Lecturer
Chemistry
University College Cork
Cork,
Ireland

T: +353 21 490 1695
F: +353 21 427 1656
E: f.mccarthy@ucc.ie

Florence McCarthy graduated from the School of Pharmacy, University of Sunderland, UK winning the Pfizer prize for Excellence in Medicinal Chemistry. After a year of registration to the Royal Pharmaceutical Society of Great Britain register as a pharmacist in Glasgow, his subsequent PhD was undertaken in Medicinal Chemistry with Prof. Paul Groundwater at the University of Sunderland and entitled "Synthesis of Novel Ellipticines as Molecular Probes and DNA Binders" funded by the EPSRC. 

In 2001, Dr. McCarthy joined Prof. Bill Denny at the Auckland Cancer Society Research Centre (ACSRC), University of Auckland, New Zealand in conjunction with Pfizer Global Research and Development working on inhibitors of the Wee1 and Chk1 checkpoint kinases and the ErbB kinase inhibitor programme. On his return to Ireland, he joined UCC as a part-time Lecturer in the School of Pharmacy and the Department of Chemistry in 2003 before being made permanent in the Department of Chemistry in 2005.

Currently, Dr. McCarthy leads a team of researchers in medicinal and pharmaceutical chemistry investigating the synthesis and evaluation of diverse bioactive molecules from steroids to complex heterocycles. Key to the approach of the group is the development of novel molecules for the treatment of diseases such as cancer and HIV and to this end, lead compounds are devised and synthesised to address a particular receptor in the body. Once the synthesised molecules have been validated these are taken forward (both in-house and in collaboration) toward biological evaluation. This drug discovery approach has so far yielded many interesting publications concerning the synthesis of novel heterocycles and the relationship of these compounds to biological processes.

He is a Principal investigator in the Analytical and Biological Chemistry Research Facility (ABCRF) and also runs the ABCRF mass spectrometry laboratory providing LCMS services to most of the multinational pharmaceutical corporations in Ireland, as well as within UCC and to many other third level institutions.

Dr. McCarthy is currently module coordinator for CM4108, CM4109, PF1101 and PF3102 on the B.Sc. Chemistry, B.Sc. Chemistry of Pharmaceutical Chemistry and B.Sc. Pharmacy degree programmes and chairs the Staff Student Committee for the Department of Chemistry.

Research Interests

Dr. McCarthy currently leads a group of 7 researchers (1 post-doctoral researcher and 6 PhD students) as well as various visiting students from Ireland, UK and France in the field of drug discovery. Key to the approach of the group is to identify key novel compounds with interesting potential biology and devise valid routes to their synthesis. Biological evaluation of the compounds produced is undertaken both in-house and via collaboration with researchers in Ireland and abroad.

The current focus of the group centres on the following:

Indole and carbazole chemistry and their heterocyclic variants.Identification of new molecular templates for drug discovery.Ellipticine derivatives and their mechanism of biological effect.Erb B, Wee 1, and Chk 1 kinase inhibitors for the treatment of cancer.  Phytosterols and the toxicity of their oxygenated products.Specific interests in molecular modelling and mass spectrometry and their application to medicinal chemistry.Utilisation of LCMS in the improvement of pharmaceutical process and impurity profiling.

The group is funded by the following partners: Irish Research Council for Science, Engineering and Technology (IRCSET), Department of Agriculture, Fisheries and Food (DAFF), PRTLI, Enterprise Ireland and various pharmaceutical companies.
 
Dr. McCarthy also runs the ABCRF mass spectrometry service laboratory offering analytical services to industry and other third level institutions.

Book Chapters

YearPublication
(2012)'Emerging targets in the bioactivity of Ellipticines and derivatives'
E.C. O’ Sullivan, C.M. Miller, F.M. Deane, F.O. McCarthy (2012) 'Emerging targets in the bioactivity of Ellipticines and derivatives' In: Studies in Natural Products Chemistry. Amsterdam, Netherlands: Elsevier Science Publishers. [Details]

