoptosis in the rd mouse'. Investigative Ophthalmology & Visual Science, 46 :3530-3538 [DOI] [Details]
(2005)'Multiple death pathways in retina-derived 661W cells following growth factor deprivation: crosstalk between caspases and calpains'
Gomez-Vicente, V,Donovan, M,Cotter, TG; (2005) 'Multiple death pathways in retina-derived 661W cells following growth factor deprivation: crosstalk between caspases and calpains'. Cell, 12 :796-804 [DOI] [Details]
(2005)'Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis'
Coffey, JC,Wang, JH,Smith, MJF,Laing, A,Bouchier-Hayes, D,Cotter, TG,Redmond, HP (2005) 'Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis'. The Journal of Biological Chemistry, 280 :20968-20977 [Details]
(2004)'The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF)'
Duverger V, Murphy AM, Sheehan D, England K, Cotter TG, Hayes I, Murphy FJ; (2004) 'The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF)'. British Journal of Cancer, 90 (10):2025-2031 [DOI] [Details]
(2004)'Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death'
Donovan M, Cotter TG; (2004) 'Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death'. Biochimica Et Biophysica Acta, 1644 (2-3):133-147 [DOI] [Details]
(2004)'JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells'
Curtin JF, Cotter TG; (2004) 'JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells'. The Journal of Biological Chemistry, 279 (17):17090-17100 [DOI] [Details]
(2004)'EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion'
Smith LM, Walsh PT, Rüdiger T, Cotter TG, Mc Carthy TV, Marx A, O'Connor R; (2004) 'EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion'. Experimental cell research, 292 (2):295-303   [Details]
(2004)'Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6'
Sanvicens N, Gómez-Vicente V, Masip I, Messeguer A, Cotter TG; (2004) 'Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6'. The Journal of biological chemistry, 279 (38):39268-39278 [DOI] [Details]
(2004)'Apoptosis: a potential therapeutic target for retinal degenerations'
Doonan F, Cotter TG; (2004) 'Apoptosis: a potential therapeutic target for retinal degenerations'. Current Neurovascular Research, 1 (1):41-53 [Details]
(2004)'Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor'
Stitt AW, Hughes SJ, Canning P, Lynch O, Cox O, Frizzell N, Thorpe SR, Cotter TG, Curtis TM, Gardiner TA; (2004) 'Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor'. Diabetologia, 47 (10):1735-1746 [DOI] [Details]
(2004)'Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis'
England K, O'Driscoll C, Cotter TG; (2004) 'Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis'. Cell Death and Differentiation, 11 (3):252-260 [DOI] [Details]
(2004)'Expression of the Eph A3 receptor tyrosine kinases is enhanced by CD28 and IGF-1 stimulation in neoplastic T cells Exp'
Smith, LM; Walsh, PT, Rudiger, T; Cotter, TG, McCarthy, TV; Marx, A; (2004) 'Expression of the Eph A3 receptor tyrosine kinases is enhanced by CD28 and IGF-1 stimulation in neoplastic T cells Exp'. 292 (*):295-303 [Details]
(2004)'Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis'
England, K,O'Driscoll, C,Cotter, TG; (2004) 'Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis'. Cell, 11 :252-260 [DOI] [Details]
(2004)'The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF)'
Duverger, V,Murphy, AM,Sheehan, D,England, K,Cotter, TG,Hayes, I,Murphy, FJ; (2004) 'The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF)'. British Journal of Cancer, 90 :2025-2031 [DOI] [Details]
(2004)'JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells'
Curtin, JF,Cotter, TG (2004) 'JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells'. The Journal of Biological Chemistry, 279 :17090-17100 [DOI] [Details]
(2003)'Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration'
Doonan, F,Donovan, M,Cotter, TG; (2003) 'Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration'. The Journal of Neuroscience, 23 :5723-5731 [Details]
(2003)'Apoptosis: Historical perspectives'
Curtin JF, Cotter TG; (2003) 'Apoptosis: Historical perspectives'. Essays In Biochemistry, 39 :1-10 [Details]
(2003)'Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1 by a phosphoinositide-3-kinase (PI3K)-independent pathway'
Keeshan K, Cotter TG, McKenna SL; (2003) 'Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1 by a phosphoinositide-3-kinase (PI3K)-independent pathway'. British Journal of Haematology, 123 (1):34-44 [Details]
(2003)'Live and let die: regulatory mechanisms in Fas-mediated apoptosis'
Curtin JF, Cotter TG; (2003) 'Live and let die: regulatory mechanisms in Fas-mediated apoptosis'. Cellular Signalling, 15 (11):983-992 [Details]
(2003)'Targeting inflammatory diseases via apoptotic mechanisms'
Murphy FJ, Hayes I, Cotter TG; (2003) 'Targeting inflammatory diseases via apoptotic mechanisms'. Current Opinion In Pharmacology, 3 (4):412-419 [Details]
(2003)'Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells'
Curtin, JF; Cotter, TG; (2003) 'Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells'. 17 (89 (10)):1950-1957 [Details]
(2003)'Caspase-indepentent photoreceptor apoptosis in mouse models of retinal degeneration'
Doonan, F; Donovan, M; Cotter, TG; (2003) 'Caspase-indepentent photoreceptor apoptosis in mouse models of retinal degeneration'. 2 (23 (13)):5723-5731 [Details]
(2003)'Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1 by a phosphoinositide-3-kinase (PI3K)-independent pathway'
Keeshan, K; Cotter, TG; McKenna, SL; (2003) 'Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1 by a phosphoinositide-3-kinase (PI3K)-independent pathway'. British Journal of Haematology, 123 (1):983-992 [Details]
(2003)'Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration'
Doonan F, Donovan M, Cotter TG; (2003) 'Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration'. The Journal of Neuroscience, 23 (13):5723-5731 [Details]
(2003)'Excisional surgery for cancer cure: therapy at a cost'
Coffey JC, Wang JH, Smith MJ, Bouchier-Hayes D, Cotter TG, Redmond HP; (2003) 'Excisional surgery for cancer cure: therapy at a cost'. The Lancet Oncology, 4 (12):760-768 [Details]
(2003)'Gene expression profiling in biliary atresia'
Smith MJ, Coffey JC, Wang JH, Cotter TG, Redmond HP; (2003) 'Gene expression profiling in biliary atresia'. Lancet, 361 (9361):971-91 [Details]
(2003)'Excisional surgery for cancer cure: therapy at a cost'
Coffey, JC,Wang, JH,Smith, MJF,Bouchier-Hayes, D,Cotter, TG,Redmond, HP; (2003) 'Excisional surgery for cancer cure: therapy at a cost'. The Lancet Oncology, 4 :760-768 [Details]
(2003)'Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells'
Curtin, JF,Cotter, TG; (2003) 'Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells'. British Journal of Cancer, 89 :1950-1957 [DOI] [Details]
(2003)'Targeting inflammatory diseases via apoptotic mechanisms'
Murphy, FJ,Hayes, I,Cotter, TG; (2003) 'Targeting inflammatory diseases via apoptotic mechanisms'. Current Opinion In Pharmacology, 3 :412-419 [DOI] [Details]
(2002)'High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion'
Keeshan, K; Cotter, TG; McKenna, SL; (2002) 'High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion'. Leukemia, 16 (9):1725-1734 [Details]
(2002)'p53 expression in K562 cells is associated with caspase-mediated cleavage of c-ABL and BCR-ABL protein kinases'
Di Bacco, AM; Cotter, TG; (2002) 'p53 expression in K562 cells is associated with caspase-mediated cleavage of c-ABL and BCR-ABL protein kinases'. British Journal of Haematology, 117 (3):588-597 [Details]
