Biography
In a scientific career initiated with a B.Sc. in Biochemistry from the University of St. Andrews, Scotland and a Ph.D from the Medical Research Council, Institute of Virology, Glasgow; I ventured to Cambridge, England and back to Scotland again for post doctoral research experience in viral pathogenesis before landing in UCC.
I now teach and examine over 500 undergraduate students every year ( in the second, third and fourth years of their degrees), with responsibility for lecture modules encompassing Virology, Epidemiology and Microbial Pathogenesis. Each year I also host undergraduate fourth year research projects in Virology and Cell Biology for the Microbiology and Biomedical Science B.Sc. degrees (4 to 5) and Postgraduate Projects for the M.Sc. in Molecular Cell Biology and Bio-innovation and M.Sc. Biomedical Science. In addition to other administrative roles, I have chaired the School of Microbiology Teaching, Learrning and Student Experience committee (TLSE) and the Teaching & Curriculum Development committee and have been an active member of the corresponding college-level committees.
With research expertise in classical and molecular virology and cell culture, I established a Category II Virus Research Laboratory at UCC, and have been happy to welcome collaborators. In that environment I have trained and supervised 9 PhD and 9 M.Sc. students to graduation. With research projects directed towards dissecting the molecular interplay between viruses and their host cells. Collaboration within and beyond UCC has supported our research in the field of virus vectors for therapeutic intervention in the face of cancer, neurodegeneration and genetic disease. Innovation funding has recently supported our investigation of 3-D culture systems as a platform for virus-vector based production systems.
Research Grants
| Project | Funding Body | Start Date | End Date | Award | |
|---|---|---|---|---|---|
| New product and processdevelopment in animal cell bioprocessing and tissue engineering. | Enterprise Irl | 01-JUN-14 | 31-AUG-14 | €6,500.00 | |
| Permanent correction of 80% of Disease causing Mutations in Human CF cells. | Cystic Fibrosis Trust | 01-OCT-13 | 30-SEP-14 | €59,000.00 | |
| Gene repair Conference. | Health Research Board | 01-DEC-12 | 30-JUN-14 | €14,000.00 | |
| Cystinosis Gene Repair | Other: Not Listed | 01-OCT-10 | 30-SEP-12 | €110,329.00 | |
| Towards a cure of Cystinosis | Health Research Board | 01-OCT-08 | 30-SEP-12 | €148,425.00 | |
| {Scallan/Morgan} N, 'Pathogenesis' | Science Foundation of Ireland | 01-OCT-03 | 31-OCT-08 | €666,077.00 | |
| [HEA Cyc.3]{Harrison/Scallan/Sullivan} N | Higher Education authority | 01-JUN-02 | 30-SEP-08 | €170,769.00 |
Publications
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2013) | 'Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism' G. Loughran,JE Libbey, S Uddowla, MF Scallan,M.D.Ryan,R.S.Fujinama,E.Rider and J.F.Atkins (2013) 'Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism'. Journal of General Virology, :348-353 [Details] | |
| (2012) | 'Molecular characterization of varicella-zoster virus clinical isolates from 2006 to 2008 in a tertiary care hospital, Dublin, Ireland, using different genotyping methods' Emma Roycroft,Lisa Rose,Martina F. Scallan,Brendan Crowley. (2012) 'Molecular characterization of varicella-zoster virus clinical isolates from 2006 to 2008 in a tertiary care hospital, Dublin, Ireland, using different genotyping methods'. Journal of Medical Virology, 84 (10):1672-1679 [Details] | |
