Research Profile

Tommie McCarthy

Biography

Tommie McCarthy is a Professor in Biochemistry in the School of Biochemistry and Cell Biology at University College Cork. Professor McCarthy has a keen interest in human molecular genetics and his research experience spans across the area of human molecular genetics and functional analysis of mutated human genes. Professor McCarthy and his team have made major contributions in the human molecular genetics field to understanding the molecular basis of the life threatening inherited disorder Malignant Hyperthermia (MH) and the associated myopathy Central Core Disease (CCD). Current human molecular genetic projects in Professor McCarthy’s lab include molecular genetic analysis of gene mutations that cause inherited human lipodystrophies with a focus on lipid and cholesterol metabolism and adipocyte development. Collaborative projects include a) initiatives on the genetics of depression and anxiety with Professor Alan Wright (Edinburgh) and Professor Ted Dinan (Psychiatry, UCC) b) Irish surname genetics with Professor William Smyth (Geography, UCC) and Dr. Susan Walsh (Yale, USA) and c) forensic genetics with Dr. Susan Walsh. Professor McCarthy also has a keen interest in molecular genetic technologies. His fundamental and applied research on DNA repair enzymes led to the development of a novel platform for detection of mutations and polymorphisms in DNA.  His recent work on gene reporters has led to the development of a single secreted luciferase reporter assay for promoter analysis. Alongside Dr. Paul Young (also in Biochemistry, UCC), Professor McCarthy is currently building and developing synthetic biology initiatives at UCC.  

Professor McCarthy has more than 55 publications in international peer reviewed journals and several reviews and book chapters. His research has led to five international patent applications (three granted to date) in the DNA characterisation field, some of which have been licensed to third parties for commercial exploitation. Professor McCarthy has over 25 years of experience in competing successfully for research grant funding across several national and international research funding agencies. Professor McCarthy has extensive experience as a peer reviewer for scientific papers and research grants at the national, EU and international level. Professor McCarthy has significant experience in research strategy and planning and technology transfer.  Professor McCarthy also has significant experience in mentoring and supervision of PhD students and has directly supervised over PhD students. Professor McCarthy also has significant experience in career mentoring of undergraduates, postgraduates, postdoctoral fellows and pre-tenure career track fellows.

Professor McCarthy has a keen interest in teaching and teaching methodologies that enhance education, and learning. He has over 25 years of experience in curriculum and course development, course and degree management and course assessment at the undergraduate and postgraduate level. Professor McCarthy served as Director of the BSc degree in Biomedical Science (2004-8) and served as served as Head of Department of Biochemistry from 2000-2008.

Research Interests

Professor McCarthy has a keen interest in human molecular genetics and his research experience spans across the area of human molecular genetics and functional analysis of mutated human genes. Professor McCarthy and his team have made major contributions in the human molecular genetics field to understanding the molecular basis of the life threatening inherited disorder Malignant Hyperthermia (MH) and the associated myopathy Central Core Disease (CCD). Current human molecular genetic projects in Professor McCarthy’s lab include molecular genetic analysis of gene mutations that cause inherited human lipodystrophies with a focus on lipid and cholesterol metabolism and adipocyte development. Collaborative projects include a) initiatives on the genetics of depression and anxiety with Professor Alan Wright (Edinburgh) and Professor Ted Dinan (Psychiatry, UCC) b) Irish surname genetics with Professor William Smyth (Geography, UCC) and Dr. Susan Walsh (Yale, USA) and c) forensic genetics with Dr. Susan Walsh. Professor McCarthy also has a keen interest in molecular genetic technologies. His fundamental and applied research on DNA repair enzymes led to the development of a novel platform for detection of mutations and polymorphisms in DNA.  His recent work on gene reporters has led to the development of a single secreted luciferase reporter assay for promoter analysis. Alongside Dr. Paul Young (also in Biochemistry, UCC), Professor McCarthy is currently building and developing synthetic biology initiatives at UCC.  

