Research Profile

Stuart Collins

Biography

Dr Stuart Collins received his BSc. Degree in Chemistry, U.C.C. in 1998 and then did his PhD. in Organic Chemistry at U.C.C. under the supervision of Prof. Anita Maguire entitled "alpha-Diazosulfoxides-Synthesis and Transformations to alpha-Oxo Sulfines." He decided to follow an academic career path and worked on two Postdoctoral Research projects, the first on development of novel methodology for the synthesis of phosphononucleosides as antiviral agents (University College Cork and Tanaud Inc. Ireland) and the second on the asymmetric synthesis of unnatural amino acids (University College Cork and the Conway Institute University College Dublin). He has has been a lecturer in Organic and Pharmaceutical Chemistry here in UCC since 2004. He is a member of the Analytical and Biological Chemistry Research Facility (ABCRF) and the Synthesis and Solid State Pharmaceutical Centre (SSPC), an SFI funded collaboration involving academia and industry. Dr. Collins has had 8 PhD students and 1 MSc Research student graduated, all currently employed in the pharmaceutical industry in Ireland (4 in GSK, 1 in BMS, 1 in Merck and 1 in Eli Lilly). He currently has 5 PhD students in his research group. There have been 4 Enterprise Partnership IRCSET/IRC PhD students in his research group (sponsored by GSK and Merck), 4 independent IRCSET/IRC sponsored PhD students, 2 SFI (SSPC) funded students and 1 DAFF (FIRM) funded student, with total grant income for the period 2008-2016 €1.1M.  

Research Interests

My research is focused mainly in the area of natural product synthesis and organic synthetic methodology. The synthesis of small organic molecules that show biological activity against specific targets such as cancer, leukaemia, HIV etc. is a key overall theme of the group. Currently in my group I have 5 PhD students. There have been 4 Enterprise Partnership IRC PhD students in my research group (sponsored by GSK and Merck), 4 independent IRC sponsored PhD students, 2 SFI (SSPC) funded students and 1 DAFF (FIRM) funded student. Over the past 5 years I have also supervised 20 Final Year Projects (17 Chemistry/CPC and 3 Pharmacy) and 3 UREKA SFI students and 4 Visiting Masters students from Poitiers University and Clermont-Ferrand, France. All of my students and visiting students are doing research in the area of natural product synthesis with a view to synthesizing potential drug molecules for cancer, HIV and leukemia therapy; or organic synthetic methodology. The active research projects in my group at the moment are: 

1. The synthesis and reactivity of 2-thio-3-chloroacrylamides (beta-chloroacrylamides).

2. New insights into the synthesis of novel alpha-diazocarbonyl compounds and applications to the synthesis of beta-lactone natural products.

3. Studies towards the synthesis of lanostane-type natural products.

4. Synthesis and reactivity of novel alpha-diazosulfoxides: Formation of alpha-oxo sulfines as reactive intermediates.

5. Synthesis of neolamellarin analogues as antitumor agents

6. Synthesis of glycoalkaloid natural products isolated from potato peel

7. Synthesis of furanolipids as possible antitumor agents
 
8. The use of aryne chemistry in natural product synthesis 
 
9. Application of flow chemistry to processing involving hazardous intermediates

10. Development of tunable and scalable API processes through Advanced Process Control



Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
Using Flow Chemistry to do Hazardous Reactions in Large Scale Processes (collaboration with Prof Anita Maguire)Science Foundation Ireland01-OCT-1430-SEP-18€130,000.00
New metholds in Green Chemistry for Pharmaceutical processes.Irish Research Council01-OCT-1430-SEP-18€96,000.00
New insights into the reactivity of alpha-oxo sulfines generated from novel alpa-diazosulfoxides.Irish Research Council01-OCT-1330-SEP-17€96,000.00
Development of Tuneable and Scalable API Processes through Advanced Process Control (collaboration with Prof Anita Maguire)Science Foundation Ireland01-OCT-1330-SEP-17€130,000.00
Synthesis and reactivity of α-thio-β-chloroacrylamides and α-thio-β-chloroenones (collaboration with Prof Anita Maguire)Irish Research Council01-OCT-1230-SEP-15€72,009.00
Studies on the synthesis and reactivity of novel 1+diazocarbonyl compounds.Irish Research Council for Science, Engineering & Technology (IRCSET)01-OCT-1130-SEP-15€72,000.00
Synthesis of Furanolipids as Antitumor AgentsIrish Research Council for Science, Engineering & Technology (IRCSET)01-OCT-0930-SEP-12€72,009.00
Exploring the potential of potato peel waste as a source of phytopharmaceuticals bioactive peptides and as a control measure for potato nematodes (collaboration with Prof Anita Maguire)Department of Agriculture, Fisheries & Food (DAFF)01-DEC-0830-JUN-13€243,610.00
IRCSET PG Synthetic & Mechanistic Investigation of the Reasctivity of Diazosulfoxides Student Naomi BuckleyIrish Research Council for Science, Engineering & Technology (IRCSET)01-OCT-0830-SEP-12€72,009.00
IRCSET 'Microwave Assisted Reactions of Novel Alpha-Diazocarbonyl Compounds'Irish Research Council for Science, Engineering & Technology (IRCSET)01-OCT-0730-SEP-10€72,009.00
Synthesis and reactivity of α-thio-β-chloroacrylamides and α-thio-β-chloroenones (collaboration with Prof Anita Maguire)Irish Research Council01-OCT-0730-SEP-10€72,009.00

Publications

Book Chapters

 YearPublication
(2007)'Product Class 12:Aryl Sulfoxides and N Derivatives'
Collins, SG.; Maguire, A. R. ; (2007) 'Product Class 12:Aryl Sulfoxides and N Derivatives' In: Science of Synthesis Vol 31A 31.12. New York: Thieme Publishers. [Details]

