Biography
Professor Nora O'Brien holds a BSc (Food Science) from UCC, a MS (Nutrition) from the University of Minnesota, and a PhD (Nutritional Biochemistry) from Cornell University. She was a Postdoctoral Fellow at the University of Louvain in Belgium before returning to a Lectureship in Nutrition in her native Cork in December 1989. In subsequent years Nora achieved promotion to Senior Lecturer and currently is Professor in Nutrition.
Nora has substantial teaching commitments at undergraduate level which she finds both fulfilling and very enjoyable. Her research programme on the relationships between nutrition and health has grown very successfully through the years. Over 6 million in research funds have been generated from national and international funding sources, including a Science Foundation Ireland Investigator Award, to support her team's work. Over 50 individuals have worked under Nora's supervision at MSc, PhD and Post-doctoral levels.
The team's work has resulted in well over 160 peer-reviewed research publications in the international scientific literature as well as numerous conference presentations, invited book chapters and reviews. Research conducted by Nora's team has contributed significantly to increased understanding of the relationship between nutrition and health and, in particular, the beneficial role of fruit and vegetables in the diet.
Over the years many members of her team have received awards for their work. Professor O'Brien has been a recipient of the Royal Irish Academy Nutrition Medal in 2000. She has also been active in public service including membership of the Irish Council for Bioethics and the Scientific Advisory Committee of the Food Safety Promotion Board. Nora is a member of the Nutrition Society, the Carotenoid Society as well as other professional groups. She has given many public lectures on her research interests and other nutrition-related topics.
Research Interests
Bioactivity of dietary components
My group has developed a number of cell culture models to study the effects and mechanisms of action of a range of dietary components. We have focused on the cytoprotective, antioxidant, antigenotoxic and immunomodulatory effects of these components in cell systems. The range of dietary components we have studied to-date include carotenoids, tocopherols, flavonoids and other phytochemicals. Our basic research in this area is important in helping to understand the fundamental mechanisms of action of these phytochemicals and also has considerable practical commercial relevance in underpinning development of the emerging markets for Functional Foods. In addition to individual chemical compounds, we have also assessed the bioactivity of extracts from seaweed, herbs, potato peel extracts and brewers' spent grain. Currently, we are investigating the bioactivity of protein hydrolysates extracted from a variety of sources including milk, meat, fish, barley, potatoes and flaxseed.
Bioavailability of dietary components
We have successfully established an in vitro bioavailability model employing a simulated digestion procedure and differentiated Caco-2 cells grown on transwell plates. We have published many studies demonstrating the validity and usefulness of the model. The main chemicals whose bioavailability we have tested to-date are carotenoids and tocopherols.
Biological effects of sterols and oxysterols
Our work has focused on the cytotoxic, genotoxic and cell signalling effects of cholesterol and phytosterol oxidation products in cellular model systems. The potential protective effect of phytochemicals against the toxic action of oxysterols has also been studied. Additionally, we are systematically analysing the phytosterol and oxyphytosterol contents of plant foodstuffs.
Human Nutrition in the Developing World
In addition to longstanding teaching activities in this area, we are also involved in relevant research activities. Currently, these include the AGRIDIET project which is funded by Irish Aid. This project involves investigation of agriculture-nutrition linkages in different agro-ecological zones of Ethiopia and Tanzania. Our group is contributing the nutrition expertise for the project. Extensive fieldwork has been completed and data analysis is ongoing. Recently, our group has also been successful in obtaining significant funding from the Department of Agriculture, Food and the Marine (DAFM) for a 4 year project whose objective is the development of a novel Fortified Blended Food suitable for use by the World Food Programme and other humanitarian organisations.
Current Research Team:
5 PhD students
1 MSc student
Current Research Support Officer:
Dr. Yvonne O Callaghan
Past Post-Doctoral Researchers:
Dr. Alison Wilson
Dr. Irene O Connor
Dr. Gabriele Froemming
Dr. Helena de Vasconcelos
Dr. Christopher Jewell
Dr. Julie Woods
Dr. Aisling Aherne
Dr. Mikhail Konoplyannikov
Dr. Lisa Ryan
Dr. Sinead Lordan
Dr. Eileen Ryan
Past Research Assistants:
Ms Olivia Kenny MSc
Ms Nicole Lyons MSc
Ms Sinead O'Sullivan MSc
Mr Trevor Daly MSc
Mr Marvin Jiwan MSc
Dr. Yvonne O Callaghan
Past Post-Doctoral Researchers:
Dr. Alison Wilson
Dr. Irene O Connor
Dr. Gabriele Froemming
Dr. Helena de Vasconcelos
Dr. Christopher Jewell
Dr. Julie Woods
Dr. Aisling Aherne
Dr. Mikhail Konoplyannikov
Dr. Lisa Ryan
Dr. Sinead Lordan
Dr. Eileen Ryan
Past Research Assistants:
Ms Olivia Kenny MSc
Ms Nicole Lyons MSc
Ms Sinead O'Sullivan MSc
Mr Trevor Daly MSc
Mr Marvin Jiwan MSc
Publications
In Press
| Year | Publication | |
|---|---|---|
| (2015) | Total carotenoids and ascorbic acid content in sixty varieties of potato (Solanum tuberosum L.) grown in Ireland. Valcarcel, J, Reilly, K, Gaffnet, M, O'Brien, NM (2015) Total carotenoids and ascorbic acid content in sixty varieties of potato (Solanum tuberosum L.) grown in Ireland. In Press [Details] | |
| (2015) | Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?. McCarthy, M, O'Halloran, J, O'Brien NM, van Pelt, FNAM (2015) Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?. In Press [Details] | |
| (2014) | A study of the ability of bioactive extracts from brewers' spent grain to enhance the antioxidant and immunomodulatory potential of food formulations following in vitro digestion. McCarthy, AL, O'Callaghan, YC, Connolly, A, Piggott, CO, FitzGerald, RJ, O'Brien, NM (2014) A study of the ability of bioactive extracts from brewers' spent grain to enhance the antioxidant and immunomodulatory potential of food formulations following in vitro digestion. In Press [Details] | |
| (2014) | Anti-inflammatory effects of extracts prepared from wild Irish mushrooms in RAW264.7 mouse macrophage cells. O'Callaghan, YC, Smyth, TJ, Brunton, N, O'Brien, NM (2014) Anti-inflammatory effects of extracts prepared from wild Irish mushrooms in RAW264.7 mouse macrophage cells. In Press [Details] |
Working Paper
| Year | Publication | |
|---|---|---|
| (2015) | Levels of potential bioactive compounds including carotenoids, vitamin C and phenolic compounds, and expression of their cognate biosynthetic genes vary significantly in different varieties of potato (Solanum tuberosum L.) grown under uniform cultural conditions. Valcarcel, J, Reilly, K, Gaffnet, M, O'Brien, NM (2015) Levels of potential bioactive compounds including carotenoids, vitamin C and phenolic compounds, and expression of their cognate biosynthetic genes vary significantly in different varieties of potato (Solanum tuberosum L.) grown under uniform cultural conditions. Working Paper [Details] | |
| (2015) | Effect of pre-treatments and defatting processes of seabass (Lates calcarifer) skin on properties and fishy odour of gelatin. Sae-leaw, T, Benjakul, S, O'Brien, NM (2015) Effect of pre-treatments and defatting processes of seabass (Lates calcarifer) skin on properties and fishy odour of gelatin. Working Paper [Details] | |
| (2015) | Effect of pre-treatments and drying methods on properties and fishy odour of gelatin from seabass (Latescalcarifer) skin. Sae-leaw, T, Benjakul, S, O'Brien, NM (2015) Effect of pre-treatments and drying methods on properties and fishy odour of gelatin from seabass (Latescalcarifer) skin. Working Paper [Details] | |
| (2015) | Synthesis of novel 24-aminochol-8-enes derived from lanosterol: Cytotoxic and apoptotic potential in U937 cells. O'Keeffe, R, Kenny, O, Brunton, NP, Hossain, MP, Rai, DK, Jones, PW, O'Brien, NM, Maguire, AR, Collins, SG (2015) Synthesis of novel 24-aminochol-8-enes derived from lanosterol: Cytotoxic and apoptotic potential in U937 cells. Working Paper [Details] |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2020) | 'A marine-derived, multi-Mineral supplement influences bacterial fermentation and short chain fatty acid profile in vitro' Felice, V.D., O’Gorman, D.M., Apajalahti, J., Rinttila, T., O’Brien, N.M. and Hyland, N.P. (2020) 'A marine-derived, multi-Mineral supplement influences bacterial fermentation and short chain fatty acid profile in vitro'. Journal Of Medicinal Food, [Details] | |
| (2020) | 'Whey for sarcopenia; can whey peptides, hydrolysates or proteins play a beneficial role?' Gilmartin, S., O’Brien, N.M., Giblin, L (2020) 'Whey for sarcopenia; can whey peptides, hydrolysates or proteins play a beneficial role?'. Foods, [Details] | |
| (2020) | 'Changes in colour, water holding capacity and pasting behaviour of fortified blended foods made from different cereals on storage at different temperatures' Shevade, A., O’Callaghan, Y.C., O’Brien, N.M., O’Connor, T.P. and Guinee, T.P. (2020) 'Changes in colour, water holding capacity and pasting behaviour of fortified blended foods made from different cereals on storage at different temperatures'. Journal of Food Science and Technology, [Details] | |
| (2019) | 'Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes' Sghaier, R., Zarrouk, A., Nury, T., Ilham, B., O’Brien, N.M., Mackrill, J.J., Vejus, A., Samadi, M., Nasser, B., Caccia, A., Leoni, V., Moreau, T., Masmoudi, A.S. and Lizard, G. (2019) 'Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes'. Free Radical Research, [Details] | |
| (2019) | 'Seasonal variations in household food insecurity and dietary diversity and their association with maternal and child nutritional status in rural Ethiopia' Roba, Kedir T.; O’Connor, Thomas P.; O’Brien, Nora M.; Aweke, Chanyalew S.; Kahsay, Zenebe A.; Chisholm, Nick; Lahiff, Edward (2019) 'Seasonal variations in household food insecurity and dietary diversity and their association with maternal and child nutritional status in rural Ethiopia'. Food Security, :1-14 [DOI] [Full Text] [Details] | |
| (2019) | 'The effect of high-pressure processing on polyphenol oxidase activity, phytochemicals and proximate composition of Irish potato cultivars' Tsikrika, K., O’Brien, M.N., and Rai, D.K. (2019) 'The effect of high-pressure processing on polyphenol oxidase activity, phytochemicals and proximate composition of Irish potato cultivars'. Foods, [Details] | |
| (2019) | 'Immunomodulatory effects of casein hydrolysates generated using a range of enzymes in stimulated Jurkat T cells and RAW264.7 macrophages' O’Sullivan S.M., O’Keeffe, M.B., FitzGerald, R.J. and O’Brien, N.M. (2019) 'Immunomodulatory effects of casein hydrolysates generated using a range of enzymes in stimulated Jurkat T cells and RAW264.7 macrophages'. International Dairy Journal, [Details] | |
| (2019) | 'Development of a dehydrated fortified food base from fermented milk and parboiled wheat, and comparison of its composition and reconstitution behaviour with those of commercial dried dairy-cereal blends' Shevade, A., O’Callaghan, Y.C., O’Brien, N.M., O’Connor, T.P. and Guinee, T.P. (2019) 'Development of a dehydrated fortified food base from fermented milk and parboiled wheat, and comparison of its composition and reconstitution behaviour with those of commercial dried dairy-cereal blends'. International Journal of Food Science and Nutrition, [Details] | |
| (2019) | 'Comparison of the nutritional composition of laboratory-scale fermented blends of buttermilk and cereal in comparison with commercial kishk and tarhana products' O’Callaghan Y.C., Shevade, A., Guinee, T., O’Connor T.P. and O’Brien, N.M. (2019) 'Comparison of the nutritional composition of laboratory-scale fermented blends of buttermilk and cereal in comparison with commercial kishk and tarhana products'. Food Chemistry, [Details] | |
| (2019) | 'Fortified blended food base: Effect of co-fermentation time on composition, phytic acid content and reconstitution properties' Shevade, A., O’Callaghan, Y.C., O’Brien, N.M., O’Connor, T.P. and Guinee, T.P. (2019) 'Fortified blended food base: Effect of co-fermentation time on composition, phytic acid content and reconstitution properties'. Foods, [Details] | |
| (2019) | 'Cereal type significantly affects the composition and reconstitution characteristics of dried fermented milk-cereal composites' Shevade, A., O’Callaghan, Y.C., Kennedy, D., O’Brien, N.M., O’Connor, T.P. and Guinee, T.P (2019) 'Cereal type significantly affects the composition and reconstitution characteristics of dried fermented milk-cereal composites'. Journal of The Science of Food and Agriculture, [Details] | |
| (2019) | 'Antifungal activity of a de nova synthetic peptide and derivatives against fungal food contaminants' Thery, T.L.C., O’Callaghan, Y.C., O’Brien, N.M. and Arendt, E.K. (2019) 'Antifungal activity of a de nova synthetic peptide and derivatives against fungal food contaminants'. Journal Of Peptide Science, [Details] | |
| (2019) | 'Seasonal variations in household food insecurity and dietary diversity and their association with maternal and child nutritional status in rural Ethiopia' Roba, K.T., O’Connor, T.P., O’Brien, N.M., Aweke, C.S., Kahsay, Z.A., Chisholm, N. and Lahiff, E. (2019) 'Seasonal variations in household food insecurity and dietary diversity and their association with maternal and child nutritional status in rural Ethiopia'. Food Security, [Details] | |
| (2018) | 'Functional protein rich extracts from bovine and porcine hearts using acid or alkali solubilisation and isoelectric precipitation' Tsermoula, Paraskevi; Virgili, Claudia; Ortega, Rodrigo G.; Mullen, Anne M.; Álvarez, Carlos; O'Brien, Nora M.; O'Flaherty, Elisabeth A. A.; O'Neill, Eileen E. (2018) 'Functional protein rich extracts from bovine and porcine hearts using acid or alkali solubilisation and isoelectric precipitation'. International Journal of Food Science & Technology, 0 (0) [DOI] [Full Text] [Details] | |
| (2018) | 'Bioaccessibility and bioavailability of a marine-derived multi-mineral Aquamin-Magnesium' Felice, V.D., O’Gorman, D.M., O’Brien, N.M. and Hyland, N.P. (2018) 'Bioaccessibility and bioavailability of a marine-derived multi-mineral Aquamin-Magnesium'. Nutrients, [Details] | |
| (2018) | 'Functional protein rich extracts from bovine and porcine hearts using acid or alkali solubilisation and isoelectric precipitation' Tsermoula P., Virgilli, C., Ortega, R.G., Mullen A.M., Alvarez C., O'Brien N.M., O’Flaherty E. and O'Neill E. (2018) 'Functional protein rich extracts from bovine and porcine hearts using acid or alkali solubilisation and isoelectric precipitation'. International Journal of Food Science and Technology, [Details] | |
| (2018) | 'Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium' Felice VD, O'Gorman DM, O'Brien NM, Hyland N (2018) 'Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium'. Nutrients, 10 (7) [DOI] [Details] | |