Peer Reviewed Journals

YearPublication
(2014)'Recent advances in Phytosterol Oxidation Products'
Yvonne O’Callaghan, Florence O. McCarthy, Nora M. O’Brien (2014) 'Recent advances in Phytosterol Oxidation Products'. Biochemical Biophysical Research Communications, [DOI] [Details]
(2013)'Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells'
O'Callaghan Y, Kenny O, O'Connell NM, Maguire AR, McCarthy FO, O'Brien NM (2013) 'Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells'. Biochimie, :496-503 [DOI] [Details]
(2013)'Synthesis and evaluation of novel Ellipticines as potential anti-cancer agents'
F. M. Deane, E. C. O’Sullivan, A. R. Maguire, J. Gilbert, J. A. Sakoff, A. McCluskey and F. O. McCarthy (2013) 'Synthesis and evaluation of novel Ellipticines as potential anti-cancer agents'. Organic and Biomolecular Chemistry, 11 (8):1334-1344 [DOI] [Details]
(2012)'Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents'
L. T. Pierce, M. M. Cahill, H. J. Winfield and F. O. McCarthy (2012) 'Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents'. European Journal of Medicinal Chemistry, 56 :292-300 [DOI] [Details]
(2012)'Isolation, biological activity and synthesis of the natural product ellipticine and related pyridocarbazoles'
C. M. Miller and F. O. McCarthy (2012) 'Isolation, biological activity and synthesis of the natural product ellipticine and related pyridocarbazoles'. RSC Advances, 2 (24):8883-8918 [DOI] [Details]
(2012)'Synthetic routes to Campesterol and Dihydrobrassicasterol: a first reported synthesis of the key phytosterol Dihydrobrassicasterol'
N. M. O’Connell, Y. C. O’Callaghan, N. M. O’Brien, A. R. Maguire and F. O. McCarthy (2012) 'Synthetic routes to Campesterol and Dihydrobrassicasterol: a first reported synthesis of the key phytosterol Dihydrobrassicasterol'. Tetrahedron, 68 (25):4995-5004 [DOI] [Details]
(2012)'Synthesis and Biological Evaluation of Novel Isoellipticine Derivatives and Salts'
C. M. Miller, E. C. O’Sullivan, K. J. Devine and F. O. McCarthy (2012) 'Synthesis and Biological Evaluation of Novel Isoellipticine Derivatives and Salts'. Organic and Biomolecular Chemistry, 10 (39):7912-7921 [DOI] [Details]
(2012)'Is LCMS fast becoming an essential technique for pharmaceuticals'
F.O. McCarthy (2012) 'Is LCMS fast becoming an essential technique for pharmaceuticals'. European Pharmaceutical Review, 17 (1):54-59 Globe icon [Details]
(2012)'Oxidised Derivatives of Dihydrobrassicasterol: Cytotoxic and Apoptotic Potential in U937 and HepG2 cells'
O. Kenny, Y. O'Callaghan, N. M. O'Connell, F. O. McCarthy, A. R. Maguire and N. M. O'Brien (2012) 'Oxidised Derivatives of Dihydrobrassicasterol: Cytotoxic and Apoptotic Potential in U937 and HepG2 cells'. Journal of Agricultural and Food Chemistry, 60 (23):5952-5961 [DOI] [Details]
(2011)'Modifications to the Vilsmeier-Haack formylation of 1,4-dimethylcarbazole and its application to the synthesis of ellipticines'
Deane, FM; Miller, CM; Maguire, AR; McCarthy, FO; (2011) 'Modifications to the Vilsmeier-Haack formylation of 1,4-dimethylcarbazole and its application to the synthesis of ellipticines'. Journal of Heterocyclic Chemistry, 48 (4):814-823 Globe icon [DOI] [Details]
(2011)'Synthesis of novel 3,4-diaryl-5-aminopyrazoles as potential kinase inhibitors'
L. T. Pierce, M. M. Cahill and F. O. McCarthy (2011) 'Synthesis of novel 3,4-diaryl-5-aminopyrazoles as potential kinase inhibitors'. Tetrahedron, 67 (25):4601-4611 [DOI] [Details]
(2010)'Design And Synthesis Of Novel 5,6-Bisindolylpyrimidin-4-Ones Structurally Related To Ruboxistaurin (LY333531)'
L. T. Pierce, M. M. Cahill and F. O. McCarthy; (2010) 'Design And Synthesis Of Novel 5,6-Bisindolylpyrimidin-4-Ones Structurally Related To Ruboxistaurin (LY333531)'. Tetrahedron, 66 (51):9754-9761 [DOI] [Details]
(2010)'Cytotoxic and Apoptotic Effects of the Oxidized Derivatives of Stigmasterol in the U937 Human Monocytic Cell Line'
O'Callaghan, YC; Foley, DA; O'Connell, NM; McCarthy, FO; Maguire, AR; O'Brien, NM; (2010) 'Cytotoxic and Apoptotic Effects of the Oxidized Derivatives of Stigmasterol in the U937 Human Monocytic Cell Line'. Journal of Agricultural and Food Chemistry, 58 (19):10793-10798 [Details]
(2010)'Synthesis and characterisation of stigmasterol oxidation products'