Peer Reviewed Journals

 YearPublication
(2016)'Studies Towards Greener Diazo Transfer Methodology'
Elaine Tarrant, Claire V. O’Brien and Stuart G. Collins* (2016) 'Studies Towards Greener Diazo Transfer Methodology'. RSC Advances, 6 :31202-31209 [Details]
(2016)'Delivering enhanced efficiency in the synthesis of alpha-diazosulfoxides by exploiting the process control enabled in flow'
Patrick G. McCaw, Benjamin J. Deadman, Anita R. Maguire,* Stuart G. Collins* (2016) 'Delivering enhanced efficiency in the synthesis of alpha-diazosulfoxides by exploiting the process control enabled in flow'. Journal of Flow Chemistry, [DOI] [Details]
(2016)'Taming tosyl azide: the development of a scalable continuous diazo transfer process'
Deadman, B. J.; O’Mahony, R. M.; Lynch, D.; Crowley, D. C.; Collins, S. G.; Maguire, A. R. (2016) 'Taming tosyl azide: the development of a scalable continuous diazo transfer process'. Organic and Biomolecular Chemistry, 14 :3423-3431 [Details]
(2016)'A review on the generation, reactivity and uses of sulfines in organic synthesis'
Patrick G. McCaw, Naomi M. Buckley, Stuart G. Collins*, Anita R. Maguire* (2016) 'A review on the generation, reactivity and uses of sulfines in organic synthesis'. European Journal of Organic Chemistry, :1630-1650 [Details]
(2015)'Synthesis of novel 24-amino-25,26,27-trinorlanost-8-enes: Cytotoxic and Apoptotic Potential in U937 Cells'
O’Keeffe, R.; Kenny, O.; Brunton, N. P.; Hossain, M. B.; Rai, D. K.; Jones, P. W.; O’Brien, N.; Maguire, A. R.; Collins, S. G. (2015) 'Synthesis of novel 24-amino-25,26,27-trinorlanost-8-enes: Cytotoxic and Apoptotic Potential in U937 Cells'. Bioorganic & Medicinal Chemistry, 23 (9):2270-2280 [Details]
(2015)'Taming Hazardous Chemistry in Flow: The Continuous Processing of Diazo and Diazonium Compounds'
Deadman, B. J.; Collins, S. G.; Maguire, A. R. (2015) 'Taming Hazardous Chemistry in Flow: The Continuous Processing of Diazo and Diazonium Compounds'. Chemistry-A European Journal, 21 (6):2298-2308 [DOI] [Details]
(2014)'Hetero-Wolff Rearrangement of an a-Sulfinyl Carbene: Thermally Activated Intersystem Crossing of the Lowest Excited Triplet State of a Ground-State Singlet Carbene'
O'Sullivan, O. C. M.,Collins, S. G.,Maguire, A. R.,Buche, G. (2014) 'Hetero-Wolff Rearrangement of an a-Sulfinyl Carbene: Thermally Activated Intersystem Crossing of the Lowest Excited Triplet State of a Ground-State Singlet Carbene'. European Journal of Organic Chemistry, 2014 (1111):2297-2304 [Details]
(2014)'Taming Hazardous Chemistry in Flow: The Continuous Processing of Diazo and Diazonium Compounds'
Deadman, B. J.; Collins, S.G.; Maguire, A. R. (2014) 'Taming Hazardous Chemistry in Flow: The Continuous Processing of Diazo and Diazonium Compounds'. Chemistry-A European Journal, Article first published online [DOI] [Details]
(2013)'Cytotoxic and apoptotic potential of potato glycoalkaloids in a number of cancer cell lines'
Kenny, O. M; Brunton, N. P.; Rai, D. K.; Collins, S. G.; Jones, P. W.; Maguire, A. R.; O'Brien, N. M (2013) 'Cytotoxic and apoptotic potential of potato glycoalkaloids in a number of cancer cell lines'. Journal of Agricultural Science and Applications, 2 (4):184-192 [Details]
(2013)'Design and Synthesis of Stable alpha-Diazo-alpha-oxo sulfoxides'
Collins, Stuart G.; O'Sullivan, Orlagh C. M.; Kelleher, P. G.; Maguire, Anita R. (2013) 'Design and Synthesis of Stable alpha-Diazo-alpha-oxo sulfoxides'. Organic and Biomolecular Chemistry, 11 :1706-1725 [Details]
(2013)'Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages'
Kenny, O. M; McCarthy, C. M; Brunton, N. P.; Hossain, M. B.; Rai, D. K.; Collins, S. G.; Jones, P. W.; Maguire, A. R.; O'Brien, N. M. (2013) 'Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages'. Life Sciences, 92 :775-782 [Details]
(2012)'Development of O-H insertion for the attachment of phosphonates to nucleosides; Synthesis of α–carboxy phosphononucleosides'
Hladezuk, Isabelle; Chastagner, Veronique; Collins, Stuart G.; Plunkett, Stephen J.; Ford, Alan; Debarge, Sebastien; Maguire, Anita R. (2012) 'Development of O-H insertion for the attachment of phosphonates to nucleosides; Synthesis of α–carboxy phosphononucleosides'. Tetrahedron, 68 :1894-1909 [Details]
(2011)'ReactNMR and ReactIR as Reaction Monitoring and Mechanistic Elucidation Tools: The NCS Mediated Cascade Reaction of alpha-Thioamides to alpha-Thio-beta-chloroacrylamides'
Foley, David A. and Doecke, Christopher W. and Buser, Jonas Y. and Merritt, Jeremy M. and Murphy, Linda and Kissane, Marie and Collins, Stuart G. and Maguire, Anita R. and Kaerner, Andreas (2011) 'ReactNMR and ReactIR as Reaction Monitoring and Mechanistic Elucidation Tools: The NCS Mediated Cascade Reaction of alpha-Thioamides to alpha-Thio-beta-chloroacrylamides'. Journal of Organic Chemistry, 76 (23):9630-9640 [Details]
(2011)'Bioactivities of Glycoalkaloids and Their Aglycones from Solanum Species'
Milner, Sinead Eileen and Brunton, Nigel Patrick and Jones, Peter Wyn and O'Brien, Nora Mary and Collins, Stuart Gerard and Maguire, Anita Rose (2011) 'Bioactivities of Glycoalkaloids and Their Aglycones from Solanum Species'. Journal of Agricultural and Food Chemistry, 59 (8):3454-3484 [Details]
(2011)'Addition-substitution reactions of 2-thio-3-chloroacrylamides with carbon, nitrogen, oxygen, sulfur and selenium nucleophiles'
Kissane, M. and Murphy, M. and O'Brien, E. and Chopra, J. and Murphy, L. and Collins, S. G. and Lawrence, S. E. and Maguire, A. R.; (2011) 'Addition-substitution reactions of 2-thio-3-chloroacrylamides with carbon, nitrogen, oxygen, sulfur and selenium nucleophiles'. Organic and Biomolecular Chemistry, 9 :2452-2472 [CORA Link] [Details]
(2010)'Cell-based impedance spectroscopy for probing inhibitory effects of steroids and ergostane/lanosta-related compounds'
Male, Keith B; Crowley, Stephan M; Collins, Stuart G; Tzeng, Yew-Min; Luong, John HT; (2010) 'Cell-based impedance spectroscopy for probing inhibitory effects of steroids and ergostane/lanosta-related compounds'. Analytical Methods, 2 (7):870-877 [Details]
(2008)'Microwave-assisted reactions of alpha-diazosulfoxides to form alpha-oxo sulfines'
O'Sullivan, Orlagh C. M.; Collins, Stuart G.; Maguire, Anita R.; (2008) 'Microwave-assisted reactions of alpha-diazosulfoxides to form alpha-oxo sulfines'. Synlett, 5 :659-662 [Details]
(2007)'Phenylalanine dehydrogenase mutants: Efficient biocatalysts for synthesis of non-natural phenylalanine derivatives'
Paradisi, Francesca; Collins, Stuart; Maguire, Anita R.; Engel, Paul C.; (2007) 'Phenylalanine dehydrogenase mutants: Efficient biocatalysts for synthesis of non-natural phenylalanine derivatives'. Journal of Biotechnology, 128(2) (*):408-411 [Details]
(2006)'Amino acid dehydrogenase-derived biocatalysts'
Engel, Paul; Paradisi, Francesca; McCrohan, Oliver; Maguire, Anita; Collins, Stuart Gerard; Busca, Patricia; Giacomini, Daria.; (2006) 'Amino acid dehydrogenase-derived biocatalysts'. World Patent Information, PCT Int. Appl. CODEN: PIXXD2 WO 2006015885 A1 20060216 (*):*-* [Details]
(2006)'Photochemistry of cis-3-diazo-5,6-dimethyl-1,4-oxathian-2-one S-Oxide in argon matrices'
O'Sullivan, Orlagh C. M.; Collins, Stuart G.; Maguire, Anita R.; Bohm, Matthias; Sander, Wolfram.; (2006) 'Photochemistry of cis-3-diazo-5,6-dimethyl-1,4-oxathian-2-one S-Oxide in argon matrices'. European Journal of Organic Chemistry, 13 (*):2918-2924 [Details]
(2003)'Chemoenzymatic methods in the asymmetric synthesis of alpha-diazosulfoxides'
Maguire, Anita R.; Collins, Stuart G.; Ford, Alan.; (2003) 'Chemoenzymatic methods in the asymmetric synthesis of alpha-diazosulfoxides'. Arkivoc, 7 (*):96-109 [Details]
(2000)'Matrix isolation and photochemistry of a-diazo sulfoxides: formation of a-oxo sulfine as an intermediate'
Sander, Wolfram; Strehl, Anja; Maguire, Anita R.; Collins, Stuart; Kelleher, Patrick G.; (2000) 'Matrix isolation and photochemistry of a-diazo sulfoxides: formation of a-oxo sulfine as an intermediate'. European Journal of Organic Chemistry, 19 (*):3329-3335 [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
2007Royal Society of Chemistry Research Fund Overseas Winner 2007 Royal Society of Chemistry
2014Arkivoc Top Referee 2013 Arkivoc Control Board
2009Ireland Representative at EUCHEMS Young Investigator Workshop Prague EUCHEMS Organic Division