| (2018) | 'The proportion of fermented milk in dehydrated fermented milk–parboiled wheat composites significantly affect their composition, pasting behaviour, and flow properties on reconstitution' Shevade, A., O’Callaghan, Y.C., O’Brien, N.M., O’Connor T.P. and Guinee, T.P (2018) 'The proportion of fermented milk in dehydrated fermented milk–parboiled wheat composites significantly affect their composition, pasting behaviour, and flow properties on reconstitution'. Foods, [Details] | |
| (2018) | 'Co-products of beef processing enhance non-heme iron absorption in an in vitro digestion/caco-2 cell model' O’Flaherty, E., Tsermoula, P., O’Neill, E. and O’Brien, N.M. (2018) 'Co-products of beef processing enhance non-heme iron absorption in an in vitro digestion/caco-2 cell model'. International Journal of Food Science and Technology, [Details] | |
| (2018) | 'Immunomodulatory activity of 5 kDa permeate fractions of casein hydrolysates generated using a range of enzymes in Jurkat T cells and RAW264.7 macrophages' O’Sullivan, Siobhan M.; O’Callaghan, Yvonne C.; O’Keeffe, Martina B.; FitzGerald, Richard J.; O’Brien, Nora M. (2018) 'Immunomodulatory activity of 5 kDa permeate fractions of casein hydrolysates generated using a range of enzymes in Jurkat T cells and RAW264.7 macrophages'. International Dairy Journal, [DOI] [Full Text] [Details] | |
| (2018) | 'Angiotensin converting enzyme and dipeptidyl peptidase-IV inhibitory activities of transglutaminase treated sodium caseinate hydrolysates' Cermeno, M., O’Brien, N.M. and FitzGerald, R.J. (2018) 'Angiotensin converting enzyme and dipeptidyl peptidase-IV inhibitory activities of transglutaminase treated sodium caseinate hydrolysates'. International Dairy Journal, [Details] | |
| (2018) | 'Co-products of beef processing enhance non-haem iron absorption in an in vitro digestion/caco-2 cell model' O'Flaherty, Elisabeth A. A.; Tsermoula, Paraskevi; O'Neill, Eileen E.; O'Brien, Nora M. (2018) 'Co-products of beef processing enhance non-haem iron absorption in an in vitro digestion/caco-2 cell model'. International Journal of Food Science and Technology, [DOI] [Full Text] [Details] | |
| (2018) | 'Effect of antioxidants and packing conditions on storage stability of cereal bar fortified with hydrolyzed collagen from seabass skin' Benjakul, S., Pisuchpen, S. O’Brien, N.M. and Karnjanapratum, S., (2018) 'Effect of antioxidants and packing conditions on storage stability of cereal bar fortified with hydrolyzed collagen from seabass skin'. Italian Journal of Food Science, [Details] | |
| (2018) | 'Concurrent micronutrient deficiencies in lactating mothers and their children 6-23 months of age in two agro-ecological zones of rural Ethiopia' Roba, K.T., O’Connor, T.P., Belachew, T. and O’Brien, N.M. (2018) 'Concurrent micronutrient deficiencies in lactating mothers and their children 6-23 months of age in two agro-ecological zones of rural Ethiopia'. European Journal of Nutrition, [Details] | |
| (2018) | 'Characterisation of the in vitro bioactive peptides of alkaline and enzyme extracted brewers’ spent grain protein hydrolysates' Connolly, A., Cermeno, M., Crowley, D., O’Callaghan, Y.C., O’Brien, N.M. and FitzGerald, R.J. (2018) 'Characterisation of the in vitro bioactive peptides of alkaline and enzyme extracted brewers’ spent grain protein hydrolysates'. Food Research International, [Details] | |
| (2017) | 'Purification and identification of antioxidative peptide from gelatin hydrolysates of unicorn leatherjacket skin' Karnjanapratum, S., Benjakul, S., O’Callaghan, Y.C., O’Keeffe, M.B., FitzGerald, R.J. and O’Brien, N.M (2017) 'Purification and identification of antioxidative peptide from gelatin hydrolysates of unicorn leatherjacket skin'. Italian Journal of Food Science, [Details] | |
| (2017) | 'Optimisation of the antifungal potency of the amidated peptide H-OOWW-NH2 against food contaminants' Thery, T., O’Callaghan, Y.C., O’Brien, N.M. and Arendt, E.K. (2017) 'Optimisation of the antifungal potency of the amidated peptide H-OOWW-NH2 against food contaminants'. International Journal of Food Microbiology, [Details] | |
| (2017) | 'Bioactivity of bovine lung hydrolysates prepared using different enzymes: papain, pepsin and alcalase' O’Sullivan S.M., Lafarga, T., Hayes, M. and O’Brien, N.M. (2017) 'Bioactivity of bovine lung hydrolysates prepared using different enzymes: papain, pepsin and alcalase'. Journal of Food Biochemistry, [Details] | |
| (2017) | 'Purification and identification of antioxidant peptides from gelatin hydrolysate of seabass skin' Sea-leaw, T., Karnjanapratum, S., O’Callaghan, Y.C., O’Keeffe, M.B., FitzGerald, R.J., O’Brien, N.M. and Benjakul, S. (2017) 'Purification and identification of antioxidant peptides from gelatin hydrolysate of seabass skin'. Journal of Food Biochemistry, [Details] | |
| (2017) | 'Anti-proliferative activity of bovine blood hydrolysates towards cancer cells in culture' O’Sullivan S.M., Lafarga, T., Hayes, M. and O’Brien, N.M. (2017) 'Anti-proliferative activity of bovine blood hydrolysates towards cancer cells in culture'. International Journal of Food Science & Technology, [Details] | |
| (2017) | 'Aqueous and enzyme-extracted phenolic compounds from Brewers’ Spent Grain (BSG): assessment of their antioxidant potential' Crowley, D., O’Callaghan Y.C., McCarthy, A., Connolly, A., FitzGerald, R.J. and O’Brien, N.M. (2017) 'Aqueous and enzyme-extracted phenolic compounds from Brewers’ Spent Grain (BSG): assessment of their antioxidant potential'. Journal of Food Biochemistry, [Details] | |
| (2017) | 'Production of antioxidative Maillard reaction product from gelatin hydrolysate of unicorn leatherjacket skin' Karnjanapratum, S., Benjakul, S. and O'Brien, N.M, (2017) 'Production of antioxidative Maillard reaction product from gelatin hydrolysate of unicorn leatherjacket skin'. Journal of Aquatic Food Product Technology, [Details] | |
| (2016) | 'Antioxidant activities and selected characteristics of gelatin hydrolysates from seabass (Lates calcarifer) skin as affected by production processes' Sae-leaw, T;O'Callaghan, YC;Benjakul, S;O'Brien, NM (2016) 'Antioxidant activities and selected characteristics of gelatin hydrolysates from seabass (Lates calcarifer) skin as affected by production processes'. Journal Of Food Science And Technology-Mysore, 53 :197-208 [DOI] [Details] | |
| (2016) | 'Effect of Pretreatments and Drying Methods on the Properties and Fishy Odor/Flavor of Gelatin from Seabass (Lates calcarifer) skin' Sae-Leaw, T;Benjakul, S;O'Brien, NM (2016) 'Effect of Pretreatments and Drying Methods on the Properties and Fishy Odor/Flavor of Gelatin from Seabass (Lates calcarifer) skin'. Drying Technology, 34 :53-65 [DOI] [Details] | |
| (2016) | 'In vitro antioxidant and immunomodulatory activity of transglutaminase (TGase) treated sodium caseinate (NaCN) hydrolysates' Cermeno, M., FitzGerald, R.J. and O’Brien N.M. (2016) 'In vitro antioxidant and immunomodulatory activity of transglutaminase (TGase) treated sodium caseinate (NaCN) hydrolysates'. International Dairy Journal, [Details] | |
| (2016) | 'Levels of potential bioactive compounds including carotenoids, vitamin C and phenolic compounds, and expression of their cognate biosynthetic genes vary significantly in different varieties of potato (Solanum tuberosum L.) grown under uniform cultural conditions' Valcarcel, J., Reilly, K., Gaffney, M. and O’Brien, N.M. (2016) 'Levels of potential bioactive compounds including carotenoids, vitamin C and phenolic compounds, and expression of their cognate biosynthetic genes vary significantly in different varieties of potato (Solanum tuberosum L.) grown under uniform cultural conditions'. Journal of The Science of Food and Agriculture, [Details] | |
| (2016) | 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia' Roba, K.T., O’Connor, T.P., Belachew, T. and O’Brien, N.M. (2016) 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia'. [Details] | |
| (2016) | 'Antioxidant, immunomodulatory and antiproliferative effects of gelatin hydrolysate from seabass (Lates calcarifer) skin' Sae-leaw, T., O’Callaghan, Y.C., Benjakul, S. and O’Brien, N.M. (2016) 'Antioxidant, immunomodulatory and antiproliferative effects of gelatin hydrolysate from seabass (Lates calcarifer) skin'. International Journal of Food Science and Technology, [Details] | |
| (2016) | 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia' Roba, K.T., O’Connor, T.P., Belachew, T. and O’Brien, N.M. (2016) 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia'. [Details] | |
| (2016) | 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia' Roba, K.T., O’Connor, T.P., Belachew, T. and O’Brien, N.M. (2016) 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia'. [Details] | |
| (2016) | 'Concurrent iron and zinc deficiencies in lactating mothers and their children 6-23 months of age in two agro-ecological zones of rural Ethiopia' Roba, K.T.; O’Connor, T.P.; Belachew, T.; O’Brien, N.M. (2016) 'Concurrent iron and zinc deficiencies in lactating mothers and their children 6-23 months of age in two agro-ecological zones of rural Ethiopia'. European Journal of Nutrition, :1-13 [DOI] [Full Text] [Details] | |
| (2016) | 'Serum zinc, iron and urinary iodine levels and their relationship to other indices of malnutrition among lactating mothers in two agro-ecological zones of rural Ethiopia' Roba, K.T., O’Connor, T.P., Belachew, T. and O’Brien, N.M (2016) 'Serum zinc, iron and urinary iodine levels and their relationship to other indices of malnutrition among lactating mothers in two agro-ecological zones of rural Ethiopia'. [Details] | |
| (2016) | 'Antioxidant, immunomodulatory and anticancer effects of Maillard reaction products from gelatin hydrolysate of unicorn leatherjacket skin' Karnjanapratum, S., O’Callaghan, Y.C., Benjakul, S. and O’Brien, N.M. (2016) 'Antioxidant, immunomodulatory and anticancer effects of Maillard reaction products from gelatin hydrolysate of unicorn leatherjacket skin'. Journal Of Functional Foods, [Details] | |
| (2016) | 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia' Roba, K.T., O’Connor, T.P., Belachew, T. and O’Brien, N.M. (2016) 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia'. [Details] | |
| (2016) | 'Prevalence of stunting and anaemia among children 6-23 months of age in two agro-ecological zones of rural Ethiopia' Roba, K.T., O’Connor, T.P., Belachew, T. and O’Brien, N.M. (2016) 'Prevalence of stunting and anaemia among children 6-23 months of age in two agro-ecological zones of rural Ethiopia'. Pediatric Health Medicine And Therapeutics, [Details] | |
| (2016) | 'Investigation of the genotoxic potential of the marine biotoxins azaspiracid 1-3' Doerr, B., O’Halloran, J., O’Brien, N.N. and van Pelt, F.N.A.M. (2016) 'Investigation of the genotoxic potential of the marine biotoxins azaspiracid 1-3'. Toxicon, [Details] | |
| (2016) | 'Antioxidant, immunomodulatory and antiproliferative effects of gelatin hydrolysate from unicorn leatherjacket skin' Karnjanapratum, S., O’Callaghan, Y.C., Benjakul, S. and O’Brien, N.M. (2016) 'Antioxidant, immunomodulatory and antiproliferative effects of gelatin hydrolysate from unicorn leatherjacket skin'. Journal of The Science of Food and Agriculture, [Details] | |
| (2016) | 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia' Roba, K.T., O’Connor, T.P., Belachew, T. and O’Brien, N.M. (2016) 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia'. [Details] | |
| (2016) | 'Variations between post- and pre-harvest seasons in stunting, wasting, and Infant and Young Child Feeding (IYCF) practices among children 6-23 months of age in lowland and midland agro-ecological zones of rural Ethiopia' Roba, K.T., O’Connor, T.P., Belachew, T. and O’Brien, N.M. (2016) 'Variations between post- and pre-harvest seasons in stunting, wasting, and Infant and Young Child Feeding (IYCF) practices among children 6-23 months of age in lowland and midland agro-ecological zones of rural Ethiopia'. The Pan African Medical Journal, [Details] | |
| (2016) | 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia' Roba, K.T., O’Connor, T.P., Belachew, T. and O’Brien, N.M. (2016) 'Infant and Young Child Feeding (IYCF) practices among mothers of children aged 6–23 months in two agro-ecological zones of rural Ethiopia'. [Details] | |
| (2016) | 'Effect of pre-treatments and defatting of seabass skins on properties and fishy odour of gelatin' Sae-leaw, T., Benjakul, S. and O’Brien, N.M. (2016) 'Effect of pre-treatments and defatting of seabass skins on properties and fishy odour of gelatin'. Journal of Food Biochemistry, [Details] | |
| (2016) | 'Effects of defatting and tannic acid incorporation during extraction on properties and fishy odour of gelatin from seabass skin' Sae-Leaw, T;Benjakul, S;O'Brien, NM (2016) 'Effects of defatting and tannic acid incorporation during extraction on properties and fishy odour of gelatin from seabass skin'. Food Science And Technology-Lebensmittel-Wissenschaft & Technologie, 65 :661-667 [DOI] [Details] | |
| (2016) | 'Characteristics and functional properties of gelatin from seabass skin as influenced by defatting' Sae-leaw, T., Benjakul, S., O’Brien, N.M. and Hideki Kishimura, H. (2016) 'Characteristics and functional properties of gelatin from seabass skin as influenced by defatting'. International Journal of Food Science & Technology, [Details] | |
| (2016) | 'Seaweed extracts as potential functional ingredients in yogurt' O’Sullivan, A.M., O’Grady, N.M., O’Callaghan, Smyth, T., O’Brien, N.M. and Kerry, J.P. (2016) 'Seaweed extracts as potential functional ingredients in yogurt'. Innovative Food Science & Emerging Technologies, [Details] | |
| (2015) | 'Cellular Transport and Bioactivity of a Major Saffron Apocarotenoid, Picrocrocin (4-(beta-D-Glucopyranosyloxy)-2,6,6-trimethyl-1-cyclohexene-1-carboxaldehyde)' Kyriakoudi, A,O'Callaghan, YC,Galvin, K,Tsimidou, MZ,O'Brien, NM (2015) 'Cellular Transport and Bioactivity of a Major Saffron Apocarotenoid, Picrocrocin (4-(beta-D-Glucopyranosyloxy)-2,6,6-trimethyl-1-cyclohexene-1-carboxaldehyde)'. Journal of Agricultural and Food Chemistry, 63 :8662-8668 [DOI] [Details] | |
| (2015) | 'Seasonal variation in nutritional status and anemia among lactating mothers in two agro-ecological zones of rural Ethiopia: A longitudinal study' Roba, KT;O'Connor, TP;Belachew, T;O'Brien, NM (2015) 'Seasonal variation in nutritional status and anemia among lactating mothers in two agro-ecological zones of rural Ethiopia: A longitudinal study'. The Journal of Nutrition, 31 :1213-1218 [DOI] [Details] | |
| (2015) | 'Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7 beta-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of alpha-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3)' Nury, T,Zarrouk, A,Mackrill, JJ,Samadi, M,Durand, P,Riedinger, JM,Doria, M,Vejux, A,Limagne, E,Delmas, D,Prost, M,Moreau, T,Hammami, M,Delage-Mourroux, R,O'Brien, NM,Lizard, G (2015) 'Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7 beta-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of alpha-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3)'. Steroids, 99 :194-203 [DOI] [Details] | |
| (2015) | 'Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3)' Zarrouk, A,Nury, T,Samadi, M,O'Callaghan, Y,Hammami, M,O'Brien, NM,Lizard, G,Mackrill, JJ (2015) 'Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3)'. Steroids, 99 :238-247 [DOI] [Details] | |