Foley, DA; O'Callaghan, Y; O'Brien, NM; McCarthy, FO; Maguire, AR; (2010) 'Synthesis and characterisation of stigmasterol oxidation products'. Journal of Agricultural and Food Chemistry, 58 :1165-1173 [Details]
(2009)'Design and synthesis of novel indolocarbazole derivatives as anti-cancer agents'
Pierce, Larry T; Cahill, Michael M; McCarthy, Florence O; (2009) 'Design and synthesis of novel indolocarbazole derivatives as anti-cancer agents'. Drugs of the Future, 34 (Suppl A):100-100 [Details]
(2009)'Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects'
E. Ryan, F. O. McCarthy, A. R. Maguire and N. M. O'Brien. ; (2009) 'Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects'. Food Reviews International, 25 :157-174 [Details]
(2009)'Design and synthesis of novel ellipticine c-Kit Kinase inhibitors'
Miller, C; Thompson, D; McCarthy, FO; (2009) 'Design and synthesis of novel ellipticine c-Kit Kinase inhibitors'. Drugs of the Future, 34 (Suppl A):102-102 [Details]
(2008)'Computer Simulations Reveal a Novel Nucleotide-type Binding Orientation for Ellipticine-based Anticancer c-kit Kinase Inhibitors'
D. Thompson, C. Miller, F.O. McCarthy; (2008) 'Computer Simulations Reveal a Novel Nucleotide-type Binding Orientation for Ellipticine-based Anticancer c-kit Kinase Inhibitors'. Biochemistry, 47 :10333-10344 [Details]
(2007)'Exploring DNA topoisomerase I inhibition by the benzo[c]phenanthridines fagaronine and ethoxidine using steered molecular dynamics'
R. L. Clark, F. M. Deane, N. G. Anthony, B. F. Johnston, F. O. McCarthy and S. P. Mackay. ; (2007) 'Exploring DNA topoisomerase I inhibition by the benzo[c]phenanthridines fagaronine and ethoxidine using steered molecular dynamics'. Bioorganic and Medicinal Chemistry, 15 :4741-4752 [Details]
(2005)'Phytosterol, tocopherol and squalene content of five edible nuts (Brazil, Pecan, Pine, Pistachio, Cashew)'
Ryan E., Galvin K., O'Connor T.P., McCarthy F.O., Maguire A.R. and O'Brien N.M.; (2005) 'Phytosterol, tocopherol and squalene content of five edible nuts (Brazil, Pecan, Pine, Pistachio, Cashew)'. Proceedings of The Nutrition Society, * (*):*-* [Details]
(2005)'Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts'
Ryan E., Galvin K., O’Connor T.P., McCarthy F.O., Maguire A.R. and O’Brien N.M.; (2005) 'Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts'. International Journal of Food Sciences and Nutrition, * (*):*-* [Details]
(2005)'Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products'
Ryan, E., Chopra, J., McCarthy, F., Maguire, A.R. and O'Brien, N.M.; (2005) 'Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products'. British Journal of Nutrition, 94 (*):443-451 [Details]
(2005)'Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives'
F. O. McCarthy, J. Chopra, A. Ford, S. A. Hogan, J. P. Kerry, N. O'Brien, E. Ryan and A. R. Maguire; (2005) 'Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives'. Organic and Biomolecular Chemistry, 3 (16):3059-3065 [Details]
(2005)'Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products'
E. Ryan;J. Chopra;F. McCarthy;A. R. Maguire;N. M. O'Brien; (2005) 'Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products'. British Journal of Nutrition, 94 :443-451 Globe icon [DOI] [Full Text] [Details]
(2002)'Molecular modelling of novel ellipticine-amino acid inhibitors of topoisomerase I'
F. O. McCarthy, D. Cairns, P. W. Groundwater and S. P. Mackay; (2002) 'Molecular modelling of novel ellipticine-amino acid inhibitors of topoisomerase I'. J. Pharm. Pharmacol, 54(Suppl) [Details]
(2000)'The design of novel ellipticine-amino acid topoisomerase I inhibitors'
D. Cairns, F.O. McCarthy, P.W. Groundwater and S.P. Mackay; (2000) 'The design of novel ellipticine-amino acid topoisomerase I inhibitors'. Clinical Cancer Research, 6 [Details]
(1998)'A mechanistic investigation into the microbial chiral inversion of 2-arylpropionic acids using deuterated derivatives of 2-phenylpropionic acid'
W. Rhys-Williams, F. McCarthy, J. Baker, Y.F. Hung, M. Thomason, A. W. Lloyd and G. W. Hanlon; (1998) 'A mechanistic investigation into the microbial chiral inversion of 2-arylpropionic acids using deuterated derivatives of 2-phenylpropionic acid'. Enzyme Microb. Technol, 22 (4):281-287 [Details]