(2002)'Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis'
Curtin JF, Cotter TG; (2002) 'Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis'. British Journal of Cancer, 87 (10):1188-1194 [DOI] [Details]
(2002)'High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion'
Keeshan K, Cotter TG, McKenna SL; (2002) 'High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion'. Official Journal of The Leukemia Society of America, 16 (9):1725-1734 [DOI] [Details]
(2002)'Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development'
Donovan M, Cotter TG; (2002) 'Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development'. Cell Death and Differentiation, 9 (11):1220-1231 [DOI] [Details]
(2002)'Between-group analysis of microarray data'
Culhane AC, Perrière G, Considine EC, Cotter TG, Higgins DG; (2002) 'Between-group analysis of microarray data'. Bioinformatics (Oxford, England), 18 (12):1600-1608 [Details]
(2002)'High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion'
Keeshan, K,Cotter, TG,McKenna, SL; (2002) 'High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion'. Official Journal of The Leukemia Society of America, 16 :1725-1734 [DOI] [Details]
(2002)'Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis'
Curtin, JF,Cotter, TG; (2002) 'Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis'. British Journal of Cancer, 87 :1188-1194 [DOI] [Details]
(2002)'Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X-L'
Walsh, M,Lutz, RJ,Cotter, TG,O'Conner, R; (2002) 'Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X-L'. Blood, 99 :3439-3448 [Details]
(2002)'Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development'
Donovan, M,Cotter, TG; (2002) 'Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development'. Cell, 9 :1220-1231 [DOI] [Details]
(2002)'Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X(L)'
Walsh, M; Lutz, RJ; Cotter, TG; O'Connor, R; (2002) 'Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X(L)'. Blood, 99 (9):3439-3448 [Details]
(2002)'Between-group analysis of microarray data'
Culhane, AC,Perriere, G,Considine, EC,Cotter, TG,Higgins, DG; (2002) 'Between-group analysis of microarray data'. Bioinformatics (Oxford, England), 18 :1600-1608 [Details]
(2002)'Regulation and measurement of oxidative stress in apoptosis'
Curtin JF, Donovan M, Cotter TG; (2002) 'Regulation and measurement of oxidative stress in apoptosis'. Methods, 265 (1-2):49-72 [Details]
(2001)'Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent'
Donovan, M; Carmody, RJ; Cotter, TG; (2001) 'Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent'. Journal of Biological Chemistry, 276 (25):23000-23008 [Details]
(2001)'Inhibition of PI3-kinase sensitises HL60 human leukaemia cells to both chemotherapeutic drug- and Fas-induced apoptosis by a JNK indeptendent pathway'
O'Gorman, DM; McKenna, SL; McGahon, AJ; Cotter, TG; (2001) 'Inhibition of PI3-kinase sensitises HL60 human leukaemia cells to both chemotherapeutic drug- and Fas-induced apoptosis by a JNK indeptendent pathway'. Leukemia, 25 (9):801-811 [Details]
(2001)'Light-induced photoreceptor apoptosis in vivo is caspase independent and mediated by nitric oxide'
Donovan, M; Carmody, RJ; Cotter, tg; (2001) 'Light-induced photoreceptor apoptosis in vivo is caspase independent and mediated by nitric oxide'. 1 :1-52 [Details]
(2001)'Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype'
Keeshan, K; Mills, KI; Cotter, TG; McKenna, SL; (2001) 'Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype'. Leukemia, 15 (12):1823-1833 [Details]
(2001)'Signalling apoptosis: a radical approach'
Carmody, RJ; Cotter, TG; (2001) 'Signalling apoptosis: a radical approach'. 6 (2):77-90 [Details]
(2001)'Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions'
Finnegan, NM; Curtin, JF; Prevost, G; Morgan, B; Cotter, TG; (2001) 'Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions'. 85 (1):115-121 [Details]
(2001)'Prion protein fragment PrP-(106-126) induces apoptosis via mitochondrial disruption in human neuronal SH-SY5Y cells'
O'Donovan, CN; Tobin, D; Cotter, TG; (2001) 'Prion protein fragment PrP-(106-126) induces apoptosis via mitochondrial disruption in human neuronal SH-SY5Y cells'. Journal of Biological Chemistry, 276 (47):43516-43523 [Details]
(2001)'Signalling apoptosis: a radical approach'
Carmody RJ, Cotter TG; (2001) 'Signalling apoptosis: a radical approach'. Redox Report : Communications In Free Radical Research, 6 (2):77-90 [Details]
(2001)'Molecular signals in anti-apoptotic survival pathways'
O'Gorman DM, Cotter TG; (2001) 'Molecular signals in anti-apoptotic survival pathways'. Official Journal of The Leukemia Society of America, 15 (1):21-34 [Details]
(2001)'Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype'
Keeshan K, Mills KI, Cotter TG, McKenna SL; (2001) 'Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype'. Official Journal of The Leukemia Society of America, 15 (12):1823-1833 [Details]
(2001)'Molecular signals in anti-apoptotic survival pathways'
O'Gorman, DM; Cotter, TG; (2001) 'Molecular signals in anti-apoptotic survival pathways'. Leukemia, 15 (1):21-34 [Details]
(2001)'Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype'
Keeshan, K,Mills, KI,Cotter, TG,McKenna, SL; (2001) 'Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype'. Official Journal of The Leukemia Society of America, 15 :1823-1833 [Details]
(2001)'Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions'
Finnegan, NM,Curtin, JF,Prevost, G,Morgan, B,Cotter, TG; (2001) 'Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions'. British Journal of Cancer, 85 :115-121 [Details]
(2001)'Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3 independent'
Donovan, M,Carmody, RJ,Cotter, TG; (2001) 'Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3 independent'. The Journal of Biological Chemistry, 276 :23000-23008 [Details]
(2001)'Inhibition of PI3-kinase sensitises HL60 human leukaemia cells to both chemotherapeutic drug- and Fas-induced apoptosis by a JNK independent pathway'
O'Gorman, DM,McKenna, SL,McGahon, AJ,Cotter, TG; (2001) 'Inhibition of PI3-kinase sensitises HL60 human leukaemia cells to both chemotherapeutic drug- and Fas-induced apoptosis by a JNK independent pathway'. Official Journal of The Leukemia Society of America, 25 :801-811 [Details]
(2000)'Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis'
Costa-Pereira AP, McKenna SL, Cotter TG; (2000) 'Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis'. British Journal of Cancer, 82 (11):1827-1834 [DOI] [Details]
(2000)'Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals'
O'Gorman DM, McKenna SL, McGahon AJ, Knox KA, Cotter TG; (2000) 'Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals'. Official Journal of The Leukemia Society of America, 14 (4):602-611 [Details]
(2000)'Oxidative stress induces caspase-independent retinal apoptosis in vitro'
Carmody RJ, Cotter TG; (2000) 'Oxidative stress induces caspase-independent retinal apoptosis in vitro'. Cell Death and Differentiation, 7 (3):282-291 [DOI] [Details]
(2000)'Oxidative stress induces caspase-independent retinal apoptosis in vitro'
Carmody, RJ,Cotter, TG; (2000) 'Oxidative stress induces caspase-independent retinal apoptosis in vitro'. Cell, 7 :282-291 [Details]
(2000)'Inhibition of caspase activity delays apoptosis in a transfected NS/0 myeloma cell line'
