Professor
School of Food & Nutritional Sciences
University College Cork

T: +353 21 4902884
F: +353 21 4270244
E: nob@ucc.ie

                                                   

Professor Nora O'Brien holds a BSc (Food Science) from UCC, a MS (Nutrition) from the University of Minnesota, and a PhD (Nutritional Biochemistry) from Cornell University.  She was a Postdoctoral Fellow at the University of Louvain in Belgium before returning to a Lectureship in Nutrition in her native Cork in December 1989.  In subsequent years Nora achieved promotion to Senior Lecturer and currently is Professor in Nutrition.  

Nora has substantial teaching commitments at undergraduate level which she finds both fulfilling and very enjoyable.  Her research programme on the relationships between nutrition and health has grown very successfully through the years.  Over 6 million in research funds have been generated from national and international funding sources, including a Science Foundation Ireland Investigator Award, to support her team's work.  Over 50 individuals have worked under Nora's supervision at MSc, PhD and Post-doctoral levels.  
The team's work has resulted in well over 160 peer-reviewed research publications in the international scientific literature as well as numerous conference presentations, invited book chapters and reviews.  Research conducted by Nora's team has contributed significantly to increased understanding of the relationship between nutrition and health and, in particular, the beneficial role of fruit and vegetables in the diet. 

Over the years many members of her team have received awards for their work.  Professor O'Brien has been a recipient of the Royal Irish Academy Nutrition Medal in 2000.  She has also been active in public service including membership of the Irish Council for Bioethics and the Scientific Advisory Committee of the Food Safety Promotion Board.  Nora is a member of the Nutrition Society, the Carotenoid Society as well as other professional groups.  She has given many public lectures on her research interests and other nutrition-related topics. 

 

Research Interests

                         

Bioactivity of dietary components

My group has developed a number of cell culture models to study the effects and mechanisms of action of a range of dietary components.  We have focused on the cytoprotective, antioxidant, antigenotoxic and immunomodulatory effects of these components in cell systems.  The range of dietary components we have studied to-date include carotenoids, tocopherols, flavonoids and other phytochemicals.  Our basic research in this area is important in helping to understand the fundamental mechanisms of action of these phytochemicals and also has considerable practical commercial relevance in underpinning development of the emerging markets for Functional Foods.  In addition to individual chemical compounds, we have also assessed the bioactivity of extracts from seaweed, herbs, potato peel extracts and brewers' spent grain. Currently, we are investigating the bioactivity of protein hydrolysates extracted from a variety of sources including milk, meat, fish, barley, potatoes and flaxseed.  

 

Bioavailability of dietary components

We have successfully established an in vitro bioavailability model employing a simulated digestion procedure and differentiated Caco-2 cells grown on transwell plates.  We have published many studies demonstrating the validity and usefulness of the model.  The main chemicals whose bioavailability we have tested to-date are carotenoids and tocopherols. 

 

Biological effects of sterols and oxysterols

Our work has focused on the cytotoxic, genotoxic and cell signalling effects of cholesterol and phytosterol oxidation products in cellular model systems.  The potential protective effect of phytochemicals against the toxic action of oxysterols has also been studied.  Additionally, we are systematically analysing the phytosterol and oxyphytosterol contents of plant foodstuffs.

 

Human Nutrition in the Developing World

In addition to longstanding teaching activities in this area, we are also involved in relevant research activities.  Currently, these include the AGRIDIET project which is funded by Irish Aid.  This project involves investigation of agriculture-nutrition linkages in different agro-ecological zones of Ethiopia and Tanzania.  Our group is contributing the nutrition expertise for the project.  Extensive fieldwork has been completed and data analysis is ongoing.  Recently, our group has also been successful in obtaining significant funding from the Department of Agriculture, Food and the Marine (DAFM) for a 4 year project whose objective is the development of a novel Fortified Blended Food suitable for use by the World Food Programme and other humanitarian organisations.