Other Journals

YearPublication
(2011)'ChemInform Abstract: Modifications to the Vilsmeier—Haack Formylation of 1,4-Dimethylcarbazole and Its Application to the Synthesis of Ellipticines'
Fiona M. Deane, Charlotte M. Miller, Anita R. Maguire, Florence O. McCarthy (2011) 'ChemInform Abstract: Modifications to the Vilsmeier—Haack Formylation of 1,4-Dimethylcarbazole and Its Application to the Synthesis of Ellipticines' Cheminform, 42 (51) . [DOI] [Details]

Conference Publications

YearPublication
(2011)XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique
Elaine C. O'Sullivan, Charlotte M. Miller, Ken Devine and Florence O. McCarthy. ; (2011) Synthesis and evaluation of novel Ellipticine derivatives as anti-cancer agents XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique [Details]
(2011)XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique
Michael M. Cahill, Larry T. Pierce, Hannah J. Winfield, Florence O. McCarthy; (2011) Anticancer activity of novel azaindole derivatives related to the bisindolemaleimides XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique [Details]
(2011)XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique
Hannah J. Winfield, Michael M. Cahill, Larry T. Pierce, Florence O. McCarthy; (2011) Synthesis of novel functionalised imidazoles as potential anticancer agents XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique [Details]
(2011)(Bio)Pharmaceutical and Pharmacological Sciences (BPS) Conference
Kieran Greaney and Florence O. McCarthy; (2011) Synthesis of Novel Quinoxalines as Potential HIV Integrase Inhibitors (Bio)Pharmaceutical and Pharmacological Sciences (BPS) Conference Dublin City University, Dublin, , 11-JAN-11 - 11-JAN-11 [Details]
(2010)XIXth European Conference of GP2A Groupement des Pharmacochimistes de l'Arc Atlantique
Greaney, Kieran; McCarthy, Florence O; (2010) Synthesis of Novel Quinoxalines as Potential HIV Integrase Inhibitors XIXth European Conference of GP2A Groupement des Pharmacochimistes de l'Arc Atlantique Rouen, France, , 01-SEP-10 - 02-SEP-10 , pp.27-27 [Details]
(2010)XIXth European Conference of GP2A Groupement des Pharmacochimistes de l'Arc Atlantique
Cahill, Michael M; Pierce, Larry T; Devine, Ken J; McCarthy, Florence O; (2010) Synthetic Studies towards Novel Azaindolocarbazoles XIXth European Conference of GP2A Groupement des Pharmacochimistes de l'Arc Atlantique Rouen, France, , 01-SEP-10 - 02-SEP-10 , pp.36-36 [Details]
(2009)XVIIIth European Conference of GP2A Groupement des Pharmacochimistes de l'Arc Atlantique
C. Miller, D. Thompson and F. O. McCarthy; (2009) Design and synthesis of novel ellipticine c-Kit kinase inhibitors XVIIIth European Conference of GP2A Groupement des Pharmacochimistes de l'Arc Atlantique Trinity College Dublin, Ireland, , 03-SEP-09 - 04-SEP-09 , pp.35-35 [Details]
(2009)XVIIIth European Conference of GP2A Groupement des Pharmacochimistes de l'Arc Atlantique
