BIOGRAPHY
I am a principal investigator in the UCC Biosciences Research Institute.
Research Interests
Maternal-Fetal Interactions: Evolution, Mechanisms & Disease
One of our major interests is in understanding aspects of the evolutionary genetics and physiological mechanisms underlying normal and pathological pregnancy in the mouse and human. Currently, we are investigating the function of the Pregnancy-specific glycoprotein (PSG) multigene family (http://www.med.uni-muenchen.de/cea/) using a variety of approaches, including bioinformatics and biochemical approaches, and mouse genome manipulation by transgenesis and gene targeting. We are developing novel transgenic techniques in mice to manipulate placental function in vivo using inducible gene promoters expressed in various trophoblast cell lineages. In collaboration with Prof. T.V. McCarthy, are initiating genetic investigations of human reproductive disorders, which will identify candidate genes for functional analysis in mouse genetic models. We have an ongoing interest in genomic imprinting and in imprinted gene evolution and function (http://www.mgu.har.mrc.ac.uk/imprinting/imprinting.html) , particularly in relation to placental growth in normal pregnancy, and in reproductive disorders such as IUGR and preeclampsia.
Publications
Book Chapters
| Year | Publication | |
|---|---|---|
| (1996) | 'The imprinted insulin-like growth factor 2 gene' Feil R, Moore TF, Oswald J, Walter J, Sun F, Reik W; (1996) 'The imprinted insulin-like growth factor 2 gene' In: Genomic Imprinting in Mammals: Frontiers in Molecular Biology. Unknown: IRL Press/OUP. [Details] |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2013) | 'Pregnancy-specific glycoproteins bind integrin αIIbβ3 and inhibit the platelet-fibrinogen interaction' Shanley DK, Kiely PA, Golla K, Allen S, Martin K, O'Riordan RT, Ball M, Aplin JD, Singer BB, Caplice N, Moran N, Moore T (2013) 'Pregnancy-specific glycoproteins bind integrin αIIbβ3 and inhibit the platelet-fibrinogen interaction' [DOI] [Details] | |
| (2005) | 'Optical oxygen micro-respirometry as a platform for environmental toxicology and animal model studies' O’MAHONY, F.C., O’DONOVAN, C., HYNES, J., MOORE, T., DAVENPORT, J & PAPKOVSKY, D.B.; (2005) 'Optical oxygen micro-respirometry as a platform for environmental toxicology and animal model studies' [Details] | |
| (2009) | 'Expression of pleiotrophin and its receptors in human placenta suggests roles in trophoblast life cycle and angiogenesis' Ball M, Carmody M, Wynne F, Dockery P, Aigner A, Cameron I, Higgins J, Smith SD, Aplin JD, Moore T; (2009) 'Expression of pleiotrophin and its receptors in human placenta suggests roles in trophoblast life cycle and angiogenesis' [DOI] [Details] | |
| (2008) | 'Evolutionary Theories of Imprinting - Enough Already!' Moore, T, Mills, W; (2008) 'Evolutionary Theories of Imprinting - Enough Already!' [Details] | |
| (2008) | 'Genetic Conflict and Imprinting' Moore, Tom; (2008) 'Genetic Conflict and Imprinting' [Details] | |
| (2006) | 'Development of A Respirometric Biochip For Embryo Assessment' O'Donovan, C, Twomey, E, Alderman, J, Moore, T, Papkovsky, D; (2006) 'Development of A Respirometric Biochip For Embryo Assessment' [DOI] [Details] | |
| (2006) | 'Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature' Wynne F, Ball M, McLellan AS, Dockery P, Zimmermann W, Moore T; (2006) 'Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature' [DOI] [Details] | |