| (2011) | 'E47 retroviral rescue of intrinsic B-cell defects in senescent mice' Landin, AM,Frasca, D,Harrison, P,Scallan, M,Riley, RL,Blomberg, BB; (2011) 'E47 retroviral rescue of intrinsic B-cell defects in senescent mice'. Aging Cell, 10 :327-337 [DOI] [Details] | |
| (2012) | 'Correction of the ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Gene by Zinc-Finger Nuclease Homology-Directed Repair' Ciaran M. Lee, Rowan Flynn, Jennifer A. Hollywood, Martina F. Scallan, and Patrick T. Harrison (2012) 'Correction of the ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Gene by Zinc-Finger Nuclease Homology-Directed Repair'. BioResearch Open Access, 1 (3):99-108 [Details] | |
| (2011) | 'The role of Pax5 and E47 on AID expression in B lymphocytes of Aged BALB/c Mice' Ana Marie Landin,Daniela Frasca,Martina Scallan,Patrick Harrison,James Hagman, and Bonnie Blomberg (2011) 'The role of Pax5 and E47 on AID expression in B lymphocytes of Aged BALB/c Mice'. The Journal of Immunology, 186 [Details] | |
| (2010) | 'AAV2-mediated in vivo immune gene therapy of solid tumours' Collins, S. A.,Buhles, A.,Scallan, M. F.,Harrison, P. T.,O'Hanlon, D. M.,O'Sullivan, G. C.,Tangney, M.; (2010) 'AAV2-mediated in vivo immune gene therapy of solid tumours'. Genetic vaccines and therapy, 8 [Details] | |
| (2010) | 'Pax5 and E47 regulate AID and class switch recombination in young and aged BALB/c mice' Ana Marie Landin,Daniela Frasca,Patrick Harrison,Martina Scallan,James Hagman, and Bonnie Blomberg (2010) 'Pax5 and E47 regulate AID and class switch recombination in young and aged BALB/c mice'. Journal of Immunology, 184 [Details] | |
| (2008) | 'Viral vectors in cancer immunotherapy: which vector for which strategy?' Collins, S. A.,Guinn, B. A.,Harrison, P. T.,Scallan, M. F.,O'Sullivan, G. C.,Tangney, M.; (2008) 'Viral vectors in cancer immunotherapy: which vector for which strategy?'. Curr Gene Ther, 8 (22):66-7866 [Details] | |
| (2007) | 'In vitro replication models for the hepatitis C virus' Sheehy P, Mullan B, Moreau I, Kenny-Walsh E, Shanahan F, Scallan M, Fanning LJ.; (2007) 'In vitro replication models for the hepatitis C virus'. Journal of Viral Hepatitis, 14 (1):2-10 [Details] | |
| (2005) | 'A strategy for obtaining near full-length HCV cDNA clones (assemblicons) by assembly PCR' Sheehy, P.,Scallan, M.,Kenny-Walsh, E.,Shanahan, F.,Fanning, L. J. (2005) 'A strategy for obtaining near full-length HCV cDNA clones (assemblicons) by assembly PCR'. Journal of Virological Methods, 123 (2):115-124 [Details] | |
| (2000) | 'The impact of survival signalling on Semliki Forest virus replication and on virus-induced cell-death' Cusack, J., O'Brien, D., Regan, C., O'Connor, R. & Scallan, M.F.; (2000) 'The impact of survival signalling on Semliki Forest virus replication and on virus-induced cell-death'. Journal of Clinical Virology, 18 (1-3) [Details] | |
| (2000) | 'An in vitro investigation of the effects of sodium aurothiomalte on the replication of Semliki Forest virus' Walshe, T., Cusack, J. & Scallan, M. F.; (2000) 'An in vitro investigation of the effects of sodium aurothiomalte on the replication of Semliki Forest virus'. Journal of Clinical Virology, 18 (1-3) [Details] | |
| (1999) | 'Aurothiolates enhance the replication of Semliki Forest virus in the CNS and the exocrine pancreas' Scallan, M. F. & Fazakerley, J.K.; (1999) 'Aurothiolates enhance the replication of Semliki Forest virus in the CNS and the exocrine pancreas'. Journal of Neurovirology, 5 (4):392-400 [Details] | |