Professional Associations

 AssociationFunctionFrom / To
Royal Society of Chemistry Member01-JAN-98 /
American Chemical Society Member01-JAN-09 / 01-JUN-15
Arkivoc Editorial Board of Referees Member/Referee01-JAN-08 /

Patents

 Patent NumberTitleGranted
CODEN: PIXXD2Amino acid dehydrogenase-derived biocatalysts. 16-FEB-06

Conference Contributions

 YearPublication
(2016)Technical Meeting SSPC March,
Rosella O’Mahony, Stuart Collins, Ben Deadman, Denis Lynch and Anita R. Maguire (2016) Enabling Synthesis with Hazardous Reagents through Flow Chemistry. [Oral Presentation], Technical Meeting SSPC March, UCC , 30-MAR-16 - 30-MAR-16. [Details]
(2016)Technical Meeting SSPC June,
Stuart Collins, Ben Deadman, Denis Lynch, Rosella O’Mahony, Patrick McCaw, Humphrey Moynihan and Anita R. Maguire (2016) Collaboration and Future Ideas - Flow Chemistry. [Invited Lectures (Conference)], Technical Meeting SSPC June, University of Limerick , 01-JUN-16 - 02-JUN-16. [Details]
(2016)68th Irish Universities Chemistry Research Colloquium, University College Cork,
McCaw, P.G., Maguire, A.R. and Collins, S.G. (2016) Synthesis and reactivity of alpha-Diazosulfoxides in a continuous flow system. [Poster Presentation], 68th Irish Universities Chemistry Research Colloquium, University College Cork, UCC , 23-JUN-16 - 24-JUN-16. [Details]
(2016)SCI/RSC Continuous Flow Technology III,
Patrick G. McCaw, Stuart Collins, Anita Maguire (2016) Synthesis and reactivity of alpha-Diazosulfoxides in a continuous flow system. [Poster Presentation], SCI/RSC Continuous Flow Technology III, Cambridge University , 14-MAR-16 - 16-MAR-16. [Details]
(2016)API Continuous Technology Review,
Stuart Collins, Ben Deadman, Denis Lynch, Rosella O’Mahony, Patrick McCaw, Humphrey Moynihan and Anita R. Maguire (2016) Development of a Continuous Diazo Transfer Process. [Invited Lectures (Conference)], API Continuous Technology Review, University of Limerick , 21-JUN-16 - 21-JUN-16. [Details]
(2016)SCI/RSC Continuous Flow Technology III,
Rosella M. O’Mahony, Denis J. Lynch, Benjamin J. Deadman, Stuart G. Collins, Anita R. Maguire (2016) Optimisation of the Diazo Transfer Process in Flow: In Situ Generation and Use of Sulfonyl Azides. [Poster Presentation], SCI/RSC Continuous Flow Technology III, Cambridge University , 14-MAR-16 - 16-MAR-16. [Details]
(2015)Chemistry Research Day 2015, UCC,
Patrick McCaw, Stuart Collins and Anita Maguire (2015) New Methodology for the Synthesis of alpha-diazosulfoxides and their reactivity in 1,3-dipolarcycloadditions. [Poster Presentation], Chemistry Research Day 2015, UCC, UCC , 21-AUG-15 - 21-AUG-15. [Details]
(2015)Chemistry Research Day 2015, UCC,
Valerie Cacheux, Stuart Collins and Anita Maguire (2015) Studies into controlling reactivity and product formation in the oxidative transformation of alpha-thioamides to alpha-thio-β-chloroacrylamides via NCS. [Poster Presentation], Chemistry Research Day 2015, UCC, UCC , 21-AUG-15 - 21-AUG-15. [Details]
(2015)Technical Meeting SSPC April,
Rosella O’Mahony, Benjamin J. Deadman, Daniel Crowley, Stuart G. Collins, Humphrey Moynihan, Anita R. Maguire (2015) Innovative Approaches and Technologies in Pharmaceutical Process Chemistry and Engineering. [Oral Presentation], Technical Meeting SSPC April, Trinity College Dublin , 08-APR-15 - 09-APR-16. [Details]
(2015)Chemistry Research Day 2015, UCC,
Chloe Murphy, Stuart Collins and Anita Maguire (2015) Synthesis and Reactivity of alpha–Thio-beta-chloroenones and Initial Investigations into the Extension to the Novel alpha–Thio-beta-chloroenal. [Oral Presentation], Chemistry Research Day 2015, UCC, UCC , 21-AUG-15 - 21-AUG-15. [Details]
(2015)13th Annual Eli Lilly Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry,
Chloe Murphy, Stuart Collins and Anita Maguire (2015) Synthesis and Reactivity of alpha–Thio-beta-chloroenones and Initial Investigations into the Extension to the Novel alpha–Thio-beta-chloroenal. [Oral Presentation], 13th Annual Eli Lilly Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry, UCC , 25-SEP-15 - 25-SEP-15. [Details]
(2015)67th Irish Universities Chemistry Research Colloquium, University of Maynooth,
Claire O Brien and Stuart G. Collins (2015) A Fresh Approach towards the Synthesis of alpha-Diazocarbonyl Compounds. [Poster Presentation], 67th Irish Universities Chemistry Research Colloquium, University of Maynooth, University of Maynooth , 25-JUN-15 - 26-JUN-15. [Details]
(2015)13th Annual Eli Lilly Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry,
Chloe Murphy, Stuart Collins and Anita Maguire (2015) Synthesis and Reactivity of alpha–Thio-beta-chloroenones and Initial Investigations into the Extension to the Novel alpha–Thio-beta-chloroenal. [Oral Presentation], 13th Annual Eli Lilly Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry, UCC , 25-SEP-15 - 25-SEP-15. [Details]
(2015)Technical Meeting SSPC Sept,