Publications

Book Chapters

 YearPublication
(2005)'Molecular and Clinical Genetics of RYR1 Disorders'
McCarthy, TV; Heffron, JJA; Mackrill, J.; (2005) 'Molecular and Clinical Genetics of RYR1 Disorders' In: Ryanodine Receptors: Structure, function, and dysfunction in clinical disease. USA: Springer Science + Business Media. [Details]
(1990)'Molecular Genetics of Malignant Hyperthermia in Malignant Hyperthermia'
McCarthy, TV; Healy, SJM; Lehane, M; Heffron, JJA; Deufel, T; Lehmann-Horn, F; Farrall, M; Johnson, K; (1990) 'Molecular Genetics of Malignant Hyperthermia in Malignant Hyperthermia' In: Neuoromuscular Diseases and Anaesthesia. [Details]

Peer Reviewed Journals

 YearPublication
(2009)''Shotgun immunological' approach for analysis of a complex subcellular system'
Mackrill JJ, England K, Flucher BE, McCarthy TV; (2009) ''Shotgun immunological' approach for analysis of a complex subcellular system'. International Journal of Molecular Medicine, 23 (3):399-405 [Details]
(2009)'Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1beta and IL-8 gene expression'
Beecher C, Daly M, Berry DP, Klostermann K, Flynn J, Meaney W, Hill C, McCarthy TV, Ross RP, Giblin L; (2009) 'Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1beta and IL-8 gene expression'. The Journal of Dairy Research, 76 (3):340-348 [DOI] [Details]
(2005)'Atypical L-type channels are down-regulated in hypoxia'
Callinan L, McCarthy TV, Maulet Y, Mackrill JJ; (2005) 'Atypical L-type channels are down-regulated in hypoxia'. Biochemical Society Transactions, 33 (Pt 5):1137-1139 [DOI] [Details]
(2005)'The 110kDa glutathione transferase of Yarrowia lipolytica is encoded by a homologue of the TEF3 gene from Saccharomyces cerevisiae: cloning, expression, and homology modeling of the recombinant protein'
McGoldrick S, McCarthy TV, Sheehan D; (2005) 'The 110kDa glutathione transferase of Yarrowia lipolytica is encoded by a homologue of the TEF3 gene from Saccharomyces cerevisiae: cloning, expression, and homology modeling of the recombinant protein'. Biochemical and Biophysical Research Communications, 337 (4):1125-1132 [DOI] [Details]
(2004)'Unravelling calcium-release channel gating: clues from a 'hot' disease'
McCarthy TV, Mackrill JJ; (2004) 'Unravelling calcium-release channel gating: clues from a 'hot' disease'. The Biochemical Journal, 380 (Pt 2):1-3 [DOI] [Details]
(2004)'EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion'
Smith LM, Walsh PT, Rüdiger T, Cotter TG, Mc Carthy TV, Marx A, O'Connor R; (2004) 'EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion'. Experimental cell research, 292 (2):295-303   [Details]
(2003)'Activation of ryanodine receptor/Ca2+ release channels downregulates CD38 in the Namalwa B lymphoma'
McCarthy TV, Datar S, Mackrill JJ; (2003) 'Activation of ryanodine receptor/Ca2+ release channels downregulates CD38 in the Namalwa B lymphoma'. FEBS letters, 554 (1-2):133-137   [Details]
(2003)'Characterisation of Archaeglobus fulgidus AlkA hypoxanthine DNA glycosylase activity'
Mansfield C, Kerins SM, McCarthy TV; (2003) 'Characterisation of Archaeglobus fulgidus AlkA hypoxanthine DNA glycosylase activity'. FEBS letters, 540 (1-3):171-175   [Details]
(2003)'Characterization of an endonuclease IV 3'-5' exonuclease activity'
Kerins SM, Collins R, McCarthy TV; (2003) 'Characterization of an endonuclease IV 3'-5' exonuclease activity'. The Journal of Biological Chemistry, 278 (5):3048-3054 [DOI] [Details]
(2001)'Analysis of type 1 ryanodine receptor-12 kDa FK506-binding protein interaction'
Mackrill JJ, O'Driscoll S, Lai FA, McCarthy TV; (2001) 'Analysis of type 1 ryanodine receptor-12 kDa FK506-binding protein interaction'. Biochemical and Biophysical Research Communications, 285 (1):52-57 [DOI] [Details]
(2001)'Rapid detection of the R408W and I65T mutations in phenylketonuria by glycosylase mediated polymorphism detection'
