Microbiology
UCC

T: +353 21 490 2392
E: M.Scallan@ucc.ie

In a scientific career initiated with a B.Sc. in Biochemistry from the University of St. Andrews, Scotland and a Ph.D from the Medical Research Council, Institute of Virology, Glasgow; I ventured to Cambridge, England and back to Scotland again for post doctoral research experience in viral pathogenesis before landing in UCC.

I now teach and examine over 500 undergraduate students every year ( in the second, third and fourth years of their degrees), with responsibility for lecture modules encompassing Virology, Epidemiology and Microbial Pathogenesis.  Each year I also host undergraduate fourth year research projects in Virology and Cell Biology for the Microbiology and Biomedical Science B.Sc. degrees (4 to 5) and Postgraduate Projects for the M.Sc. in Molecular Cell Biology and Bio-innovation and M.Sc. Biomedical Science.  In addition to other administrative roles, I have chaired the School of Microbiology Teaching, Learrning and Student Experience committee (TLSE) and the Teaching & Curriculum Development committee and have been an active member of the corresponding college-level committees.

With research expertise in classical and molecular virology and cell culture, I established a Category II Virus Research Laboratory at UCC, and have been happy to welcome collaborators.  In that environment I have trained and supervised 9 PhD and 9 M.Sc. students to graduation.  With research projects directed towards dissecting the molecular interplay between viruses and their host cells. Collaboration within and beyond UCC has supported our research in the field of virus vectors for therapeutic intervention in the face of cancer, neurodegeneration and genetic disease.  Innovation funding has recently supported our investigation of 3-D culture systems as a platform for virus-vector based production systems. 

Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
New product and processdevelopment in animal cell bioprocessing and tissue engineering.Enterprise Irl01-JUN-1431-AUG-14€6,500.00
Permanent correction of 80% of Disease causing Mutations in Human CF cells.Cystic Fibrosis Trust01-OCT-1330-SEP-14€59,000.00
Gene repair Conference.Health Research Board01-DEC-1230-JUN-14€14,000.00
Cystinosis Gene RepairOther: Not Listed01-OCT-1030-SEP-12€110,329.00
Towards a cure of CystinosisHealth Research Board01-OCT-0830-SEP-12€148,425.00
{Scallan/Morgan} N, 'Pathogenesis'Science Foundation of Ireland01-OCT-0331-OCT-08€666,077.00
[HEA Cyc.3]{Harrison/Scallan/Sullivan} NHigher Education authority01-JUN-0230-SEP-08€170,769.00