L. T. Pierce, M. M. Cahill and F. O. McCarthy; (2009) Design and synthesis of novel indolocarbazole derivatives as anticancer agents XVIIIth European Conference of GP2A Groupement des Pharmacochimistes de l'Arc Atlantique Trinity College Dublin, , 03-SEP-09 - 04-SEP-09 , pp.48-48 [Details]
(2008)XVIIth European conference of GP2A
Larry T. Pierce, Michael M. Cahill, Florence O. McCarthy ; (2008) Design, synthesis and development of novel indolocarbazole derivatives as potential anti-cancer agents XVIIth European conference of GP2A Caen, France, , 28-MAY-08 - 30-MAY-08 [Details]
(2008)XVIIth European conference of GP2A
N. O' Connell, F. O. McCarthy, A. R. Maguire, N. O' Brien ; (2008) A novel route to individual phytosterols XVIIth European conference of GP2A Caen, France, , 28-MAY-08 - 30-MAY-08 [Details]
(2007)XVIèmes Rencontres Europeennes du Groupment des Pharmacochimistes de L'Arc Atlantique (GP2A)
F.O. McCarthy; (2007) Novel Ellipticines in Cancer research XVIèmes Rencontres Europeennes du Groupment des Pharmacochimistes de L'Arc Atlantique (GP2A) Bordeaux, France, , 06-SEP-07 - 07-SEP-07 [Details]
(2006)XVth European conference of GP2A
F.O. McCarthy; (2006) Explaining the dual mechanism of DNA topoisomerase I inhibition by the benzo[c]phenanthridines fagaronine and ethoxidine by molecular modeling XVth European conference of GP2A University of Bath, UK, , 07-SEP-06 - 08-SEP-06 [Details]
(2006)XVth European conference of GP2A
F. M. Deane, F. O. McCarthy, A. R. Maguire, H. Major and S. Preece; (2006) Synthesis and evaluation of ellipticine derivatives as potential anti-cancer agents XVth European conference of GP2A Bath, UK, , 07-SEP-06 - 08-SEP-06 [Details]
(2005)Phytosterol, tocopherol and squalene content of five edible nuts (Brazil, pecan, pine, pistachio, cashew)
E. Ryan, K. Galvin, T.P. O'Connor, F.O. McCarthy, A. R. Maguire and N. M. O¿Brien; (2005) Phytosterol, tocopherol and squalene content of five edible nuts (Brazil, pecan, pine, pistachio, cashew) , pp.41-41 [Details]
(2002)British Pharmaceutical Conference
F.O. McCarthy, D. Cairns, P.W. Groundwater and S.P. Mackay; (2002) Molecular modelling of novel ellipticine-amino acid inhibitors of topoisomerase I British Pharmaceutical Conference Manchester, UK, , 23-SEP-02 - 25-SEP-02 [Details]
(2000)EORTC
D. Cairns, F.O. McCarthy, P.W. Groundwater and S.P. Mackay ; (2000) The design of novel ellipticine-amino acid topoisomerase I inhibitors EORTC Amsterdam, , 07-NOV-00 - 10-NOV-00 [Details]

Professional Associations

 AssociationFunctionFrom / To
Royal Pharmaceutical Society of Great Britain Member/
Pharmaceutical Society of Ireland Member/
Royal Society of Chemistry Member/
Groupement des Pharmacochimistes de l'Arc Atlantique Member/

Patents

 Patent NumberTitleInventorGranted
WO 2003091255Preparation of pyrrolocarbazoles, benzofuroisoindoles, and azacyclopentafluorenes inhibitors of checkpoint kinases WEE1 and CHK1 Booth, R. J.; Denny, W. A.; Dobrusin, E. M.; Kraker, A. J.; Mitchell, L. H.; Smaill, J. B.; Thompson, A. M.; Lee, H. H.; McCarthy, F. O.; Palmer, B. D. (Warner-Lambert Company Llc; et al., USA).15-APR-03