McKenna, SL,Cotter, TG; (2000) 'Inhibition of caspase activity delays apoptosis in a transfected NS/0 myeloma cell line'. Biotechnology and Bioengineering, 67 :165-176 [Details]
(2000)'Inhibition of caspase activity delays apoptosis in a transfected NS/0 myeloma cell line'
McKenna, SL; Cotter, TG; (2000) 'Inhibition of caspase activity delays apoptosis in a transfected NS/0 myeloma cell line'. Biotechnology & Bioengineering, 67 (2):165-176 [Details]
(2000)'Regulation of apoptosis by heat-shock proteins in leukemia cells'
Creagh, EM; Sheehan, D; Cotter, TG; (2000) 'Regulation of apoptosis by heat-shock proteins in leukemia cells'. Leukemia, 14 (*):1161-1173 [Details]
(2000)'Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis'
Di Bacco, A; Keeshan, K; McKenna, SL; Cotter, TG; (2000) 'Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis'. 5 (5):405-415 [Details]
(2000)'Heat shock proteins-modulators of apoptosis in tumour cells'
Creagh, EM; Sheehan, D; Cotter, TG; (2000) 'Heat shock proteins-modulators of apoptosis in tumour cells'. Leukemia, 14 (7):1161-1173 [Details]
(2000)'Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells'
Creagh, EM; Carmody, RJ; Cotter, TG; (2000) 'Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells'. Experimental Cell Research, 257 (1):58-66 [Details]
(2000)'Oxidative stress induces caspase-independent retinal apoptosis in vitro'
Carmody, RJ; Cotter, TG; (2000) 'Oxidative stress induces caspase-independent retinal apoptosis in vitro'. Cell Death &Differentiation, 7 (3):282-291 [Details]
(2000)'Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals'
O'Gorman, DM,McKenna, SL,McGahon, AJ,Knox, KA,Cotter, TG; (2000) 'Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals'. Official Journal of The Leukemia Society of America, 14 :602-611 [Details]
(1999)'Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells'
Finucane DM, Waterhouse NJ, Amarante-Mendes GP, Cotter TG, Green DR; (1999) 'Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells'. Experimental Cell Research, 251 (1):166-174 [DOI] [Details]
(1999)'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'
Gorman AM, Heavey B, Creagh E, Cotter TG, Samali A; (1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'. Febs Letters, 445 (1):98-102 [Details]
(1999)'Inhibition of neutrophil apoptosis after elective surgery'
Fanning NF, Porter J, Shorten GD, Kirwan WO, Bouchier-Hayes D, Cotter TG, Redmond HP; (1999) 'Inhibition of neutrophil apoptosis after elective surgery'. Journal of Surgery, 126 (3):527-534 [Details]
(1999)'Molecular and cellular biology of prostate cancer-the role of apoptosis as a target for therapy'
Costa-Pereira AP, Cotter TG; (1999) 'Molecular and cellular biology of prostate cancer-the role of apoptosis as a target for therapy'. Prostate Cancer and Prostatic Diseases, 2 (3):126-139 [DOI] [Details]
(1999)'Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL'
Finucane DM, Bossy-Wetzel E, Waterhouse NJ, Cotter TG, Green DR; (1999) 'Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL'. The Journal of Biological Chemistry, 274 (4):2225-2233 [Details]
(1999)'The antioxidant 4b,5,9b,10-tetrahydroindeno[1,2-b]indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization'
Devitt, GP,Creagh, EM,Cotter, TG; (1999) 'The antioxidant 4b,5,9b,10-tetrahydroindeno[1,2-b]indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization'. Biochemical and Biophysical Research Communications, 264 :622-629 [Details]
(1999)'Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL'
Finucane, DM,Bossy-Wetzel, E,Waterhouse, NJ,Cotter, TG,Green, DR; (1999) 'Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL'. The Journal of Biological Chemistry, 274 :2225-2233 [Details]
(1999)'Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis'
Creagh EM, Cotter TG; (1999) 'Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis'. The Journal of Immunology, 97 (1):36-44 [Details]
(1999)'Circulating granulocyte macrophage colony-stimulating factor in plasma of patients with the systemic inflammatory response syndrome delays neutrophil apoptosis through inhibition of spontaneous reactive oxygen species generation'
Fanning NF, Kell MR, Shorten GD, Kirwan WO, Bouchier-Hayes D, Cotter TG, Redmond HP; (1999) 'Circulating granulocyte macrophage colony-stimulating factor in plasma of patients with the systemic inflammatory response syndrome delays neutrophil apoptosis through inhibition of spontaneous reactive oxygen species generation'. Shock, 11 (3):167-174 [Details]
(1999)'The antioxidant 4b,5,9b,10-Tetrahydroindeno[1,2-b]indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization'
Devitt GP, Creagh EM, Cotter TG; (1999) 'The antioxidant 4b,5,9b,10-Tetrahydroindeno[1,2-b]indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization'. Biochemical and Biophysical Research Communications, 264 (3):622-629 [DOI] [Details]
(1999)'Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis'
Creagh, EM,Cotter, TG; (1999) 'Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis'. The Journal of Immunology, 97 :36-44 [Details]
(1999)'Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell'
Creagh, EM; Cotter, TG; (1999) 'Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell'. The Journal of Immunology, 97 (1):36-44 [Details]
(1999)'Reactive oxygen species as mediators of photoreceptor apoptosis in vitro'
Carmody, RJ; McGowan, AJ; Cotter, TG; (1999) 'Reactive oxygen species as mediators of photoreceptor apoptosis in vitro'. Experimental Cell Research, 248 (2):520-530 [Details]
(1999)'Circulating granulocyte macrophage colony-stimulating factor in plasma of patients with the systemic inflammatory response syndrome delays neutrophil apoptosis through inhibition of spontaneous reactive oxygen species generation'
Fanning NF, Kell MR, Shorten GD, Kirwan WO, Bouchier-Hayes D, Cotter TG, Redmond HP; (1999) 'Circulating granulocyte macrophage colony-stimulating factor in plasma of patients with the systemic inflammatory response syndrome delays neutrophil apoptosis through inhibition of spontaneous reactive oxygen species generation'. 11 (3):167-174 [Details]
(1999)'Camptothecin sensitizes androgen-independent prostate cancer cells to anti-Fas-induced apoptosis'
Costa-Pereira AP, Cotter TG; (1999) 'Camptothecin sensitizes androgen-independent prostate cancer cells to anti-Fas-induced apoptosis'. British Journal of Cancer, 80 (3-4):371-378 [DOI] [Details]
(1999)'Reactive oxygen species as mediators of photoreceptor apoptosis in vitro'
Carmody RJ, McGowan AJ, Cotter TG; (1999) 'Reactive oxygen species as mediators of photoreceptor apoptosis in vitro'. Experimental Cell Research, 248 (2):520-530 [DOI] [Details]
(1999)'Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells'
Finucane, DM,Waterhouse, NJ,Amarante-Mendes, GP,Cotter, TG,Green, DR; (1999) 'Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells'. Cell, 251 :166-174 [Details]
(1999)'Reactive oxygen species as mediators of photoreceptor apoptosis in vitro'
Carmody, RJ,McGowan, AJ,Cotter, TG; (1999) 'Reactive oxygen species as mediators of photoreceptor apoptosis in vitro'. Cell, 248 :520-530 [Details]
(1999)'The antioxidant 4b, 5, 9b, 10-tetrahydroindeno[1,2-b] indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization'
Devitt, GP, Creagh, EM; Cotter, TG; (1999) 'The antioxidant 4b, 5, 9b, 10-tetrahydroindeno[1,2-b] indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization'. Biochem Biophys Res Commun, 264 (3):622-629 [Details]