| (2015) | 'Anti-Inflammatory Effects of Wild Irish Mushroom Extracts in RAW264.7 Mouse Macrophage Cells' O'Callaghan, YC;O'Brien, NM;Kenny, O;Harrington, T;Brunton, N;Smyth, TJ (2015) 'Anti-Inflammatory Effects of Wild Irish Mushroom Extracts in RAW264.7 Mouse Macrophage Cells'. Journal Of Medicinal Food, 18 :202-207 [DOI] [Details] | |
| (2015) | 'A study of the ability of bioactive extracts from brewers' spent grain to enhance the antioxidant and immunomodulatory potential of food formulations following in vitro digestion' McCarthy, AL;O'Callaghan, YC;Connolly, A;Piggott, CO;FitzGerald, RJ;O'Brien, NM (2015) 'A study of the ability of bioactive extracts from brewers' spent grain to enhance the antioxidant and immunomodulatory potential of food formulations following in vitro digestion'. International Journal of Food Sciences and Nutrition, 66 :230-235 [DOI] [Details] | |
| (2015) | 'Antioxidant Activity, Total Phenolic and Total Flavonoid Content in Sixty Varieties of Potato (Solanum tuberosum L.) Grown in Ireland' Valcarcel, J;Reilly, K;Gaffney, M;O'Brien, NM (2015) 'Antioxidant Activity, Total Phenolic and Total Flavonoid Content in Sixty Varieties of Potato (Solanum tuberosum L.) Grown in Ireland'. Potato Research, 58 :221-244 [DOI] [Details] | |
| (2015) | 'Evaluation of the protective effects of docosahexenoic acid (DHA; C22:6 n-3) on 7-ketocholesterol, 7beta-hydroxycholesterol-,and 24(S)-hydroxycholesterol-treated 158N murine oligodendrocytes: attenuation of oxysterol-induced oxiapoptophagy and enhancement of alpha-tocopherol protective effects' Nury, T, Zarrouk, A, Samadi, M, Durand, P, Doria, M, Riedinger, M, Limagne, E, Mackrill, J, Vejus, A, Delmas, D, Prost, M, Moreau, T, Hammami, M, Delage-Mourroux, R, O'Brien, NM, Lizard, G (2015) 'Evaluation of the protective effects of docosahexenoic acid (DHA; C22:6 n-3) on 7-ketocholesterol, 7beta-hydroxycholesterol-,and 24(S)-hydroxycholesterol-treated 158N murine oligodendrocytes: attenuation of oxysterol-induced oxiapoptophagy and enhancement of alpha-tocopherol protective effects'. [Details] | |
| (2015) | 'Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3)' Zarrouk A;Nury T;Samadi M;O'Callaghan Y;Hammami M;O'Brien NM;Lizard G;Mackrill JJ; (2015) 'Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3)'. Steroids, 99 (Pt B) [DOI] [Details] | |
| (2015) | 'Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7ß-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of a-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3)' Nury T;Zarrouk A;Mackrill JJ;Samadi M;Durand P;Riedinger JM;Doria M;Vejux A;Limagne E;Delmas D;Prost M;Moreau T;Hammami M;Delage-Mourroux R;O'Brien NM;Lizard G; (2015) 'Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7ß-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of a-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3)'. Steroids, 99 (Pt B) [DOI] [Details] | |
| (2014) | 'An examination of the potential of seaweed extracts as functional ingredients in milk' O'Sullivan, AM,O'Callaghan, YC,O'Grady, MN,Waldron, DS,Smyth, TJ,O'Brien, NM,Kerry, JP (2014) 'An examination of the potential of seaweed extracts as functional ingredients in milk'. International Journal of Dairy Technology, 67 :182-193 [DOI] [Details] | |
| (2014) | 'Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?' McCarthy, M;O'Halloran, J;O'Brien, NM;van Pelt, FFNAM (2014) 'Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?'. Marine Environmental Research, 101 :153-160 [DOI] [Details] | |
| (2014) | 'Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?' McCarthy M; O'Halloran J; O'Brien NM; van Pelt FF (2014) 'Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?'. Marine Environmental Research, 101 :153-160 [Details] | |
| (2013) | 'Antioxidant Capacity of Flaxseed Products: The Effect of In vitro Digestion' Silva, FGD;O'Callagahan, Y;O'Brien, NM;Netto, FM (2013) 'Antioxidant Capacity of Flaxseed Products: The Effect of In vitro Digestion'. Plant Foods For Human Nutrition, 68 :24-30 [DOI] [Details] | |
| (2013) | 'Characterisation of the physicochemical, residual antigenicity and cell activity properties of transglutaminase cross-linked sodium caseinate hydrolysates' O'Sullivan, D;Lahart, N;O'Callaghan, Y;O'Brien, NM;FitzGerald, RJ (2013) 'Characterisation of the physicochemical, residual antigenicity and cell activity properties of transglutaminase cross-linked sodium caseinate hydrolysates'. International Dairy Journal, 33 :49-54 [DOI] [Details] | |
| (2013) | 'Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages' Kenny, OM;McCarthy, CM;Brunton, NP;Hossain, MB;Rai, DK;Collins, SG;Jones, PW;Maguire, AR;O'Brien, NM (2013) 'Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages'. Life sciences, 92 :775-782 [DOI] [Details] | |
| (2013) | 'Brewers' spent grain (BSG) protein hydrolysates decrease hydrogen peroxide (H2O2)-induced oxidative stress and concanavalin-A (con-A) stimulated IFN-gamma production in cell culture' McCarthy, AL;O'Callaghan, YC;Connolly, A;Piggott, CO;FitzGerald, RJ;O'Brien, NM (2013) 'Brewers' spent grain (BSG) protein hydrolysates decrease hydrogen peroxide (H2O2)-induced oxidative stress and concanavalin-A (con-A) stimulated IFN-gamma production in cell culture'. Food & Function, 4 :1709-1716 [DOI] [Details] | |
| (2012) | 'Synthetic routes to campesterol and dihydrobrassicasterol: a first reported synthesis of the key phytosterol dihydrobrassicasterol' O'Connell, NM;O'Callaghan, YC;O'Brien, NM;Maguire, AR;McCarthy, FO (2012) 'Synthetic routes to campesterol and dihydrobrassicasterol: a first reported synthesis of the key phytosterol dihydrobrassicasterol'. Tetrahedron, 68 :4995-5004 [DOI] [Details] | |
| (2012) | 'Oxidized Derivatives of Dihydrobrassicasterol: Cytotoxic and Apoptotic Potential in U937 and HepG2 Cells' Kenny, O;O'Callaghan, Y;O'Connell, NM;McCarthy, FO;Maguire, AR;O'Brien, NM (2012) 'Oxidized Derivatives of Dihydrobrassicasterol: Cytotoxic and Apoptotic Potential in U937 and HepG2 Cells'. Journal of Agricultural and Food Chemistry, 60 :5952-5961 [DOI] [Details] | |
| (2012) | 'Phenolic extracts of brewers' spent grain (BSG) as functional ingredients - Assessment of their DNA protective effect against oxidant-induced DNA single strand breaks in U937 cells' McCarthy, AL;O'Callaghan, YC;Connolly, A;Piggott, CO;FitzGerald, RJ;O'Brien, NM (2012) 'Phenolic extracts of brewers' spent grain (BSG) as functional ingredients - Assessment of their DNA protective effect against oxidant-induced DNA single strand breaks in U937 cells'. Food Chemistry, 134 :641-646 [DOI] [Details] | |
| (2011) | 'Extent of hydrolysis effects on casein hydrolysate bioactivity: Evaluation using the human Jurkat T cell line' Lahart, N;O'Callaghan, Y;Aherne, SA;O'Sullivan, D;FitzGerald, RJ;O'Brien, NM (2011) 'Extent of hydrolysis effects on casein hydrolysate bioactivity: Evaluation using the human Jurkat T cell line'. International Dairy Journal, 21 :777-782 [DOI] [Details] | |
| (2010) | 'Carotenoid Content of Commonly Consumed Herbs and Assessment of Their Bioaccessibility Using an In Vitro Digestion Model' Daly, T;Jiwan, MA;O'Brien, NM;Aherne, SA (2010) 'Carotenoid Content of Commonly Consumed Herbs and Assessment of Their Bioaccessibility Using an In Vitro Digestion Model'. Plant Foods For Human Nutrition, 65 :164-169 [DOI] [Details] | |
| (2010) | 'Bioaccessibility, Uptake, and Transport of Carotenoids from Peppers (Capsicum Spp.) Using the Coupled in Vitro Digestion and Human Intestinal Caco-2 Cell Model' O'Sullivan, L;Jiwan, MA;Daly, T;O'Brien, NM;Aherne, SA (2010) 'Bioaccessibility, Uptake, and Transport of Carotenoids from Peppers (Capsicum Spp.) Using the Coupled in Vitro Digestion and Human Intestinal Caco-2 Cell Model'. Journal of Agricultural and Food Chemistry, 58 :5374-5379 [DOI] [Details] | |
| (2010) | 'Cytotoxic and Apoptotic Effects of the Oxidized Derivatives of Stigmasterol in the U937 Human Monocytic Cell Line' O'Callaghan, YC;Foley, DA;O'Connell, NM;McCarthy, FO;Maguire, AR;O'Brien, NM (2010) 'Cytotoxic and Apoptotic Effects of the Oxidized Derivatives of Stigmasterol in the U937 Human Monocytic Cell Line'. Journal of Agricultural and Food Chemistry, 58 :10793-10798 [DOI] [Details] | |
| (2009) | 'Potential bioactive effects of casein hydrolysates on human cultured cells' Phelan, M;Aherne-Bruce, SA;O'Sullivan, D;FitzGerald, RJ;O'Brien, NM (2009) 'Potential bioactive effects of casein hydrolysates on human cultured cells'. International Dairy Journal, 19 :279-285 [DOI] [Details] | |
| (2009) | 'Lack of genoprotective effect of phytosterols and conjugated linoleic acids on Caco-2 cells' Daly, TJ;Aherne, SA;O'Connor, TP;O'Brien, NM (2009) 'Lack of genoprotective effect of phytosterols and conjugated linoleic acids on Caco-2 cells'. Food and Chemical Toxicology, 47 :1791-1796 [DOI] [Details] | |
| (2009) | 'Geographical Location has Greater Impact on Carotenoid Content and Bioaccessibility from Tomatoes than Variety' Aherne, SA;Jiwan, MA;Daly, T;O'Brien, NM (2009) 'Geographical Location has Greater Impact on Carotenoid Content and Bioaccessibility from Tomatoes than Variety'. Plant Foods For Human Nutrition, 64 :250-256 [DOI] [Details] | |
| (2009) | 'Bioactivity of Herb-Enriched Beef Patties' Ryan, Eileen,Aherne, S. Aisling,O'Grady, Michael N.,McGovern, Laura,Kerry, Joseph P.,O'Brien, Nora M. (2009) 'Bioactivity of Herb-Enriched Beef Patties'. Journal of Medicinal Food, 12 (4):893-901 [Details] | |
| (2009) | 'The Role of Calcium in Apoptosis Induced by 7 beta-Hydroxycholesterol and Cholesterol-5 beta,6 beta-Epoxide' Lordan, S;O'Brien, NM;Mackrill, JJ (2009) 'The Role of Calcium in Apoptosis Induced by 7 beta-Hydroxycholesterol and Cholesterol-5 beta,6 beta-Epoxide'. Journal of Biochemical and Molecular Toxicology, 23 :324-332 [DOI] [Details] | |
| (2009) | 'Bioactive Properties of Wood Knot Extracts on Cultured Human Cells' Phelan, M;Aherne, SA;Wong, A;O'Brien, NM (2009) 'Bioactive Properties of Wood Knot Extracts on Cultured Human Cells'. Journal Of Medicinal Food, 12 :1245-1251 [DOI] [Details] | |
| (2009) | 'Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases' Lordan S, Mackrill JJ, O'Brien NM (2009) 'Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases'. Journal of Nutritional Biochemistry, 20 (5):321-336 [DOI] [Details] | |
| (2009) | 'The effects of salinity on the Manila clam (Ruditapes philippinarum) using the neutral red retention assay with adapted physiological saline solutions' Coughlan, BM;Moroney, GA;van Pelt, FNAM;O'Brien, NM;Davenport, J;O'Halloran, J (2009) 'The effects of salinity on the Manila clam (Ruditapes philippinarum) using the neutral red retention assay with adapted physiological saline solutions'. Marine Pollution Bulletin, 58 :1680-1684 [DOI] [Details] | |
| (2008) | 'Cellular transport of lutein is greater from uncooked rather than cooked spinach irrespective of whether it is fresh, frozen, or canned' O'Sullivan, L;Ryan, L;Aherne, SA;O'Brien, NM (2008) 'Cellular transport of lutein is greater from uncooked rather than cooked spinach irrespective of whether it is fresh, frozen, or canned'. Nutrition Research, 28 :532-538 [DOI] [Details] | |
| (2008) | 'Micellarisation of carotenoids from raw and cooked vegetables' Ryan, L;O'Connell, O;O'Sullivan, L;Aherne, SA;O'Brien, NM (2008) 'Micellarisation of carotenoids from raw and cooked vegetables'. Plant Foods For Human Nutrition, 63 :127-133 [DOI] [Details] | |
| (2008) | 'Effects of ingredient incorporation into sausage meat on the micellarisation and uptake of alpha-tocopherol by Caco-2 human intestinal cells' Kenny, O;O'Callaghan, Y;O'Brien, NM (2008) 'Effects of ingredient incorporation into sausage meat on the micellarisation and uptake of alpha-tocopherol by Caco-2 human intestinal cells'. Food Science and Technology International, 14 :79-86 [DOI] [Details] | |
| (2007) | 'Death-signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide' Lordan, S;O'Callaghan, YC;O'Brien, NM (2007) 'Death-signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide'. Journal of Biochemical and Molecular Toxicology, 21 :362-372 [Details] | |
| (2006) | 'A two-species biomarker model for the assessment of sediment toxicity in the marine and estuarine environment using the comet assay' Hartl, MGJ;Kilemade, M;Coughlan, BM;O'Halloran, J;van Pelt, FNAM;Sheehan, D;Mothersill, C;O'Brien, NM (2006) 'A two-species biomarker model for the assessment of sediment toxicity in the marine and estuarine environment using the comet assay'. Journal Of Environmental Science And Health Part A-Toxic/Hazardous Substances & Environmental Engineering, 41 :939-953 [DOI] [Details] | |
| (2006) | 'Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells' Carpenter, R;O'Callaghan, YC;O'Grady, MN;Kerry, JP;O'Brien, NM (2006) 'Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells'. Journal Of Medicinal Food, 9 :187-195 [Details] | |
| (2005) | 'The role of the mitochondria in apoptosis induced by 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide' Ryan, L;O'Callaghan, YC;O'Brien, NM (2005) 'The role of the mitochondria in apoptosis induced by 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide'. British Journal of Nutrition, 94 :519-525 [DOI] [Details] | |
| (2005) | 'Differential effects of mixtures of cholesterol oxidation products on bovine aortic endothelial cells and human monocytic U937 cells' O'Sullivan, AJ;O'Callaghan, YC;O'Brien, NM (2005) 'Differential effects of mixtures of cholesterol oxidation products on bovine aortic endothelial cells and human monocytic U937 cells'. International Journal of Toxicology, 24 :173-179 [DOI] [Details] | |
| (2004) | 'Phytosterols: lack of cytotoxicity but interference with beta-carotene uptake in Caco-2 cells in culture' Fahy, DM;O'Callaghan, YC;O'Brien, NM (2004) 'Phytosterols: lack of cytotoxicity but interference with beta-carotene uptake in Caco-2 cells in culture'. Food Additives and Contaminants, 21 :42-51 [DOI] [Details] | |
| (2004) | 'Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments' Hartl, MGJ;Coughlan, BM;Sheehan, D;Mothersill, C;van Pelt, FNAM;O'Reilly, SJ;Heffron, JJA;O'Halloran, J;O'Brien, NM (2004) 'Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments'. Marine Environmental Research, 57 :295-310 [DOI] [Details] | |
| (2004) | 'Genotoxicity of field-collected inter-tidal sediments from Cork Harbor, Ireland, to juvenile turbot (Scophthalmus maximus L.) as measured by the Comet assay' Kilemade, MF;Hartl, MGJ;Sheehan, D;Mothersill, C;van Pelt, FNAM;O'Halloran, J;O'Brien, NM (2004) 'Genotoxicity of field-collected inter-tidal sediments from Cork Harbor, Ireland, to juvenile turbot (Scophthalmus maximus L.) as measured by the Comet assay'. Environmental and Molecular Mutagenesis, 44 :56-64 [DOI] [Details] | |
| (2004) | 'Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut' Maguire, LS;O'Sullivan, SM;Galvin, K;O'Connor, TP;O'Brien, NM (2004) 'Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut'. International Journal of Food Sciences and Nutrition, 55 :171-178 [DOI] [Details] | |
| (2002) | 'Squalene but not n-3 fatty acids protect against hydrogen peroxide-induced sister chromatid exchanges in Chinese hamster V79 cells' O'Sullivan, L;Woods, JA;O'Brien, NM (2002) 'Squalene but not n-3 fatty acids protect against hydrogen peroxide-induced sister chromatid exchanges in Chinese hamster V79 cells'. Nutrition Research, 22 :847-857 [Details] | |