Peer Reviewed Journals

YearPublication
(2013)'Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism'
G. Loughran,JE Libbey, S Uddowla, MF Scallan,M.D.Ryan,R.S.Fujinama,E.Rider and J.F.Atkins (2013) 'Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism'. Journal of General Virology, :348-353 [Details]
(2012)'Molecular characterization of varicella-zoster virus clinical isolates from 2006 to 2008 in a tertiary care hospital, Dublin, Ireland, using different genotyping methods'
Emma Roycroft,Lisa Rose,Martina F. Scallan,Brendan Crowley. (2012) 'Molecular characterization of varicella-zoster virus clinical isolates from 2006 to 2008 in a tertiary care hospital, Dublin, Ireland, using different genotyping methods'. Journal of Medical Virology, 84 (10):1672-1679 [Details]
(2011)'E47 retroviral rescue of intrinsic B-cell defects in senescent mice'
Landin, AM,Frasca, D,Harrison, P,Scallan, M,Riley, RL,Blomberg, BB; (2011) 'E47 retroviral rescue of intrinsic B-cell defects in senescent mice'. Aging Cell, 10 :327-337 [DOI] [Details]
(2012)'Correction of the ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Gene by Zinc-Finger Nuclease Homology-Directed Repair'
Ciaran M. Lee, Rowan Flynn, Jennifer A. Hollywood, Martina F. Scallan, and Patrick T. Harrison (2012) 'Correction of the ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Gene by Zinc-Finger Nuclease Homology-Directed Repair'. BioResearch Open Access, 1 (3):99-108 [Details]
(2011)'The role of Pax5 and E47 on AID expression in B lymphocytes of Aged BALB/c Mice'
Ana Marie Landin,Daniela Frasca,Martina Scallan,Patrick Harrison,James Hagman, and Bonnie Blomberg (2011) 'The role of Pax5 and E47 on AID expression in B lymphocytes of Aged BALB/c Mice'. The Journal of Immunology, 186 [Details]
(2010)'AAV2-mediated in vivo immune gene therapy of solid tumours'
Collins, S. A.,Buhles, A.,Scallan, M. F.,Harrison, P. T.,O'Hanlon, D. M.,O'Sullivan, G. C.,Tangney, M.; (2010) 'AAV2-mediated in vivo immune gene therapy of solid tumours'. Genetic vaccines and therapy, 8 Globe icon [Details]
(2010)'Pax5 and E47 regulate AID and class switch recombination in young and aged BALB/c mice'
Ana Marie Landin,Daniela Frasca,Patrick Harrison,Martina Scallan,James Hagman, and Bonnie Blomberg (2010) 'Pax5 and E47 regulate AID and class switch recombination in young and aged BALB/c mice'. Journal of Immunology, 184 [Details]
(2008)'Viral vectors in cancer immunotherapy: which vector for which strategy?'
Collins, S. A.,Guinn, B. A.,Harrison, P. T.,Scallan, M. F.,O'Sullivan, G. C.,Tangney, M.; (2008) 'Viral vectors in cancer immunotherapy: which vector for which strategy?'. Curr Gene Ther, 8 (22):66-7866 Globe icon [Details]
(2007)'In vitro replication models for the hepatitis C virus'
Sheehy P, Mullan B, Moreau I, Kenny-Walsh E, Shanahan F, Scallan M, Fanning LJ.; (2007) 'In vitro replication models for the hepatitis C virus'. Journal of Viral Hepatitis, 14 (1):2-10 [Details]
(2005)'A strategy for obtaining near full-length HCV cDNA clones (assemblicons) by assembly PCR'
Sheehy, P.,Scallan, M.,Kenny-Walsh, E.,Shanahan, F.,Fanning, L. J. (2005) 'A strategy for obtaining near full-length HCV cDNA clones (assemblicons) by assembly PCR'. Journal of Virological Methods, 123 (2):115-124 Globe icon [Details]
(2000)'The impact of survival signalling on Semliki Forest virus replication and on virus-induced cell-death'
Cusack, J., O'Brien, D., Regan, C., O'Connor, R. & Scallan, M.F.; (2000) 'The impact of survival signalling on Semliki Forest virus replication and on virus-induced cell-death'. Journal of Clinical Virology, 18 (1-3) [Details]
(2000)'An in vitro investigation of the effects of sodium aurothiomalte on the replication of Semliki Forest virus'
Walshe, T., Cusack, J. & Scallan, M. F.; (2000) 'An in vitro investigation of the effects of sodium aurothiomalte on the replication of Semliki Forest virus'. Journal of Clinical Virology, 18 (1-3) [Details]
(1999)'Aurothiolates enhance the replication of Semliki Forest virus in the CNS and the exocrine pancreas'
Scallan, M. F. & Fazakerley, J.K.; (1999) 'Aurothiolates enhance the replication of Semliki Forest virus in the CNS and the exocrine pancreas'. Journal of Neurovirology, 5 (4):392-400 [Details]
(1998)'Virus infection induces neuronal apoptosis: A comparison with trophic factor withdrawal'
Allsopp, T. E., Scallan, M. F., Williams, A., Fazakerley, J. K.; (1998) 'Virus infection induces neuronal apoptosis: A comparison with trophic factor withdrawal'. Cell Death and Differentiation, 5 :50-59 [Details]
(1998)'Sexual transmission of GB virus C/hepatitis G virus'
Scallan M. F., Clutterbuck D., Jarvis L.M., Scott G.R., Simmonds P.; (1998) 'Sexual transmission of GB virus C/hepatitis G virus'. Journal of Medical Virology, 55 (3):203-208 [Details]
(1997)'{Bcl}-2 Acts Early to Restrict Semliki Forest Virus Replication and Delays Virus-Induced Programmed Cell Death [B2334]'
Scallan, Martina; Allsopp, T.; Fazakerley, J.; (1997) '{Bcl}-2 Acts Early to Restrict Semliki Forest Virus Replication and Delays Virus-Induced Programmed Cell Death [B2334]'. Journal of Virology, 71 :1583-1590 [Details]
(1997)'Susceptibility to a Neurotropic Virus and Its Changing Distribution in the Developing Brain Is a Function of CNS Maturity [B2335]'
Fazakerley, J.; Oliver, K.; Dyson, H.; Scallan, Martina; (1997) 'Susceptibility to a Neurotropic Virus and Its Changing Distribution in the Developing Brain Is a Function of CNS Maturity [B2335]'. Journal of Neurovirology, :38-48 [Details]
(1996)'Role of Immune Responses in Protection and Pathogenesis During Semliki Forest Virus Encephalitis [B2333]'
Fazakerley, J.; Scallan, Martina; Amor, S.; Morris, M.; Dyson, H.; (1996) 'Role of Immune Responses in Protection and Pathogenesis During Semliki Forest Virus Encephalitis [B2333]'. Journal of General Virology, :281-291 [Details]
(1995)'Age-related restricted replication and spread of Semliki forest virus is related to synaptogenesis and maturity of neuronal systems'
Fazakerley JK, Oliver K, Scallan MF; (1995) 'Age-related restricted replication and spread of Semliki forest virus is related to synaptogenesis and maturity of neuronal systems'. Journal of Cellular Biochemistry, 19A [Details]
(1993)'Replication of the A7(74) Strain of Semliki Forest Virus Is Restricted in Neurons [B2332]'
Fazakerley, J.; Pathak, S.; Amor, M.; Dyson, H.; Scallan, Martina; (1993) 'Replication of the A7(74) Strain of Semliki Forest Virus Is Restricted in Neurons [B2332]'. Virology, 195 :627-637 [Details]
(1992)'Extra-pair paternity in the Shag, Phalacrocorax Aristotelis as determined by DNA fingerprinting'
Graves, J., Hay, R. T., Scallan, M. and Rowe, S. ; (1992) 'Extra-pair paternity in the Shag, Phalacrocorax Aristotelis as determined by DNA fingerprinting'. Journal of Zoology, 226 (3):339-408 [Details]
(1987)'Glucosylation of Human Fibrinogen: possible relevance to the complications of Diabetes'
Scallan, M. et al.; (1987) 'Glucosylation of Human Fibrinogen: possible relevance to the complications of Diabetes'. Physiology and Clinical Relevance, :107-110 [Details]
(1992)'Defective RNAs in Mosquito Cells Persistently Infected With Bunyamwera Virus [B2331]'
Elliot, R.; Scallan, Martina; (1992) 'Defective RNAs in Mosquito Cells Persistently Infected With Bunyamwera Virus [B2331]'. Journal of General Virology, 73 :53-60 [Details]