(1998)'Molecular mechanisms of programmed cell death'
McKenna SL, McGowan AJ, Cotter TG; (1998) 'Molecular mechanisms of programmed cell death'. Advances In Biochemical Engineering & Biotechnology, 62 :1-31 [Details]
(1998)'Rapid detection of rod photoreceptor apoptosis by flow cytometry'
Carmody RJ, McGowan AJ, Cotter TG; (1998) 'Rapid detection of rod photoreceptor apoptosis by flow cytometry'. Cytometry, 33 (1):89-92 [Details]
(1998)'The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult'
McGowan AJ, Bowie AG, O'Neill LA, Cotter TG; (1998) 'The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult'. Experimental Cell Research, 238 (1):248-256 [DOI] [Details]
(1998)'Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux'
McCarthy, JV; Cotter, TG; (1998) 'Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux'. Cell Death &Differentiation, 4 (8):756-770 [Details]
(1998)'p53 mediates breakdown of the anti-apoptotic protein Bcr-Abl in K562 leukaemia cells'
Di Bacco, A; Cotter, TG; (1998) 'p53 mediates breakdown of the anti-apoptotic protein Bcr-Abl in K562 leukaemia cells'. 78 (*):23-23 [Details]
(1998)'Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death'
Amarante-Mendes, GP,Finucane, DM,Martin, SJ,Cotter, TG,Salvesen, GS,Green, DR; (1998) 'Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death'. Cell, 5 :298-306 [Details]
(1998)'Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death'
Amarante-Mendes GP, Finucane DM, Martin SJ, Cotter TG, Salvesen GS, Green DR; (1998) 'Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death'. Cell Death and Differentiation, 5 (4):298-306 [DOI] [Details]
(1998)'Rapid detection of rod photoreceptor apoptosis by flow cytometry'
Carmody, RJ,McGowan, AJ,Cotter, TG; (1998) 'Rapid detection of rod photoreceptor apoptosis by flow cytometry'. Cytometry, 33 :89-92 [Details]
(1998)'Chemotherapeutic drug-induced apoptosis in human leukaemic cells is independent of the Fas (APO-1/CD95) receptor/ligand system'
McGahon AJ, Costa Pereira AP, Daly L, Cotter TG; (1998) 'Chemotherapeutic drug-induced apoptosis in human leukaemic cells is independent of the Fas (APO-1/CD95) receptor/ligand system'. British Journal of Haematology, 101 (3):539-547 [Details]
(1997)'Cell shrinkage and apoptosis: A role for potassium and sodium efflux'
McCarthy, JV; Cotter, TG; (1997) 'Cell shrinkage and apoptosis: A role for potassium and sodium efflux'. Cell Death and Differentiation, 4 (*):756-770 [Details]
(1997)'Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: Characterization of the apoptotic death'
McGahon, AJ,Brown, DG,Martin, SJ,AmaranteMendes, GP,Cotter, TG,Cohen, GM,Green, DR; (1997) 'Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: Characterization of the apoptotic death'. Cell, 4 :95-104 [Details]
(1997)'Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux'
McCarthy, JV,Cotter, TG; (1997) 'Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux'. Cell, 4 :756-770 [Details]
(1997)'The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation'
Samali, A,Gilje, B,Doskeland, SO,Cotter, TG,Houge, G; (1997) 'The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation'. Cell, 4 :289-293 [Details]
(1997)'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'
Gorman, AM,Samali, A,McGowan, AJ,Cotter, TG; (1997) 'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'. Cytometry, 29 :97-105 [Details]
(1997)'Role of peroxide and superoxide anion during tumour cell apoptosis'
Gorman, A,McGowan, A,Cotter, TG (1997) 'Role of peroxide and superoxide anion during tumour cell apoptosis'. Febs Letters, 404 :27-33 [Details]
(1997)'Functional aspects of apoptosis in hematopoiesis and consequences of failure'
McKenna SL, Cotter TG; (1997) 'Functional aspects of apoptosis in hematopoiesis and consequences of failure'. Advances In Cancer Research, 71 :121-164 [Details]
(1997)'Role of Bcr-Abl kinase in resistance to apoptosis'
Samali A, Gorman AM, Cotter TG; (1997) 'Role of Bcr-Abl kinase in resistance to apoptosis'. Advances In Pharmacology, 41 :533-552 [Details]
(1997)'Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: characterization of the apoptotic death'
McGahon AJ, Brown DG, Martin SJ, Amarante-Mendes GP, Cotter TG, Cohen GM, Green DR; (1997) 'Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: characterization of the apoptotic death'. Cell Death and Differentiation, 4 (2):95-104 [DOI] [Details]
(1997)'Role of peroxide and superoxide anion during tumour cell apoptosis'
Gorman A, McGowan A, Cotter TG; (1997) 'Role of peroxide and superoxide anion during tumour cell apoptosis'. Febs Letters, 404 (1):27-33 [Details]
(1997)'The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation'
Samali A, Gilje B, Døskeland SO, Cotter TG, Houge G; (1997) 'The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation'. Cell death and differentiation, 4 (4):289-293 [DOI] [Details]
(1997)'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'
Gorman AM, Samali A, McGowan AJ, Cotter TG; (1997) 'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'. Cytometry, 29 (2):97-105 [Details]
(1997)'Abl expression in human fetal and adult tissues, tumours, and tumour microvessels'
O'Neill AJ, Cotter TG, Russell JM, Gaffney EF; (1997) 'Abl expression in human fetal and adult tissues, tumours, and tumour microvessels'. The Journal of Pathology, 183 (3):325-329 [DOI] [Details]
(1996)'Anti-oxidants and apoptosis'
McGowan AJ, Fernandes RS, Samali A, Cotter TG; (1996) 'Anti-oxidants and apoptosis'. Biochemical Society Transactions, 24 (1):229-233 [Details]
(1996)'Heat shock proteins increase resistance to apoptosis'
Samali A, Cotter TG; (1996) 'Heat shock proteins increase resistance to apoptosis'. Experimental Cell Research, 223 (1):163-170 [DOI] [Details]
(1996)'Mutant H-ras overexpression inhibits drug and UV induced apoptosis'
Fernandes, RS,McGowan, AJ,Cotter, TG; (1996) 'Mutant H-ras overexpression inhibits drug and UV induced apoptosis'. Cancer, 16 :1691-1705 [Details]
(1996)'Heat shock proteins increase resistance to apoptosis'
Samali, A,Cotter, TG; (1996) 'Heat shock proteins increase resistance to apoptosis'. Cell, 223 :163-170 [Details]
(1996)'Morphologic evidence of apoptosis in childhood acute myeloblastic leukemia treated with high-dose methylprednisolone'
Hiçsnömez G, Erdemli E, Tekelioglu M, Tuncer AM, Ozbek N, Cetin M, Cotter TG; (1996) 'Morphologic evidence of apoptosis in childhood acute myeloblastic leukemia treated with high-dose methylprednisolone'. Leukemia & lymphoma, 22 (1-2):91-1 [Details]
(1996)'Mutant H-ras overexpression inhibits drug and U.V. induced apoptosis'
Fernandes RS, McGowan AJ, Cotter TG; (1996) 'Mutant H-ras overexpression inhibits drug and U.V. induced apoptosis'. Anticancer Research, 16 (4A):1691-1705 [Details]
(1996)'Apoptosis -- the story so far'
Samali A, Gorman AM, Cotter TG; (1996) 'Apoptosis -- the story so far'. Experientia, 52 (10-11):933-941 [Details]
(1996)'Reactive oxygen intermediate(s) (ROI): common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis'
McGowan AJ, Ruiz-Ruiz MC, Gorman AM, Lopez-Rivas A, Cotter TG; (1996) 'Reactive oxygen intermediate(s) (ROI): common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis'. Febs Letters, 392 (3):299-303 [Details]
(1996)'The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia'
Fernandes RS, Gorman AM, McGahon A, Lawlor M, McCann S, Cotter TG; (1996) 'The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia'. Official Journal of The Leukemia Society of America, 10 Suppl 2 :1-21 [Details]