| (2002) | 'Genotoxicity of fecal water in a free-living Irish population' Woods, JA;Dunne, C;Collins, JK;Shanahan, F;O'Brien, NM (2002) 'Genotoxicity of fecal water in a free-living Irish population'. Nutrition and Cancer-An International Journal, 42 :62-69 [Details] | |
| (2001) | 'Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols' O'Callaghan, YC;Woods, JA;O'Brien, NM (2001) 'Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols'. Cell Biology and Toxicology, 17 :127-137 [Details] | |
| (2001) | 'gamma-tocopherol is less effective than alpha-tocopherol in preventing oxidant-induced sister chromatid exchanges in Chinese hamster V79 cells' O'Leary, KA;Woods, JA;O'Brien, NM (2001) 'gamma-tocopherol is less effective than alpha-tocopherol in preventing oxidant-induced sister chromatid exchanges in Chinese hamster V79 cells'. Free Radical Research, 35 :917-924 [Details] | |
| (2001) | 'Susceptibility of LDL to oxidative modification in healthy volunteers supplemented with low doses of n-3 polyunsaturated fatty acids' Higgins, S;Carroll, YL;McCarthy, SN;Corridan, BM;Roche, HM;Wallace, JMW;O'Brien, NM;Morrissey, PA (2001) 'Susceptibility of LDL to oxidative modification in healthy volunteers supplemented with low doses of n-3 polyunsaturated fatty acids'. British Journal of Nutrition, 85 :23-31 [Details] | |
| (2000) | 'Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated fatty acids' Higgins, S;McCarthy, SN;Corridan, BM;Roche, HM;Wallace, JMW;O'Brien, NM;Morrissey, PA (2000) 'Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated fatty acids'. Nutrition Research, 20 :1091-1102 [Details] | |
| (1999) | 'Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts' Higgins, S;Vasconcelos, MH;O'Brien, NM (1999) 'Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts'. Mutagenesis, 14 :335-338 [Details] | |
| (1999) | 'Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations' O'Callaghan, YC;Woods, JA;O'Brien, NM (1999) 'Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations'. European Journal of Nutrition, 38 :255-262 [Details] | |
| (1999) | 'The flavonoids, myricetin, quercetin and rutin, protect against cholestan-3 beta, 5 alpha, 6 beta-triol - Induced toxicity in Chinese hamster ovary cells in vitro' Aherne, SA;O'Brien, NM (1999) 'The flavonoids, myricetin, quercetin and rutin, protect against cholestan-3 beta, 5 alpha, 6 beta-triol - Induced toxicity in Chinese hamster ovary cells in vitro'. Nutrition Research, 19 :749-760 [Details] | |
| (1998) | 'Investigation of the potential genotoxicity of cholesterol oxidation products in two mammalian fibroblast cell lines' Woods, JA;O'Brien, NM (1998) 'Investigation of the potential genotoxicity of cholesterol oxidation products in two mammalian fibroblast cell lines'. Nutrition and Cancer-An International Journal, 31 :192-198 [Details] | |
| (2014) | 'Formation of cytotoxic alpha-Lactalbumin / sodium oleate complexes: concentration and temperature effects' Kehoe, JJ, Liskova, K, Mok, KH, O'Brien, NM, Kelly, AL, Brodkorb, A (2014) 'Formation of cytotoxic alpha-Lactalbumin / sodium oleate complexes: concentration and temperature effects'. International Dairy Journal, 38 :65-73 [Details] | |
| (2014) | 'Effect of genotype and environment on the glycoalkaloid content of rare, heritage and commercial potato varieties' Valcarcel, J, Reilly, K, Gaffney, M, O'Brien, NM (2014) 'Effect of genotype and environment on the glycoalkaloid content of rare, heritage and commercial potato varieties'. Journal of Food Science, 79 :1039-1048 [Details] | |
| (2014) | 'Phenolic-enriched fractions from brewers' spent grain possess cellular antioxidant and immunomodulatory effects in cell culture model systems' McCarthy, AL,O'Callaghan, YC,Connolly, A,Piggott, CO,FitzGerald, RJ,O'Brien, NM (2014) 'Phenolic-enriched fractions from brewers' spent grain possess cellular antioxidant and immunomodulatory effects in cell culture model systems'. Journal of The Science of Food and Agriculture, 94 :1373-1379 [DOI] [Details] | |
| (2013) | 'Antioxidant and Pro-Apoptotic Effects of Marine-Derived, Multi-Mineral Aquamin Supplemented with a Pine Bark Extract, Enzogenol, and a Green Tea Extract, Sunphenon' O'Callaghan, YC,Drummond, E,O'Gorman, DM,O'Brien, NM (2013) 'Antioxidant and Pro-Apoptotic Effects of Marine-Derived, Multi-Mineral Aquamin Supplemented with a Pine Bark Extract, Enzogenol, and a Green Tea Extract, Sunphenon'. Journal Of Medicinal Food, 16 :920-926 [DOI] [Details] | |
| (2013) | 'Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells' O'Callaghan Y, Kenny O, O'Connell NM, Maguire AR, McCarthy FO, O'Brien NM (2013) 'Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells'. Biochimie, 95 (3):496-503 [DOI] [Details] | |
| (2013) | 'The effect of solvents on the antioxidant activity in Caco-2 cells of Irish brown seaweed extracts prepared using accelerated solvent extraction (ASE (R))' O'Sullivan, AM,O'Callaghan, YC,O'Grady, MN,Hayes, M,Kerry, JP,O'Brien, NM (2013) 'The effect of solvents on the antioxidant activity in Caco-2 cells of Irish brown seaweed extracts prepared using accelerated solvent extraction (ASE (R))'. Journal Of Functional Foods, 5 :940-948 [DOI] [Details] | |
| (2013) | 'Changes in Total and Individual Crocetin Esters upon in Vitro Gastrointestinal Digestion of Saffron Aqueous Extracts' Kyriakoudi, A,Tsimidou, MZ,O'Callaghan, YC,Galvin, K,O'Brien, NM (2013) 'Changes in Total and Individual Crocetin Esters upon in Vitro Gastrointestinal Digestion of Saffron Aqueous Extracts'. Journal of Agricultural and Food Chemistry, 61 :5318-5327 [DOI] [Details] | |
| (2013) | 'In vitro antioxidant and anti-inflammatory effects of brewers' spent grain protein rich isolate and its associated hydrolysates' McCarthy, AL,O'Callaghan, YC,Connolly, A,Piggott, CO,FitzGerald, RJ,O'Brien, NM (2013) 'In vitro antioxidant and anti-inflammatory effects of brewers' spent grain protein rich isolate and its associated hydrolysates'. Food Research International, 50 :205-212 [DOI] [Details] | |
| (2013) | 'The hydroxycinnamic acid content of barley and brewers' spent grain (BSG) and the potential to incorporate phenolic extracts of BSG as antioxidants into fruit beverages' McCarthy AL, O'Callaghan YC, Neugart S, Piggott CO, Connolly A, Jansen MA, Krumbein A, Schreiner M, FitzGerald RJ, O'Brien NM (2013) 'The hydroxycinnamic acid content of barley and brewers' spent grain (BSG) and the potential to incorporate phenolic extracts of BSG as antioxidants into fruit beverages'. Food chemistry, 141 (3):2567-2574 [DOI] [Details] | |
| (2013) | 'Comparison of the Antioxidant Activity of Commercial Honeys, Before and After In-Vitro Digestion' O'Sullivan, AM,O'Callaghan, YC,O'Connor, TR,O'Brien, NM (2013) 'Comparison of the Antioxidant Activity of Commercial Honeys, Before and After In-Vitro Digestion'. Polish Journal Of Food And Nutrition Sciences, 63 :167-171 [DOI] [Details] | |
| (2013) | 'Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages' Kenny, OM,McCarthy, CM,Brunton, NP,Hossain, MB,Rai, DK,Collins, SG,Jones, PW,Maguire, AR,O'Brien, NM (2013) 'Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages'. Life sciences, 92 :775-782 [DOI] [Details] | |
| (2013) | 'The effect of domestic processing on the content and bioaccessibility of carotenoids from chili peppers (Capsicum species)' Pugliese, A, Loizzo, MR, Tundis, R, O'Callaghan, Y, Galvin, K, Menichini, F, O'Brien, NM (2013) 'The effect of domestic processing on the content and bioaccessibility of carotenoids from chili peppers (Capsicum species)'. Food Chemistry, [Details] | |
| (2013) | 'Assessment of the cytotoxic and apoptotic potential of potato glycoalkaloids in a number of cancer cell lines' Kenny, O, Brunton, N, Rai, D, Collins, SG, Maguire, AR, Jones, P, O'Brien, NM (2013) 'Assessment of the cytotoxic and apoptotic potential of potato glycoalkaloids in a number of cancer cell lines'. Journal of Agricultural Science and Applications, [Details] | |
| (2013) | 'In vitro investigation of the bioaccessibility of carotenoids from raw, frozen and boiled red chilli peppers (Capsicum annuum)' Pugliese, A, O'Callaghan, YC, Tundis, R, Galvin, K, Menichini, F, O'Brien, NM, Loizzo, MR (2013) 'In vitro investigation of the bioaccessibility of carotenoids from raw, frozen and boiled red chilli peppers (Capsicum annuum)'. European Journal of Nutrition, [Details] | |
| (2012) | 'Phenolic extracts of brewers' spent grain (BSG) as functional ingredients - Assessment of their DNA protective effect against oxidant-induced DNA single strand breaks in U937 cells' McCarthy, AL,O'Callaghan, YC,Connolly, A,Piggott, CO,FitzGerald, RJ,O'Brien, NM (2012) 'Phenolic extracts of brewers' spent grain (BSG) as functional ingredients - Assessment of their DNA protective effect against oxidant-induced DNA single strand breaks in U937 cells'. Food Chemistry, 134 :641-646 [DOI] [Details] | |
| (2012) | 'Assessment of the ability of seaweed extracts to protect against hydrogen peroxide and tert-butyl hydroperoxide induced cellular damage in Caco-2 cells' O'Sullivan, AM,O'Callaghan, YC,O'Grady, MN,Queguineur, B,Hanniffy, D,Troy, DJ,Kerry, JP,O'Brien, NM (2012) 'Assessment of the ability of seaweed extracts to protect against hydrogen peroxide and tert-butyl hydroperoxide induced cellular damage in Caco-2 cells'. Food Chemistry, 134 :1137-1140 [DOI] [Details] | |
| (2011) | 'In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland' O'Sullivan, A. M. and O'Callaghan, Y. C. and O'Grady, M. N. and Queguineur, B. and Hanniffy, D. and Troy, D. J. and Kerry, J. P. and O'Brien, N. M. (2011) 'In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland'. Food Chemistry, 126 (3):1064-1070 [Details] | |
| (2011) | 'Extent of hydrolysis effects on casein hydrolysate bioactivity: Evaluation using the human Jurkat T cell line' Lahart, Natasha and O'Callaghan, Yvonne and Aherne, S. Aisling and O'Sullivan, Dara and FitzGerald, Richard J. and O'Brien, Nora M. (2011) 'Extent of hydrolysis effects on casein hydrolysate bioactivity: Evaluation using the human Jurkat T cell line'. International Dairy Journal, 21 (10):777-782 [Details] | |
| (2011) | 'Cytotoxic complexes of sodium oleate with beta-lactoglobulin' Liskova, K, Auty, MAE, Chaurin, V, Min, S, Mok, KH, O'Brien, NM, Kelly, AL, Brodkorb, A (2011) 'Cytotoxic complexes of sodium oleate with beta-lactoglobulin'. European Journal of Lipid Science and Technology, 113 :1207-1218 [Details] | |
| (2010) | 'Content and bioaccessibility of carotenoids from organic and non-organic baby foods' Jiwan, M. A. and Duane, P. and O'Sullivan, L. and O'Brien, N. M. and Aherne, S. A. (2010) 'Content and bioaccessibility of carotenoids from organic and non-organic baby foods'. Journal of Food Composition and Analysis, 23 (4):346-352 [Details] | |
| (2010) | 'Effect of alpha-lactalbumin denaturation on its potential anti-cancer properties' Liskova, K, Kelly, AL, O'Brien, NM, Brodkorb, A (2010) 'Effect of alpha-lactalbumin denaturation on its potential anti-cancer properties'. Journal of Agricultural and Food Chemistry, [Details] | |
| (2010) | 'Bioaccessibility, Uptake, and Transport of Carotenoids from Peppers (Capsicum Spp.) Using the Coupled in Vitro Digestion and Human Intestinal Caco-2 Cell Model' O'Sullivan, Laurie and Jiwan, Marvin A. and Daly, Trevor and O'Brien, Nora M. and Aherne, S. Aisling (2010) 'Bioaccessibility, Uptake, and Transport of Carotenoids from Peppers (Capsicum Spp.) Using the Coupled in Vitro Digestion and Human Intestinal Caco-2 Cell Model'. Journal of Agricultural and Food Chemistry, 58 (9):5374-5379 [Details] | |
| (2010) | 'Bioavailability of beta-carotene isomers from raw and cooked carrots using an in vitro digestion model coupled with a human intestinal Caco-2 cell model' Aherne, S. Aisling and Daly, Trevor and Jiwan, Marvin A. and O'Sullivan, Laurie and O'Brien, Nora M. (2010) 'Bioavailability of beta-carotene isomers from raw and cooked carrots using an in vitro digestion model coupled with a human intestinal Caco-2 cell model'. Food Research International, 43 (5):1449-1454 [Details] | |
| (2010) | 'Cytotoxic and Apoptotic Effects of the Oxidized Derivatives of Stigmasterol in the U937 Human Monocytic Cell Line' O'Callaghan YC, Foley DA, O'Connell NM, McCarthy FO, Maguire AR, O'Brien NM; (2010) 'Cytotoxic and Apoptotic Effects of the Oxidized Derivatives of Stigmasterol in the U937 Human Monocytic Cell Line'. Journal of Agricultural and Food Chemistry, 58 :10793-10798 [DOI] [Details] | |
| (2010) | 'Growth inhibitory effects of casein hydrolysates on human cancer cell lines' Phelan, Martha and Aherne, S. Aisling and O'Sullivan, Dara and FitzGerald, Richard J. and O'Brien, Nora M. (2010) 'Growth inhibitory effects of casein hydrolysates on human cancer cell lines'. Journal of Dairy Research, 77 (2):176-182 [Details] | |
| (2010) | 'Effects of cooking on the profile and micellarization of 9-cis-, 13-cis- and all-trans-beta-carotene in green vegetables' O'Sullivan, L; Galvin, K; Aherne, SA; O'Brien, NM; (2010) 'Effects of cooking on the profile and micellarization of 9-cis-, 13-cis- and all-trans-beta-carotene in green vegetables'. Food Research International, 43 :1130-1135 [DOI] [Details] | |
| (2010) | 'Synthesis and characterization of stigmasterol oxidation products' Foley DA, O'Callaghan Y, O'Brien NM, McCarthy FO, Maguire AR; (2010) 'Synthesis and characterization of stigmasterol oxidation products'. Journal of Agricultural and Food Chemistry, 58 (2):1165-1173 [DOI] [Details] | |
| (2010) | 'Bioactivity of ellagic acid-, lutein- or sesamol-enriched meat patties assessed using an in vitro digestion and Caco-2 cell model system' Daly, T,Ryan, E,Aherne, SA,O'Grady, MN,Hayes, J,Allen, P,Kerry, JP,O'Brien, NM (2010) 'Bioactivity of ellagic acid-, lutein- or sesamol-enriched meat patties assessed using an in vitro digestion and Caco-2 cell model system'. Food Research International, 43 :753-760 [DOI] [Details] | |
| (2010) | 'Effect of denaturation of alpha-lactalbumin on the formation of BAMLET (Bovine alpha-lactalbumin made lethal to tumor cells)' Liskova, K, Kelly, AL, O'Brien, NM, Brodkorb, A (2010) 'Effect of denaturation of alpha-lactalbumin on the formation of BAMLET (Bovine alpha-lactalbumin made lethal to tumor cells)'. Food Chemistry, 58 :4421-4427 [Details] | |
| (2009) | 'Effects of Contaminated Sediment From Cork Harbour, Ireland On The Cytochrome P450 System of Turbot' Kilemade, M, Hartl, MGJ, O'Halloran, J, O'Brien, NM, Sheehan, D, Mothersill, C, van Pelt, FNAM; (2009) 'Effects of Contaminated Sediment From Cork Harbour, Ireland On The Cytochrome P450 System of Turbot'. Ecotoxicology and Environmental Safety, 72 (3):747-755 [DOI] [Details] | |
| (2009) | 'Bioactivity of Herb-Enriched Beef Patties' Ryan, E,Aherne, SA,O'Grady, MN,McGovern, L,Kerry, JP,O'Brien, NM (2009) 'Bioactivity of Herb-Enriched Beef Patties'. Journal Of Medicinal Food, 12 :893-901 [DOI] [Details] | |
| (2009) | 'Investigation of beta-carotene and Lutein Transport in Caco-2 Cells: Carotenoid-carotenoid Interactions and Transport Inhibition by Ezetimibe' O'Sullivan, L,Aherne, SA,O'Brien, NM; (2009) 'Investigation of beta-carotene and Lutein Transport in Caco-2 Cells: Carotenoid-carotenoid Interactions and Transport Inhibition by Ezetimibe'. International Journal For Vitamin and Nutrition Research, 79 :337-347 [DOI] [Details] | |
