Lecturer, Organic and Pharmaceutical Chemistry
Chemistry
Kane Building
University College Cork
Cork
Ireland

T: +353-21-490-2866
E: g.mcglacken@ucc.ie

Dr Gerard McGlacken obtained his B.Sc. at the National University of Ireland, Galway. He remained in Galway for his Ph.D. studies where he focused on hydrazones as building blocks for asymmetric synthesis under the direction of Dr. Simon W. Breeden. He then moved to the University of York (UK) where his research interests diversified to organometallic transformations and molecules of biological importance with Prof. Ian J. S. Fairlamb. A year later, he took up a 'Molecular Design and Synthesis Post-Doctoral Fellowship' at Florida State University (US) working with Prof. Robert A. Holton on the total synthesis of the large polyether antibiotic lonomycin A. He obtained a Lectureship position at University College Cork in 2007 and a permanent position in 2011.

His current research is in the area of organic synthesis applied to biologically significant molecules. En route to these compounds, novel methodology involving organometallic and asymmetric synthesis is being employed.

Dr McGlacken has published widely in high impact journals such as Angew. Chem. Int. Ed., Chem. Commun., ACS Catalysis and Chem. Eur. J., has received over 500 citations and has produced two book chapters.

He has received over €1 million in competitive funding as part of the Science Foundation Ireland Research Frontiers Program (2009), the Investigators Program (2011) and others. He has also received a Technology and Innovation Development Award from SFI.

He works closely with the Pharmaceutical Industry both in Ireland and the United States and has received applied grants with Eli Lilly (2010) and Merck (2015) as part of the Enterprise Ireland Innovation Partnership program. He also collaborates with the large Pharma company Syngenta and has placed PhD students in Basel, Switzerland. He also collaborated with Pfizer as part of the Irish Research Council Industry Partnership Program which resulted in the funding of two PhD positions.

He has been invited to give several guest lectures most recently at the 8th Symposium on Metal-Mediated Efficient Organic Synthesis Sep 7-10 2014 Cesme, Turkey and 2nd International Symposium on C-H Activation June 30-July 3 2014 Rennes, France.

Dr McGlacken is part of the European COST Action CM1407: Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery.

He was also the External Examiner for the Dundalk Institute of Technology Pharmaceutical Sciences Program from 2010-2014. He is the UCC Royal Society of Chemistry representative and sits on the Departmental and Research Committees. He served as the Chemistry Seminar Series Coordinator (2009-2013) and Year 2 Coordinator (2009-2013). Dr McGlacken's Group has been involved in a number of popular science and dissemination programs including the receipt of First Prize by PhD student Sarah Clarke in the UCC Doctoral Showcase, and a publication by undergraduate students in Chemistry Review (aimed at an A-level / Leaving cert audience).

Finally Dr McGlacken is a Funded Investigator within the Synthesis and Solid State Pharmaceutical Centre (SSPC) research centre. It is a Global Hub of Pharmaceutical Process Innovation and Advanced Manufacturing, and a unique collaboration between 17 industry partners, 8 academic institutions and 12 international academic collaborators.

Dr McGlacken has a keen interest in the 'Research of Teaching' and treating Teaching as a discipline in itself. This has motivated him to complete a Certificate in 'Teaching and Learning in High Education' and he is currently undertaking a Higher Diploma in 'Teaching and Learning in High Education'.

 

 

Research Interests

Organic Synthesis 


The Irish Chemical Industry exported 44.17 billion euro worth of Pharmaceuticals in 2009. It remains one of the strongest performing industries and has been largely recession-proof. Ireland is moving away from Process Chemistry, up the value chain towards Research and Discovery. Key skills acquired during a PhD term within my group will equip researchers with the essentials to progress into this Sector. 

Area 1 Asymmetric Synthesis

Importantly, 60% of all drugs now containing at least one chiral centre (this is usually a carbon atom bound to four different groups). Thus asymmetric synthesis is of upmost importance.