(1995)'BCR-ABL: an anti-apoptosis gene in chronic myelogenous leukemia'
Cotter TG; (1995) 'BCR-ABL: an anti-apoptosis gene in chronic myelogenous leukemia'. Leukemia & Lymphoma, 18 (3-4):231-236 [Details]
(1995)'CELL-DEATH (APOPTOSIS) IN CELL-CULTURE SYSTEMS'
COTTER, TG,ALRUBEAI, M; (1995) 'CELL-DEATH (APOPTOSIS) IN CELL-CULTURE SYSTEMS'. Trends In Biotechnology, 13 :150-155 [Details]
(1995)'Regulation of the Fas apoptotic cell death pathway by Abl'
McGahon AJ, Nishioka WK, Martin SJ, Mahboubi A, Cotter TG, Green DR; (1995) 'Regulation of the Fas apoptotic cell death pathway by Abl'. The Journal of Biological Chemistry, 270 (38):22625-22631 [Details]
(1995)'Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line'
Verhaegen S, McGowan AJ, Brophy AR, Fernandes RS, Cotter TG; (1995) 'Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line'. Biochemical Pharmacology, 50 (7):1021-1029 [Details]
(1995)'Cell death (apoptosis) in cell culture systems'
Cotter TG, al-Rubeai M; (1995) 'Cell death (apoptosis) in cell culture systems'. Trends In Biotechnology, 13 (4):150-155 [DOI] [Details]
(1995)'REGULATION OF THE FAS APOPTOTIC CELL-DEATH PATHWAY BY ABL'
MCGAHON, AJ,NISHIOKA, WK,MARTIN, SJ,MAHBOUBI, A,COTTER, TG,GREEN, DR; (1995) 'REGULATION OF THE FAS APOPTOTIC CELL-DEATH PATHWAY BY ABL'. The Journal of Biological Chemistry, 270 :22625-22631 [Details]
(1994)'The role of oncogene products in neutrophil apoptosis'
Hannah S, Cotter TG, Wyllie AH, Haslett C; (1994) 'The role of oncogene products in neutrophil apoptosis'. Biochemical Society Transactions, 22 (3) [Details]
(1994)'Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death'
Fernandes RS, Cotter TG; (1994) 'Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death'. Biochemical Pharmacology, 48 (4):675-681 [Details]
(1994)'Zinc inhibits UV radiation-induced apoptosis but fails to prevent subsequent cell death'
McGowan AJ, Fernandes RS, Verhaegen S, Cotter TG; (1994) 'Zinc inhibits UV radiation-induced apoptosis but fails to prevent subsequent cell death'. International Journal of Radiation Biology, 66 (4):343-349 [Details]
(1994)'The abl oncogene family and apoptosis'
McGahon AJ, Cotter TG, Green DR; (1994) 'The abl oncogene family and apoptosis'. Cell Death and Differentiation, 1 (2):77-83 [Details]
(1994)'Genes and Apoptosis'
Cotter, TG; McCarthy, JV; (1994) 'Genes and Apoptosis'. Biochemical Society Transactions, 22 (*):591-593 [Details]
(1994)'Increased resistance to apoptosis associated with HL-60 myeloid differentiations status'
McCarthy, JV; Fernandes, RS; Cotter, TG.; (1994) 'Increased resistance to apoptosis associated with HL-60 myeloid differentiations status'. Anti-Cancer Research, 14 (*):2063-2072 [Details]
(1994)'Cell death in the myeloid lineage'
Cotter, TG; Fernandes, RS; Verhagen, S; McCarthy, JV; (1994) 'Cell death in the myeloid lineage'. Immunological Reviews, 142 (*):93-112 [Details]
(1994)'Dicing with death: dissecting the components of the apoptosis machinery'
Martin SJ, Green DR, Cotter TG; (1994) 'Dicing with death: dissecting the components of the apoptosis machinery'. Trends In Biochemical Sciences, 19 (1):26-30 [Details]
(1994)'Apoptosis and cancer'
Green DR, Bissonnette RP, Cotter TG; (1994) 'Apoptosis and cancer'. Important Advances In Oncology, :37-52 [Details]
(1994)'BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death'
McGahon A, Bissonnette R, Schmitt M, Cotter KM, Green DR, Cotter TG; (1994) 'BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death'. Blood, 83 (5):1179-1187 [Details]
(1994)'Meeting Report: The high-tech aspect of death'
Cotter TG, Melino G; (1994) 'Meeting Report: The high-tech aspect of death'. Cell Death and Differentiation, 1 (1):67-68 [Details]
(1993)'Activation of a calcium magnesium independent endonuclease in human leukemic cell apoptosis'
Fernandes RS, Cotter TG; (1993) 'Activation of a calcium magnesium independent endonuclease in human leukemic cell apoptosis'. Anticancer Research, 13 (5A):1253-1259 [Details]
(1993)'DNA fragmentation induced by cytotoxic T lymphocytes can result in target cell death'
Helgason CD, Shi L, Greenberg AH, Shi Y, Bromley P, Cotter TG, Green DR, Bleackley RC; (1993) 'DNA fragmentation induced by cytotoxic T lymphocytes can result in target cell death'. Experimental Cell Research, 206 (2):302-310 [DOI] [Details]
(1993)'An immune suppressive factor derived from esophageal squamous carcinoma induces apoptosis in normal and transformed cells of lymphoid lineage'
O'Mahony AM, O'Sullivan GC, O'Connell J, Cotter TG, Collins JK; (1993) 'An immune suppressive factor derived from esophageal squamous carcinoma induces apoptosis in normal and transformed cells of lymphoid lineage'. Journal of Immunology, 151 (9):4847-4856 [Details]
(1993)'AN IMMUNE SUPPRESSIVE FACTOR DERIVED FROM ESOPHAGEAL SQUAMOUS CARCINOMA INDUCES APOPTOSIS IN NORMAL AND TRANSFORMED-CELLS OF LYMPHOID LINEAGE'
OMAHONY, AM,OSULLIVAN, GC,OCONNELL, J,COTTER, TG,COLLINS, JK; (1993) 'AN IMMUNE SUPPRESSIVE FACTOR DERIVED FROM ESOPHAGEAL SQUAMOUS CARCINOMA INDUCES APOPTOSIS IN NORMAL AND TRANSFORMED-CELLS OF LYMPHOID LINEAGE'. Journal of Immunology, 151 :4847-4856 [Details]
(1992)'The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle'
Cotter TG, Glynn JM, Echeverri F, Green DR; (1992) 'The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle'. Anticancer Research, 12 (3):773-779 [Details]
(1992)'Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas'
Shi Y, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP, Green DR; (1992) 'Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas'. Science, 257 (5067):212-214 [Details]
(1992)'Introduction: apoptosis in the immune system'
Green DR, Cotter TG; (1992) 'Introduction: apoptosis in the immune system'. Seminars In Immunology, 4 (6):355-362 [Details]
(1992)'Induction of apoptosis in cells of the immune system by cytotoxic stimuli'
Cotter TG; (1992) 'Induction of apoptosis in cells of the immune system by cytotoxic stimuli'. Seminars In Immunology, 4 (6):399-405 [Details]
(1992)'Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukaemia cells'
Lennon SV, Kilfeather SA, Hallett MB, Campbell AK, Cotter TG; (1992) 'Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukaemia cells'. Clinical and Experimental Immunology, 87 (3):465-471 [Details]
(1992)'The role of calcium in the induction of apoptosis in human tumour cell lines'
Lennon SV, Kilfeather SA, Cotter TG; (1992) 'The role of calcium in the induction of apoptosis in human tumour cell lines'. Biochemical Society Transactions, 20 (1) [Details]
(1992)'The regulatory role of zinc in apoptosis in human tumour cell lines'
Lennon SV, Cotter TG; (1992) 'The regulatory role of zinc in apoptosis in human tumour cell lines'. Biochemical Society Transactions, 20 (1) [Details]
(1992)'Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis'
Cotter TG, Lennon SV, Glynn JM, Green DR; (1992) 'Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis'. Cancer Research, 52 (4):997-1005 [Details]
(1992)'Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle'
Glynn JM, Cotter TG, Green DR; (1992) 'Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle'. Biochemical Society Transactions, 20 (1) [Details]
(1991)'Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency'
Martin SJ, Mazdai G, Strain JJ, Cotter TG, Hannigan BM; (1991) 'Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency'. Clinical and Experimental Immunology, 83 (2):338-343 [Details]