Stuart G. Collins, Rosella O'Mahony, Benjamin J. Deadman, Denis Lynch, Humphrey Moynihan, Anita R. Maguire (2015) Innovative Approaches and Technologies in Pharmaceutical Process Chemistry and Engineering. [Oral Presentation], Technical Meeting SSPC Sept, UCD , 02-SEP-15 - 02-SEP-15. [Details]
(2015)Technical Meeting SSPC Dec,
ROSELLA M. O’MAHONY, DENIS J. LYNCH, BENJAMIN J. DEADMAN, STUART G. COLLINS, ANITA R. MAGUIRE (2015) Taming Tosyl Azide: In Situ Generation And Use Of Sulfonyl Azides. [Poster Presentation], Technical Meeting SSPC Dec, University of Limerick , 10-DEC-15 - 11-DEC-15. [Details]
(2015)Technical Meeting SSPC Dec,
Valerie Cacheux, Benjamin J. Deadman, Denis J. Lynch, Stuart G. Collins, Anita R. Maguire (2015) Studies into Controlling Reactivity and Product Formation in the Synthesis of α-Thio-β-chloroacrylamides. [Poster Presentation], Technical Meeting SSPC Dec, University of Limerick , 10-DEC-15 - 11-DEC-15. [Details]
(2014)Waste Not Want Not-Recovering Value from Food Waste,
Stuart G. Collins, Roisin O'Keeffe and Anita R. Maguire (2014) The Synthesis and Biological Evaluation of Lanostane and Cholestane Type Natural Products. [Invited Lectures (Conference)], Waste Not Want Not-Recovering Value from Food Waste, Teagasc, Ashtown, Dublin , 07-FEB-14. [Details]
(2014)Masterclass in Synthetic Organic Chemistry,
Stuart Collins (2014) Sulfoxides in Synthesis. [Invited Lectures (Conference)], Masterclass in Synthetic Organic Chemistry, University College Dublin , 02-SEP-14. [Details]
(2014)Chemistry Research Day 2014,
Patricia Hanlon and Stuart Collins (2014) The Application of Aryne Chemistry and Use of α-Diazo Carbonyl Derivatives in Indazole Synthesis. [Oral Presentation], Chemistry Research Day 2014, UCC , 28-AUG-14 - 28-AUG-14. [Details]
(2014)12th Annual Eli Lilly Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry,
Patricia Hanlon and Stuart Collins (2014) The Application of Aryne Chemistry and Use of α-Diazo Carbonyl Derivatives in Indazole Synthesis. [Oral Presentation], 12th Annual Eli Lilly Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry, UCC , 05-SEP-14 - 05-SEP-14. [Details]
(2014)Chemistry Research Day 2014,
Chloe Murphy, Stuart Collins and Anita Maguire (2014) Synthesis and Reactivity of α–Thio-β-chloroenones and Initial Investigations into the Extension to the Novel α–Thio-β-chloroenal. [Poster Presentation], Chemistry Research Day 2014, UCC , 28-AUG-14 - 28-AUG-14. [Details]
(2014)12th Annual Eli Lilly Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry (1st Prize),
Claire O'Brien and Stuart Collins (2014) A Fresh Approach Towards the Synthesis of a-Diazocarbonyl Compounds and Novel Dioxinones. [Oral Presentation], 12th Annual Eli Lilly Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry (1st Prize), UCC , 05-SEP-14 - 05-SEP-14. [Details]
(2014)Chemistry Research Day 2014,
Claire O'Brien and Stuart Collins (2014) A Fresh Approach Towards the Synthesis of a-Diazocarbonyl Compounds and Novel Dioxinones. [Oral Presentation], Chemistry Research Day 2014, UCC , 28-AUG-14 - 28-AUG-14. [Details]
(2014)T&L National Forum Seminar Series,
Stuart Collins (2014) The pedagogical challenges of teaching chemistry through a blended learning approach. [Invited Lectures (Conference)], T&L National Forum Seminar Series, Cavanagh Pharmacy Building, UCC , 13-JUN-14 - 13-JUN-14. [Details]
(2014)Technical Meeting SSPC,
Stuart Collins, Ben Deadman and Anita Maguire (2014) Taming Hazardous Reactions in Flow Chemistry. [Oral Presentation], Technical Meeting SSPC, Trinity , 08-APR-14. [Details]
(2013)Technical Meeting SSPC,
Stuart Collins and Anita Maguire (2013) Fresh Insights into the Synthesis and Reactivity of alpha-diazocarbonyl compounds. [Oral Presentation], Technical Meeting SSPC, UCC , 10-DEC-13. [Details]
(2013)Chemistry Research Day 2013,
Patricia Hanlon and Stuart Collins (2013) The Application of Aryne Chemistry and Use of α-Diazo Carbonyl Derivatives in Indazole Synthesis. [Poster Presentation], Chemistry Research Day 2013, UCC , 29-AUG-13 - 29-AUG-13. [Details]
(2013)Chemistry Research Day 2013,
Claire O'Brien and Stuart Collins (2013) A Fresh Look at the Regitz Diazo Transfer Reaction in the Synthesis of alpha-Diazocarboonyl Compounds Including Mechanistic Aspects. [Poster Presentation], Chemistry Research Day 2013, UCC , 29-AUG-13 - 29-AUG-13. [Details]
(2013)65th Irish Universities Chemistry Research Colloquium, University of Limerick,
Donal Harrold and Stuart Collins (2013) Synthesis of Furanolipids as Potential Antitumor Agents. [Oral Presentation], 65th Irish Universities Chemistry Research Colloquium, University of Limerick, Trinity College Dublin , 27-JUN-13 - 28-JUN-13. [Details]
(2012)RSC All Ireland Award Lecture Series,
Stuart Collins and Elaine Tarrant (2012) Fresh Insights into the Synthesis and Reactivity of alpha-Diazocarbonyl Compounds. [Invited Lectures (Conference)], RSC All Ireland Award Lecture Series, Queens University Belfast , 02-MAY-12. [Details]
(2012)10th Annual Eli Lilly Research Symposium in Organic & Pharmaceutical Chemistry,