| (2006) | 'Epigenetics and imprinting of the trophoblast -- a workshop report' Ferguson-Smith AC, Moore T, Detmar J, Lewis A, Hemberger M, Jammes H, Kelsey G, Roberts CT, Jones H, Constancia M; (2006) 'Epigenetics and imprinting of the trophoblast -- a workshop report' [DOI] [Details] | |
| (2006) | 'Evolution of mammalian X chromosome-linked imprinting' Mills W, Moore T; (2006) 'Evolution of mammalian X chromosome-linked imprinting' [DOI] [Details] | |
| (2005) | 'Conservation of pregnancy-specific glycoprotein (PSG) N domains following independent expansions of the gene families in rodents and primates' McLellan AS, Zimmermann W, Moore T; (2005) 'Conservation of pregnancy-specific glycoprotein (PSG) N domains following independent expansions of the gene families in rodents and primates' [DOI] [Details] | |
| (2005) | 'Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus' McLellan AS, Fischer B, Dveksler G, Hori T, Wynne F, Ball M, Okumura K, Moore T, Zimmermann W; (2005) 'Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus' [DOI] [Details] | |
| (2005) | 'Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family' Zebhauser R, Kammerer R, Eisenried A, McLellan A, Moore T, Zimmermann W; (2005) 'Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family' [DOI] [Details] | |
| (2005) | 'Explaining the X-linkage bias of placentally expressed genes' Moore T, McLellan A, Wynne F, Dockery P; (2005) 'Explaining the X-linkage bias of placentally expressed genes' [DOI] [Details] | |
| (2004) | 'An abundant placental transcript containing an IAP-LTR is allelic to mouse pregnance-specific glycoprotein 23 (Psg23):cloning and genetic analysis' Ball, M; McLellan, A; Collins, B; Coadwell, J; Stewart, F; Moore, T.; (2004) 'An abundant placental transcript containing an IAP-LTR is allelic to mouse pregnance-specific glycoprotein 23 (Psg23):cloning and genetic analysis' [Details] | |
| (2004) | 'Maternally and paternally silenced imprinted genes differ in their intron content' Fahey ME, Mills W, Higgins DG, Moore T; (2004) 'Maternally and paternally silenced imprinted genes differ in their intron content' [DOI] [Details] | |
| (2004) | 'Complex regulation and nuclear localization of JRK protein' Waldron R, Moore T; (2004) 'Complex regulation and nuclear localization of JRK protein' [DOI] [Details] | |
| (2004) | 'Kaguya, the first parthenogenetic mammal - engineering triumph or lottery winner?' Moore T, Ball M; (2004) 'Kaguya, the first parthenogenetic mammal - engineering triumph or lottery winner?' [DOI] [Details] | |
| (2004) | 'Polyandry, life-history trade-offs and the evolution of imprinting at Mendelian loci' Mills W, Moore T; (2004) 'Polyandry, life-history trade-offs and the evolution of imprinting at Mendelian loci' [DOI] [Details] | |
| (2003) | 'Genetic conflict and imprinting' Moore T; (2003) 'Genetic conflict and imprinting' [Details] | |
| (2002) | 'Overlapping antisense transcription in the human genome' Fahey, ME; Moore, TF, Higgins, DG; (2002) 'Overlapping antisense transcription in the human genome' [Details] | |
| (2002) | 'Marsupial sperm pairing: a case of 'sticky' green beards?' Moore, T; Moore, HD; (2002) 'Marsupial sperm pairing: a case of 'sticky' green beards?' [Details] | |
| (2001) | 'Genetic conflict, genomic imprinting and establishment of the epigenotype in relation to growth' Moore T; (2001) 'Genetic conflict, genomic imprinting and establishment of the epigenotype in relation to growth' [Details] | |