 

Current Research Team:

5 PhD students

1 MSc student

Current Research Support Officer:
Dr. Yvonne O Callaghan


Past Post-Doctoral Researchers:
Dr. Alison Wilson
Dr. Irene O Connor
Dr. Gabriele Froemming
Dr. Helena de Vasconcelos
Dr. Christopher Jewell
Dr. Julie Woods
Dr. Aisling Aherne
Dr. Mikhail Konoplyannikov
Dr. Lisa Ryan
Dr. Sinead Lordan
Dr. Eileen Ryan

Past Research Assistants:
Ms Olivia Kenny MSc  
Ms Nicole Lyons MSc
Ms Sinead O'Sullivan MSc
Mr Trevor Daly MSc
Mr Marvin Jiwan MSc

In Press

YearPublication
(2015)Total carotenoids and ascorbic acid content in sixty varieties of potato (Solanum tuberosum L.) grown in Ireland.
Valcarcel, J, Reilly, K, Gaffnet, M, O'Brien, NM (2015) Total carotenoids and ascorbic acid content in sixty varieties of potato (Solanum tuberosum L.) grown in Ireland. In Press [Details]
(2015)Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?.
McCarthy, M, O'Halloran, J, O'Brien NM, van Pelt, FNAM (2015) Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?. In Press [Details]
(2014)A study of the ability of bioactive extracts from brewers' spent grain to enhance the antioxidant and immunomodulatory potential of food formulations following in vitro digestion.
McCarthy, AL, O'Callaghan, YC, Connolly, A, Piggott, CO, FitzGerald, RJ, O'Brien, NM (2014) A study of the ability of bioactive extracts from brewers' spent grain to enhance the antioxidant and immunomodulatory potential of food formulations following in vitro digestion. In Press [Details]
(2014)Anti-inflammatory effects of extracts prepared from wild Irish mushrooms in RAW264.7 mouse macrophage cells.
O'Callaghan, YC, Smyth, TJ, Brunton, N, O'Brien, NM (2014) Anti-inflammatory effects of extracts prepared from wild Irish mushrooms in RAW264.7 mouse macrophage cells. In Press [Details]