Book Chapters

YearPublication
(2011)'Comparison of DNA Delivery and Expression Using Frequently Used Delivery Methods'
Sara A. Collins, David Morrissey, Simon Rajendran, Garrett Casey, Martina F. Scallan, Patrick T. Harrison, Gerald C. O’Sullivan and Mark Tangney (2011) 'Comparison of DNA Delivery and Expression Using Frequently Used Delivery Methods' In: Gene Therapy - Developments and Future Perspectives. USA: ISBN. [Details]

Book Reviews

YearPublication
(2007)In vitro replication models for the hepatitis C virus.
Sheehy, P,Mullan, B,Moreau, I,Kenny-Walsh, E,Shanahan, F,Scallan, M,Fanning, LJ (2007) In vitro replication models for the hepatitis C virus. Book Reviews [DOI] [Details]

Conference Publications

YearPublication
(2014)11th European Cystic Fibrosis Society Meeting, Malta
Hollywood, JA, Lee, CM, Scallan, MF and Harrison, PT. (2014) Strategy to correct >80% of CF-causing mutations using CRISPR/Cas9 and mini-gene constructs 11th European Cystic Fibrosis Society Meeting, Malta [Details]
(2013)22nd European Gene and Cell Therapy Conference, Madrid, Spain
Hollywood, JA, Lee, CM1, Kaschig, K., Artemiuk, P., Scallan, MF and Harrison, PT. (2013) Gene editing of CFTR and CTNS mutations using ZFNs and CRISPr/Cas-9 guide RNAs 22nd European Gene and Cell Therapy Conference, Madrid, Spain [Details]
(2011)European Society of Gene and Cell Therapy, Brighton UK
Kaschig, K,Lee, CM,Hollywood, JA,Scallan, MF,Harrison, PT (2011) Kaschig, K,Lee, CM,Hollywood, JA,Scallan, MF,Harrison, PT European Society of Gene and Cell Therapy, Brighton UK [Details]
(2011)European Society of Gene and Cell Therapy, Brighton UK
Lee, CM,Scallan, MF,Harrison, PT (2011) The development of zinc finger nucleases to target mutations in the cystinosin gene using the rapid OPEN screening method European Society of Gene and Cell Therapy, Brighton UK [Details]
(2007)15th Annual Congress of the European Society of Gene and Cell Therapy
Collins S., Harrison PT, Scallan MF; (2007) Adeno-associated virus-mediated gene therapy for cancer . In: Human Gene Therapy 18 (10) eds. 15th Annual Congress of the European Society of Gene and Cell Therapy , pp.999-999 [Details]
(2005)Viral vectors to deliver neurotrophin genes to a rat model of Parkinson's disease
Kelly, TA, Harrison, PT, Scallan, MF and Sullivan, AM; (2005) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson's disease Viral vectors to deliver neurotrophin genes to a rat model of Parkinson's disease , pp.529-530 [Details]
(2005)16th International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany
Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2005) Lentiviral-mediated delivery of growth/differentiation factor-5 attenuates parkinsonian symptoms in the rat . In: Parkinsonism & Related Disorders Volume 11, Supplement 2 eds. 16th International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany Berlin, [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland
Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson’s disease . In: J. Anat. 205 (6) eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details]
(2004)Physiological Society meeting, Bristol, UK
Kelly T.A., Harrison P.T., Scallan M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson’s disease Physiological Society meeting, Bristol, UK [Details]