(1991)'Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli'
Lennon SV, Martin SJ, Cotter TG; (1991) 'Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli'. Cell Proliferation, 24 (2):203-214 [Details]
(1991)'Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis'
Martin SJ, Cotter TG; (1991) 'Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis'. International Journal of Radiation Biology, 59 (4):1001-1016 [Details]
(1990)'The granulocyte cell surface during differentiation'
Cotter TG; (1990) 'The granulocyte cell surface during differentiation'. Biochemical Society Transactions, 18 (2):228-229 [Details]
(1990)'Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL-60 cells'
Martin SJ, Cotter TG; (1990) 'Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL-60 cells'. Cell and Tissue Kinetics, 23 (6):545-559 [Details]
(1990)'Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells'
Cotter TG, Lennon SV, Glynn JG, Martin SJ; (1990) 'Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells'. Anticancer Research, 10 (5A):1153-1159 [Details]
(1990)'Specific loss of microtubules in HL-60 cells leads to programmed cell death (apoptosis)'
Martin SJ, Cotter TG; (1990) 'Specific loss of microtubules in HL-60 cells leads to programmed cell death (apoptosis)'. Biochemical Society Transactions, 18 (2):299-301 [Details]
(1990)'Induction of apoptosis (programmed cell death) in tumour cell lines by widely diverging stimuli'
Lennon SV, Martin SJ, Cotter TG; (1990) 'Induction of apoptosis (programmed cell death) in tumour cell lines by widely diverging stimuli'. Biochemical Society Transactions, 18 (2):343-345 [Details]
(1990)'Biochemical studies on a human leukaemia-associated antigen'
Weedle RM, Cotter TG; (1990) 'Biochemical studies on a human leukaemia-associated antigen'. Biochemical Society Transactions, 18 (2):345-346 [Details]
(1990)'The involvement of RNA and protein synthesis in programmed cell death (apoptosis) in human leukaemia HL-60 cells'
Martin SJ, Bonham AM, Cotter TG; (1990) 'The involvement of RNA and protein synthesis in programmed cell death (apoptosis) in human leukaemia HL-60 cells'. Biochemical Society Transactions, 18 (4):634-636 [Details]
(1990)'Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis'
Cotter TG, Martin SJ, Lennon SV, Bonham AM; (1990) 'Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis'. Journal of Immunology, 145 (6):1859-1867 [Details]
(1990)'HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis'
Martin SJ, Bradley JG, Cotter TG; (1990) 'HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis'. Clinical and Experimental Immunology, 79 (3):448-453 [Details]
(1990)'Biochemical characterisation studies on a leukocyte alloantigen expressed with high frequency in leukaemia patients'
Weedle RM, Cotter TG; (1990) 'Biochemical characterisation studies on a leukocyte alloantigen expressed with high frequency in leukaemia patients'. Leukemia Research, 14 (9):761-770 [Details]
(1989)'Identification of a leukocyte alloantigen with a high-frequency expression in leukemia patients'
O'Connor R, Bradley JG, O'Meara A, Cotter TG; (1989) 'Identification of a leukocyte alloantigen with a high-frequency expression in leukemia patients'. Blood, 73 (2):553-558 [Details]
(1988)'The degranulation response in differentiated HL-60 cells'
Meagher LC, Cotter TG; (1988) 'The degranulation response in differentiated HL-60 cells'. Clinical and Experimental Immunology, 74 (3):483-488 [Details]
(1987)'Production and characterization of a monoclonal antibody to a myeloid specific differentiation antigen'
O'Connor R, Bradley JG, Lawlor E, Cotter TG; (1987) 'Production and characterization of a monoclonal antibody to a myeloid specific differentiation antigen'. Leukemia Research, 11 (5):481-488 [Details]
(1986)'Age-related differences in granulocyte chemotaxis and degranulation'
McLaughlin B, O'Malley K, Cotter TG; (1986) 'Age-related differences in granulocyte chemotaxis and degranulation'. Clinical Science, 70 (1):59-62 [Details]
(1985)'Neutrophil differentiation antigens'
Cotter TG; (1985) 'Neutrophil differentiation antigens'. Biochemical Society Transactions, 13 (2):417-418 [Details]
(1984)'Purification and characterization of an antigen involved in neutrophil chemotaxis and degranulation using a monoclonal antibody'
Cotter TG, Henson PM; (1984) 'Purification and characterization of an antigen involved in neutrophil chemotaxis and degranulation using a monoclonal antibody'. Journal of Immunology, 14 (7):605-609 [Details]
(1983)'Decreased neutrophil cyclic AMP response to isoprenaline stimulation in the elderly'
Cotter TG, O'Malley K; (1983) 'Decreased neutrophil cyclic AMP response to isoprenaline stimulation in the elderly'. Clinical Science, 65 (2):155-157 [Details]
(1983)'A cell surface differentiation antigen involved in human neutrophil chemotaxis and degranulation'
Cotter TG, Henson PM; (1983) 'A cell surface differentiation antigen involved in human neutrophil chemotaxis and degranulation'. Clinical and Experimental Immunology, 53 (1):249-253 [Details]
(1981)'A monoclonal antibody inhibiting human neutrophil chemotaxis and degranulation'
Cotter TG, Spears P, Henson PM; (1981) 'A monoclonal antibody inhibiting human neutrophil chemotaxis and degranulation'. Journal of Immunology, 127 (4):1355-1360 [Details]
(1981)'A monoclonal antibody-inhibiting FMLP-induced chemotaxis of human neutrophils'
Cotter TG, Keeling PJ, Henson PM; (1981) 'A monoclonal antibody-inhibiting FMLP-induced chemotaxis of human neutrophils'. Journal of Immunology, 127 (6):2241-2245 [Details]
(1980)'Purification and characterisation of an 'elastase-like' enzyme from rabbit polymorphonuclear leucocytes'
Cotter TG, Robinson GB; (1980) 'Purification and characterisation of an 'elastase-like' enzyme from rabbit polymorphonuclear leucocytes'. Biochimica Et Biophysica Acta, 615 (2):414-425 [Details]
(1980)'The effects of proteinases on the filtration properties of isolated basement membranes'
Cotter TG, Robinson GB; (1980) 'The effects of proteinases on the filtration properties of isolated basement membranes'. The International Journal of Biochemistry, 12 (1-2):191-194 [Details]
(1979)'Studies on the filtration properties of isolated renal basement membranes'
Robinson GB, Cotter TG; (1979) 'Studies on the filtration properties of isolated renal basement membranes'. Biochimica Et Biophysica Acta, 551 (1):85-94 [Details]
(1978)'Effects of concentration-polarization on the filtration of proteins through filters constructed from isolated renal basement membrane'
Cotter TG, Robinson GB; (1978) 'Effects of concentration-polarization on the filtration of proteins through filters constructed from isolated renal basement membrane'. Clinical Science and Molecular Medicine, 55 (1):113-119 [Details]
(1978)'The filtration of protein solutions across films of renal basement membrane in vitro [proceedings]'
Robinson GB, Cotter TG; (1978) 'The filtration of protein solutions across films of renal basement membrane in vitro [proceedings]'. Biochemical Society Transactions, 6 (6):1356-1358 [Details]
(1978)'Degradation of renal basement membrane by neutral proteinases from rabbit polymorphonuclear leucocytes [proceedings]'
Cotter TG, Robinson GB; (1978) 'Degradation of renal basement membrane by neutral proteinases from rabbit polymorphonuclear leucocytes [proceedings]'. Biochemical Society Transactions, 6 (6):1359-1361 [Details]
‍