Roisin O'Keeffe and Stuart Collins (2012) The Synthesis and Biological Evaluation of Lanostane type Natural Products. [Oral Presentation], 10th Annual Eli Lilly Research Symposium in Organic & Pharmaceutical Chemistry, UCC , 28-SEP-12 - 28-SEP-12. [Details]
(2012)41st Annual UCC Food Research Conference,
C.M. McCarthy, O. Kenny, M. Hossain, N. Brunton, S.G. Collins, A.R. Maguire, P. Jones, T.P. O’Connor, N.M. O’Brien (2012) The anti-inflammatory potential of potato glycoalkaloids and potato peel extracts in cellular in vitro model systems. [Oral Presentation], 41st Annual UCC Food Research Conference, UCC , 26-APR-12 - 27-APR-12. [Details]
(2012)10th Annual Eli Lilly Research Symposium in Organic & Pharmaceutical Chemistry (1st Prize),
Donal Harrold and Stuart Collins (2012) Synthesis of furanolipids as antitumour agents. [Oral Presentation], 10th Annual Eli Lilly Research Symposium in Organic & Pharmaceutical Chemistry (1st Prize), UCC , 28-SEP-12 - 28-SEP-12. [Details]
(2012)Chemistry Research Day 2012,
Donal Harrold and Stuart Collins (2012) Synthesis of Furanolipids as Antitumor Agents. [Oral Presentation], Chemistry Research Day 2012, UCC , 30-AUG-12 - 30-AUG-12. [Details]
(2012)Chemistry Research Day 2012,
Roisin O'Keeffe and Stuart Collins (2012) The Synthesis and Biological Evaluation of Lanostane type Natural Products. [Oral Presentation], Chemistry Research Day 2012, UCC , 30-AUG-12 - 30-AUG-12. [Details]
(2012)UCC Doctoral Showcase 2012 (1st Prize Best Presentation),
Donal Harrold and Stuart Collins (2012) Tackling Cancer Using Marine Life. [Oral Presentation], UCC Doctoral Showcase 2012 (1st Prize Best Presentation), UCC , 07-JUN-12 - 07-JUN-12. [Details]
(2011)Creativity and Innovation for Postgraduate Students,
Deirdre Cunningham and Stuart Collins (2011) The Synthesis of Neolamellarin/Lamellarin Analogues as Potential Anti-Tumor Agents. [Oral Presentation], Creativity and Innovation for Postgraduate Students, Tyndall Research Institute Cork , 09-DEC-11 - 09-DEC-11. [Details]
(2011)Creativity and Innovation for Postgraduate Students,
Naomi Buckley, Stuart Collins and Anita R Maguire (2011) Simplifying the Synthesis of Cyclic Sulfoxides. [Oral Presentation], Creativity and Innovation for Postgraduate Students, Tyndall Research Institute Cork , 09-DEC-11 - 09-DEC-11. [Details]
(2011)9th Annual Eli Lilly Research Symposium in Organic & Pharmaceutical Chemistry,
Deirdre Cunningham and Stuart Collins (2011) The Synthesis of Neolamellarin/lamellarin Analogues as Anti-Tumor Agents. [Oral Presentation], 9th Annual Eli Lilly Research Symposium in Organic & Pharmaceutical Chemistry, UCC , 16-SEP-11 - 16-SEP-11. [Details]
(2011)9th Annual Eli Lilly Research Symposium in Organic & Pharmaceutical Chemistry,
Naomi Buckley, Stuart Collins and Anita R Maguire (2011) Diverse Reaction Pathways of alpha-Oxo Sulfines Generated from alpha-Diazosulfoxides. [Oral Presentation], 9th Annual Eli Lilly Research Symposium in Organic & Pharmaceutical Chemistry, University College Cork , 16-SEP-11. [Details]
(2011)Groupement des Pharmacochimistes de l'Arc Atlantique GP2A,
Stuart Collins (2011) Organising Committee Member. [Conference Organising Committee Member], Groupement des Pharmacochimistes de l'Arc Atlantique GP2A, University College Cork , 01-SEP-11 - 02-SEP-12. [Details]
(2011)Groupement des Pharmacochimistes de l'Arc Atlantique GP2A,
Naomi Buckley, Stuart Collins and Anita R Maguire (2011) Nucleophilic Addition Reactions of alpha-Oxo Sulfines: A Novel Route Towards 3-Substituted-2(5H)furanones. [Oral Presentation], Groupement des Pharmacochimistes de l'Arc Atlantique GP2A, UCC , 01-SEP-11 - 02-SEP-11. [Details]
(2011)Chemistry Research Day 2011,
Naomi Buckley, Stuart Collins and Anita R Maguire (2011) Nucleophilic Addition Reactions of alpha-Oxo Sulfines: A Novel Route Towards 3-Substituted-2(5H)furanones. [Oral Presentation], Chemistry Research Day 2011, UCC , 25-AUG-11 - 25-AUG-11. [Details]
(2011)Chemistry Research Day 2011,
Roisin O'Keeffe and Stuart Collins (2011) Studies Towards the Synthesis of Lanostane type Natural Products with Anti-Cancer Activity. [Poster Presentation], Chemistry Research Day 2011, UCC , 25-AUG-11 - 25-AUG-11. [Details]
(2011)Groupement des Pharmacochimistes de l'Arc Atlantique GP2A,
Donal Harrold and Stuart Collins (2011) The Synthesis of Furanolipids as Antitumor Agents. [Oral Presentation], Groupement des Pharmacochimistes de l'Arc Atlantique GP2A, UCC , 01-SEP-11 - 02-SEP-11. [Details]
(2011)Chemistry Research Day 2011,
Deirdre Cunningham and Stuart Collins (2011) The Synthesis of Neolamellarin/Lamellarin Analogues as Anti-Tumor Agents. [Oral Presentation], Chemistry Research Day 2011, UCC , 25-AUG-11 - 25-AUG-11. [Details]
(2011)Chemistry Research Day 2011,
Donal Harrold and Stuart Collins (2011) Synthesis of Furanolipids as Antitumor Agents. [Poster Presentation], Chemistry Research Day 2011, UCC , 25-AUG-11 - 25-AUG-11. [Details]
(2011)63rd Irish Universities Chemistry Research Colloquium 2011,