A: The synthesis of chiral α-substituted ketones  

The introduction of such a chiral centre is challenging but potentially very useful to the Pharmaceutical Sector. (-)-Sparteine, isolated from thermopsis lanceolatais plant is chiral. We use this inbuilt chirality from nature and transfer it to ketones.  

B: The synthesis of chiral amino acids.   

The 1,3-hydroxyketone in a very common and important moiety in pharmaceutical compounds. This project involves the asymmetric synthesis of these compounds containing two, three or even more centres all in the one-pot experiment.   

Area 2 Organometallic transformations   

The abundance of the biaryl structural motif in natural products, biologically active molecules and in materials chemistry has positioned aryl-aryl (Ar-Ar) bond formation high on the agenda of synthetic chemists. For decades well-known reactions such as the Mizoroki-Heck and Suzuki-Miyaura have been the methods of choice to furnish biaryls. More recently however, alternative methods, most notably direct arylation via C-H activation, have become the focus of many research groups including ours. Compared to traditional methods, direct arylation affords ArAr compounds in fewer steps by removing the need for pre-functionalisation. Furthermore, given that either one or two hydrogens are targeted, less waste and good atom economy are features of this methodology. We use C-H activation in biologically important synthons.

Area 3 Synthesis of non-traditional antibiotics and biomarker detection

Bacteria produce small-molecule signals to help coordinate their behaviour. This communication system serves many purposes, including cooperative tasks such as the formation of protective biofilms. These protective sheets greatly impair the effectiveness of antibiotics. This, added to the growing resistance to antibiotics, necessitates an alternative look at treating bacteria infections. We prepare analogues of bacteria communication molecules to interrupt their communication systems and prevent biofilm formation. In this non-biocidal approach, developed resistance is avoided. In parallel, early detection of these molecules allows for early medical intervention.


Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Suppored Nanocatalysts for the Pharmaceutical Industry.Industry/EI Projects01-JAN-1231-JUL-13€30,860.00
Direct Arylation and Fluorination using Supported Palladium Catalysts.Enterprise Irl01-NOV-1401-SEP-16€169,851.00
Heterogeneeous Catalysis for the Direct Arylation of Heterocycles.Irish Research Council01-OCT-1430-SEP-16€91,790.00
The asymmetric synthesis of 1,3 aminoalchols.Irish Research Council for Science, Engineering & Technology (IRCSET)01-SEP-1030-SEP-13€72,009.00
The asymmetric synthesis of a-substituted ketones and application to Total Synthesis.Irish Research Council for Science, Engineering & Technology (IRCSET)01-SEP-1031-AUG-14€72,009.00
Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical applicationScience Foundation of Ireland01-JAN-1331-MAR-14€128,295.00
SFI The asymmetric synthesis of 1.3-hydroxyketones using hydrazones with (-) sparteine as a chiral ligand and 1.3-aminoalcohols using an aldol-Tishchenko type reaction with sulfinylimines.Science Foundation of Ireland01-SEP-0931-AUG-13€198,831.00
New metholdology towards chiral ketones and animoalcohols.Irish Research Council01-OCT-1430-SEP-18€96,000.00
The catalytic asymmetric Alkylation of KetonesIrish Research Council for Science, Engineering & Technology (IRCSET)29-AUG-1128-AUG-15€72,000.00
The Direct Arylation of Pyrones, Courmarins.Science Foundation of Ireland01-APR-1331-DEC-17€377,092.00
Supported Nanocatgalysts for the Pharmaceutical Industry.Enterprise Irl01-JAN-1207-OCT-13€98,807.00
Direct Arylation and Fluorination using Supported Palladium Catalysts.Industry/EI Projects01-NOV-1401-SEP-16€40,854.00
The synthesis of biologically important heterocycles.Irish Research Council01-OCT-1330-SEP-17€96,000.00