| (1998) | 'Virus infection induces neuronal apoptosis: A comparison with trophic factor withdrawal' Allsopp, T. E., Scallan, M. F., Williams, A., Fazakerley, J. K.; (1998) 'Virus infection induces neuronal apoptosis: A comparison with trophic factor withdrawal'. Cell Death and Differentiation, 5 :50-59 [Details] | |
| (1998) | 'Sexual transmission of GB virus C/hepatitis G virus' Scallan M. F., Clutterbuck D., Jarvis L.M., Scott G.R., Simmonds P.; (1998) 'Sexual transmission of GB virus C/hepatitis G virus'. Journal of Medical Virology, 55 (3):203-208 [Details] | |
| (1997) | '{Bcl}-2 Acts Early to Restrict Semliki Forest Virus Replication and Delays Virus-Induced Programmed Cell Death [B2334]' Scallan, Martina; Allsopp, T.; Fazakerley, J.; (1997) '{Bcl}-2 Acts Early to Restrict Semliki Forest Virus Replication and Delays Virus-Induced Programmed Cell Death [B2334]'. Journal of Virology, 71 :1583-1590 [Details] | |
| (1997) | 'Susceptibility to a Neurotropic Virus and Its Changing Distribution in the Developing Brain Is a Function of CNS Maturity [B2335]' Fazakerley, J.; Oliver, K.; Dyson, H.; Scallan, Martina; (1997) 'Susceptibility to a Neurotropic Virus and Its Changing Distribution in the Developing Brain Is a Function of CNS Maturity [B2335]'. Journal of Neurovirology, :38-48 [Details] | |
| (1996) | 'Role of Immune Responses in Protection and Pathogenesis During Semliki Forest Virus Encephalitis [B2333]' Fazakerley, J.; Scallan, Martina; Amor, S.; Morris, M.; Dyson, H.; (1996) 'Role of Immune Responses in Protection and Pathogenesis During Semliki Forest Virus Encephalitis [B2333]'. Journal of General Virology, :281-291 [Details] | |
| (1995) | 'Age-related restricted replication and spread of Semliki forest virus is related to synaptogenesis and maturity of neuronal systems' Fazakerley JK, Oliver K, Scallan MF; (1995) 'Age-related restricted replication and spread of Semliki forest virus is related to synaptogenesis and maturity of neuronal systems'. Journal of Cellular Biochemistry, 19A [Details] | |
| (1993) | 'Replication of the A7(74) Strain of Semliki Forest Virus Is Restricted in Neurons [B2332]' Fazakerley, J.; Pathak, S.; Amor, M.; Dyson, H.; Scallan, Martina; (1993) 'Replication of the A7(74) Strain of Semliki Forest Virus Is Restricted in Neurons [B2332]'. Virology, 195 :627-637 [Details] | |
| (1992) | 'Extra-pair paternity in the Shag, Phalacrocorax Aristotelis as determined by DNA fingerprinting' Graves, J., Hay, R. T., Scallan, M. and Rowe, S. ; (1992) 'Extra-pair paternity in the Shag, Phalacrocorax Aristotelis as determined by DNA fingerprinting'. Journal of Zoology, 226 (3):339-408 [Details] | |
| (1987) | 'Glucosylation of Human Fibrinogen: possible relevance to the complications of Diabetes' Scallan, M. et al.; (1987) 'Glucosylation of Human Fibrinogen: possible relevance to the complications of Diabetes'. Physiology and Clinical Relevance, :107-110 [Details] | |
| (1992) | 'Defective RNAs in Mosquito Cells Persistently Infected With Bunyamwera Virus [B2331]' Elliot, R.; Scallan, Martina; (1992) 'Defective RNAs in Mosquito Cells Persistently Infected With Bunyamwera Virus [B2331]'. Journal of General Virology, 73 :53-60 [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2011) | 'Comparison of DNA Delivery and Expression Using Frequently Used Delivery Methods' Sara A. Collins, David Morrissey, Simon Rajendran, Garrett Casey, Martina F. Scallan, Patrick T. Harrison, Gerald C. O’Sullivan and Mark Tangney (2011) 'Comparison of DNA Delivery and Expression Using Frequently Used Delivery Methods' In: Gene Therapy - Developments and Future Perspectives. USA: ISBN. [Details] |