| (2009) | 'The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide' Lordan S, O'Brien NM, Mackrill JJ (2009) 'The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide'. Journal of Biochemical and Molecular Toxicology, 23 (5):324-332 [DOI] [Details] | |
| (2009) | 'Bioactive Properties of Wood Knot Extracts on Cultured Human Cells' Phelan, Martha and Aherne, S. Aisling and Wong, Alfred and O'Brien, Nora M. (2009) 'Bioactive Properties of Wood Knot Extracts on Cultured Human Cells'. Journal of Medicinal Food, 12 (6):1245-1251 [Details] | |
| (2009) | 'Potential Bioactive Effects of Casein Hydrolysates On Human Cultured Cells' Phelan, M, Aherne-Bruce, SA, O'Sullivan, D, FitzGerald, RJ, O'Brien, NM; (2009) 'Potential Bioactive Effects of Casein Hydrolysates On Human Cultured Cells'. International Dairy Journal, 19 (5):279-285 [DOI] [Details] | |
| (2009) | 'Lack of Genoprotective Effect of Phytosterols and Conjugated Linoleic Acids On Caco-2 Cells' Daly, TJ, Aherne, SA, O'Connor, TP, O'Brien, NM; (2009) 'Lack of Genoprotective Effect of Phytosterols and Conjugated Linoleic Acids On Caco-2 Cells'. Food and Chemical Toxicology, 47 (8):1791-1796 [DOI] [Details] | |
| (2009) | 'The Effect of Lutein, Sesamol, Ellagic Acid and Olive Leaf Extract On Lipid Oxidation and Oxymyoglobin Oxidation In Bovine and Porcine Muscle Model Systems' Hayes, JE, Stepanyan, V, Allen, P, O'Grady, MN, O'Brien, NM, Kerry, JP; (2009) 'The Effect of Lutein, Sesamol, Ellagic Acid and Olive Leaf Extract On Lipid Oxidation and Oxymyoglobin Oxidation In Bovine and Porcine Muscle Model Systems'. Meat Science, 83 (2):201-208 [DOI] [Details] | |
| (2008) | 'Addition of Grape Seed Extract and Bearberry to Porcine Diets: Influence On Quality Attributes of Raw and Cooked Pork' O'Grady, MN, Carpenter, R, Lynch, PB, O'Brien, NM, Kerry, JP; (2008) 'Addition of Grape Seed Extract and Bearberry to Porcine Diets: Influence On Quality Attributes of Raw and Cooked Pork'. Meat Science, 78 (4):438-446 [DOI] [Details] | |
| (2008) | 'Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells' Aherne, SA,O'Brien, NM; (2008) 'Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells'. Molecular Nutrition & Food Research, 52 :664-673 [DOI] [Details] | |
| (2008) | 'Carotenoid Micellarization Varies Greatly Between Individual and Mixed Vegetables With or Without The Addition of Fat or Fiber' O'Connell, O, Ryan, L, O'Sullivan, L, Aherne-Bruce, SA, O'Brien, NM; (2008) 'Carotenoid Micellarization Varies Greatly Between Individual and Mixed Vegetables With or Without The Addition of Fat or Fiber'. International Journal For Vitamin and Nutrition Research, 78 (4-5):238-246 [DOI] [Details] | |
| (2008) | 'Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells' Lordan S, O'Neill C, O'Brien NM; (2008) 'Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells'. British Journal of Nutrition, 100 (2):287-296 [DOI] [Full Text] [Details] | |
| (2008) | 'Involvement of Fas signalling in 7beta-hydroxycholesterol-and cholesterol-5beta,6beta-epoxide-induced apoptosis' Lordan S, Mackrill JJ, O'Brien NM (2008) 'Involvement of Fas signalling in 7beta-hydroxycholesterol-and cholesterol-5beta,6beta-epoxide-induced apoptosis'. International Journal of Toxicology, 27 (3):279-285 [DOI] [Details] | |
| (2008) | 'Micellarisation of carotenoids from raw and cooked vegetables' Ryan, L,O'Connell, O,O'Sullivan, L,Aherne, SA,O'Brien, NM; (2008) 'Micellarisation of carotenoids from raw and cooked vegetables'. Plant Foods For Human Nutrition, 63 :127-133 [DOI] [Details] | |
| (2008) | 'Plant stress and human health: Do human consumers benefit from UV-B acclimated crops?' Jansen, Marcel A. K. and Hectors, Kathleen and O'Brien, Nora M. and Guisez, Yves and Potters, Geert (2008) 'Plant stress and human health: Do human consumers benefit from UV-B acclimated crops?'. Plant Science, 175 (4):449-458 [Details] | |
| (2008) | 'Cellular transport of lutein is greater from uncooked rather than cooked spinach irrespective of whether it is fresh, frozen, or canned' O'Sullivan, Laurie and Ryan, Lisa and Aherne, S. Aisling and O'Brien, Nora M. (2008) 'Cellular transport of lutein is greater from uncooked rather than cooked spinach irrespective of whether it is fresh, frozen, or canned'. Nutrition Research, 28 (8):532-538 [Details] | |
| (2008) | 'Effects of Ingredient Incorporation Into Sausage Meat On The Micellarisation and Uptake of Alpha-Tocopherol By Caco-2 Human Intestinal Cells' Kenny, O, O'Callaghan, Y, O'Brien, NM; (2008) 'Effects of Ingredient Incorporation Into Sausage Meat On The Micellarisation and Uptake of Alpha-Tocopherol By Caco-2 Human Intestinal Cells'. Food Science and Technology International, 14 (1):79-86 [DOI] [Details] | |
| (2007) | 'Effects of Plant Extracts On Antioxidant Status and Oxidant-Induced Stress In Caco-2 Cells' Aherne, SA, Kerry, JP, O'Brien, NM; (2007) 'Effects of Plant Extracts On Antioxidant Status and Oxidant-Induced Stress In Caco-2 Cells'. British Journal of Nutrition, 97 (2):321-328 [DOI] [Details] | |
| (2007) | 'Xanthophyll carotenoids are more bioaccessible from fruits than dark green vegetables' O'Connell, Orla F. and Ryan, Lisa and O'Brien, Nora M. (2007) 'Xanthophyll carotenoids are more bioaccessible from fruits than dark green vegetables'. Nutrition Research, 27 (5):258-264 [Details] | |
| (2007) | 'Immunomodulatory effects of beta-sitosterol on human Jurkat' Aherne, S. A. and Daly, T. and O'Connor, T. and O'Brien, N. M. (2007) 'Immunomodulatory effects of beta-sitosterol on human Jurkat'. Planta Medica, 73 (9):827-827 [Details] | |
| (2007) | 'Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes' Ryan, E,Galvin, K,O'Connor, TP,Maguire, AR,O'Brien, NM; (2007) 'Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes'. Plant Foods For Human Nutrition, 62 :85-91 [DOI] [Details] | |
| (2007) | 'Death-Signaling Pathways In Human Myeloid Cells By Oxldl and Its Cytotoxic Components 7 Beta-Hydroxycholesterol and Cholesterol-5 Beta,6 Beta-Epoxide' Lordan, S, O'Callaghan, YC, O'Brien, NM; (2007) 'Death-Signaling Pathways In Human Myeloid Cells By Oxldl and Its Cytotoxic Components 7 Beta-Hydroxycholesterol and Cholesterol-5 Beta,6 Beta-Epoxide'. Journal of Biochemical and Molecular Toxicology, 21 (6):362-372 [Details] | |
| (2007) | 'Hepatic biomarkers of sediment-associated pollution in juvenile turbot, Scophthalmus maximus L' Hartl, MGJ,Kilemade, M,Sheehan, D,Mothersill, C,O'Halloran, J,O'Brien, NM,van Pelt, FNAM; (2007) 'Hepatic biomarkers of sediment-associated pollution in juvenile turbot, Scophthalmus maximus L'. Marine Environmental Research, 64 :191-208 [DOI] [Details] | |
| (2007) | 'Evaluation of The Antioxidant Potential of Grape Seed and Bearberry Extracts In Raw and Cooked Pork' Carpenter, R, O'Grady, MN, O'Callaghan, YC, O'Brien, NM, Kerry, JP; (2007) 'Evaluation of The Antioxidant Potential of Grape Seed and Bearberry Extracts In Raw and Cooked Pork'. Meat Science, 76 (4):604-610 [DOI] [Details] | |
| (2007) | 'In Vivo Exposure to Microcystins Induces Dna Damage In The Haemocytes of The Zebra Mussel, Dreissena Polymorpha, As Measured With The Comet Assay' Juhel, G, O'Halloran, J, Culloty, SC, O'Riordan, RM, Davenport, J, O'Brien, NM, James, KF, Furey, A, Allis, O; (2007) 'In Vivo Exposure to Microcystins Induces Dna Damage In The Haemocytes of The Zebra Mussel, Dreissena Polymorpha, As Measured With The Comet Assay'. Environmental and Molecular Mutagenesis, 48 (1):22-29 [DOI] [Details] | |
| (2006) | 'A two-species biomarker model for the assessment of sediment toxicity in the marine and estuarine environment using the comet assay' Hartl MG, Kilemade M, Coughlan BM, O'Halloran J, van Pelt FN, Sheehan D, Mothersill C, and O'Brien NM.; (2006) 'A two-species biomarker model for the assessment of sediment toxicity in the marine and estuarine environment using the comet assay'. Journal of Environmental Science & Health Part A-Environmental Science & Engineering, 41 (5):939-953 [Details] | |
| (2006) | 'Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells' Carpenter, Rosemary and O'Callaghan, Yvonne C. and O'Grady, Michael N. and Kerry, Joseph P. and O'Brien, Nora M. (2006) 'Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells'. Journal of Medicinal Food, 9 (2):187-195 [Details] | |
| (2006) | 'Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts' Ryan, E. and Galvin, K. and O'Connor, T. P. and Maguire, A. R. and O'Brien, N. M. (2006) 'Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts'. International Journal of Food Sciences and Nutrition, 57 (3-4):219-228 [Details] | |
| (2006) | 'Involvement of calcium in 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide-induced apoptosis' Ryan, L. and O'Callaghan, Y. C. and O'Brien, N. M. (2006) 'Involvement of calcium in 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide-induced apoptosis'. International Journal of Toxicology, 25 (1):35-39 [Details] | |
| (2006) | 'Fatty Acid Profile, Tocopherol, Squalene and Phytosterol Content of Brazil, Pecan, Pine, Pistachio and Cashew Nuts' Ryan, E, Galvin, K, O'Connor, TP, Maguire, AR, O'Brien, NM; (2006) 'Fatty Acid Profile, Tocopherol, Squalene and Phytosterol Content of Brazil, Pecan, Pine, Pistachio and Cashew Nuts'. International Journal of Food Sciences and Nutrition, 57 (3-4):219-228 [DOI] [Details] | |
| (2005) | 'Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives' McCarthy FO, Chopra J, Ford A, Hogan SA, Kerry JP, O'Brien NM, Ryan E, Maguire AR; (2005) 'Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives'. Organic & Biomolecular Chemistry, 3 (16):3059-3065 [DOI] [Details] | |
| (2005) | 'Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products' E. Ryan;J. Chopra;F. McCarthy;A. R. Maguire;N. M. O'Brien; (2005) 'Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products'. British Journal of Nutrition, 94 :443-451 [DOI] [Full Text] [Details] | |
| (2005) | 'Assessing the potential of fish cell lines as tools for the cytotoxicity testing of estuarine sediment aqueous elutriates' Davoren, M. and Ni-Shuilleabhain, S. and Hartl, M. G. J. and Sheehan, D. and O'Brien, N. M. and O'Halloran, J. and Van Pelt, Fnam and Mothersill, C. (2005) 'Assessing the potential of fish cell lines as tools for the cytotoxicity testing of estuarine sediment aqueous elutriates'. Toxicology in Vitro, 19 (3):421-431 [Details] | |
| (2005) | 'A test battery approach for the ecotoxicological evaluation of estuarine sediments' Davoren, M,Shuilleabhain, SN,O'Halloran, J,Hartl, MGJ,Sheehan, D,O'Brien, NM,Van Pelt, FNAM,Mothersill, C (2005) 'A test battery approach for the ecotoxicological evaluation of estuarine sediments'. Ecotoxicology, 14 :741-755 [DOI] [Details] | |
| (2005) | 'Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity' Shuilleabhain, SN,Davoren, M,Mothersill, C,Sheehan, D,Hartl, MGJ,Kilemade, M,O'Brien, NM,O'Halloran, J,Van Pelt, FNAM,Lyng, FM; (2005) 'Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity'. Aquatic Toxicology, 73 :115-127 [DOI] [Details] | |
| (2004) | 'Comparison of the apoptotic processes induced by the oxysterols 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide' Ryan, L,O'Callaghan, YC,O'Brien, NM; (2004) 'Comparison of the apoptotic processes induced by the oxysterols 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide'. Cell Biology and Toxicology, 20 :313-323 [Details] | |
| (2004) | 'In vitro cytotoxicity testing of three zinc metal salts using established fish cell lines' Ni Shuilleabhain, S,Mothersill, C,Sheehan, D,O'Brien, NM,O' Halloran, J,Van Pelt, FNAM,Davoren, M; (2004) 'In vitro cytotoxicity testing of three zinc metal salts using established fish cell lines'. Toxicology In Vitro, 18 :365-376 [DOI] [Details] | |
| (2004) | 'Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription' O'Leary, K. A. and de Pascual-Tereasa, S. and Needs, P. W. and Bao, Y. P. and O'Brien, N. M. and Williamson, G. (2004) 'Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription'. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 551 (1-2):245-254 [Details] | |
| (2004) | 'Use of Tween 40 and Tween 80 to deliver a mixture of phytochemicals to human colonic adenocarcinoma cell (CaCo-2) monolayers' O'Sullivan, S. M. and Woods, J. A. and O'Brien, N. M. (2004) 'Use of Tween 40 and Tween 80 to deliver a mixture of phytochemicals to human colonic adenocarcinoma cell (CaCo-2) monolayers'. British Journal of Nutrition, 91 (5):757-764 [Details] | |
| (2004) | 'Phytosterols: lack of cytotoxicity but interference with beta-carotene uptake in Caco-2 cells in culture' Fahy, D. M. and O'Callaghan, Y. C. and O'Brien, N. M. (2004) 'Phytosterols: lack of cytotoxicity but interference with beta-carotene uptake in Caco-2 cells in culture'. Food Additives and Contaminants, 21 (1):42-51 [Details] | |
| (2004) | 'Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments' Hartl MG, Coughlan BM, Sheehan D, Mothersill C, van Pelt FN, O'Reilly SJ, Heffron JJ, O'Halloran J, O'Brien NM; (2004) 'Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments'. Marine Environmental Research, 57 (4):295-310 [DOI] [Details] | |
| (2004) | 'An assessment of the pollutant status of surficial sediment in Cork Harbour in the South East of Ireland with particular reference to polycyclic aromatic hydrocarbons' Kilemade M, Hartl MG, Sheehan D, Mothersill C, van Pelt FN, O'Brien NM, O'Halloran J; (2004) 'An assessment of the pollutant status of surficial sediment in Cork Harbour in the South East of Ireland with particular reference to polycyclic aromatic hydrocarbons'. Marine Pollution Bulletinetin, 49 (11-12):1084-1096 [DOI] [Details] | |
| (2004) | 'Generation of an oxidative stress precedes caspase activation during 7 beta-hydroxycholesterol-induced apoptosis in U937 cells' Ryan, L,O'Callaghan, YC,O'Brien, NM; (2004) 'Generation of an oxidative stress precedes caspase activation during 7 beta-hydroxycholesterol-induced apoptosis in U937 cells'. Journal of Biochemical and Molecular Toxicology, 18 :50-59 [DOI] [Details] | |
| (2003) | 'Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: Modulatory effects of alpha- and gamma-tocopherol' O'Sullivan, A. J. and O'Callaghan, Y. C. and Woods, J. A. and O'Brien, N. M. (2003) 'Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: Modulatory effects of alpha- and gamma-tocopherol'. Journal of Applied Toxicology, 23 (3):191-197 [Details] | |
| (2003) | 'Variability of heat shock proteins and glutathione S-transferase in gill and digestive gland of blue mussel, Mytilus edulis' Lyons, C, Dowling, V, Tedengren, M., Gardestrom, J., Hartl, GJ, O’Brien, NM, Van Peltt, FNAM, O’Halloran, Sheehan, D; (2003) 'Variability of heat shock proteins and glutathione S-transferase in gill and digestive gland of blue mussel, Mytilus edulis'. Marine Environmental Research, 56 (*):585-597 [Details] | |
| (2003) | 'Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7beta-hydroxycholesterol, in cultured mammalian cells' Maguire L, Konoplyannikov M, Ford A, Maguire AR, O'Brien NM; (2003) 'Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7beta-hydroxycholesterol, in cultured mammalian cells'. Journal of Nutrition, 90 (4):767-775 [Details] | |