Linda Murphy, Marie Kissane, Stuart Collins and Anita Maguire (2011) Synthesis and reactivity of alpha-thio-beta-chloroacrylamides and alpha-thio-beta-chloroenones. [Poster Presentation], 63rd Irish Universities Chemistry Research Colloquium 2011, University College Dublin , 23-JUN-11 - 24-JUN-11. [Details]
(2011)The Synthesis of Bioactive Molecules VI,
Stuart Collins (2011) Studies towards the synthesis of lanostane-type natural products and beta-lactones. [Invited Lectures (Conference)], The Synthesis of Bioactive Molecules VI, Analytical and Biological Chemical Research Facility, University College Cork , 29-JUN-11 - 29-JUN-11. [Details]
(2010)8th Annual Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry,
Elaine Tarrant and Stuart Collins (2010) Investigation Into Decomposition Pathways of α-Diazocarbonyl Compounds. [Oral Presentation], 8th Annual Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry, UCC , 16-SEP-10 - 16-SEP-10. [Details]
(2010)8th Annual Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry,
Linda Murphy, S G Collins, Anita R Maguire (2010) Nucleophilic Addition Reactions of 2-Thio-3-chloroacrylamides and their Derivatives. [Oral Presentation], 8th Annual Postgraduate Research Symposium in Organic & Pharmaceutical Chemistry, University College Cork , 16-SEP-10. [Details]
(2010)ICOS-18, 18th International conference on organic synthesis,
Naomi M. Buckley, Stuart G. Collins and Anita R. Maguire (2010) Diverse reaction pathways of alpha-oxo sulfines generated from alpha-diazosulfoxides. [Poster Presentation], ICOS-18, 18th International conference on organic synthesis, Bergen, Norway , 01-AUG-10. [Details]
(2010)Presentation to GSK, Ireland,
Elaine Tarrant and Stuart Collins (2010) Investigation Into Decomposition Pathways of α-Diazocarbonyl Compounds. [Oral Presentation], Presentation to GSK, Ireland, GSK, Cork , 31-MAY-10 - 31-MAY-10. [Details]
(2010)Joint Schools of Pharmacy Research Seminar 2010,
O'Keeffe, R.; Crowley, Stephan M.; Choi, S-E.; Male, Keith B.; Tzeng, Yew-Min; Luong, John H.T.; Collins, Stuart G.; (2010) The synthesis of lanostane-type natural products as possible antitumor agents. [Poster Presentation], Joint Schools of Pharmacy Research Seminar 2010, Queens University Belfast , 29-MAR-10 - 30-MAR-10. [Details]
(2009)EUCHEMS Organic Division, Young Investigator Workshop 2009,
Collins, S.; Maguire, A.R.; (2009) alpha-Diazosulfoxides: Synthesis and Transformation to alpha-oxo sulfines. [Invited Lectures (Workshops)], EUCHEMS Organic Division, Young Investigator Workshop 2009, Liblice, Czech Republic , 16-JUL-09 - 18-JUL-09. [Details]
(2008)Undergraduate PharmaChemical Research Opportunities (UPCRO) Workshop,
Stuart Collins, Marie Kissane and Anita Maguire (2008) - Use of Microwave Technology in Organic Synthesis. [Oral Presentation], Undergraduate PharmaChemical Research Opportunities (UPCRO) Workshop, UCC , 25-JUN-08 - 25-JUN-08. [Details]
(2008)60th Irish Universities Chemistry Research Colloquium,
Collins, S; (2008) Conference organisation. [Conference Organising Committee Member], 60th Irish Universities Chemistry Research Colloquium, UCC , 11-JUN-08 - 13-JUN-08. [Details]
(2006)58th Irish Universities Research Colloquium,
O¿Sullivan, O.C.M.,* Collins, S.G., Kelleher, P.G., Böhm, M., Sander, W. and Maguire A.R.; (2006) Identifying Reactive Intermediates Formed During the Decomposition of α-Diazosulfoxides. [Poster Presentation], 58th Irish Universities Research Colloquium, NUIG , 14-JUN-06 - 16-JUN-06. [Details]
(2006)COST D24 -WG0008-02,
Collins, Stuart; Maguire Anita. R. ; (2006) Synthesis and Reactivity of alpha-diazosulfoxides. [Oral Presentation], COST D24 -WG0008-02, Valencia Spain , 30-MAR-06 - 31-MAR-06. [Details]
(2005)Biotrans 2005,
F. Paradisi, S. Collins, A.R. Maguire, and P.C.Engel; (2005) Enantioselective synthesis of non-natural amino acids via enzymatic reductive amination. [Plenary Lecture], Biotrans 2005, Delft , 03-JUL-05 - 08-JUL-05. [Details]
(2005)Frontiers in Chemical Biology: Mechanistic Enzymology and Biocatalysis,
F. Paradisi, S. Collins, A.R. Maguire, and P.C.Engel; (2005) Enantioselective synthesis of non-natural amino acids via enzymatic reductive amination. [Poster Presentation], Frontiers in Chemical Biology: Mechanistic Enzymology and Biocatalysis, Exeter , 31-AUG-05 - 02-SEP-05. [Details]
(2003)Eli Lilly Organic Symposium,
Collins, S.; Maguire, A.R.; Kelleher, P.G. - Eli Lilly,; (2003) alpha-Diazosulfoxides: Precursors to alpha-oxo sulfines. [Oral Presentation], Eli Lilly Organic Symposium, UCC , 13-SEP-03 - 13-SEP-03. [Details]
(2000)19th International Symposium Organic Chemistry of Sulfur,
Collins, S.; Maguire, A.R.; Kelleher, P.G.; Lawrence, S.E.; Sander, W.; Strehl, A. ; (2000) Synthesis and Reactivity of alpha-Diazosulfoxides. [Oral Presentation], 19th International Symposium Organic Chemistry of Sulfur, Sheffield, UK , 25-JUN-00 - 30-JUN-00. [Details]
(2000)52th Irish Universities Chemistry Research Colloquium,
Collins, S; (2000) Conference organisation. [Conference Organising Committee Member], 52th Irish Universities Chemistry Research Colloquium, UCC , 08-MAY-00 - 10-MAY-00. [Details]