Abstract

 YearPublication
(2014)ONCOGENE DRIVEN REDOX SURVIVAL SIGNALLING IN TUMOUR CELLS.
Cotter, TG,Stanicka, J,Landry, W (2014) ONCOGENE DRIVEN REDOX SURVIVAL SIGNALLING IN TUMOUR CELLS. Abstract [Details]
(2013)Nox-derived H2O2 mediates colon cancer cell metastatic colonisation and liver metastasis in response to bacterial endotoxin.
O'Leary, DP,Wang, JH,Cotter, TG,Redmond, HP (2013) Nox-derived H2O2 mediates colon cancer cell metastatic colonisation and liver metastasis in response to bacterial endotoxin. Abstract [Details]
(2013)Bacterial endotoxin enhances metastatic colonisation and liver metastasis in colon cancer cells via Nox derived H2O2.
O'Leary, DP,Wang, JH,Cotter, TG,Redmond, HP (2013) Bacterial endotoxin enhances metastatic colonisation and liver metastasis in colon cancer cells via Nox derived H2O2. Abstract [Details]
(2012)Toll-like receptor-4 signalling confers tumour survival via NOX generated reactive oxygen species in colon cancer.
O'Leary, DP,Bhatt, L,Wang, JH,Cotter, TG,Redmond, HP (2012) Toll-like receptor-4 signalling confers tumour survival via NOX generated reactive oxygen species in colon cancer. Abstract [Details]
(2012)Toll-like receptor 4 signalling facilitates metastasis and confers chemoresistance via Nox generated reactive oxygen species in colon cancer.
O'Leary, DP,Bhatt, L,Wang, JH,Cotter, TG,Redmond, HP (2012) Toll-like receptor 4 signalling facilitates metastasis and confers chemoresistance via Nox generated reactive oxygen species in colon cancer. Abstract [Details]
(2011)Toll-like receptor-4 signalling induces tumour survival and treatment resistance in colon cancer cells via an NADPH oxidase dependent mechanism.
O'Leary, DP,Gough, DR,Wang, JH,Cotter, TG,Redmond, HP (2011) Toll-like receptor-4 signalling induces tumour survival and treatment resistance in colon cancer cells via an NADPH oxidase dependent mechanism. Abstract [Details]
(2009)Flow-activated cell-sorting of primary and metastatic tumour cells expressing green fluorescence protein for gene expression microarray analysis.
Al-Sahaf, O,Wang, JH,Pettigrew, C,Cotter, M,Cotter, TG,Redmond, HP (2009) Flow-activated cell-sorting of primary and metastatic tumour cells expressing green fluorescence protein for gene expression microarray analysis. Abstract [Details]
(2006)Ceramide is the key mediator of oxidative stress-induced retinal cell apoptosis.
Cotter, TG,Sanvicens, N (2006) Ceramide is the key mediator of oxidative stress-induced retinal cell apoptosis. Abstract [Details]
(2005)The endoplasmic reticulum plays a key role in regulating sensitivity to apoptosis in Bcr-Abl expressing cells.
Vejda, S,Piwocka, K,Cotter, TG,Mckenna, SL (2005) The endoplasmic reticulum plays a key role in regulating sensitivity to apoptosis in Bcr-Abl expressing cells. Abstract [Details]
(2005)A novel Bcr-Abl mediated pro-survival pathway: Reduction of releasable calcium levels in the endoplasmic reticulum inhibits calcium dependent apoptotic signaling.
Piwocka, K,Vejda, S,Cotter, TG,Mckenna, SL (2005) A novel Bcr-Abl mediated pro-survival pathway: Reduction of releasable calcium levels in the endoplasmic reticulum inhibits calcium dependent apoptotic signaling. Abstract [Details]
(2005)Administration of a perioperative multiple heat shock protein dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo.
Smith, MJ,Shilling, DA,Kelly, MA,England, KE,Culhane, A,Wang, JH,O'Mahony, L,Cotter, TG,Redmond, HP (2005) Administration of a perioperative multiple heat shock protein dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo. Abstract [Details]
(2005)A novel Bcr-Abl mediated pro-survival pathway: Reduction of releasable calcium levels in the endoplasmic reticulum inhibits calcium dependent apoptotic signaling.
Vejda, S,Piwocka, K,Cotter, TG,O'Sullivan, GC,McKenna, SL (2005) A novel Bcr-Abl mediated pro-survival pathway: Reduction of releasable calcium levels in the endoplasmic reticulum inhibits calcium dependent apoptotic signaling. Abstract [Details]
(2005)Glucose induction of apoptosis in human retinal pericytes.
Browne, JG,Kane, R,Godson, C,Cotter, TG,O'Brien, CJ (2005) Glucose induction of apoptosis in human retinal pericytes. Abstract [Details]
(2005)Upregulation of the receptor tyrosine kinase DDR1 may induce AKT activation in a model of local breast cancer recurrence.
Smith, MJ,Kelly, MA,Shilling, DA,Culhane, A,Coffey, JC,Wang, JH,Cotter, TG,Redmond, HP (2005) Upregulation of the receptor tyrosine kinase DDR1 may induce AKT activation in a model of local breast cancer recurrence. Abstract [Details]
(2005)Administration of a novel perioperative multiple heat shock protein-loaded dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo.
Smith, MJ,Shilling, DA,Killeen, S,Kelly, MA,Tyther, R,England, K,Wang, JH,Cotter, TG,O'Mahony, L,Redmond, HP (2005) Administration of a novel perioperative multiple heat shock protein-loaded dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo. Abstract [Details]
(2004)CUH1 - a novel dendritic cell vaccine that protects against surgically induced activation of dormant micrometastases.
Coffey, JC,Shilling, D,Smith, MJF,McCarthy, F,Wang, JH,O'Mahony, L,Kavanagh, E,Cotter, TG,Redmond, HP (2004) CUH1 - a novel dendritic cell vaccine that protects against surgically induced activation of dormant micrometastases. Abstract [Details]
(2004)Transcriptional regulation of pro-apoptotic Bcl-2 family members during retinal development and photoreceptor cell death.
Cotter, TG (2004) Transcriptional regulation of pro-apoptotic Bcl-2 family members during retinal development and photoreceptor cell death. Abstract [Details]
(2004)Rectal cancer excision is followed by a profound dendritic cell immunoalteration.
Coffey, JC,Shilling, D,Kavanagh, E,O'Mahony, L,Kirwan, WO,Cotter, TG,Redmond, HP (2004) Rectal cancer excision is followed by a profound dendritic cell immunoalteration. Abstract [Details]
(2004)Novel assessment of the breast cancer proteosome using heat shock protein purification.
Smith, MJ,Shilling, DA,Tither, R,England, K,Kelly, MA,Sheahan, D,Cotter, TG,Redmond, HP (2004) Novel assessment of the breast cancer proteosome using heat shock protein purification. Abstract [Details]
(2004)Mechanism of pericyte apoptosis following glucose exposure.
Browne, JG,Kane, R,Godson, C,Cotter, TG,O'Brien, CJ (2004) Mechanism of pericyte apoptosis following glucose exposure. Abstract [Details]
(2003)PI-3 kinase inhibition protects against perioperative metastatic tumour growth.
Coffey, JC,Wang, JH,Cotter, TG,Redmond, HP (2003) PI-3 kinase inhibition protects against perioperative metastatic tumour growth. Abstract [Details]
(2003)Cytoreductive surgery enhances tumorogenicity by downregulating mitochondrial apoptosis.
Coffey, JC,Wang, JH,Cotter, TG,Redmond, HP (2003) Cytoreductive surgery enhances tumorogenicity by downregulating mitochondrial apoptosis. Abstract [Details]
(2003)Isolation and detection of a pure population of retinal ganglion cells from the adult rat retina by flow immunocytometry.
Caplis, C,O'Brien, C,Cotter, TG (2003) Isolation and detection of a pure population of retinal ganglion cells from the adult rat retina by flow immunocytometry. Abstract [Details]
(2003)Inhibition of phosphatidylinositol T-kinase abrogates tumour acceleration following cytoreductive surgery.
Coffey, JC,Wang, JH,Cotter, TG,Redmond, HP (2003) Inhibition of phosphatidylinositol T-kinase abrogates tumour acceleration following cytoreductive surgery. Abstract [Details]
(1999)Abl and abl mRNA expression in liposarcoma: Correlation with tumor cell differentiation, angiogenesis and extent of apoptosis.
O'Donovan, M,Russell, JM,Cotter, TG,Lawler, M,Fletcher, CDM,O'Leary, JJ,Gaffney, EF (1999) Abl and abl mRNA expression in liposarcoma: Correlation with tumor cell differentiation, angiogenesis and extent of apoptosis. Abstract [Details]
(1998)Selective sensitisation of tumour cells to the induction of apoptosis with inhibitors of PI3-kinase and PKC.
O'Gorman, D,McGahon, A,Cotter, TG (1998) Selective sensitisation of tumour cells to the induction of apoptosis with inhibitors of PI3-kinase and PKC. Abstract [Details]
(1998)p53 mediates breakdown of the anti-apoptotic protein Bcr-Abl in K562 leukaemia cells.
DiBacco, A,Cotter, TG (1998) p53 mediates breakdown of the anti-apoptotic protein Bcr-Abl in K562 leukaemia cells. Abstract [Details]
(1998)Oxidative stress and apoptosis.
Cotter, TG (1998) Oxidative stress and apoptosis. Abstract [Details]
(1998)Expression of the abl oncoprotein in the neovasculature during enchondral ossification and in tumour angiogenesis.
Russell, JM,O'Neill, AJ,Dunne, BM,O'Donovan, M,Gillan, JE,Cotter, TG,Lawler, M,Gaffney, EF (1998) Expression of the abl oncoprotein in the neovasculature during enchondral ossification and in tumour angiogenesis. Abstract [Details]
(1998)Abl expression, angiogenesis, and apoptosis in diffuse gastric adenocarcinoma and liposarcoma.
Russell, JM,Dunne, BM,O'Donovan, M,O'Neill, AJ,Cotter, TG,Lawler, M,Fletcher, CDM,O'Leary, JJ,Gaffney, EF (1998) Abl expression, angiogenesis, and apoptosis in diffuse gastric adenocarcinoma and liposarcoma. Abstract [Details]
(1998)ABL expression in liposarcomas with particular reference to angiogenic tumour microvessels.
Russell, JM,O'Neill, AJ,Dunne, BM,O'Donovan, M,Fletcher, CDM,Cotter, TG,Lawler, M,Gaffney, EF (1998) ABL expression in liposarcomas with particular reference to angiogenic tumour microvessels. Abstract [Details]
(1997)Abl expression in developing human fetal cartilage and chondrosarcoma: Relationship to chondrocyte differentiation and inhibition of apoptosis.
Russell, JM,ODonovan, M,ONeill, AJ,Dunne, BM,Cotter, TG,Gillan, JE,Dervan, PA,Lawler, M,Gaffney, EF (1997) Abl expression in developing human fetal cartilage and chondrosarcoma: Relationship to chondrocyte differentiation and inhibition of apoptosis. Abstract [Details]
(1996)Abl expression in human fetal tissues, spontaneous human tumours and tumour microvessels.
Gaffney, EF,ONeill, AJ,Cotter, TG (1996) Abl expression in human fetal tissues, spontaneous human tumours and tumour microvessels. Abstract [Details]
(1995)PROGRAMMED CELL-DEATH - MAKING FRIENDS WITH DEATH GENES.
COTTER, TG,FERNANDES, R,SAMALI, A,MCGAHON, A (1995) PROGRAMMED CELL-DEATH - MAKING FRIENDS WITH DEATH GENES. Abstract [Details]
‍