| (2003) | 'Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7 beta-hydroxycholesterol, in cultured mammalian cells' Maguire, L. and Konoplyannikov, M. and Ford, A. and Maguire, A. R. and O'Brien, N. M. (2003) 'Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7 beta-hydroxycholesterol, in cultured mammalian cells'. British Journal of Nutrition, 90 (4):767-775 [Details] | |
| (2003) | 'The effect of dietary supplementation with the citrus limonoids, limonin and nomilin on xenobiotic-metabolizing enzymes in the liver and small intestine of the rat' Kelly, C,Jewell, C,O'Brien, NM; (2003) 'The effect of dietary supplementation with the citrus limonoids, limonin and nomilin on xenobiotic-metabolizing enzymes in the liver and small intestine of the rat'. Nutrition Research, 23 :681-690 [DOI] [Details] | |
| (2003) | 'Metabolism of quercetin-7-and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism' O'Leary, KA,Day, AJ,Needs, PW,Mellon, FA,O'Brien, NM,Williamson, G; (2003) 'Metabolism of quercetin-7-and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism'. Biochemical Pharmacology, 65 :479-491 [DOI] [Details] | |
| (2002) | 'Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture' Lyons, N. M. and O'Brien, N. M. (2002) 'Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture'. Journal of Dermatological Science, 30 (1):73-84 [Details] | |
| (2002) | 'Detecting genotoxicity using the comet assay following chronic exposure of Manila clam, Tapes semideussatus to polluted estuarine sediments' Coughlan, BM; Hartl, MGJ; O'Reilly, SJ; Sheehan, D; Mothersill, C; van Pelt, FNAM; O'Halloran, J; O'Brien, NM.; (2002) 'Detecting genotoxicity using the comet assay following chronic exposure of Manila clam, Tapes semideussatus to polluted estuarine sediments'. Marine Pollution Bulletinetin, 44 (*):38-44 [Details] | |
| (2002) | 'Characteristics of 7 beta-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937, and a human hepatoma cell line, HepG2' O'Callaghan, YC,Woods, JA,O'Brien, NM; (2002) 'Characteristics of 7 beta-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937, and a human hepatoma cell line, HepG2'. Toxicology In Vitro, 16 :245-251 [DOI] [Details] | |
| (2001) | 'alpha-Tocopherol, but not gamma-tocopherol inhibits 7 beta-hydroxycholesterol-induced apoptosis in human U937 cells' Lyons, NM,Woods, JA,O'Brien, NM; (2001) 'alpha-Tocopherol, but not gamma-tocopherol inhibits 7 beta-hydroxycholesterol-induced apoptosis in human U937 cells'. Free Radical Research, 35 :329-339 [Details] | |
| (2001) | 'Susceptibility of LDL to oxidative modification in healthy volunteers supplemented with low doses of n-3 polyunsaturated fatty acids' Higgins, S. and Carroll, Y. L. and McCarthy, S. N. and Corridan, B. M. and Roche, H. M. and Wallace, J. M. W. and O'Brien, N. M. and Morrissey, P. A. (2001) 'Susceptibility of LDL to oxidative modification in healthy volunteers supplemented with low doses of n-3 polyunsaturated fatty acids'. British Journal of Nutrition, 85 (1):23-31 [Details] | |
| (2001) | 'Limitations of the single-cell gel electrophoresis assay to monitor apoptosis in U937 and HepG2 cells exposed to 7 beta-hydroxycholesterol' O'Callaghan, YC,Woods, JA,O'Brien, NM; (2001) 'Limitations of the single-cell gel electrophoresis assay to monitor apoptosis in U937 and HepG2 cells exposed to 7 beta-hydroxycholesterol'. Biochemical Pharmacology, 61 :1217-1226 [Details] | |
| (2001) | 'Flavonoid glucuronides are substrates for human liver beta-glucuronidase' O'Leary, K. A. and Day, A. J. and Needs, P. W. and Sly, W. S. and O'Brien, N. M. and Williamson, G. (2001) 'Flavonoid glucuronides are substrates for human liver beta-glucuronidase'. Febs Letters, 503 (1):103-106 [Details] | |
| (2001) | 'Sedanolide, a natural phthalide from celery seed oil: Effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines' Woods, J. A. and Jewell, C. and O'Brien, N. M. (2001) 'Sedanolide, a natural phthalide from celery seed oil: Effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines'. In Vitro & Molecular Toxicology-a Journal of Basic and Applied Research, 14 (3):233-240 [Details] | |
| (2000) | 'Lack of effect of the flavonoids, myricetin, quercetin, and rutin, on repair of H(2)O(2)-induced DNA single-strand breaks in Caco-2, Hep G2, and V79 cells' Aherne, S. A. and O'Brien, N. M. (2000) 'Lack of effect of the flavonoids, myricetin, quercetin, and rutin, on repair of H(2)O(2)-induced DNA single-strand breaks in Caco-2, Hep G2, and V79 cells'. Nutrition and Cancer-an International Journal, 38 (1):106-115 [Details] | |
| (2000) | 'Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals' O'Brien, N. M. and Woods, J. A. and Aherne, S. A. and O'Callaghan, Y. C. (2000) 'Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals'. Biochemical Society Transactions, 28 :22-26 [Details] | |
| (2000) | 'Mechanism of protection by the flavonoids, quercetin and rutin, against tert-butylhydroperoxide- and menadione induced DNA single strand breaks in Caco-2 cells' Aherne, SA,O'Brien, NM; (2000) 'Mechanism of protection by the flavonoids, quercetin and rutin, against tert-butylhydroperoxide- and menadione induced DNA single strand breaks in Caco-2 cells'. Free Radical Biology and Medicine, 29 :507-514 [Details] | |
| (2000) | 'Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated fatty acids' Higgins, S. and McCarthy, S. N. and Corridan, B. M. and Roche, H. M. and Wallace, J. M. W. and O'Brien, N. M. and Morrissey, P. A. (2000) 'Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated fatty acids'. Nutrition Research, 20 (8):1091-1102 [Details] | |
| (2000) | 'Biological effects of dietary cholesterol oxidation products' O'Brien, N. M. and O'Callaghan, Y. C. and Lyons, N. M. and Woods, J. A. (2000) 'Biological effects of dietary cholesterol oxidation products'. Irish Journal of Agricultural and Food Research, 39 (2):265-273 [Details] | |
| (1999) | 'Preservation of comet assay slides: comparison with fresh slides' Woods, JA,O'Leary, KA,McCarthy, RP,O'Brien, NM; (1999) 'Preservation of comet assay slides: comparison with fresh slides'. Mutation Research, 429 :181-187 [Details] | |
| (1999) | 'Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat' Jewell, C,O'Brien, NM; (1999) 'Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat'. British Journal of Nutrition, 81 :235-242 [Details] | |
| (1999) | 'Use of microencapsulated fish oil as a means of increasing n-3 polyunsaturated fatty acid intake' Higgins, S. and Carroll, Y. L. and O'Brien, N. M. and Morrissey, P. A. (1999) 'Use of microencapsulated fish oil as a means of increasing n-3 polyunsaturated fatty acid intake'. Journal of Human Nutrition and Dietetics, 12 (4):265-271 [Details] | |
| (1999) | 'Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells' Aherne, S. A. and O'Brien, N. M. (1999) 'Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells'. Nutrition and Cancer-an International Journal, 34 (2):160-166 [Details] | |
| (1999) | 'The flavonoids, myricetin, quercetin and rutin, protect against cholestan-3 beta, 5 alpha, 6 beta-triol - Induced toxicity in Chinese hamster ovary cells in vitro' Aherne, S. A. and O'Brien, N. M. (1999) 'The flavonoids, myricetin, quercetin and rutin, protect against cholestan-3 beta, 5 alpha, 6 beta-triol - Induced toxicity in Chinese hamster ovary cells in vitro'. Nutrition Research, 19 (5):749-760 [Details] | |
| (1999) | 'Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations' O'Callaghan, Y. C. and Woods, J. A. and O'Brien, N. M. (1999) 'Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations'. European Journal of Nutrition, 38 (6):255-262 [Details] | |
| (1998) | 'Dietary antioxidants in health and disease' Morrissey, P.A. and O'Brien, N.M.; (1998) 'Dietary antioxidants in health and disease'. International Dairy Journal, 8 (*):463-472 [Details] | |
| (1998) | 'Investigation of the potential genotoxicity of cholesterol oxidation products in two mammalian fibroblast cell lines' Woods, J. A. and O'Brien, N. M. (1998) 'Investigation of the potential genotoxicity of cholesterol oxidation products in two mammalian fibroblast cell lines'. Nutrition and Cancer-an International Journal, 31 (3):192-198 [Details] | |
| (1995) | 'Modulation of oxidative stress by beta-carotene in chicken embryo fibroblasts' Lawlor, SM, O'Brien, NM (1995) 'Modulation of oxidative stress by beta-carotene in chicken embryo fibroblasts'. British Journal of Nutrition, [Details] | |
| (1993) | 'Natural toxicants in the food supply: In vitro investigation of the potential mechanism of action of the dietary flavonoid quercetin' O'Brien, Nora M. and Cronin, Susan M. and Morrissey, Patrick A. (1993) 'Natural toxicants in the food supply: In vitro investigation of the potential mechanism of action of the dietary flavonoid quercetin'. International Journal of Food Sciences and Nutrition, 44 (2):85-90 [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2014) | 'Nutritional aspects of cheese' O'Callaghan, YC, O'Connor, TP, O'Brien, NM (2014) 'Nutritional aspects of cheese' In: Fundamentals of Cheese Science. Maryland, USA: Aspen Publication. [Details] | |
| (2013) | 'Cheese in the context of diet and nutrition' McCarthy, A, O'Connor, TP, O'Brien, NM (2013) 'Cheese in the context of diet and nutrition' In: Handbook of cheese in health: Production, Nutrition and Medical Sciences. Wageningen: Wageningen Academic Publishers. [Details] | |
| (2011) | 'Milk Lipids: Nutritional significance' O'Brien, NM; O'Connor, TP; (2011) 'Milk Lipids: Nutritional significance' In: Encyclopaedia of Dairy Science, 2nd edition. London: Elsevier Publishers. [Details] | |
| (2011) | 'Butter and other milk fat products: Fat Replacers' O'Connor, TP; O'Brien, NM; (2011) 'Butter and other milk fat products: Fat Replacers' In: Encyclopaedia of Dairy Science, 2nd Edition. London: Elsevier Publishers. [Details] | |
| (2010) | 'Milk Lipids: Oxidation' O'Brien, NM; O'Connor, TP; (2010) 'Milk Lipids: Oxidation' In: Encyclopaedia of Dairy Science, 2nd Edition. London: Elsevier Publishers. [Details] | |
| (2006) | 'Nutritional aspects of cheese' O'Brien, N.M.; (2006) 'Nutritional aspects of cheese' In: Cheese Problems Solved. [Details] | |
| (2004) | 'Toxins in Cheese-Biogenic Amines and Mycotoxins' O'Brien, N.M., O'Connor, T.P., O'Callaghan, J. and Dobson, A.D.W.; (2004) 'Toxins in Cheese-Biogenic Amines and Mycotoxins' In: Cheese: Chemistry, Physics and Microbiology,3rd Edition: General Aspects - Volume 1. [Details] | |
| (2004) | 'Nutritional aspects of cheese' O'Brien, N.M. and O'Connor, T.P.; (2004) 'Nutritional aspects of cheese' In: Cheese, chemistry, physics and microbiology, third edition. [Details] | |
| (2004) | 'Carotenoids effects on cellular processes: Induction of phase I and phase II enzymes' O'Brien, N.M. and O'Connor, T.P.; (2004) 'Carotenoids effects on cellular processes: Induction of phase I and phase II enzymes' In: Carotenoids in health and disease. [Details] | |
| (2003) | 'Toxicology of cheese' Dobson, A., O'Connor, T.P. and O'Brien, N.M.; (2003) 'Toxicology of cheese' In: Cheese: Chemistry, Physics and Microbiology. [Details] | |
| (2002) | 'Lipids: nutritional significance' O'Brien, N.M. and O'Connor, T.P.; (2002) 'Lipids: nutritional significance' In: Encyclopedia of dairy sciences. [Details] | |
| (2002) | 'Formation and content of cholesterol oxidation products in meat and meat products' Kerry, J., Gilroy, D. and O'Brien, N.M.; (2002) 'Formation and content of cholesterol oxidation products in meat and meat products' In: Sterol oxidation products in foods and biological samples: analysis, content and biological effects. [Details] | |
| (2002) | 'Lipids: Oxidation' O'Brien, N.M. and O'Connor, T.P.; (2002) 'Lipids: Oxidation' In: Encyclopedia of Dairy Sciences. [Details] | |
| (2002) | 'Lipid analysis in dairy products' O'Connor, T.P. and O'Brien, N.M.; (2002) 'Lipid analysis in dairy products' In: Encyclopedia of Dairy Sciences. [Details] | |
| (2002) | 'Fat replacers' O'Connor, T.P. and O'Brien, N.M.; (2002) 'Fat replacers' In: Encyclopedia of Dairy Sciences. [Details] | |
| (2002) | 'Nutritional significance of dairy products' O'Brien, N.M. and O'Connor, T.P.; (2002) 'Nutritional significance of dairy products' In: Encyclopedia of Dairy Sciences. [Details] | |
| (2000) | 'Nutritional Aspects of Cheese' O'connor, T.P. and O'Brien, N.M.; (2000) 'Nutritional Aspects of Cheese' In: Fundamentals of Cheese Science. [Details] | |
| (1995) | 'Lipid Oxidation' O,Connor, T.P. and O'Brien, N.M.; (1995) 'Lipid Oxidation' In: Advanced dairy chemistry, volume 2. [Details] | |
| (1992) | 'Nutrition and Health' O'Brien, N.M.; (1992) 'Nutrition and Health' In: Town and Gown: UCC Public Lecture Series. [Details] | |
| (1991) | 'Significance of lipoxygenase in fruits and vegetables' O'Connor, TP, O'Brien, NM (1991) 'Significance of lipoxygenase in fruits and vegetables' In: Food enzymology. London: Elsevier Applied Science. [Details] |
Reviews
| Year | Publication | |
|---|---|---|
| (2018) | The immunomodulatory potential of cereal grains. Crowley, D., O’Callaghan, Y.C. and O’Brien, N.M. (2018) The immunomodulatory potential of cereal grains. Reviews [Details] | |
| (2015) | Involvement of oxysterols in age related diseases and ageing processes. Zarrouk, A, Vejux, A, Mackrill, J, O'Callaghan, YC, Hammami, M, O'Brien, NM, Lizard, G (2015) Involvement of oxysterols in age related diseases and ageing processes. Reviews [Details] | |
| (2013) | Brewers' spent grain; bioactivity of phenolic component, its role in animal nutrition and potential for incorporation in functional foods: a review. McCarthy, AL;O'Callaghan, YC;Piggott, CO;FitzGerald, RJ;O'Brien, NM (2013) Brewers' spent grain; bioactivity of phenolic component, its role in animal nutrition and potential for incorporation in functional foods: a review. CAMBRIDGE: Reviews [DOI] [Details] | |
| (2009) | Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects. Ryan, E;McCarthy, FO;Maguire, AR;O'Brien, NM (2009) Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects. PHILADELPHIA: Reviews [DOI] [Details] | |
| (2014) | Recent advances in Phytosterol Oxidation Products. O'Callaghan, Y,McCarthy, FO,O'Brien, NM (2014) Recent advances in Phytosterol Oxidation Products. Reviews [DOI] [Details] | |
| (2014) | Brewers' spent grain; bioactivity of phenolic component, its role in animal nutrition and potential for incorporation in functional foods: a review. McCarthy, AL, O'Callaghan, YC, Piggott, CO, FitzGerald, RJ, O'Brien, NM (2014) Brewers' spent grain; bioactivity of phenolic component, its role in animal nutrition and potential for incorporation in functional foods: a review. Reviews [Details] | |
| (2013) | Protein hydrolysates from agricultural crops- bioactivity and potential for functional food development. McCarthy, AL, O'Callaghan, YC, O'Brien, NM (2013) Protein hydrolysates from agricultural crops- bioactivity and potential for functional food development. Reviews [Details] | |
| (2013) | Bioaccessibility of functional ingredients. McCarthy, AL, O'Brien, NM (2013) Bioaccessibility of functional ingredients. Reviews [Details] | |
| (2012) | UV-B induced secondary plant metabolites - potential benefits for plant and human health. Schreiner, M, Mewis, I, Huyskens-Keil, S, Jansen, MAK, Zrenner, R, Winkler, JB, O'Brien, NM, Krumbein, A (2012) UV-B induced secondary plant metabolites - potential benefits for plant and human health. Reviews [Details] | |