| (2001) | 'Polymorphism analysis of JRK/JH8, the human homologue of mouse jerky, and description of a rare mutation in a case of CAE evolving to JME' Moore T, Hecquet S, McLellann A, Ville D, Grid D, Picard F, Moulard B, Asherson P, Makoff AJ, McCormick D, Nashef L, Froguel P, Arzimanoglou A, LeGuern E, Bailleul B; (2001) 'Polymorphism analysis of JRK/JH8, the human homologue of mouse jerky, and description of a rare mutation in a case of CAE evolving to JME' [Details] | |
| (2001) | 'Southern analysis using methyl-sensitive restriction enzymes' Moore T; (2001) 'Southern analysis using methyl-sensitive restriction enzymes' [DOI] [Details] | |
| (2000) | 'Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19' Constância M, Dean W, Lopes S, Moore T, Kelsey G, Reik W; (2000) 'Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19' [DOI] [Details] | |
| (1999) | 'Imprinting and monogamy' Moore T, Mills W; (1999) 'Imprinting and monogamy' [DOI] [Details] | |
| (1998) | 'Syntenic organisation of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5' Paulsen, M; Davies, KR; Bowden, LM, Villar, AJ; Franck, O; Fuermann, M; Dean, WL, Moore, TF; Rodrigues, N; Davies, KE, Hu, RJ; Feinberg, AP, Maher, ER; Reik, W; Walter, J; (1998) 'Syntenic organisation of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5' [Details] | |
| (1998) | 'Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes' Dean W, Bowden L, Aitchison A, Klose J, Moore T, Meneses JJ, Reik W, Feil R; (1998) 'Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes' [Details] | |
| (1998) | 'Commentary on Epigenetic inheritance in evolution' Moore T; (1998) 'Commentary on Epigenetic inheritance in evolution' [Details] | |
| (1998) | 'Stranger than fiction. Book Review of 'Epigenetics'' Moore T; (1998) 'Stranger than fiction. Book Review of 'Epigenetics'' [Details] | |
| (1997) | 'From Birds and Bees to Babies? Can theories on genetic conflict aid the clinician?' Moore, T; Collins, B; (1997) 'From Birds and Bees to Babies? Can theories on genetic conflict aid the clinician?' [Details] | |
| (1997) | 'Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2' Moore T, Constancia M, Zubair M, Bailleul B, Feil R, Sasaki H, Reik W; (1997) 'Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2' [Details] | |
| (1996) | 'Genetic conflict in early development: parental imprinting in normal and abnormal growth' Moore, T; Reik, W; (1996) 'Genetic conflict in early development: parental imprinting in normal and abnormal growth' [Details] | |
| (1996) | 'Imprinted genes have few and small introns' Hurst LD, McVean G, Moore T; (1996) 'Imprinted genes have few and small introns' [DOI] [Details] | |
| (1996) | 'Regulation of Igf2 imprinting in development and disease' Reik W, Bowden L, Constancia M, Dean W, Feil R, Forné T, Kelsey G, Maher E, Moore T, Sun FL, Walter J; (1996) 'Regulation of Igf2 imprinting in development and disease' [Details] | |
| (1996) | 'Genomic evolution in mice and men: imprinted genes have little intronic content' McVean GT, Hurst LD, Moore T; (1996) 'Genomic evolution in mice and men: imprinted genes have little intronic content' [DOI] [Details] | |
| (1996) | 'Nucleotide sequence of a 28-kb mouse genomic region comprising the imprinted Igf2 gene' Shimozaki K, Zubair M, Aoki N, Ohta K, Hatano N, Moore T, Feil R, Constancia M, Reik W, Rotwein P, Sasaki H; (1996) 'Nucleotide sequence of a 28-kb mouse genomic region comprising the imprinted Igf2 gene' [Details] | |
| (1995) | 'Imprinted Genes, allelic methylation, and imprinting modifiers of methylation' Reik W, Feil R, Allen ND, Moore T, Walter J.; (1995) 'Imprinted Genes, allelic methylation, and imprinting modifiers of methylation' [Details] | |