Conference Contributions

YearPublication
(2011)NUI Maynooth Seminar Series,
Florence O. McCarthy; (2011) Departent of Chemistry Seminar series 2011. [Invited Seminars/Guest Lectures], NUI Maynooth Seminar Series, Maynooth, Ireland , 14-APR-11 - 14-APR-11. [Details]
(2011)1st European Network on Oxysterols Research (ENOR) Symposium,
Florence O. McCarthy; (2011) International conference on Oxysterol research. [Invited Lectures (Conference)], 1st European Network on Oxysterols Research (ENOR) Symposium, Rome, Italy , 22-SEP-11 - 24-SEP-11. [Details]
(2011)XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique,
Florence O. McCarthy; (2011) International conference in Pharmaceutical Chemistry. [Conference Organising Committee Chairperson], XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique, University College Cork, Cork, Ireland , 01-SEP-11 - 02-SEP-11. [Details]
(2011)XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique,
Florence O. McCarthy; (2011) International conference in Pharmaceutical Chemistry. [Conference Organising Committee Chairperson], XXth Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique, University College Cork, Cork, Ireland , 01-SEP-11 - 02-SEP-11. [Details]
(2008)Waters Mass Spectrometry Symposium,
F.O. McCarthy; (2008) . [Conference Organising Committee Chairperson], Waters Mass Spectrometry Symposium, UCC , 16-JUL-08 - 16-JUL-08. [Details]
(2008)Irish Schools of Pharmacy Research Conference,
F.O. McCarthy; (2008) Design, synthesis and development of novel indolocarbazole derivatives as potential anticancer agents. [Oral Presentation], Irish Schools of Pharmacy Research Conference, UCC, Ireland , 02-APR-08 - 02-APR-08. [Details]
(2008)Eli Lilly Research Symposium,
F.O. McCarthy and L.T. Pierce; (2008) Design, synthesis and development of novel indolocarbazole derivatives as potential anticancer agents. [Oral Presentation], Eli Lilly Research Symposium, UCC, Ireland , 18-SEP-08 - 18-SEP-08. [Details]
(2008)National Access Programme Symposium,
F.O. McCarthy; (2008) NAP 109 - Design of novel Ellipticine c-KIT kinase inhibitors. [Invited Lectures (Workshops)], National Access Programme Symposium, Dublin Institute of Technology, Dublin , 24-JAN-08 - 24-JAN-08. [Details]
(2008)Irish Schools of Pharmacy Research Seminar,
N. O¿ Connell, F. O. McCarthy, A. R. Maguire, N. O¿ Brien ; (2008) Phytosterol oxides: a complete individual toxicology profile. [Poster Presentation], Irish Schools of Pharmacy Research Seminar, Ireland , 02-APR-08 - 02-APR-08. [Details]
(2007)LCMS applications in the pharmaceutical industry,
F.O. McCarthy; (2007) LCMS applications in the pharmaceutical industry. [Invited Oral Presentation], LCMS applications in the pharmaceutical industry, Boston Scientific, Galway , 06-JUN-07 - 06-JUN-07. [Details]
(2007)Eli Lilly Research Symposium,
F.O. McCarthy; (2007) Synthesis and Evaluation of Ellipticine Derivatives as Potential Anti-cancer Agents. [Oral Presentation], Eli Lilly Research Symposium, UCC, Ireland , 17-SEP-07 - 17-SEP-07. [Details]
(2007)Waters UPLC workshop,
F.O. McCarthy; (2007) . [Conference Organising Committee Member], Waters UPLC workshop, UCC , 03-APR-07 - 04-APR-07. [Details]
(2007)Waters Ireland Innovations Meeting,
F.O. McCarthy; (2007) Identification of unknown impurities using Time of Flight MS. [Invited Oral Presentation], Waters Ireland Innovations Meeting, Radisson, Little Island, Cork , 09-OCT-07 - 10-OCT-07. [Details]
(2007)Advances in Synthesis and Chemical Biology VI symposium,
Larry T. Pierce, Michael M. Cahill, Florence O. McCarthy ; (2007) Design, synthesis and development of novel indolocarbazole derivatives as potential anti-cancer agents. [Poster Presentation], Advances in Synthesis and Chemical Biology VI symposium, Trinity College Dublin , 14-DEC-07 - 14-DEC-07. [Details]
(2006)Advances in Synthesis and Chemical Biology V symposium,
F. M. Deane, F. O. McCarthy, A. R. Maguire, H. Major and S. Preece ; (2006) Synthesis and evaluation of ellipticine derivatives as potential anti-cancer agents. [Poster Presentation], Advances in Synthesis and Chemical Biology V symposium, Trinity College Dublin , 15-DEC-06 - 15-DEC-06. [Details]
(2005)Irish Schools of Pharmacy Research Seminar,
F.O. McCarthy, J. Chopra, A. Ford, E. Ryan, N. O¿Brien and A.R. Maguire; (2005) Potential health impact of dietary β-sitosterol and β-sitosterol oxidation products. [Poster Presentation], Irish Schools of Pharmacy Research Seminar, Ireland , 01-MAR-05 - 01-MAR-05. [Details]
(2003)Faculty of Medicine and Health Sciences seminar series,
F.O. McCarthy; (2003) Bioactive Discovery in the New Millenium. [Invited Oral Presentation], Faculty of Medicine and Health Sciences seminar series, University of Auckland, New Zealand , 19-FEB-03 - 19-FEB-03. [Details]
(2005)Royal Society of Chemistry/ Institute of Chemistry/ Society of Chemical Industry Joint Conference The Synthesis of Bioactive Molecules,
F.O. McCarthy; (2005) Medicinal Chemistry Approaches to Optimize EGFR Kinase Inhibitors. [Invited Oral Presentation], Royal Society of Chemistry/ Institute of Chemistry/ Society of Chemical Industry Joint Conference The Synthesis of Bioactive Molecules, University College Cork , 09-JUN-05 - 09-JUN-05. [Details]
(2002)Faculty of Medicine and Health Sciences seminar series,
F.O. McCarthy; (2002) Synthesis and evaluation of ellipticine derivatives as potential anti-cancer agents. [Invited Oral Presentation], Faculty of Medicine and Health Sciences seminar series, University of Auckland, New Zealand , 24-JUL-02 - 24-JUL-02. [Details]