| (2011) | Bioactivities of glycolkaloids and their aglycones from solanum species. Milner, SE, Brunton, NP, Jones, PW, O'Brien, NM, Collins, SG, Maguire, AR (2011) Bioactivities of glycolkaloids and their aglycones from solanum species. Reviews [Details] | |
| (2009) | Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects. Ryan, E,McCarthy, FO,Maguire, AR,O'Brien, NM (2009) Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects. Reviews [DOI] [Details] | |
| (2009) | Casein-derived bioactive peptides: Absorption, metabolism, and biological effects. Phelan, M, Aherne, SA, FitzGerald, R, O'Brien, NM (2009) Casein-derived bioactive peptides: Absorption, metabolism, and biological effects. Reviews [Details] | |
| (2009) | Oxysterols and mechanisms of apoptotic signalling: implications in the pathology of degenerative diseases. Lordan, S, Mackrill, JJ, O'Brien, NM (2009) Oxysterols and mechanisms of apoptotic signalling: implications in the pathology of degenerative diseases. Reviews [Details] | |
| (2005) | Oxidised products of cholesterol: Their role in apoptosis. Ryan, L, O'Callaghan, YC, O'Brien, NM (2005) Oxidised products of cholesterol: Their role in apoptosis. Reviews [Details] | |
| (2004) | The importance of nutrition and diet in cancer prevention. O'Brien, NM, O'Connor, TP (2004) The importance of nutrition and diet in cancer prevention. Reviews [Details] | |
| (2004) | Potential uses and benefits of plant sterols (phytosterols and phytostanols): future directions. O'Brien, NM (2004) Potential uses and benefits of plant sterols (phytosterols and phytostanols): future directions. Reviews [Details] | |
| (2003) | Diet, nutrition and cancer prevention. O'Brien, NM, O'Connor, TP (2003) Diet, nutrition and cancer prevention. Reviews [Details] | |
| (2002) | Nutrition and cancer. O'Brien, NM, O'Connor, TP (2002) Nutrition and cancer. Reviews [Details] | |
| (2001) | Dietary flavonols: chemistry, food content and metabolism. Aherne, SA, O'Brien, NM (2001) Dietary flavonols: chemistry, food content and metabolism. Reviews [Details] | |
| (2001) | A critical evaluation of the application of biomarkers in epidemiological studies on diet and health. Wild, CP,Andersson, C,O'Brien, NM,Wilson, L,Woods, JA (2001) A critical evaluation of the application of biomarkers in epidemiological studies on diet and health. Reviews [Details] | |
| (2001) | Nutrition and health. O'Brien, NM (2001) Nutrition and health. Reviews [Details] | |
| (1998) | Dietary antioxidants in health and disease. Morrissey, PA, O'Brien, NM (1998) Dietary antioxidants in health and disease. Reviews [Details] | |
| (1996) | Cheese: physical, chemical and nutritional aspects. Fox, PF, O'Connor, TP, Guinee, T, McSweeney, P, O'Brien, NM (1996) Cheese: physical, chemical and nutritional aspects. Reviews [Details] | |
| (1993) | Milk, cheese and dental caries. O'Brien, N.M. and O'Connot T.P.; (1993) Milk, cheese and dental caries. Reviews [Details] | |
| (1993) | Natural toxicants in the food supply: in vitro investigation of the potential mechanism of action of the dietary flavonoid quercetin. O'Brien N.M. Cronin S.M. and Morrissey P.A.; (1993) Natural toxicants in the food supply: in vitro investigation of the potential mechanism of action of the dietary flavonoid quercetin. Reviews [Details] |
Other Journals
| Year | Publication | |
|---|---|---|
| (2014) | 'An examination of the potential of seaweed extracts as functional ingredients in milk' O'Sullivan, Anthoney M and O'Callaghan, Yvonne C and O'Grady, Michael N and Waldron, David S and Smyth, Thomas J and O'Brien, Nora M and Kerry, Joseph P (2014) 'An examination of the potential of seaweed extracts as functional ingredients in milk' International Journal of Dairy Technology, 67 (2) :182-193. [DOI] [Details] | |
| (2004) | 'Potential uses and benefits of plant sterols (phytosterols and phytostanols): future directions' O'Brien, N.M.; (2004) 'Potential uses and benefits of plant sterols (phytosterols and phytostanols): future directions' RELAY e-Newsletter, * :*-*. [Details] | |
| (2001) | 'Diet, nutrition and health: evidence for the beneficial effects of fruits and vegetables' O'Brien, N.M.; (2001) 'Diet, nutrition and health: evidence for the beneficial effects of fruits and vegetables' Irish Scientist Yearbook, 9 :206-208. [Details] |
Book Reviews
| Year | Publication | |
|---|---|---|
| (2009) | Casein-derived bioactive peptides: Biological effects, industrial uses, safety aspects and regulatory status. Phelan, M,Aherne, A,FitzGerald, RJ,O'Brien, NM (2009) Casein-derived bioactive peptides: Biological effects, industrial uses, safety aspects and regulatory status. Book Reviews [DOI] [Details] | |
| (2009) | Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases. Lordan, S,Mackrill, JJ,O'Brien, NM (2009) Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases. Book Reviews [DOI] [Details] | |
| (2008) | Plant stress and human health: Do human consumers benefit from UV-B acclimated crops?. Jansen, MAK,Hectors, K,O'Brien, NM,Guisez, Y,Potters, G (2008) Plant stress and human health: Do human consumers benefit from UV-B acclimated crops?. Book Reviews [DOI] [Details] | |
| (2002) | Dietary flavonols: Chemistry, food content, and metabolism. Aherne, SA,O'Brien, NM (2002) Dietary flavonols: Chemistry, food content, and metabolism. Book Reviews [Details] |
Published Reports
| Year | Publication | |
|---|---|---|
| (2005) | Education for Health - Shaping our Future. Food Safety and Nutrition in Schools. O'Brien NM, et al; (2005) Education for Health - Shaping our Future. Food Safety and Nutrition in Schools. Food Safety Promotion Board, Ireland. [Details] | |
| (2005) | Genetically modified crops and food: threat or opportunity for Ireland?. O'Brien NM, et al; (2005) Genetically modified crops and food: threat or opportunity for Ireland?. Irish Council for Bioethics Report, Ireland. [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2010) | Proceedings of the 38th Annual Research Conference on Food Daly, TJ; Aherne-Bruce, SA; O'Connor, TP; O'Brien, NM; (2010) Determination of the genoprotective and Cox-2 modulatory effects of phytosterols in Caco-2 cells Proceedings of the 38th Annual Research Conference on Food [Details] | |
| (2010) | Proceeding of the International Conference on Traditional Dairy Foods O'Brien, NM; O'Connor, TP; Ryan, E; (2010) Bioactivity of functional food Proceeding of the International Conference on Traditional Dairy Foods [Details] | |
| (2010) | Proceedings of the Euro Fed Lipid Congress, Athens O'Brien, NM; O'Connor, TP; (2010) Sterols: natural levels in foods, fortification of foods, health aspects and potential toxicity Proceedings of the Euro Fed Lipid Congress, Athens [Details] | |
| (2010) | Proceedings of the 38th Annual Research Conference on Food, Nutrition & Consumer Sciences O'Connor, MP; O'Brien, NM; O'Sullivan, K; O'Connor, TP; (2010) Contribution of food groups to energy and macronutrient intakes of school-going Irish adolescents Proceedings of the 38th Annual Research Conference on Food, Nutrition & Consumer Sciences UCC, Cork, , 04-SEP-10 - 04-SEP-10 [Details] | |
| (2008) | 12th International Conference on Harmful Algal Blooms Juhel, G., O'Halloran, J., Culloty, S.C., O'Riordan, R.M., Davenport, J., O'Brien N.M., James, K.F., Furey, A. & Allis, O.; (2008) In vivo exposure to microcystins induced DNA damage in haemocytes of the zebra mussel as measured with the Comet assay 12th International Conference on Harmful Algal Blooms Copenhagen, Denmark, , 04-SEP-06 - 08-SEP-06 [Details] | |
| (2008) | Nutrition Society Meeting Lordan S, Mackrill JJ, O'Brien NM (2008) Influence of intracellular calcium on apoptosis in differentiated U937 cells following long-term exposure to oxysterols Nutrition Society Meeting [DOI] [Details] | |
| (2007) | Joint Health Research Day Lordan S, O’Neill C, O’Brien NM (2007) The effects of apigenin, lycopene and astaxanthin on 7β-hydroxycholesterol-induced apoptosis in U937 cells Joint Health Research Day [Details] | |
| (2007) | 37th Annual Research Conference Food, Nutrition and Consumer Sciences Lordan S, Mackrill JJ, O’Brien NM (2007) Involvement of calcium signalling in oxysterol-induced apoptosis in differentiated U937 cells 37th Annual Research Conference Food, Nutrition and Consumer Sciences [Details] | |
| (2006) | The 14th Annual Cork University Hospital Medical Faculty Research Day Lordan S, O’Callaghan, O’Brien NM (2006) An investigation into the caspase-2 signalling pathway of oxLDL- and oxysterol-induced apoptosis in U937 cells The 14th Annual Cork University Hospital Medical Faculty Research Day [Details] | |
| (2006) | Nutrition Society Meeting Lordan S, O'Callaghan YC, O'Brien NM (2006) Oxidised low-density lipoprotein- and oxysterol-induced cell death in U937 and HL-60 blood cells Nutrition Society Meeting [Details] | |
| (2005) | Nutrition Society Meeting - Irish Section Lordan S, O'Callaghan YC, O'Brien NM (2005) An investigation of the anti-apoptotic efficiency of apigenin, astaxanthin and lycopene in cholesterol oxide-treated human monocytic blood cells Nutrition Society Meeting - Irish Section [Details] | |
| (2005) | The 13th Annual Cork University Hospital Medical Faculty Research Day Lordan S, O’Callaghan, O’Brien NM (2005) Comparison of the cytotoxic effects of oxidised low density lipoprotein and oxysterols in human monocytic cell lines The 13th Annual Cork University Hospital Medical Faculty Research Day [Details] |
Articles
| Year | Publication | |
|---|---|---|
| (1994) | Education for a lifetime of learning. O'Connor, T.P. and O'Brien, N.M.; (1994) Education for a lifetime of learning. Articles [Details] |
Abstract
| Year | Publication | |
|---|---|---|
| (2015) | The effect of a caseinate hydrolysate on cytokine release and RNA expression in TNF- stressed 3T3-L1 adipocytes. O'Sullivan, SM;O'Callaghan, YC;O'Keeffe, MB;FitzGerald, RJ;O'Brien, NM (2015) The effect of a caseinate hydrolysate on cytokine release and RNA expression in TNF- stressed 3T3-L1 adipocytes. CAMBRIDGE: Abstract [DOI] [Details] | |
| (2015) | The immunomodulatory potential of in vitro digested low-fat milk supplemented with brewers' spent grain protein hydrolysate; selection of a non-cytotoxic level of digestate. Crowley, DJ;O'Callaghan, YC;McCarthy, AL;Piggott, CO;FitzGerald, RJ;O'Brien, NM (2015) The immunomodulatory potential of in vitro digested low-fat milk supplemented with brewers' spent grain protein hydrolysate; selection of a non-cytotoxic level of digestate. CAMBRIDGE: Abstract [DOI] [Details] | |
| (2011) | Bioaccessibility of polyphenol and carotenoid from wild Irish berries subjected to an in vitro digestion procedure. O'Sullivan, AM,O'Callaghan, YC,O'Connor, TP,O'Brien, NM (2011) Bioaccessibility of polyphenol and carotenoid from wild Irish berries subjected to an in vitro digestion procedure. Abstract [DOI] [Details] | |
| (2011) | The content and bioaccessibility of carotenoids from selected commercially available health supplements. O'Sullivan, AM,O'Callaghan, YC,O'Connor, TP,O'Brien, NM (2011) The content and bioaccessibility of carotenoids from selected commercially available health supplements. Abstract [DOI] [Details] | |
| (2011) | The influence of the extraction method on the DNA protective effects of seaweed extracts in Caco-2 cells. O'Sullivan, AM,O'Callaghan, YC,O'Grady, MN,Hayes, M,Kerry, JP,O'Brien, NM (2011) The influence of the extraction method on the DNA protective effects of seaweed extracts in Caco-2 cells. Abstract [DOI] [Details] | |
| (2011) | The content and bioaccessibility of carotenoids from selected commercially available health supplements. O'Sullivan, AM;O'Callaghan, YC;O'Connor, TP;O'Brien, NM (2011) The content and bioaccessibility of carotenoids from selected commercially available health supplements. CAMBRIDGE: Abstract [DOI] [Details] | |
| (2009) | [beta]-Carotene content and bioaccessibility from organic and non-organic baby meals. Aherne-Bruce, A,Jiwan, MA,Duane, P,O'Sullivan, L,O'Brien, NM (2009) [beta]-Carotene content and bioaccessibility from organic and non-organic baby meals. Abstract [Details] | |
| (2007) | The bioaccessibility of alpha-tocopherol and retinol from a range of vitamin-enriched foods. O'Callaghan, YC,Kenny, O,O'Brien, NM (2007) The bioaccessibility of alpha-tocopherol and retinol from a range of vitamin-enriched foods. Abstract [Details] | |
| (2007) | Phytosterol, tocopherol and squalene content of selected nuts, seeds, legumes and cereals. Ryan, E;Galvin, K;O'Connor, TP;O'Brien, NM (2007) Phytosterol, tocopherol and squalene content of selected nuts, seeds, legumes and cereals. STUTTGART: Abstract [Details] | |
| (2007) | Uptake and secretion of micellarised lutein from spinach (Spinacia oteracea) using a Caco-2 intestinal cell model. O'Sullivan, LP;Ryan, L;O'Brien, NM (2007) Uptake and secretion of micellarised lutein from spinach (Spinacia oteracea) using a Caco-2 intestinal cell model. CAMBRIDGE: Abstract [Details] | |
| (2007) | The effects of plant sterols on the viability and proliferation of Caco-2 cells. Daly, TJ;Aherne, SA;O'Connor, TP;O'Brien, NM (2007) The effects of plant sterols on the viability and proliferation of Caco-2 cells. CAMBRIDGE: Abstract [Details] | |
| (2007) | Effect of fibre on the bioaccessibility of carotenoids from a combination of vegetables. O'Connell, OF,Ryan, L,O'Brien, NM (2007) Effect of fibre on the bioaccessibility of carotenoids from a combination of vegetables. Abstract [Details] | |
| (2007) | Immunomodulatory effects of beta-sitosterol on human Jurkat. Aherne, SA,Daly, T,O'Connor, T,O'Brien, NM (2007) Immunomodulatory effects of beta-sitosterol on human Jurkat. Abstract [Details] | |
| (2007) | Phytosterol, tocopherol and squalene content of selected nuts, seeds, legumes and cereals. Ryan, E,Galvin, K,O'Connor, TP,O'Brien, NM (2007) Phytosterol, tocopherol and squalene content of selected nuts, seeds, legumes and cereals. Abstract [Details] | |
| (2007) | The effects of plant sterols on the viability and proliferation of Caco-2 cells. Daly, TJ,Aherne, SA,O'Connor, TP,O'Brien, NM (2007) The effects of plant sterols on the viability and proliferation of Caco-2 cells. Abstract [Details] | |
| (2007) | Analysis of the effect of different cooking processes on the percentage bioaccessibility of carotenoids from tomato and red pepper (Capiscum annuum L). Ryan, L,O'Connell, OF,O'Brien, NM (2007) Analysis of the effect of different cooking processes on the percentage bioaccessibility of carotenoids from tomato and red pepper (Capiscum annuum L). Abstract [Details] | |
| (2007) | Uptake and secretion of micellarised lutein from spinach (Spinacia oteracea) using a Caco-2 intestinal cell model. O'Sullivan, LP,Ryan, L,O'Brien, NM (2007) Uptake and secretion of micellarised lutein from spinach (Spinacia oteracea) using a Caco-2 intestinal cell model. Abstract [Details] | |
| (2007) | The effects of lignan-rich extracts on human Jurkat T-cells. Phelan, M,Aherne, SA,Wong, A,O'brien, NM (2007) The effects of lignan-rich extracts on human Jurkat T-cells. Abstract [Details] | |
| (2006) | Bioavailability of carotenoids determined by a Caco-2 cell model. O'Sullivan, LP,Ryan, L,O'Brien, NM (2006) Bioavailability of carotenoids determined by a Caco-2 cell model. Abstract [Details] | |