Peer Reviewed Journals

YearPublication
(2017)'Direct Asymmetric Alkylation of Ketones: Still Unconquered'
Rafael Cano, Armen Zakarian, and Gerard P. McGlacken (2017) 'Direct Asymmetric Alkylation of Ketones: Still Unconquered'. Angewandte Chemie International Edition, [DOI] [Details]
(2017)'Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives'
Eoin Ó Muimhneacháin, Leticia M. Pardo, Lorraine M. Bateman, U. B. Rao Khandavilli, Simon E. Lawrence and Gerard P. McGlacken (2017) 'Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives'. Advanced Synthesis and Catalysis, [DOI] [Details]
(2017)'Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation'
Dr. Sarah L. Clarke and Dr. Gerard P. McGlacken (2017) 'Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation'. Chemistry - A European Journal, [DOI] [Details]
(2017)'Direct and Rapid Electrochemical Detection of Pseudomonas aeruginosa Quorum Signaling Molecules in Bacterial Cultures and Cystic Fibrosis Sputum Samples through Cationic Surfactant-Assisted Membrane Disruption'
Alyah Buzid, F. Jerry Reen, Victor K. Langsi, Eoin Ó Muimhneacháin, Fergal O'Gara, Gerard P. McGlacken, John H. T. Luong, Jeremy D. Glennon (2017) 'Direct and Rapid Electrochemical Detection of Pseudomonas aeruginosa Quorum Signaling Molecules in Bacterial Cultures and Cystic Fibrosis Sputum Samples through Cationic Surfactant-Assisted Membrane Disruption'. ChemElectroChem, 4 (3) [DOI] [Details]
(2017)'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa'
Shanahan, R;Reen, FJ;Cano, R;O'Gara, F;McGlacken, GP (2017) 'The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa'. Organic & Biomolecular Chemistry, 15 :306-310 [DOI] [Details]
(2017)'Liquid-phase monolayer doping of InGaAs with Si-, S- and Sn-containing organic molecular layers'
O’Connell, J.; Napolitani, E.; Impellizzeri, G.; Glynn, C.; McGlacken, G. P.; O’Dwyer, C.; Duffy, R.; Holmes, J. D. (2017) 'Liquid-phase monolayer doping of InGaAs with Si-, S- and Sn-containing organic molecular layers'. ACS Omega, 2 (5):1750-1759 Globe icon [DOI] [CORA Link] [Details]
(2016)'A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo'
Pastor-Cavada, E; Pardo, LM; Kandil, D; Torres-Fuentes, C; Clarke, SL; Shaban, H;McGlacken, GP; Schellekens, H (2016) 'A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo'. Scientific Reports, 6 :1-13 [DOI] [CORA Link] [Details]
(2016)'Monolayer Doping of Si with Improved Oxidation Resistance'
O'Connell, J;Collins, G;McGlacken, GP;Duffy, R;Holmes, JD (2016) 'Monolayer Doping of Si with Improved Oxidation Resistance'. Acs Applied Materials & Interfaces, 8 :4101-4108 [DOI] [Details]
(2016)'Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation'
Reen, FJ;Phelan, JP;Gallagher, L;Woods, DF;Shanahan, RM;Cano, R;Muimhneachain, EO;McGlacken, GP;O'Gara, F (2016) 'Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation'. Antimicrobial Agents and Chemotherapy, 60 :5894-5905 [DOI] [Details]
(2016)'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa'
Buzid, A,Muimhneachain, EO,Reen, FJ,Hayes, PE,Pardo, LM,Shang, FJ,O'Gara, F,Sperry, J,Luong, JHT,Glennon, JD,McGlacken, GP (2016) 'Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa'. Analytical and Bioanalytical Chemistry, 408 :6361-6367 [DOI] [Details]
(2016)'Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode'
Buzid, A;Shang, FJ;Reen, FJ;Muimhneachain, EO;Clarke, SL;Zhou, L;Luong, JHT;O'Gara, F;McGlacken, GP;Glennon, JD (2016) 'Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode'. Scientific Reports, 6 [DOI] [Details]
(2016)'Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C–H Activation'
Katrina Mackey, Leticia M. Pardo, Aisling M. Prendergast, Marie-T. Nolan, Lorraine M. Bateman, and Gerard P. McGlacken (2016) 'Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C–H Activation'. Organic letters, [DOI] [Details]
(2016)'Palladium(II) oxide impregnated on magnetite as a catalyst for the synthesis of 4-arylcoumarins via a Heck-arylation/cyclization process'