Book Reviews
| Year | Publication | |
|---|---|---|
| (2007) | In vitro replication models for the hepatitis C virus. Sheehy, P,Mullan, B,Moreau, I,Kenny-Walsh, E,Shanahan, F,Scallan, M,Fanning, LJ (2007) In vitro replication models for the hepatitis C virus. Book Reviews [DOI] [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2014) | 11th European Cystic Fibrosis Society Meeting, Malta Hollywood, JA, Lee, CM, Scallan, MF and Harrison, PT. (2014) Strategy to correct >80% of CF-causing mutations using CRISPR/Cas9 and mini-gene constructs 11th European Cystic Fibrosis Society Meeting, Malta [Details] | |
| (2013) | 22nd European Gene and Cell Therapy Conference, Madrid, Spain Hollywood, JA, Lee, CM1, Kaschig, K., Artemiuk, P., Scallan, MF and Harrison, PT. (2013) Gene editing of CFTR and CTNS mutations using ZFNs and CRISPr/Cas-9 guide RNAs 22nd European Gene and Cell Therapy Conference, Madrid, Spain [Details] | |
| (2011) | European Society of Gene and Cell Therapy, Brighton UK Kaschig, K,Lee, CM,Hollywood, JA,Scallan, MF,Harrison, PT (2011) Kaschig, K,Lee, CM,Hollywood, JA,Scallan, MF,Harrison, PT European Society of Gene and Cell Therapy, Brighton UK [Details] | |
| (2011) | European Society of Gene and Cell Therapy, Brighton UK Lee, CM,Scallan, MF,Harrison, PT (2011) The development of zinc finger nucleases to target mutations in the cystinosin gene using the rapid OPEN screening method European Society of Gene and Cell Therapy, Brighton UK [Details] | |
| (2007) | 15th Annual Congress of the European Society of Gene and Cell Therapy Collins S., Harrison PT, Scallan MF; (2007) Adeno-associated virus-mediated gene therapy for cancer . In: Human Gene Therapy 18 (10) eds. 15th Annual Congress of the European Society of Gene and Cell Therapy , pp.999-999 [Details] | |
| (2005) | Viral vectors to deliver neurotrophin genes to a rat model of Parkinson's disease Kelly, TA, Harrison, PT, Scallan, MF and Sullivan, AM; (2005) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson's disease Viral vectors to deliver neurotrophin genes to a rat model of Parkinson's disease , pp.529-530 [Details] | |
| (2005) | 16th International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2005) Lentiviral-mediated delivery of growth/differentiation factor-5 attenuates parkinsonian symptoms in the rat . In: Parkinsonism & Related Disorders Volume 11, Supplement 2 eds. 16th International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany Berlin, [Details] | |
| (2004) | Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson’s disease . In: J. Anat. 205 (6) eds. Anatomical Society of Great Britain and Ireland Summer Meeting 2004, Cork, Ireland [Details] | |
| (2004) | Physiological Society meeting, Bristol, UK Kelly T.A., Harrison P.T., Scallan M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson’s disease Physiological Society meeting, Bristol, UK [Details] |
Professional Activities
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| Society of General Microbiology | Member | 01-JAN-88 / 31-DEC-15 |
Conference Contributions
| Year | Publication | |
|---|---|---|
| (2006) | UK network of young (non-professorial) virologists, Scallan, M.; (2006) Intracellular virus-host interactions. [Conference Organising Committee Chairperson], UK network of young (non-professorial) virologists, Derby, UK , 01-JAN-06 - 01-JAN-06. [Details] | |