| (2006) | An in vitro method to determine the micellarisation percentage of carotenoids in a variety of vegetables. Ryan, L,O'Connell, OF,O'Brien, NM (2006) An in vitro method to determine the micellarisation percentage of carotenoids in a variety of vegetables. Abstract [Details] | |
| (2006) | Oxidised low-density lipoprotein- and oxysterol-induced cell death in U937 and HL-60 blood cells. Lordan, S,O'Callaghan, YC,O'Brien, NM (2006) Oxidised low-density lipoprotein- and oxysterol-induced cell death in U937 and HL-60 blood cells. Abstract [Details] | |
| (2005) | Modulatory effects of resveratol, citroflavan-3-ol and plant-derived extracts oil oxidative stress in U937 cells. Carpenter, R,O'Callaghan, YC,O'Grady, M,Kerry, JP,O'Brien, NM (2005) Modulatory effects of resveratol, citroflavan-3-ol and plant-derived extracts oil oxidative stress in U937 cells. Abstract [Details] | |
| (2005) | An investigation of the anti-apoptotic efficiency of apigenin, astaxanthin and lycopene in cholesterol oxide-treated human monocytic blood cells. Lordan, S;O'Callaghan, YC;O'Brien, NM (2005) An investigation of the anti-apoptotic efficiency of apigenin, astaxanthin and lycopene in cholesterol oxide-treated human monocytic blood cells. CAMBRIDGE: Abstract [Details] | |
| (2005) | An investigation of the anti-apoptotic efficiency of apigenin, astaxanthin and lycopene in cholesterol oxide-treated human monocytic blood cells. Lordan, S,O'Callaghan, YC,O'Brien, NM (2005) An investigation of the anti-apoptotic efficiency of apigenin, astaxanthin and lycopene in cholesterol oxide-treated human monocytic blood cells. Abstract [Details] | |
| (2000) | Modulation by alpha-tocopherol and alpha-tocopherol acetate of oxysterol-induced apoptosis in U937 cells. Lyons, NM;Woods, JA;O'Brien, NM (2000) Modulation by alpha-tocopherol and alpha-tocopherol acetate of oxysterol-induced apoptosis in U937 cells. WALLINGFORD: Abstract [Details] | |
| (2000) | DNA repair in hydrogen peroxide-treated Caco-2, HepG2 and V79 cells. Aherne, SA;O'Brien, NM (2000) DNA repair in hydrogen peroxide-treated Caco-2, HepG2 and V79 cells. WALLINGFORD: Abstract [Details] | |
| (2000) | The effect of alpha-tocopherol, gamma-tocopherol and beta-carotene on oxidant-induced injury of proliferating human intestinal CaCo-2 cells. Woods, JA;O'Brien, NM (2000) The effect of alpha-tocopherol, gamma-tocopherol and beta-carotene on oxidant-induced injury of proliferating human intestinal CaCo-2 cells. WALLINGFORD: Abstract [Details] | |
| (2000) | Modulation by alpha-tocopherol and alpha-tocopherol acetate of oxysterol-induced apoptosis in U937 cells. Lyons, NM,Woods, JA,O'Brien, NM (2000) Modulation by alpha-tocopherol and alpha-tocopherol acetate of oxysterol-induced apoptosis in U937 cells. Abstract [Details] | |
| (2000) | The effect of flavonoids on repair of hydrogen peroxide-induced DNA damage in Caco-2 cells. Aherne, SA,O'Brien, NM (2000) The effect of flavonoids on repair of hydrogen peroxide-induced DNA damage in Caco-2 cells. Abstract [Details] | |
| (2000) | Effect of vitamin E on hydrogen peroxide and menadione-induced Sister Chromatid Exchange (SCE) in V79 cells. O'Leary, KA,Woods, JA,O'Brien, NM (2000) Effect of vitamin E on hydrogen peroxide and menadione-induced Sister Chromatid Exchange (SCE) in V79 cells. Abstract [Details] | |
| (2000) | The effect of the citrus phytochemicals limonin and nomilin on glutathione-S-transferase activity in rat liver. Kelly, C;Jewell, C;O'Brien, NM (2000) The effect of the citrus phytochemicals limonin and nomilin on glutathione-S-transferase activity in rat liver. WALLINGFORD: Abstract [Details] | |
| (2000) | The use of the comet assay to determine the mode of cell death induced by oxyterols in vitro. O'Callaghan, YC,Woods, JA,O'Brien, NM (2000) The use of the comet assay to determine the mode of cell death induced by oxyterols in vitro. Abstract [Details] | |
| (2000) | The effect of the citrus phytochemicals limonin and nomilin on glutathione-S-transferase activity in rat liver. Kelly, C,Jewell, C,O'Brien, NM (2000) The effect of the citrus phytochemicals limonin and nomilin on glutathione-S-transferase activity in rat liver. Abstract [Details] | |
| (2000) | DNA repair in hydrogen peroxide-treated Caco-2, HepG2 and V79 cells. Aherne, SA,O'Brien, NM (2000) DNA repair in hydrogen peroxide-treated Caco-2, HepG2 and V79 cells. Abstract [Details] | |
| (2000) | The effect of alpha-tocopherol, gamma-tocopherol and beta-carotene on oxidant-induced injury of proliferating human intestinal CaCo-2 cells. Woods, JA,O'Brien, NM (2000) The effect of alpha-tocopherol, gamma-tocopherol and beta-carotene on oxidant-induced injury of proliferating human intestinal CaCo-2 cells. Abstract [Details] | |
| (2000) | Effect of supplementing healthy volunteers with low dose n-3 polyunsaturated fatty acids (n-3 PUFA) on the susceptibility of low density lipoprotein (LDL) to oxidative modification. Higgins, S,Carroll, YL,O'Brien, NM,Morrissey, PA (2000) Effect of supplementing healthy volunteers with low dose n-3 polyunsaturated fatty acids (n-3 PUFA) on the susceptibility of low density lipoprotein (LDL) to oxidative modification. Abstract [Details] |
Other
| Year | Publication | |
|---|---|---|
| (2007) | The Effects of Plant Sterols On The Viability and Proliferation of Caco-2 Cells. Daly, TJ, O'Connor, TP, O'Brien, NM, Aherne, SA; (2007) The Effects of Plant Sterols On The Viability and Proliferation of Caco-2 Cells. Other [Details] | |
| (2007) | Phytosterol, Tocopherol and Squalene Content of Selected Nuts, Seeds, Legumes and Cereals. Ryan, E, Galvin, K, O'Connor, TP, O'Brien, NM; (2007) Phytosterol, Tocopherol and Squalene Content of Selected Nuts, Seeds, Legumes and Cereals. Other [Details] | |
| (2007) | Uptake and Secretion of Micellarised Lutein From Spinach (Spinacia Oteracea) Using A Caco-2 Intestinal Cell Model. O'Sullivan, LP, Ryan, L, O'Brien, NM; (2007) Uptake and Secretion of Micellarised Lutein From Spinach (Spinacia Oteracea) Using A Caco-2 Intestinal Cell Model. Other [Details] | |
| (2007) | The Effects of Lignan-Rich Extracts On Human Jurkat T-Cells. Phelan, M, Aherne, SA, Wong, A, O'brien, NM; (2007) The Effects of Lignan-Rich Extracts On Human Jurkat T-Cells. Other [Details] | |
| (2007) | Immunomodulatory Effects of Beta-Sitosterol On Human Jurkat. Aherne, SA, Daly, T, O'Connor, T, O'Brien, NM; (2007) Immunomodulatory Effects of Beta-Sitosterol On Human Jurkat. Other [Details] | |
| (2006) | Oxidised Low-Density Lipoprotein- and Oxysterol-Induced Cell Death In U937 and Hl-60 Blood Cells. Lordan, S, O'Callaghan, YC, O'Brien, NM; (2006) Oxidised Low-Density Lipoprotein- and Oxysterol-Induced Cell Death In U937 and Hl-60 Blood Cells. Other [Details] | |
| (2006) | Bioavailability of Carotenoids Determined By A Caco-2 Cell Model. O'Sullivan, LP, Ryan, L, O'Brien, NM; (2006) Bioavailability of Carotenoids Determined By A Caco-2 Cell Model. Other [Details] | |
| (2006) | An In Vitro Method to Determine The Micellarisation Percentage of Carotenoids In A Variety of Vegetables. Ryan, L, O'Connell, OF, O'Brien, NM; (2006) An In Vitro Method to Determine The Micellarisation Percentage of Carotenoids In A Variety of Vegetables. Other [Details] | |
| (2005) | An Investigation of The Anti-Apoptotic Efficiency of Apigenin, Astaxanthin and Lycopene In Cholesterol Oxide-Treated Human Monocytic Blood Cells. Lordan, S, O'Callaghan, YC, O'Brien, NM; (2005) An Investigation of The Anti-Apoptotic Efficiency of Apigenin, Astaxanthin and Lycopene In Cholesterol Oxide-Treated Human Monocytic Blood Cells. Other [Details] | |
| (2005) | Modulatory Effects of Resveratol, Citroflavan-3-Ol and Plant-Derived Extracts Oil Oxidative Stress In U937 Cells. Carpenter, R, O'Callaghan, YC, O'Grady, M, Kerry, JP, O'Brien, NM; (2005) Modulatory Effects of Resveratol, Citroflavan-3-Ol and Plant-Derived Extracts Oil Oxidative Stress In U937 Cells. Other [Details] | |
| (2004) | Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription. O'Leary, KA,de Pascual-Tereasa, S,Needs, PW,Bao, YP,O'Brien, NM,Williamson, G (2004) Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription. Other [DOI] [Details] | |
| (2000) | Biological effects of dietary cholesterol oxidation products. O'Brien, NM,O'Callaghan, YC,Lyons, NM,Woods, JA (2000) Biological effects of dietary cholesterol oxidation products. Other [Details] | |
| (2000) | Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals. O'Brien, NM,Woods, JA,Aherne, SA,O'Callaghan, YC (2000) Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals. Other [Details] | |
| (1998) | Dietary antioxidants in health and disease. Morrissey, PA,O'Brien, NM (1998) Dietary antioxidants in health and disease. Other [Details] |
Newspaper Articles
| Year | Publication | |
|---|---|---|
| (2008) | Evening Echo. Obesity a 21st century epidemic. O'Brien NM; (2008) Evening Echo. Obesity a 21st century epidemic. Newspaper Articles [Details] | |
| (2006) | Sunday Tribune. Nutrition and obesity. Interview with Aileen O'Meara. O'Brien NM; (2006) Sunday Tribune. Nutrition and obesity. Interview with Aileen O'Meara. Newspaper Articles [Details] | |
| (2005) | Inside Cork. Live the good life at UCC. O'Brien NM; (2005) Inside Cork. Live the good life at UCC. Newspaper Articles [Details] | |
| (2005) | Irish Times. Time for a rethink about the way we eat and what. Interview with Hayden Shaughnessy. O'Brien NM; (2005) Irish Times. Time for a rethink about the way we eat and what. Interview with Hayden Shaughnessy. Newspaper Articles [Details] | |
| (2004) | Irish Examiner. Details of public lecture on Nutrition and Improved Public Health. O'Brien NM; (2004) Irish Examiner. Details of public lecture on Nutrition and Improved Public Health. Newspaper Articles [Details] | |
| (2004) | How Ireland is getting fatter. O'Brien NM; (2004) How Ireland is getting fatter. Newspaper Articles [Details] | |
| (2004) | Irish Examiner. Blowing raspberries at detoxing. O'Brien NM; (2004) Irish Examiner. Blowing raspberries at detoxing. Newspaper Articles [Details] | |
| (2004) | Evening Echo. Obesity, a modern killer. O'Brien NM; (2004) Evening Echo. Obesity, a modern killer. Newspaper Articles [Details] | |
| (2003) | UCC Student Newspaper - Campus Chronicle. Healthy eating. O'Brien NM; (2003) UCC Student Newspaper - Campus Chronicle. Healthy eating. Newspaper Articles [Details] | |
| (2001) | Irish Times. Slim down and trim your risk of disease. O'Brien NM; (2001) Irish Times. Slim down and trim your risk of disease. Newspaper Articles [Details] | |
| (2001) | Irish Independent. Junk food nation has an appetite for ill health. O'Brien NM; (2001) Irish Independent. Junk food nation has an appetite for ill health. Newspaper Articles [Details] | |
| (2001) | Irish Examiner. No easy end to battle of the bulge. O'Brien NM; (2001) Irish Examiner. No easy end to battle of the bulge. Newspaper Articles [Details] | |
| (2001) | The Mirror. Island of fatties. Health fears as levels of obesity rise. O'Brien NM; (2001) The Mirror. Island of fatties. Health fears as levels of obesity rise. Newspaper Articles [Details] | |
| (2001) | RTE Guide. The gift of good health. O'Brien NM; (2001) RTE Guide. The gift of good health. Newspaper Articles [Details] | |
| (2001) | Irish Times, Apple a day is best medicine for keeping chronic diseases away. O'Brien NM; (2001) Irish Times, Apple a day is best medicine for keeping chronic diseases away. Newspaper Articles [Details] | |
| (2000) | Irish Times, Research on fruit's benefit honoured. O'Brien NM; (2000) Irish Times, Research on fruit's benefit honoured. Newspaper Articles [Details] |
Professional Activities
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 1981 | University College Cork | BSc | Dairy Science | |
| 1983 | University of Minnesota, USA | MS | Human Nutrition | |
| 1987 | Cornell University, USA | PhD | Nutritional Biochemistry |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| University College Cork | Professor Scale 2 | 01-JAN-05 / | |
| University College Cork | Senior Lecturer | 01-JAN-99 / 01-JAN-05 | |
| University College Cork | Lecturer | 01-DEC-89 / 01-JAN-99 | |
| University of Louvain, Belgium | Postdoctoral Research Fellow | 01-JAN-88 / 01-JAN-89 |
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 1980 | Undergraduate Scholarship | ||
| 1981 | Undergraduate Scholarship | ||
| 1978 | College Scholar, University College Cork | ||
| 2000 | Royal Irish Academy Award in Nutritional Sciences | ||
| 1988 | International Institute of Cellular and Molecular Pathology | ||
| 1987 | Graduate Student Travel Award | ||
| 1983 | Finalist-American Institute of Nutrition | ||
| 1982 | Dairy Science Bursary | ||
| 1979 | Undergraduate Scholarship |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| The Nutrition Society | * | 01-JAN-97 / 31-DEC-14 | |
| The Irish Society of Toxicology | * | 30-DEC-99 / 31-DEC-11 | |
| The International Carotenoid Society | * | 30-DEC-99 / 31-DEC-14 | |
| American Oil Chemists Society (AOCS) | member | 01-NOV-14 / 31-DEC-15 |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| Irish Council for Bioethics | Member | 2002 / 2005 | |
| Food Safety Promotion Board: Scientific Advisory Committee (North-South Committee) | Member | 2001 / 2005 | |
| Royal Irish Academy: National Committee for Nutritional Sciences | Member | 1998 / 2003 | |
| Food Safety Authority of Ireland- Committee on Food Additives, Contaminants and Irradiated Foods | Memeber | 1999 / 2001 | |
| Management Committee of an EU Concerted Action Project entitled: Biomarkers of Exposure and Effect in Relation to Quality of Life and Human Risk Assessment | Member | 1996 / 1998 | |
| External Assessor on Promotion Board - Lecturer to Senior Lecturer grade. | External Assessor | 2008 / 2008 |
Journal Activities
| Journal | Role | To / From | |
|---|---|---|---|
| Nutrition Research | Member of Editorial Board | 01-JAN-08 - | |
| British Journal Of Nutrition | Referee | 01-JAN-03 - 01-JAN-08 | |
| Journal Of Nutrition | Referee | 01-JAN-03 - 01-JAN-05 | |
| Journal Of Agricultural And Food Chemistry | Referee | 01-JAN-03 - 01-JAN-08 | |
| European Journal Of Nutrition | Referee | 01-JAN-03 - 01-JAN-08 | |
| Biochimica Et Biophysica Acta | Referee | 01-JAN-03 - 01-JAN-08 | |
| Cell Biology And Toxicology | Referee | 01-JAN-03 - 01-JAN-08 | |
| International Journal Of Vitamin And Nutrition Research | Referee | 01-JAN-03 - 01-JAN-08 | |
| Toxicology In Vitro | Referee | 01-JAN-03 - | |
| Cancer Letters | Referee | 01-JAN-03 - 01-JAN-08 | |
| Nutrition And Cancer | Referee | 01-JAN-03 - 01-JAN-08 | |
| International Journal Of Food Science And Nutrition | Referee | 01-JAN-03 - 01-JAN-08 | |
| Cell Biology And Toxicology | Referee | 01-JAN-03 - 01-JAN-05 | |
| Cell Death And Differentiation | Referee | 01-JAN-03 - 01-JAN-05 | |
| Plant Foods For Human Nutrition | Member of Editorial Board | 01-JAN-10 - |
Teaching Activities
Teaching Interests
Modules Taught
| Term (ID)) | Title | Link | Subject | |
|---|---|---|---|---|
| 2021 | Food Security and Implications for Human Nutrition | NT6110 | Food Security and Implications for Human Nutrition | |
| 2021 | Human Nutrition in the Developing World | NT4008 | Human Nutrition in the Developing World | |
| 2021 | Topics in Nutrition and Food Toxicology | NT4010 | Topics in Nutrition and Food Toxicology |
Contact details
- Professor (Scale 2) PhD (Cornell), MS (Minn), BSc
- nob@ucc.ie
- University College Cork
- +353 21 4902884
- +353 21 4270244