Juana M. Pérez, Rafael Cano, Gerard P. McGlacken and Diego J. Ramón (2016) 'Palladium(II) oxide impregnated on magnetite as a catalyst for the synthesis of 4-arylcoumarins via a Heck-arylation/cyclization process'. RSC Advances, 6 :36932-36941 [Details]
(2016)'Monolayer doping of Si with improved oxidation resistance'
O’Connell, J.; Collins, G.; McGlacken, G. P.; Duffy, R.; Holmes, J. D. (2016) 'Monolayer doping of Si with improved oxidation resistance'. ACS applied materials & interfaces, 8 (6):4101-4108 Globe icon [DOI] [CORA Link] [Details]
(2016)'Impregnated palladium on magnetite as catalyst for direct arylation of heterocycles'
Rafael Cano, Juana M. Pérez, Diego J. Ramón, Gerard P. McGlacken (2016) 'Impregnated palladium on magnetite as catalyst for direct arylation of heterocycles'. Tetrahedron, 72 [Details]
(2015)'Asymmetric Aldol–Tishchenko Reaction of Sulfinimines'
Vera M. Foley, Christina M. McSweeney, Kevin S. Eccles, Simon E. Lawrence, and Gerard P. McGlacken (2015) 'Asymmetric Aldol–Tishchenko Reaction of Sulfinimines'. Organic letters, [DOI] [Details]
(2015)'Intramolecular Direct Arylation of 3-Halo-2-pyrones and 2-Coumarins'
Marie-T. Nolan, Leticia M. Pardo, Aisling M. Prendergast, and Gerard P. McGlacken (2015) 'Intramolecular Direct Arylation of 3-Halo-2-pyrones and 2-Coumarins'. Journal of Organic Chemistry, 80 (21):10904-10913 [DOI] [Details]
(2015)'Direct arylation and heterogeneous catalysis; ever the twain shall meet'
Rafael Cano, Alexander F. Schmidt and Gerard P. McGlacken (2015) 'Direct arylation and heterogeneous catalysis; ever the twain shall meet'. Chemical Science, [DOI] [Details]
(2015)'Organo-arsenic molecular layers on silicon for high density doping'
O’Connell, J.; Alessio Verni, G.; Gangnaik, A.; Shayesteh, M.; Long, B.; Georgiev, Y. M.; Petkov, N.; McGlacken, G. P.; Morris, M. A.; Duffy, R.; Holmes, J. D. (2015) 'Organo-arsenic molecular layers on silicon for high density doping'. Acs Applied Materials & Interfaces, 7 (28):15514-15521 Globe icon [DOI] [CORA Link] [Details]
(2015)'A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus'
Reen, J., Shanahan, R., Cano, R., O’Gara, F., and McGlacken, G.P. (2015) 'A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus'. Organic and Biomolecular Chemistry, :5537-5541 [CORA Link] [Details]
(2015)'Access to trifluoromethylated 4-alkoxy-2-pyrones, pyridones and quinolones'
Sarah L. Clarke, Gerard P. McGlacken (2015) 'Access to trifluoromethylated 4-alkoxy-2-pyrones, pyridones and quinolones'. Tetrahedron, 71 (19):2906-2913 [Details]
(2015)'Pd/Pivalic Acid Mediated Direct Arylation of 2-Pyrones and Related Heterocycles'
Leticia M. Pardo, Aisling M. Prendergast, Marie-T. Nolan, Eoin Ó Muimhneacháin and Gerard P. McGlacken (2015) 'Pd/Pivalic Acid Mediated Direct Arylation of 2-Pyrones and Related Heterocycles'. European Journal of Organic Chemistry, [DOI] [Details]
(2014)'The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand'
Christina McSweeney, Vera Foley, Gerard P. McGlacken (2014) 'The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand'. Chem. Commun, 50 (94) [Details]
(2014)'Pd-catalysed intramolecular regioselective arylation of 2-pyrones, pyridones, coumarins and quinolones by C–H bond functionalization'
Marie-Therese Nolan, Joshua T.W. Bray, Kevin Eccles, Man Sing Cheung, Zhenyang Lin, Simon E. Lawrence, Adrian C. Whitwood, Ian J.S. Fairlamb, Gerard P. McGlacken (2014) 'Pd-catalysed intramolecular regioselective arylation of 2-pyrones, pyridones, coumarins and quinolones by C–H bond functionalization'. Tetrahedron, 70 (40) [Details]
(2014)'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa'
F. Shang, E. O'Muimhneachain, F. Jerry Reen, A. Buzid, F. O'Gara, John H. T. Luong, J. D. Glennon, Gerard P. McGlacken (2014) 'One step preparation and electrochemical analysis of IQS, a cell-cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa'. Bioorganic & Medicinal Chemistry Letters, 24 (19) [Details]