Committees

 CommitteeFunctionFrom / To
SEFS Research Committee Member2015 / 2016
Teaching and Examinations Examinations Coordinator2015 / 2016
SEFS Graduate Studies Member2015 / 2016
Chemistry Staff-Student Committee Member2006 /
Outreach and Promotion of Chemistry Committee Member2008 / 2012
Research and Graduate Studies Committee Member2010 /

Employment

 EmployerPositionFrom / To
Chemistry Dept/ABCRF Lecturer in Organic and Pharmaceutical Chemistry (Permanent)01-OCT-07 /
UCC Lecturer (Temporary)01-OCT-06 / 30-SEP-07
UCC/Conway Institute UCD Postdoctoral Researcher01-OCT-04 / 30-SEP-06
UCC/Tanaud Inc Ireland Postdoctoral Researcher01-OCT-02 / 30-SEP-04

Education

 YearInstitutionQualificationSubject
1998UCC BSC (HONS)CHEMISTRY
2015UCC Postgraduate Diploma in Teaching and Learning in Higher EducationEducation
2002UCC PhDChemistry
2014UCC Certificate in Teaching and Learning in Higher EduTeaching and Learning

Outreach Activities

 Description

International Year of Chemistry 2011 National Committee (2010-2011) – invited UCC delegate on this committee which was run principally by the Institute of Chemistry Ireland and PharmaChem Ireland- involved in the organisation, planning and running of national events throughout the IYOC 2011. In 2012 involved with a Young Scientist project on sunscreens with students from Colaiste Colm, Ballincollig.

UCC Open Day Chemistry and CPC Promotion- Coordinator (Oct 2010 and April 2011) of this very important outreach and promotion event, with responsibility for the preparation and running of the Chemistry and CPC stands, brochure production and distribution and talking to potential students and their parents in the promotion of Chemistry, SEFS and UCC in general.