O'Donnell KA, Tighe O, O'Neill C, Naughten E, Mayne PD, McCarthy TV, Vaughan P, Croke DT; (2001) 'Rapid detection of the R408W and I65T mutations in phenylketonuria by glycosylase mediated polymorphism detection'. Human Mutation, 17 (5) [DOI] [Details]
(2001)'Guidelines for Molecular genetic detection of susceptibility to malignant hyperthermia'
Urwyler, A; Deufel, T; McCarthy, TV; West, S;; (2001) 'Guidelines for Molecular genetic detection of susceptibility to malignant hyperthermia'. British Journal of Anaesthia, 86 (*):1-5 [Details]
(2000)'A novel ryanodine receptor mutation and genotype-phenotype correlation in a large malignant hyperthermia New Zealand Maori pedigree'
Brown RL, Pollock AN, Couchman KG, Hodges M, Hutchinson DO, Waaka R, Lynch P, McCarthy TV, Stowell KM; (2000) 'A novel ryanodine receptor mutation and genotype-phenotype correlation in a large malignant hyperthermia New Zealand Maori pedigree'. Gene, 9 (10):1515-1524 [Details]
(2000)'Ryanodine receptor mutations in malignant hyperthermia and central core disease'
McCarthy TV, Quane KA, Lynch PJ; (2000) 'Ryanodine receptor mutations in malignant hyperthermia and central core disease'. Human Mutation, 15 (5):410-417 [DOI] [Details]
(2000)'Genetics and pathogenesis of malignant hyperthermia'
Jrkat-Rott, K; McCarthy, TV; Lynch, PJ; (2000) 'Genetics and pathogenesis of malignant hyperthermia'. Muscle & Nerve, 23 (1):4-17 [Details]
(1999)'Purification, characterization and cDNA cloning of an endo-exonuclease from the basidiomycete fungus Armillaria mellea'
Healy V, Doonan S, McCarthy TV; (1999) 'Purification, characterization and cDNA cloning of an endo-exonuclease from the basidiomycete fungus Armillaria mellea'. The Biochemical Journal, 339 ( Pt 3) :713-720 [Details]
(1999)'IP3-induced Ca2+ release in A7r5 vascular smooth-muscle cells represents a partial emptying of the stores and not an all-or-none Ca2+ release of separate quanta'
Callewaert G, Hill E, McCarthy TV, De Smedt H, Missiaen L, Sipma H, Parys JB, De Smet P; (1999) 'IP3-induced Ca2+ release in A7r5 vascular smooth-muscle cells represents a partial emptying of the stores and not an all-or-none Ca2+ release of separate quanta'. European Journal of Physiology, 437 (5):691-694 [Details]
(1999)'PCR analysis of bisulfite-modified DNA to investigate development variation in micropropagated potatoes (Solanum tuberosum L)'
Joyce, SM; McCarthy, TV; Cassells, AC.; (1999) 'PCR analysis of bisulfite-modified DNA to investigate development variation in micropropagated potatoes (Solanum tuberosum L)'. 42 (*):549-558 [Details]
(1999)'Measurement of resting cytosolic Ca2+ concentrations and Ca2+ store size in HEK-293 cells transfected with malignant hyperthermia or central core disease mutant Ca2+ release channels'
Tong J, McCarthy TV, MacLennan DH; (1999) 'Measurement of resting cytosolic Ca2+ concentrations and Ca2+ store size in HEK-293 cells transfected with malignant hyperthermia or central core disease mutant Ca2+ release channels'. The Journal of Biological Chemistry, 274 (2):693-702 [Details]
(1999)'A mutation in the transmembrane/luminal domain of the ryanodine receptor is associated with abnormal Ca2+ release channel function and severe central core disease'
Lynch PJ, Tong J, Lehane M, Mallet A, Giblin L, Heffron JJ, Vaughan P, Zafra G, MacLennan DH, McCarthy TV; (1999) 'A mutation in the transmembrane/luminal domain of the ryanodine receptor is associated with abnormal Ca2+ release channel function and severe central core disease'. Proceedings of The National Academy of Sciences of The United States of America, 96 (7):4164-4169 [Details]
(1999)'Glycosylase mediated polymorphism detection (GMPD)--a novel process for genetic analysis'
Vaughan P, McCarthy TV; (1999) 'Glycosylase mediated polymorphism detection (GMPD)--a novel process for genetic analysis'. Gene, 14 (5-6):169-175 [Details]
(1999)'The lysine-specific proteinase from Armillaria mellea is a member of a novel class of metalloendopeptidases located in Basidiomycetes'