Committees

 CommitteeFunctionFrom / To
Groupement des Pharmacochimistes de l'Arc Atlantique Conference Conference Organiser/
Academic Council - Graduate Studies Committee Member/
Staff Student Committe - Department of Chemistry Chairperson/
Teaching and Examinations Committee - Department of Chemistry Member/
Research and Graduate Studies Committee - Department of Chemistry Member/
Graduate Studies Committee - SEFS Member/

Languages

 LanguageReadingWritingSpeaking
French FunctionalBasicFunctional

Reviews

 JournalRole
Rapid Communications In Mass Spectrometry : Rcm Referee
Tetrahedron Letters Referee
European Journal Of Medicinal Chemistry Referee
Medchemcomm Referee
Food And Chemical Toxicology Referee
Molecular Biosystems Referee
Tetrahedron Referee
Mini Reviews In Medicinal Chemistry Referee
Molecular Biosystems Referee
European Journal Of Organic Chemistry Referee
Organic And Biomolecular Chemistry Referee
European Journal Of Organic Chemistry Referee
Chemmedchem Referee
Phytochemistry Referee

Teaching Interests

Dr. McCarthy teaches a wide range of topics in Organic and Pharmaceutical Chemistry to programmes including B.Sc. Chemistry, Chemistry of Pharmaceutical Compounds (CPC), Pharmacy, Food and Nutritional Sciences and Nursing.

Please visit the individual Blackboard pages for relevant course material.

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2013Michael Cahill University College Cork (NUI)PhD
2012Charlotte Miller University College Cork (NUI)PhD
2011Larry Pierce University College Cork (NUI)PhD
2010Fiona Deane University College Cork (NUI)PhD

Current Postgraduate Students

 StudentDegree TypePrimary
O Sullivan Catriona Elaine Doctoral DegreeYes
Winfield Hannah Jane Doctoral DegreeYes
O Shea Kevin Doctoral DegreeYes
Mc Kee Mary Louise Doctoral DegreeYes

Modules Taught

 Term (ID))TitleLinkSubject
2015Pharmaceutical Chemistry III PF3102Pharmaceutical Chemistry III
2015Advanced Pharmaceutical Chemistry CM4108Advanced Pharmaceutical Chemistry
2015Pharmaceut. Chem: Drug Design & Development CM4109Pharmaceut. Chem: Drug Design & Development