Journal Activities

 JournalRoleTo / From
Journal Of Agriculture And Food Chemistry Referee01-JUN-11 -
Arkivoc Referee01-JAN-08 -

Other Activities

 Description

Invited Reviewer for the NUI Travelling Studentships in the Sciences 2014 and 2015

PhD External Examiner TCD on 14th Sep 2015, Andrew Byrne; Supervisor Prof. Mary Meegan

PhD External Examiner TCD on 23rd May 2014, Sivaji Gundala; Supervisor Prof. Stephen Connon

SFI/ABCRF UREKA SITE Site coordinator and member of the organizing committee for the UCC UPCRO (Undergraduate PharmaChemical Research Opportunities) site in 2007, 2008 and 2009 – this SFI funded initiative allowed the ABCRF to host a research site for undergraduate students both national and international for 10 weeks of the summer. In addition to the core research projects, the site also offered courses such as literature searching, presentation skills, scientific writing, analytical techniques etc. and site visits to local pharmaceutical industries.

International placement supervision: The following are details of the students who have done placements in my group over the past 5 years as part of their undergraduate degree programme: 1. Date: June-August 2007; Name: Mathieu Ceron; Institution: ENSCCF (Ecole Nationale Superieure de Chimie de Clermont-Ferrand 2. Date: April-May 2008; Name: Guillaume Sartori; Institution: University of Poitiers 3. Date: April-June 2009; Name: Simon Levach; Instituion: University of Poitiers 4. Date: May-June 2011; Name: Marjorie Bertrand; Institution: University of Poitiers

Visits Abroad


(2004) Ruhr-Universität-Bochum, Germany. Synthesis of a range of alpha-diazosulfoxides in UCC, Ireland (Prof. A. Maguire) and studies on their matrix isolation and photochemistry in Bochum, Germany (Prof. W. Sander). Two full papers have resulted from this collaborative work and have been published in the European Journal of Organic Chemistry. Oct 2004



 

Teaching Activities

Teaching Interests

Undergraduate teaching: Undergraduate teaching: CM1000 Introduction to Chemistry – Organic Section on Functional Groups; CM2002 Fundamentals of Organic Chemistry – Acidity and Basicity/Alkenes and Alkynes; CM2006 Carbonyl Chemistry; CM3022 Organic Synthesis, Intermediates and Heterocycles- Functional Groups and Reactive Intermediates; CM4022 Pericyclic Reactions and Heterocycles; PF6200 Pharmaceutical Chemistry (MSc. Pharmaceutical Technology and Quality Systems); CM3004 Structure and Reactivity of Organic Compounds – Amino Acids and Peptides; CM4108 Advanced Pharmaceutical Chemistry; CM1912 An Introduction to Chemistry (Environmental Management)

Course roles:

2nd Year CPC Coordinator (2008-Present)

2nd Year Undergraduate Organic Chemistry Practical Coordinator (2007-Present)

CM2002/CM3030 Module Coordinator (2007-Present)

PF6200 Module Coordinator (2011-Present)


Coordinator of the Postgraduate modules CM6101/7002/7003/7006 in Organic and Pharmaceutical Chemistry and have been instrumental in the planning and set up of these modules and how the courses run over the past 5 years. These modules involve research seminars given by postgraduate students and also teaching of advanced organic synthesis to these postgraduates by staff through problem sets and tutorials.






Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2016Patricia Hanlon University College CorkDOCTOR OF PHILOSOPHYThe Application of Aryne Chemistry and the Use of alpha-Diazocarbonyl Derivatives in Indazole Synthesis with Biological Evaluation
2014Roisin O'Keeffe UCCDOCTOR OF PHILOSOPHYThe Synthesis and Biological Evaluation of Lanostane and Cholestane-type Natural Products
2014Donal Harrold UCCDOCTOR OF PHILOSOPHYTotal Synthesis of Furospongolide and Related Furanolipid Analogues as Potential Anti-Tumour Agents
2013Linda Murphy UCCDOCTOR OF PHILOSOPHYSynthesis and Reactivity of α-Thio-β-Chloroacrylamides and α-Thio-β-Chloroenones
2013Naomi Buckley UCCDOCTOR OF PHILOSOPHYSynthesis and Reactivity of alpha-Diazo-beta-Keto Sulfoxides: Scope and Synthetic Potential
2013Deirdre Cunningham UCCDOCTOR OF PHILOSOPHYStudies Towards the Syntheis and Biological Evaluation of Novel Neolamellarin Analogues
2012Elaine Tarrant UCCDOCTOR OF PHILOSOPHYNew Insights into the Synthesis of alpha-Diazocarbonyl Compounds and their Decomposition Pathways
2012Stephan Crowley UCCMASTER OF SCIENCEStudies Toward the Synthesis of Lanostane-type Triterpenoids and their Inhibitory Effects

Current Postgraduate Students

 StudentDegree Type
O Brien Claire Valerie Doctoral Degree
Cacheux Valerie Doctoral Degree
O Mahony Rosella Maria Doctoral Degree
Mc Carthy Laura Ann Doctoral Degree
Mc Caw Patrick Gerard Doctoral Degree
Murphy Chloe Courtney Doctoral Degree
Hanlon Patricia Doctoral Degree

Modules Taught

 Term (ID))TitleLinkSubject
2016Pharmaceutical Chemistry PF6200Pharmaceutical Chemistry
2016Aromatics, Carbonyls and Alkenes CM2006Aromatics, Carbonyls and Alkenes

Research Information

Internal Collaborators

 NameInstituteCountry
Prof. Anita Maguire University College CorkIRELAND
Dr. Eric Moore Tyndall National InstituteIRELAND
Prof. Nora O'Brien University College CorkIRELAND

External Collaborators

 NameOrganisation / InstituteCountry
Dr. Nigel Brunton University College DublinIRELAND
Dr. Dilip Rai Teagasc Food Research CentreIRELAND
Dr. David Foley and Dr. Andreas Kaerner Analytical Sciences Research and Development Group, Eli Lilly, IndianapolisU.S.A.
Prof. Wolfram Sander Ruhr-Universität-BochumGERMANY
Dr. Gotz Bucher University of GlasgowSCOTLAND
Prof. John Luong Biotechnology Research Institute, National Research Council QuebecCANADA

Contact details


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