| (2005) | 16th International Conference on Parkinson's Disease, Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2005) Lentiviral-mediated delivery of growth/differentiation factor 5 attenuates parkinsonian symptoms in the rat. [Poster Presentation], 16th International Conference on Parkinson's Disease, Berlin, Germany , 05-JUN-05 - 09-JUN-05. [Details] | |
| (2004) | Anatomical Society of Great Britain and Ireland Summer Meeting, Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson's disease. [Poster Presentation], Anatomical Society of Great Britain and Ireland Summer Meeting, Cork, Ireland , 06-AUG-04 - 08-AUG-04. [Details] | |
| (2004) | Physiological Society meeting, Kelly, T.A., Harrison, P.T., Scallan, M.F., Sullivan, A.M. (2004) Viral vectors to deliver neurotrophin genes to a rat model of Parkinson’s disease. [Poster Presentation], Physiological Society meeting, Bristol, UK , 11-SEP-04 - 12-SEP-04. [Details] |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| Irish Medicines Board | Member | 1998 / | |
| SEFS Academic Programmes Curriculum Development | Committee Member | 2011 / 2013 | |
| SEFS Teaching and Learning and Student Experience Committee | Processing, Development and Approval of processes and policies affecting Teaching and Learning and Student Experience | 2014 / 2016 |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| Department of Microbiology | Lecturer | 01-OCT-97 / | |
| Department of Medical Microbiology, University of Edinburgh | Postdoctoral Research Fellow | 01-JAN-96 / 01-JAN-97 | |
| Department of Veterinary Pathology, University of Edinburgh | Postdoctoral Research Fellow | 01-JAN-94 / 01-JAN-96 | |
| Department of Pathology, University of Cambridge | Postdoctoral Research Fellow | 01-JAN-91 / 01-JAN-94 |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1987 | University of St.Andrews Scotland | BSc Hons | Biochemistry | |
| 1991 | University of Glasgow, Scotland | PhD | Virology |
Languages
| Language | Reading | Writing | Speaking | |
|---|---|---|---|---|
| French | Functional | Functional | Functional |
Teaching Activities
Recent Postgraduates
| Graduation Year | Student Name | Institution | Degree Type | Thesis Title | |
|---|---|---|---|---|---|
| 2013 | Katrin Kaschig | UCC | PhD | Zinc finger nuclease gene repair as a treatment for cystinosis | |
| 2011 | Sara Collins | UCC | PHD | Adeno-Associated virus vectors for cancer gene therapy | |
| 2013 | Jennifer Hollywood | UCC | PhD | Cystic fibrosis gene repair : correction of ΔF508 using ZFN and CRISPR/Cas9 guide RNA gene editing tools | |
| 2009 | Brendan Palmer | UCC | PhD | Mutagenesis studies of the Semliki Forest virus capsid protein | |
| 2008 | Aisling Murphy | UCC | PhD | Cellular Responses to and Probiotic Antagonism of Rotavirus Infection | |
| 2011 | Ciaran Lee | UCC | PhD | Cystic fibrosis gene repair : development of zinc finger nucleases for homology directed repair of the CFTR |
Modules Taught
| Term (ID)) | Title | Link | Subject | |
|---|---|---|---|---|
| 2015 | Advanced Virology | MB4008 | Advanced Virology | |
| 2015 | Virology | MB3002 | Virology | |
| 2015 | Research Project | MB4002 | Research Project | |
| 2015 | Transmission and Epidemiology of Infectious Disease | MB3912 | Transmission and Epidemiology of Infectious Disease | |
| 2015 | Research Frontiers in Microbiology | MB4027 | Research Frontiers in Microbiology | |
| 2015 | Transmission and Epidemiology of Infectious Disease | MB3012 | Transmission and Epidemiology of Infectious Disease | |
| 2015 | Principles of Microbiology | MB2006 | Principles of Microbiology |