(2014)'Enhanced Catalytic Activity of High Index Faceted Palladium Nanoparticles in Suzuki-Miyaura Coupling due to Efficient Leaching Mechanism'
Collins, G., Schmidt, M., O’Dwyer, C., McGlacken, G. & Holmes, J. D. (2014) 'Enhanced Catalytic Activity of High Index Faceted Palladium Nanoparticles in Suzuki-Miyaura Coupling due to Efficient Leaching Mechanism'. ACS Catalysis, 4 :3105-3111 Globe icon [DOI] [Details]
(2014)'The Origin of Shape Sensitivity in Palladium-Catalyzed Suzuki-Miyaura Cross Coupling Reactions'
Collins, G,Schmidt, M,Dwyer, CO,Holmes, JD,McGlacken, GP (2014) 'The Origin of Shape Sensitivity in Palladium-Catalyzed Suzuki-Miyaura Cross Coupling Reactions'. Angewandte Chemie-International Edition, 53 :4142-4145 [DOI] [Details]
(2014)'Investigation of a novel diamine based chiral auxiliary in the asymmetric alkylation of ketones'
Clarke, SL,McSweeney, CM,McGlacken, GP (2014) 'Investigation of a novel diamine based chiral auxiliary in the asymmetric alkylation of ketones'. Tetrahedron-Asymmetry, 25 :356-361 [DOI] [Details]
(2014)'Stability, Oxidation, and Shape Evolution of PVP-Capped Pd Nanocrystals'
Collins, Gillian and Schmidt, Michael and McGlacken, Gerard P. and O'Dwyer, Colm and Holmes, Justin D. (2014) 'Stability, Oxidation, and Shape Evolution of PVP-Capped Pd Nanocrystals'. Journal of Physical Chemistry C, 118 (12):6522-6530 Globe icon [Details]
(2014)'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients'
Reen, F.J., Woods, D.F., Mooij, M.J., Chróinín, M.N., Mullane, D., Zhou, L., Quille, J., Fitzpatrick, D., Glennon, J.D., McGlacken. G.P., Adams, C., and O'Gara, F. (2014) 'Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients'. European Journal of Clinical Microbiology & Infectious Diseases, 33 :1763-1771 [Details]
(2013)'Highly stable PEGylated gold nanoparticles in water: applications in biology and catalysis'
Rahme, K.; Nolan, M. T.; Doody, T.; McGlacken, G. P.; Morris, M. A.; O’Driscoll. C.; Holmes, J. D. (2013) 'Highly stable PEGylated gold nanoparticles in water: applications in biology and catalysis'. RSC Advances, 3 (43):21016-21024 Globe icon [DOI] [Details]
(2013)'Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'
Schellekens, H.,McNamara, O.,Dinan, T. G.,McCarthy, J. V.,McGlacken, G. P.,Cryan, J. F. (2013) 'Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor'. J Pharm Pharmacol, 65 (44):528-38528 Globe icon [Details]
(2012)'Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'
Zhou, Lin; Reen, F. Jerry; O'Gara, Fergal; McSweeney, Christina M.; Clarke, Sarah L.; Glennon, Jeremy D.; Luong, John H. T.; McGlacken, Gerard P. (2012) 'Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode'. Journal of Chromatography A, 1251 :169-175 Globe icon [Details]
(2012)'Pseudomonas aeruginosa alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1α degradation'
Legendre, Claire; Reen, F. Jerry; Mooij, Marlies J.; McGlacken, Gerard P.; Adams, Claire; O'Gara, Fergal (2012) 'Pseudomonas aeruginosa alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1α degradation'. Infection and Immunity, 80 (11):3985-3992 Globe icon [Details]
(2012)'Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'
Reen, F. Jerry; Clarke, Sarah L.; Legendre, Claire; McSweeney, Christina M.; Eccles, Kevin S.; Lawrence, Simon E.; O'Gara, Fergal; McGlacken, Gerard P (2012) 'Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS'. Organic and Biomolecular Chemistry, 10 (44):8903-8910 Globe icon [Details]
(2011)'Alkoxy‒arene cleavage using Ni catalysis'
Gerard P. McGlacken and Sarah L. Clarke; (2011) 'Alkoxy‒arene cleavage using Ni catalysis'. ChemCatChem, [DOI] [Details]
(2011)'Detection of Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'
Zhou, L., Glennon, J. D., Luong, J. H. T., Reen, F. J., O¿Gara, F., McSweeney, C. and *McGlacken, G. P. (2011) 'Detection of Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode'. Chem. Commun, [Details]
(2011)'The Pseudomonas Quinolone Signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'