Professional Associations

 AssociationFunctionFrom / To
Society of General Microbiology Member01-JAN-88 / 31-DEC-15

Conference Contributions

YearPublication
(2006)UK network of young (non-professorial) virologists,
Scallan, M.; (2006) Intracellular virus-host interactions. [Conference Organising Committee Chairperson], UK network of young (non-professorial) virologists, Derby, UK , 01-JAN-06 - 01-JAN-06. [Details]
(2005)16th International Conference on Parkinson's Disease,
Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2005) Lentiviral-mediated delivery of growth/differentiation factor 5 attenuates parkinsonian symptoms in the rat. [Poster Presentation], 16th International Conference on Parkinson's Disease, Berlin, Germany , 05-JUN-05 - 09-JUN-05. [Details]
(2004)Anatomical Society of Great Britain and Ireland Summer Meeting,
Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson's disease. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details]
(2004)Physiological Society meeting,
Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson’s disease. [Poster Presentation], Physiological Society meeting, Bristol, UK , 11-SEP-04 - 12-SEP-04. [Details]

Committees

 CommitteeFunctionFrom / To
Irish Medicines Board Member1998 /
SEFS Academic Programmes Curriculum Development Committee Member2011 / 2013
SEFS Teaching and Learning and Student Experience Committee Processing, Development and Approval of processes and policies affecting Teaching and Learning and Student Experience2014 / 2016

Employment

 EmployerPositionFrom / To
Department of Microbiology Lecturer01-OCT-97 /
Department of Medical Microbiology, University of Edinburgh Postdoctoral Research Fellow01-JAN-96 / 01-JAN-97
Department of Veterinary Pathology, University of Edinburgh Postdoctoral Research Fellow01-JAN-94 / 01-JAN-96
Department of Pathology, University of Cambridge Postdoctoral Research Fellow01-JAN-91 / 01-JAN-94

Education

 YearInstitutionQualificationSubject
1987University of St.Andrews Scotland BSc HonsBiochemistry
1991University of Glasgow, Scotland PhDVirology

Languages

 LanguageReadingWritingSpeaking
French FunctionalFunctionalFunctional

Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2013Katrin Kaschig UCCPhDZinc finger nuclease gene repair as a treatment for cystinosis
2011Sara Collins UCCPHDAdeno-Associated virus vectors for cancer gene therapy
2013Jennifer Hollywood UCCPhDCystic fibrosis gene repair : correction of ΔF508 using ZFN and CRISPR/Cas9 guide RNA gene editing tools
2009Brendan Palmer UCCPhDMutagenesis studies of the Semliki Forest virus capsid protein
2008Aisling Murphy UCCPhDCellular Responses to and Probiotic Antagonism of Rotavirus Infection
2011Ciaran Lee UCCPhDCystic fibrosis gene repair : development of zinc finger nucleases for homology directed repair of the CFTR

Modules Taught

 Term (ID))TitleLinkSubject
2015Advanced Virology MB4008Advanced Virology
2015Virology MB3002Virology
2015Research Project MB4002Research Project
2015Transmission and Epidemiology of Infectious Disease MB3912Transmission and Epidemiology of Infectious Disease
2015Research Frontiers in Microbiology MB4027Research Frontiers in Microbiology
2015Transmission and Epidemiology of Infectious Disease MB3012Transmission and Epidemiology of Infectious Disease
2015Principles of Microbiology MB2006Principles of Microbiology