| (1995) | 'Genetic conflict and evolution of mammalian X-chromosome inactivation' Moore T, Hurst LD, Reik W; (1995) 'Genetic conflict and evolution of mammalian X-chromosome inactivation' [DOI] [Details] | |
| (1994) | 'Imprinting in the region of the Igf2 gene: physiological and pathological control' Reik W, Feil R, Allen ND, Moore T, Walter J, Brown K.; (1994) 'Imprinting in the region of the Igf2 gene: physiological and pathological control' [Details] | |
| (1994) | 'Refusing the ovarian time bomb' Moore T; (1994) 'Refusing the ovarian time bomb' [Details] | |
| (1992) | 'Imprinting of Phosphoribosyltransferases during preimplantation development of the mouse mutant, Hprtb-m3' Moore T, Whittingham D.; (1992) 'Imprinting of Phosphoribosyltransferases during preimplantation development of the mouse mutant, Hprtb-m3' [Details] | |
| (1992) | 'Failure to detect age-related reactivation at the Hprt Locus' Moore T, Whittingham D; (1992) 'Failure to detect age-related reactivation at the Hprt Locus' [Details] | |
| (1991) | 'Genomic imprinting in mamalian development: a parental tug-of-war' Moore, T; Haig, D; (1991) 'Genomic imprinting in mamalian development: a parental tug-of-war' [Details] |
Conference Contributions
| Year | Publication | |
|---|---|---|
| (2008) | European Behavioural Pharmacology Society, Thomas Francis Moore; (2008) none. [Conference Organising Committee Member], European Behavioural Pharmacology Society, University College Cork, Cork, Ireland , 25-AUG-08 - 27-AUG-08 | |
| (2006) | Microsat 2006, Thomas Francis Moore; (2006) None. [Oral Presentation], Microsat 2006, Budapest, Hungary , 01-SEP-06 - 01-SEP-06 | |
| (2005) | Research Seminar, Mie University, Thomas Francis Moore; (2005) None. [Oral Presentation], Research Seminar, Mie University, Japan , 01-OCT-05 - 01-OCT-05 | |
| (2005) | BRAIN Workshop on Mammalian oogenesis and epigenetic modification, Thomas Francis Moore; (2005) None. [Oral Presentation], BRAIN Workshop on Mammalian oogenesis and epigenetic modification, Chiba, Japan , 01-OCT-05 - 01-OCT-05 | |
| (2005) | World Congress on Phychiatric Genetics XIII, Thomas Francis Moore; (2005) None. [Oral Presentation], World Congress on Phychiatric Genetics XIII, Boston, USA , 01-OCT-05 - 01-OCT-05 | |
| (2005) | 15th Annual International CEA Symposium, Thomas Francis Moore; (2005) None. [Oral Presentation], 15th Annual International CEA Symposium, Berlin, Germany , 01-JUL-05 - 01-JUL-05 | |
| (2003) | 14th International CEA Symposium, Thomas Francis Moore; (2003) None. [Oral Presentation], 14th International CEA Symposium, Munich, Germany , 01-AUG-03 - 01-AUG-03 | |
| (2000) | BSAS International Symposium on Early Regulation of Mammalian Development, Thomas Francis Moore; (2000) None. [Oral Presentation], BSAS International Symposium on Early Regulation of Mammalian Development, Aberdeen, Scotland , 01-SEP-00 - 01-SEP-00 | |
| (2000) | 191st Meeting of the Society for Endocrinology, Thomas Francis Moore; (2000) None. [Oral Presentation], 191st Meeting of the Society for Endocrinology, London, United Kingdom , 01-NOV-00 - 01-NOV-00 | |
| (1999) | 15th Annual Meeting of the European Society of Human Reproduction and Embryology, Thomas Francis Moore; (1999) None. [Oral Presentation], 15th Annual Meeting of the European Society of Human Reproduction and Embryology, Tours, France , 01-JUN-99 - 01-JUN-99 |
Book Review
| Year | Publication | |
|---|---|---|