Healy V, O'Connell J, McCarthy TV, Doonan S; (1999) 'The lysine-specific proteinase from Armillaria mellea is a member of a novel class of metalloendopeptidases located in Basidiomycetes'. Biochemical and Biophysical Research Communications, 262 (1):60-63 [DOI] [Details]
(1998)'A novel process for mutation detection using uracil DNA-glycosylase'
Vaughan P, McCarthy TV; (1998) 'A novel process for mutation detection using uracil DNA-glycosylase'. Nucleic Acids Research, 26 (3):810-815 [Details]
(1998)'Novel mutations at a CpG dinucleotide in the ryanodine receptor in malignant hyperthermia'
Manning BM, Quane KA, Lynch PJ, Urwyler A, Tegazzin V, Krivosic-Horber R, Censier K, Comi G, Adnet P, Wolz W, Lunardi J, Muller CR, McCarthy TV; (1998) 'Novel mutations at a CpG dinucleotide in the ryanodine receptor in malignant hyperthermia'. Human Mutation, 11 (1):45-50 [DOI] [Details]
(1998)'Familial adenomatous polyposis: from bedside to benchside'
O'Sullivan MJ, McCarthy TV, Doyle CT; (1998) 'Familial adenomatous polyposis: from bedside to benchside'. Journal of Clinical Pathology, 109 (5):521-526 [Details]
(1998)'Detection of five novel germline mutations of the APC gene in Irish familial adenomatous polyposis families'
O'Sullivan MJ, Mulcahy TM, Cambell J, O'Suilleabhain CB, Kirwan WO, Doyle CT, McCarthy TV; (1998) 'Detection of five novel germline mutations of the APC gene in Irish familial adenomatous polyposis families'. Human Mutation, Suppl 1 :1-3 [Details]
(1998)'Identification of novel mutations in the ryanodine-receptor gene (RYR1) in malignant hyperthermia: genotype-phenotype correlation'
Manning BM, Quane KA, Ording H, Urwyler A, Tegazzin V, Lehane M, O'Halloran J, Hartung E, Giblin LM, Lynch PJ, Vaughan P, Censier K, Bendixen D, Comi G, Heytens L, Monsieurs K, Fagerlund T, Wolz W, Heffron JJ, Muller CR, McCarthy TV; (1998) 'Identification of novel mutations in the ryanodine-receptor gene (RYR1) in malignant hyperthermia: genotype-phenotype correlation'. American Journal of Human Genetics, 62 (3):599-609 [DOI] [Details]
(1998)'Sequence analysis of DNA randomly amplified from the Saccharomyces cerevisiae genome'
McGrath A, Higgins DG, McCarthy TV; (1998) 'Sequence analysis of DNA randomly amplified from the Saccharomyces cerevisiae genome'. Molecular and Cellular Probes, 12 (6):397-405 [DOI] [Details]
(1998)'A DNA glycosylase-based fingerprint for accurate identification of amplified DNA products and its application in the accurate diagnosis of infectious organisms'
McGrath A, Vaughan P, McCarthy TV; (1998) 'A DNA glycosylase-based fingerprint for accurate identification of amplified DNA products and its application in the accurate diagnosis of infectious organisms'. Analytical Biochemistry, 259 (2):288-292 [DOI] [Details]
(1997)'Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease'
Tong J, Oyamada H, Demaurex N, Grinstein S, McCarthy TV, MacLennan DH; (1997) 'Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease'. The Journal of Biological Chemistry, 272 (42):26332-26339 [Details]
(1997)'Detection of a novel mutation at amino acid position 614 in the ryanodine receptor in malignant hyperthermia'
Quane KA, Ording H, Keating KE, Manning BM, Heine R, Bendixen D, Berg K, Krivosic-Horber R, Lehmann-Horn F, Fagerlund T, McCarthy TV; (1997) 'Detection of a novel mutation at amino acid position 614 in the ryanodine receptor in malignant hyperthermia'. British Journal of Anaesthesia, 79 (3):332-337 [Details]
(1997)'DNA repair in thermophiles: investigation of DNA-binding activities in Thermus aquaticus'
O'Grady GM, McCarthy TV, Vaughan PM; (1997) 'DNA repair in thermophiles: investigation of DNA-binding activities in Thermus aquaticus'. Biochemical Society Transactions, 25 (1):319-322 [Details]
(1997)'Detection of a novel mutation in the ryanodine receptor gene in an Irish malignant hyperthermia pedigree: correlation of the IVCT response with the affected and unaffected haplotypes'