F.J. Reen, M.J. Mooij, L.J. Holcombe, C.M. McSweeney, G.P. McGlacken, J.P. Morrissey and F. O'Gara; (2011) 'The Pseudomonas Quinolone Signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour'. FEMS Microbiol Ecol, [DOI] [Details]
(2010)'Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas quinolone signal (PQS)'
McGlacken, Gerard P; McSweeney, Christina M; O'Brien, Timothy; Lawrence, Simon E; Elcoate, Curtis J; Reen, Jerry F; O'Gara, Fergal; (2010) 'Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas quinolone signal (PQS)'. Tetrahedron Letters, 51 (45):5919-5921 [Details]
(2009)'Palladium-Catalysed Cross-Coupling and Related Processes: Some Interesting Observations That Have Been Exploited in Synthetic Chemistry'
McGlacken, Gerard P. and Fairlamb, Ian J. S.; (2009) 'Palladium-Catalysed Cross-Coupling and Related Processes: Some Interesting Observations That Have Been Exploited in Synthetic Chemistry'. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (24):4011-4029 [DOI] [Details]
(2009)'Recent advances in aryl-aryl bond formation by direct arylation'
McGlacken, Gerard P. and Bateman, Lorraine M.; (2009) 'Recent advances in aryl-aryl bond formation by direct arylation'. CHEMICAL SOCIETY REVIEWS, 38 (8):2447-2464 [DOI] [Details]
(2008)'Formation of carbanions using neutral organic molecules as electron-transfer reagents: A radical concept'
McGlacken, Gerard P. and Khan, Tanweer A.; (2008) 'Formation of carbanions using neutral organic molecules as electron-transfer reagents: A radical concept'. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (10):1819-1823 [DOI] [Details]
(2007)'Chiral mono- and bis-annelated cyclopentadienyl ligands derived from tartaric acid: Synthesis of [(eta(5)-cyclopentadienyl)RuCl(cod)] and [(eta(5)-cyclopentadienyl)(eta(6)-benzene)Ru]PF6 derivatives'
McGlacken, Gerard P. and O'Brien, Ciara T. and Whitwood, Adrian C. and Fairlamb, Ian J. S.; (2007) 'Chiral mono- and bis-annelated cyclopentadienyl ligands derived from tartaric acid: Synthesis of [(eta(5)-cyclopentadienyl)RuCl(cod)] and [(eta(5)-cyclopentadienyl)(eta(6)-benzene)Ru]PF6 derivatives'. ORGANOMETALLICS, 26 (15):3722-3728 [DOI] [Details]
(2006)'Ruthenium(II)-catalysed cycloisomerisation of 1,6-dienes by focused microwave dielectric heating: improved rates and selectivities leading to exo-methylenecyclopentanes'
Fairlamb, IJS and McGlacken, GP and Weissberger, F; (2006) 'Ruthenium(II)-catalysed cycloisomerisation of 1,6-dienes by focused microwave dielectric heating: improved rates and selectivities leading to exo-methylenecyclopentanes'. CHEMICAL COMMUNICATIONS, (9):988-990 [DOI] [Details]
(2006)'Exploiting noninnocent (E,E)-dibenzylideneacetone (dba) effects in palladium(0)-mediated cross-coupling reactions: Modulation of the electronic properties of dba affects catalyst activity and stability in ligand and ligand-free reaction systems'
Fairlamb, Ian J. S. and Kapdi, Anant R. and Lee, Adam F. and McGlacken, Gerard P. and Weissburger, Felix and de Vries, Andre H. M. and Schmieder-van de Vondervoort, Lizette; (2006) 'Exploiting noninnocent (E,E)-dibenzylideneacetone (dba) effects in palladium(0)-mediated cross-coupling reactions: Modulation of the electronic properties of dba affects catalyst activity and stability in ligand and ligand-free reaction systems'. CHEMISTRY-A EUROPEAN JOURNAL, 12 (34):8750-8761 [DOI] [Details]
(2005)'A highly enantioselective, moderately anti-selective aldol reaction using a novel hydrazone moiety as stereo director'
McGlacken, GP and Breeden, SW; (2005) 'A highly enantioselective, moderately anti-selective aldol reaction using a novel hydrazone moiety as stereo director'. TETRAHEDRON-ASYMMETRY, 16 (22):3615-3618 [DOI] [Details]
(2005)'2-Pyrone natural products and mimetics: isolation, characterisation and biological activity'
McGlacken, GP and Fairlamb, IJS; (2005) '2-Pyrone natural products and mimetics: isolation, characterisation and biological activity'. NATURAL PRODUCT REPORTS, 22 (3):369-385 [DOI] [Details]