| (2009) | Book Review: Alternative Pathways in Science and Industry: Activism, Innovation and the Environment in an Era of Globalization. Moore, A.; (2009) Book Review: Alternative Pathways in Science and Industry: Activism, Innovation and the Environment in an Era of Globalization. Book Reviews [Details] | |
| (2009) | Book Review: Political Theory and the Ecological Challenge. Moore, A.; (2009) Book Review: Political Theory and the Ecological Challenge. Book Reviews [Details] |
Review Articles
| Year | Publication | |
|---|---|---|
| (2010) | Review Article: Beyond Participation: Opening Up Political Theory in STS. Moore, Alfred; (2010) Review Article: Beyond Participation: Opening Up Political Theory in STS. Social Studies of Science: Review Articles [Details] |
Professional Activities
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 1993 | Lloyds of London Tercentrary Foundation Fellowship | ||
| 1995 | Babraham Research Fellowship | ||
| 1986 | MSc with Distinction, University of London | ||
| 2000 | Wellcome Trust / HRB 'New Blood' Research Fellowship | ||
| 1988 | Action Research Training Fellowship |
Associations
| Assocation | Function | From / To | |
|---|---|---|---|
| Royal College of Veterinary Surgeons | Member | 30-DEC-99 / 30-DEC-99 | |
| Society for Reproduction and Fertility | Member | 30-DEC-99 / 30-DEC-99 | |
| Laboratory Animal Science Association | Member | 30-DEC-99 / 30-DEC-99 | |
| International Society for Psychiatric Genetics | Member | 30-DEC-99 / 30-DEC-99 | |
| Irish Society of Human Genetics | Member | / |
Patents
| Patent Number | Title | Inventor | Granted | |
|---|---|---|---|---|
| * | Jerky protein in Alzheimer's disease | Thomas Francis Moore | 01-MAY-07 | |
| * | A Method for Screening for Autism and related disorders. | Thomas Francis Moore | 11-SEP-03 |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| Health Research Board Post-Doctoral Fellowships Panel | Member | 1899 / 1899 | |
| Health Research Board Project Grants Committee (Molecular Biology) | Member | 1899 / 1899 | |
| Enterprise Ireland / Science Foundation Ireland Basic Research Grants Scheme | Member | 1899 / 1899 | |
| Working Party of Commission for Assisted Human Reproduction | Member | 1899 / 1899 | |
| Editorial Board Member of Journal 'Reproduction' | Member | 1899 / 1899 | |
| Health Research Board Project Grants Committee (Endocrinology & Reproduction) | Member | 1899 / 1899 | |
| Enterprise Ireland Proof of Concept Grant | Member | 1899 / 1899 | |
| PhD External Examiner at University of Bath, University of Cambridge | Member | 1899 / 1899 | |
| UCC Animal Ethics and Experimentation Committee | Member | 1899 / 1899 | |
| UCD College of Life Sciences Promotion Review Panel (Senior Lecturer) 2006 | Member | 1899 / 1899 |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| SmithKline & French Research Ltd., UK | Veterinary Clinician (Part-time) | 01-JAN-87 / 31-DEC-88 | |
| Babraham Institute, Cambridge, UK | Senior Scientist and Research Fellow | 01-JAN-93 / 01-JAN-99 | |
| University College Cork | Senior lecturer & principal investigator | 01-JAN-00 / 30-DEC-99 |
Education
| Year | Instituion | Qualification | Subject | |
|---|---|---|---|---|
| 1984 | University College Dublin, Ireland | Veterinary Medical Doctor | ||
| 1992 | University of London | Doctor of Philosophy | ||
| 1986 | University of London, UK | Master of Science |
Reviews
| Journal | Role | |
|---|---|---|
| Reproduction | Editor |
Teaching Activities
Teaching Interests
Contact details
- Thomas F Moore
Senior Lecturer - t.moore@ucc.ie
- Biochemistry
University College Cork
Cork
Ireland - +353-21-490-3000
- +353 21 490 1339