Keating KE, Giblin L, Lynch PJ, Quane KA, Lehane M, Heffron JJ, McCarthy TV; (1997) 'Detection of a novel mutation in the ryanodine receptor gene in an Irish malignant hyperthermia pedigree: correlation of the IVCT response with the affected and unaffected haplotypes'. Gene, 34 (4):291-296 [Details]
(1996)'Calmodulin sensitivity of the sarcoplasmic reticulum ryanodine receptor from normal and malignant-hyperthermia-susceptible muscle'
O'Driscoll S, McCarthy TV, Eichinger HM, Erhardt W, Lehmann-Horn F, Herrmann-Frank A; (1996) 'Calmodulin sensitivity of the sarcoplasmic reticulum ryanodine receptor from normal and malignant-hyperthermia-susceptible muscle'. The Biochemical Journal, 319 ( Pt 2) :421-426 [Details]
(1996)'Diagnosis of malignant hyperthermia: a comparison of the in vitro contracture test with the molecular genetic diagnosis in a large pedigree'
Healy JM, Quane KA, Keating KE, Lehane M, Heffron JJ, McCarthy TV; (1996) 'Diagnosis of malignant hyperthermia: a comparison of the in vitro contracture test with the molecular genetic diagnosis in a large pedigree'. Gene, 33 (1):18-24 [Details]
(1995)'Haplotype analysis of the BYR1 gene in malignant hyperthermia and central core disease'
Quane KA, Keating KE, Healy JM, Heffron JJ, Lehane M, Krivosic-Horber R, Heytens L, McCarthy TV; (1995) 'Haplotype analysis of the BYR1 gene in malignant hyperthermia and central core disease'. Biochemical Society Transactions, 23 (2) [Details]
(1995)'Mutation screening of dihydropyridine receptor gamma subunit cDNA from malignant hyperthermia susceptible patients'
Lynch PJ, Couch FJ, Gregg RG, Powers PA, Hogan K, McCarthy TV; (1995) 'Mutation screening of dihydropyridine receptor gamma subunit cDNA from malignant hyperthermia susceptible patients'. Biochemical Society Transactions, 23 (2) [Details]
(1995)'Adenomatous polyposis coli gene mutations in Irish pedigrees with familial adenomatous polyposis'
O'Sullivan MJ, Mulcahy T, Suilleabhain CB, Kirwan WO, Doyle CT, McCarthy TV; (1995) 'Adenomatous polyposis coli gene mutations in Irish pedigrees with familial adenomatous polyposis'. Biochemical Society Transactions, 23 (2) [Details]
(1994)'Mutation screening of the RYR1 gene in malignant hyperthermia: detection of a novel Tyr to Ser mutation in a pedigree with associated central cores'
Quane KA, Keating KE, Healy JM, Manning BM, Krivosic-Horber R, Krivosic I, Monnier N, Lunardi J, McCarthy TV; (1994) 'Mutation screening of the RYR1 gene in malignant hyperthermia: detection of a novel Tyr to Ser mutation in a pedigree with associated central cores'. Genomics, 23 (1):236-239 [DOI] [Details]
(1994)'Detection of a novel common mutation in the ryanodine receptor gene in malignant hyperthermia: implications for diagnosis and heterogeneity studies'
Quane, KA; Keating, KE; Manning, BM; Healy, JMS; Monsieurs, K; Heffron, JJA; Lehane, M; Hyetens, L; Krisosic-Horber, R; Adnet, P; Ellis, FR; Monnier, N; Lunardi, J; McCarthy, TV.; (1994) 'Detection of a novel common mutation in the ryanodine receptor gene in malignant hyperthermia: implications for diagnosis and heterogeneity studies'. Human Molecular Genetics, 3 (*):471-476 [Details]
(1994)'The EUROGEM map of human chromosome 1'
Kumar-Singh R, Wang H, Carritt B, Kruse TA, McCarthy TV, Vergnaud G, Humphries P; (1994) 'The EUROGEM map of human chromosome 1'. Gene, 2 (3):204-205 [Details]
(1993)'A shuttle vector system for the rapid detection of recombination in murine cells'
Fanning LJ, McCarthy TV; (1993) 'A shuttle vector system for the rapid detection of recombination in murine cells'. Nucleic Acids Research, 21 (23):5530-5531 [Details]
(1992)'Dinucleotide repeat polymorphism at the D10S179 locus'
Hogan K, Gregg RG, Couch FJ, McCarthy TV; (1992) 'Dinucleotide repeat polymorphism at the D10S179 locus'. Nucleic Acids Research, 20 (6) [Details]
(1992)'Dinucleotide repeat polymorphism at the D10S178 locus'
Couch FJ, Gregg RG, McCarthy TV, Hogan K; (1992) 'Dinucleotide repeat polymorphism at the D10S178 locus'. Nucleic Acids Research, 20 (6) [Details]