Book Reviews

 YearPublication
(2012)Preventing retinal apoptosis - Is there a common therapeutic theme?.
Doonan, F,Groeger, G,Cotter, TG (2012) Preventing retinal apoptosis - Is there a common therapeutic theme?. Book Reviews [DOI] [Details]
(2011)Hydrogen peroxide: a Jekyll and Hyde signalling molecule.
Gough, DR,Cotter, TG (2011) Hydrogen peroxide: a Jekyll and Hyde signalling molecule. Book Reviews [DOI] [Details]
(2009)Apoptosis and cancer: the genesis of a research field.
Cotter, TG (2009) Apoptosis and cancer: the genesis of a research field. Book Reviews [DOI] [Details]
(2009)Hydrogen Peroxide as a Cell-Survival Signaling Molecule.
Groeger, G,Quiney, C,Cotter, TG (2009) Hydrogen Peroxide as a Cell-Survival Signaling Molecule. Book Reviews [DOI] [Details]
(2006)Retinal ganglion cells: dying to survive.
Guerin, MB,McKernan, DP,O'Brien, CJ,Cotter, TG (2006) Retinal ganglion cells: dying to survive. Book Reviews [DOI] [Details]
(2005)Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis.
England, K,Cotter, TG (2005) Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis. Book Reviews [DOI] [Details]
(2004)Apoptosis: A potential therapeutic target for retinal degenerations.
Doonan, F,Cotter, TG (2004) Apoptosis: A potential therapeutic target for retinal degenerations. Book Reviews [Details]
(2004)Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death.
Donovan, M,Cotter, TG (2004) Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Book Reviews [DOI] [Details]
(2003)Live and let die: regulatory mechanisms in Fas-mediated apoptosis.
Curtin, JF,Cotter, TG (2003) Live and let die: regulatory mechanisms in Fas-mediated apoptosis. Book Reviews [DOI] [Details]
(2002)Regulation and measurement of oxidative stress in apoptosis.
Curtin, JF,Donovan, M,Cotter, TG (2002) Regulation and measurement of oxidative stress in apoptosis. Book Reviews [DOI] [Details]
(2001)Signalling apoptosis: a radical approach.
Carmody, RJ,Cotter, TG (2001) Signalling apoptosis: a radical approach. Book Reviews [Details]
(2001)Molecular signals in anti-apoptotic survival pathways.
O'Gorman, DM,Cotter, TG (2001) Molecular signals in anti-apoptotic survival pathways. Book Reviews [Details]
(1997)Functional aspects of apoptosis in hematopoiesis and consequences of failure.
McKenna, SL,Cotter, TG (1997) Functional aspects of apoptosis in hematopoiesis and consequences of failure. Book Reviews [Details]
(1996)Apoptosis - The story so far .
Samali, A,Gorman, AM,Cotter, TG (1996) Apoptosis - The story so far . Book Reviews [Details]
(1995)BCR-ABL - AN ANTI-APOPTOSIS GENE IN CHRONIC MYELOGENOUS LEUKEMIA.
COTTER, TG (1995) BCR-ABL - AN ANTI-APOPTOSIS GENE IN CHRONIC MYELOGENOUS LEUKEMIA. Book Reviews [Details]
‍

Other

 YearPublication
(2006)Ceramide Is The Key Mediator of Oxidative Stress-Induced Retinal Cell Apoptosis.
Cotter, TG, Sanvicens, N; (2006) Ceramide Is The Key Mediator of Oxidative Stress-Induced Retinal Cell Apoptosis. Other [Details]
(1996)Anti-oxidants and apoptosis.
McGowan, AJ,Fernandes, RS,Samali, A,Cotter, TG (1996) Anti-oxidants and apoptosis. Other [Details]
(1997)Abl expression in human fetal and adult tissues, tumours, and tumour microvessels.
ONeill, AJ,Cotter, TG,Russell, JM,Gaffney, EF (1997) Abl expression in human fetal and adult tissues, tumours, and tumour microvessels. Other [Details]
‍

Reviews

 YearPublication
(2013)Redox regulation of protein kinases.
Corcoran, A,Cotter, TG (2013) Redox regulation of protein kinases. Reviews [DOI] [Details]
(2013)Redox-Regulated Growth Factor Survival Signaling.
Woolley, JF,Corcoran, A,Groeger, G,Landry, WD,Cotter, TG (2013) Redox-Regulated Growth Factor Survival Signaling. Reviews [DOI] [Details]
(2013)Recent advances in reactive oxygen species measurement in biological systems.
Woolley, JF,Stanicka, J,Cotter, TG (2013) Recent advances in reactive oxygen species measurement in biological systems. Reviews [DOI] [Details]
(2008)Mechanisms of ROS modulated cell survival during carcinogenesis.
Clerkin, JS,Naughton, R,Quiney, C,Cotter, TG (2008) Mechanisms of ROS modulated cell survival during carcinogenesis. Reviews [DOI] [Details]
‍

Professional Activities

‍

Honours and Awards

 YearTitleAwarding Body
1974College Scholar
1976Pirie-Reid Scholar
1992Royal Irish Academy Senior Visiting Fellowship USA
1992Visiting Professor, Boston, University, USA
1993Visiting Professor, Unversity of Munich, Germany
1996The Irish Research Scientists Association Gold Medal Irish research scientists association
1999Boyle Medal RDS-Irish Times
2002Royal Irish Academy Medal for Biochemistry RIA
2005RIA Membership RIA
‍

Professional Associations

 AssociationFunctionFrom / To
The Biochemical Society *30-DEC-99 / 30-DEC-99
International Society for Haematology *30-DEC-99 / 30-DEC-99
ARVO *30-DEC-99 / 30-DEC-99
ASBMB *30-DEC-99 / 30-DEC-99
‍

Committees

 CommitteeFunctionFrom / To
Scientific Advisory Committee of the Irish Environmental Protection Agency on Genetically Modified Organisms Member1899 / 1899
Irish Area Section of the Biochemical Society Chairman1899 / 1899
Irish Association for Cancer Research President1899 / 1899
Government Commission for Assisted Reproduction Member1899 / 1899
Science Foundation Ireland Board member1899 / 1899
Health Research Board of Ireland Board Member1899 / 1899
Eirx Therapeutics Ltd Board Member1899 / 1899
Luxcel Bioscience Board Member1899 / 1899
Meridian Theatre Company Board Member1899 / 1899
‍

Education

 YearInstitutionQualificationSubject
1976University College Cork BSc
1979Unviersity of Oxford PhDBiochemistry
‍

Journal Activities

 JournalRoleTo / From
Biochemistry 2157701-JAN-02 - 01-JAN-05
Cell Death And Differentiation Editor-
The International Journal Of Developmental Biology Editor-
Journal Of Cell Death Editor-
‍

Teaching Activities

‍

Teaching Interests

Contact details

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School of Biochemistry and Cell Biology

Scoil na Bithcheimice agus na Cillbhitheolaíochta

University College Cork

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