Book Chapters

YearPublication
(2015)'Pd Nanoparticles as Catalysts in Cross-coupling Reactions and the Homogeneous vs. Heterogeneous Debate'
Eoin O Muimhneachain and Gerard P. McGlacken (2015) 'Pd Nanoparticles as Catalysts in Cross-coupling Reactions and the Homogeneous vs. Heterogeneous Debate' In: Organometallic Chemistry. London: RSC. [Details]
(2009)'Recent Advances in Direction Arlyation via C-H activation'
G.P. McGlacken; (2009) 'Recent Advances in Direction Arlyation via C-H activation' In: Organometallic Chemsitry. Cambridge: RSC. [Details]

Honours and Awards

 YearTitleAwarding Body
2005Molecular Design and Synthesis Postdoctoral Fellowship Florida State University

Conference Contributions

YearPublication
(2014)8th Asian-European symposium on metal-mediated efficient organic synthesis,
Gerard P. McGlacken (2014) 8th Asian-European symposium on metal-mediated efficient organic synthesis. [Invited Lectures (Conference)], 8th Asian-European symposium on metal-mediated efficient organic synthesis, Izmir, Turkey , 07-SEP-14 - 10-SEP-14. [Details]
(2014)2nd International Symposium on C-H Activation,
Gerard P. McGlacken (2014) 2nd International Symposium on C-H Activation. [Invited Lectures (Conference)], 2nd International Symposium on C-H Activation, Rennes, France , 30-JUN-14 - 03-JUL-14. [Details]
(2013)MRS Meeting,
Collins, G., Schmidt, M., McGlacken, G., O'Dwyer, C. and Holmes, J. D. (2013) Probing the Origin of Structure Sensitivity and Facet Dependent Reactivity of Palladium Nanocatalysts in Carbon-Carbon Coupling Reactions. [Oral Presentation], MRS Meeting, Boston MA, USA . [Details]
(2013)OMCOS17,
McGlacken, G. P., Collins, G., Schmidt, M., O’Dwyer, C., Moynihan, H., deVries, K. M., May, S. A. and Holmes, J. D. (2013) Pd Nanoparticles Possessing Distinctive Facet Architecture and their Catalytic Activity in Suzuki-Miyaura Reactions. [Poster Presentation], OMCOS17, Fort Collins, Colorado, USA . [Details]