(1991)'Analysis of expression of the human ryanodine receptor gene in malignant hyperthermia skeletal muscle tissue'
Gillian CM, Heffron JJ, Lehane M, Marks A, McCarthy TV; (1991) 'Analysis of expression of the human ryanodine receptor gene in malignant hyperthermia skeletal muscle tissue'. Biochemical Society Transactions, 19 (1) [Details]
(1991)'Diagnosis of susceptibility to malignant hyperthermia with flanking DNA markers'
Healy SJ, Heffron JJ, Lehane M, Bradley DG, Johnson K, McCarthy TV; (1991) 'Diagnosis of susceptibility to malignant hyperthermia with flanking DNA markers'. BMJ (Clinical Research Ed.), 303 (6812):1225-1228 [Details]
(1991)'Dinucleotide repeat polymorphism at the RYR1 locus (19q13.1)'
Couch FJ, Hogan K, McCarthy TV, Gregg RG; (1991) 'Dinucleotide repeat polymorphism at the RYR1 locus (19q13.1)'. Nucleic Acids Research, 19 (18) [Details]
(1991)'Dinucleotide repeat polymorphism at the D8S161 locus'
Couch FJ, McCarthy TV, Gregg RG, Hogan K; (1991) 'Dinucleotide repeat polymorphism at the D8S161 locus'. Nucleic Acids Research, 19 (18) [Details]
(1991)'Dinucleotide repeat polymorphism at the D17S518 locus'
Couch FJ, McCarthy TV, Gregg RG, Hogan K; (1991) 'Dinucleotide repeat polymorphism at the D17S518 locus'. Nucleic Acids Research, 19 (18) [Details]
(1990)'Class-switch recombination in extrachromosomal DNA substrates in murine pre-B-cells'
Fanning LJ, O'Regan E, McCarthy S, McCarthy TV; (1990) 'Class-switch recombination in extrachromosomal DNA substrates in murine pre-B-cells'. Biochemical Society Transactions, 18 (2):356-357 [Details]
(1990)'Recent developments in the molecular genetics of malignant hyperthermia: implications for future diagnosis at the DNA level'
McCarthy TV, Healy JM, Lehane M, Heffron JJ; (1990) 'Recent developments in the molecular genetics of malignant hyperthermia: implications for future diagnosis at the DNA level'. Acta Anaesthesiologica Belgica, 41 (2):107-112 [Details]
(1990)'Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-13.2'
McCarthy TV, Healy JM, Heffron JJ, Lehane M, Deufel T, Lehmann-Horn F, Farrall M, Johnson K; (1990) 'Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-13.2'. Nature, 343 (6258):562-564 [DOI] [Details]
(1990)'Current views of the molecular basis of the malignant hyperthermia syndrome'
Heffron JJ, McCarthy TV; (1990) 'Current views of the molecular basis of the malignant hyperthermia syndrome'. Acta Anaesthesiologica Belgica, 41 (2):73-78 [Details]
(1990)'Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-q13.2'
Healy JM, Lehane M, Heffron JJ, Farrell M, Johnson K, McCarthy TV; (1990) 'Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-q13.2'. Biochemical Society Transactions, 18 (2) [Details]
(1986)'The intracellular signal for induction of resistance to alkylating agents in E. coli'
Teo I, Sedgwick B, Kilpatrick MW, McCarthy TV, Lindahl T; (1986) 'The intracellular signal for induction of resistance to alkylating agents in E. coli'. Cell, 45 (2):315-324 [Details]
(1985)'Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli'
McCarthy TV, Lindahl T; (1985) 'Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli'. Nucleic Acids Research, 13 (8):2683-2698 [Details]
(1984)'Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli'
McCarthy TV, Karran P, Lindahl T; (1984) 'Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli'. The Embo Journal, 3 (3):545-550 [Details]
(2007)'Microsatellite variation in cod Gadus morhua throughout its geographic range'
O'Leary, D. B.,Coughlan, J.,Dillane, E.,McCarthy, T. V.,Cross, T. F.; (2007) 'Microsatellite variation in cod Gadus morhua throughout its geographic range'. Journal of Fish Biology, 70 :310-335   [Details]
(2003)'Purification and characterization of Thermus thermophilus UvrD'
Collins, Ruairi,McCarthy, Tommie; (2003) 'Purification and characterization of Thermus thermophilus UvrD'. Extremophiles, 7 (1):35-41   [Details]

Encyclopedia Entries

 YearPublication
(2008)Central Core and Multi-Minicore Disease, Encyclopedia of Molecular Mechanisms of Disease.
McCarthy T.V.; (2008) Central Core and Multi-Minicore Disease, Encyclopedia of Molecular Mechanisms of Disease. Encyclopedia Entries [Details]
(2008)Malignant Hyperthermia, Encyclopedia of Molecular Mechanisms of Disease.
McCarthy T.V.; (2008) Malignant Hyperthermia, Encyclopedia of Molecular Mechanisms of Disease. Encyclopedia Entries [Details]
(2006)Malignant Hyperthermia, Nature Encyclopedia of the Human Genome.
McCarthy T.V.; (2006) Malignant Hyperthermia, Nature Encyclopedia of the Human Genome. Encyclopedia Entries [Details]

Professional Activities

Patents

 Patent NumberTitleInventorGranted
PCT/IE 99/00012HLA linked pre-eclampsia and miscarriage susceptibility gene. 30-DEC-99
PCT/IE 01/00139Method for the amplication and optional characterisation of nucleic acids. McCarthy, T.V and Collins R.01-NOV-06
2002/0544Method for the Characterisation of nucleic acid molecules McCarthy, T.V and Vaughan P.01-FEB-07
PCT/IE 95/00067Glycosylase mediated mutation detection of nucleotide sequences at candidate loci 30-DEC-99

Employment

 EmployerPositionFrom / To
University College Cork Senior Lecturer in Biochemistry01-JAN-95 / 01-JAN-00
University College Cork Associate Professor in Biochemistry01-JAN-00 / 01-JAN-08
University College Cork Head of Department01-JAN-00 / 01-JAN-08

Education

 YearInstituionQualificationSubject
1982National University of Ireland, Galway BSc Hons, (NUI,Galway)Not Specified
1985ICRF University College London PhDUnknown

Teaching Activities

Teaching Interests

Molecular Biology, Human Molecular Genetics, DNA Forensics

Contact details

  • Tommie McCarthy
    Professor (Scale 2)
  • t.mccarthy@ucc.ie
  • Biochemistry & Cell Biology
    School of Biochemistry and Cell Biology
    Western Gateway Building
    University College Cork
  • +353 21 420 5436

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School of Biochemistry and Cell Biology

Scoil na Bithcheimice agus na Cillbhitheolaíochta

University College Cork, Western Road, Cork.

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