Teaching Interests

Dr McGlacken has a keen interest in the 'Research of Teaching' and treating Teaching as a discipline in itself. This has motivated him to complete a Certificate in 'Teaching and Learning in Higher Education' and he is currently undertaking a Higher Diploma in 'Teaching and Learning in Higher Education'. 

He teaches on:

CM1000 Introduction to Chemistry, which includes: Fundamental and Inorganic Chemistry: elements and compounds, structure of atoms, chemical bonding, the Periodic Table, structures of compounds and chemistry of selected elements and groups. Physical Chemistry: states of matter, energetics, solutions, equilibria, kinetics, acids and basis. Organic Chemistry: historical aspects, functional groups and classes of compounds, reaction mechanisms, functional group interconversions.


CM2006 Aromatics, Carbonyls and Alkenes, which includes: Structure, synthesis, and reactivity of aromatic compounds. Synthesis, structure and reactivity of carbonyl compounds - tautomerism, nucleophilic addition, aldol, and related condensation reactions. Reactions of alpha, beta -unsaturated carbonyl compounds. Polymerisation of alkenes under different conditions, molecular and bulk properties of polymers, industrial polymers.


CM3101 Natural Products and Reaction Mechanisms, which includes: Molecular Rearrangements. Natural Product Chemistry: classification of biological molecules on the basis of chemical structure, (carbohydrates, terpenes, etc.).

CM3022  Synthesis, Structure and Reactivity of Organic Compounds, which includes: Synthesis, structure and reactions of heterocyclic aromatic compounds including pyrrole, furan, thiophene, pyridine, pyridine N-oxide, indole quinoline and isoquinoline. Functional group chemistry of organosulphur and organophosphorus compounds. Structure and reactivity of free radicals, carbenes, nitrenes and benzynes. Introduction to the design of organic synthesis; disconnections, synthons and synthetic equivalents and survey of synthetic methods. Functional group chemistry based on oxygen and nitrogen. Advanced stereochemistry. Amino acids and related compounds. Advanced 1H NMR spectroscopy. Introduction to 13C NMR. Mass spectrometry of organic compounds).

CM4101 Physical Organic Chemistry, which includes: Review of relevant mechanistic and kinetics material, linear free energy relationships, isotope effects, kinetic versus thermodynamic control, catalysis, medium effects, bio-organic mechanisms. Essentials of QSAR, structure-reactivity principle, Hammond postulate).

He has previously taught on NU2047, CM1003, CM1005, CM3001, CM3004.

He also tutors on CM4022 Advanced Organic Synthesis, Biosynthesis and Reactivity, which includes:  Modern synthetic methods, photochemical reactions of organic compounds, organophosphorus, sulphur, selenium and palladium reagents; organic synthesis; design and strategy, retrosynthetic analysis, multistep partial and total synthesis; stereoselective reactions and asymmetric synthesis; chiral auxiliaries, reagents, catalysts; concerted pericyclic reactions; analysis base on orbital symmetry considerations; synthesis and reactions of heterocyclic compounds; natural products chemistry;biosynthesis and chemical transformations; structure reactivity relationships in organic chemistry).

Dr McGlacken served as Second Year Coordinator from 2009 - 2013 and is currently the Module Coordinator for CM2006, CM3022 and for the Final Year Project in the Chemistry of Pharmaceutical Compounds Degree (CM4203).


Current Postgraduate Students

 StudentDegree Type
Shanahan Rachel Maria Doctoral Degree
Prendergast Aisling Mary Doctoral Degree
Mackey Pamela Doctoral Degree
Mackey Katrina Doctoral Degree
O Muimhneachain Eoin Doctoral Degree