Peer Reviewed Journals

YearPublication
(2014)'An examination of the potential of seaweed extracts as functional ingredients in milk'
O'Sullivan, AM,O'Callaghan, YC,O'Grady, MN,Waldron, DS,Smyth, TJ,O'Brien, NM,Kerry, JP (2014) 'An examination of the potential of seaweed extracts as functional ingredients in milk'. International Journal of Dairy Technology, 67 :182-193 [DOI] [Details]
(2014)'Formation of cytotoxic alpha-Lactalbumin / sodium oleate complexes: concentration and temperature effects'
Kehoe, JJ, Liskova, K, Mok, KH, O'Brien, NM, Kelly, AL, Brodkorb, A (2014) 'Formation of cytotoxic alpha-Lactalbumin / sodium oleate complexes: concentration and temperature effects'. International Dairy Journal, 38 :65-73 [Details]
(2014)'Effect of genotype and environment on the glycoalkaloid content of rare, heritage and commercial potato varieties'
Valcarcel, J, Reilly, K, Gaffney, M, O'Brien, NM (2014) 'Effect of genotype and environment on the glycoalkaloid content of rare, heritage and commercial potato varieties'. Journal of Food Science, 79 :1039-1048 [Details]
(2014)'Phenolic-enriched fractions from brewers' spent grain possess cellular antioxidant and immunomodulatory effects in cell culture model systems'
McCarthy, AL,O'Callaghan, YC,Connolly, A,Piggott, CO,FitzGerald, RJ,O'Brien, NM (2014) 'Phenolic-enriched fractions from brewers' spent grain possess cellular antioxidant and immunomodulatory effects in cell culture model systems'. Journal of The Science of Food and Agriculture, 94 :1373-1379 [DOI] [Details]
(2013)'Characterisation of the physicochemical, residual antigenicity and cell activity properties of transglutaminase cross-linked sodium caseinate hydrolysates'
O'Sullivan, D,Lahart, N,O'Callaghan, Y,O'Brien, NM,FitzGerald, RJ (2013) 'Characterisation of the physicochemical, residual antigenicity and cell activity properties of transglutaminase cross-linked sodium caseinate hydrolysates'. International Dairy Journal, 33 :49-54 [DOI] [Details]
(2013)'Antioxidant and Pro-Apoptotic Effects of Marine-Derived, Multi-Mineral Aquamin Supplemented with a Pine Bark Extract, Enzogenol, and a Green Tea Extract, Sunphenon'
O'Callaghan, YC,Drummond, E,O'Gorman, DM,O'Brien, NM (2013) 'Antioxidant and Pro-Apoptotic Effects of Marine-Derived, Multi-Mineral Aquamin Supplemented with a Pine Bark Extract, Enzogenol, and a Green Tea Extract, Sunphenon'. Journal Of Medicinal Food, 16 :920-926 [DOI] [Details]
(2013)'Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells'
O'Callaghan Y, Kenny O, O'Connell NM, Maguire AR, McCarthy FO, O'Brien NM (2013) 'Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells'. Biochimie, :496-503 [DOI] [Details]
(2013)'The effect of solvents on the antioxidant activity in Caco-2 cells of Irish brown seaweed extracts prepared using accelerated solvent extraction (ASE (R))'
O'Sullivan, AM,O'Callaghan, YC,O'Grady, MN,Hayes, M,Kerry, JP,O'Brien, NM (2013) 'The effect of solvents on the antioxidant activity in Caco-2 cells of Irish brown seaweed extracts prepared using accelerated solvent extraction (ASE (R))'. Journal Of Functional Foods, 5 :940-948 [DOI] [Details]
(2013)'Changes in Total and Individual Crocetin Esters upon in Vitro Gastrointestinal Digestion of Saffron Aqueous Extracts'
Kyriakoudi, A,Tsimidou, MZ,O'Callaghan, YC,Galvin, K,O'Brien, NM (2013) 'Changes in Total and Individual Crocetin Esters upon in Vitro Gastrointestinal Digestion of Saffron Aqueous Extracts'. Journal of Agricultural and Food Chemistry, 61 :5318-5327 [DOI] [Details]
(2013)'Brewers' spent grain (BSG) protein hydrolysates decrease hydrogen peroxide (H2O2)-induced oxidative stress and concanavalin-A (con-A) stimulated IFN-gamma production in cell culture'
McCarthy, AL,O'Callaghan, YC,Connolly, A,Piggott, CO,FitzGerald, RJ,O'Brien, NM (2013) 'Brewers' spent grain (BSG) protein hydrolysates decrease hydrogen peroxide (H2O2)-induced oxidative stress and concanavalin-A (con-A) stimulated IFN-gamma production in cell culture'. Food & Function, 4 :1709-1716 [DOI] [Details]
(2013)'Antioxidant Capacity of Flaxseed Products: The Effect of In vitro Digestion'
Silva, FGD,O'Callagahan, Y,O'Brien, NM,Netto, FM (2013) 'Antioxidant Capacity of Flaxseed Products: The Effect of In vitro Digestion'. Plant Foods For Human Nutrition, 68 :24-30 [DOI] [Details]
(2013)'In vitro antioxidant and anti-inflammatory effects of brewers' spent grain protein rich isolate and its associated hydrolysates'
McCarthy, AL,O'Callaghan, YC,Connolly, A,Piggott, CO,FitzGerald, RJ,O'Brien, NM (2013) 'In vitro antioxidant and anti-inflammatory effects of brewers' spent grain protein rich isolate and its associated hydrolysates'. Food Research International, 50 :205-212 [DOI] [Details]
(2013)'The hydroxycinnamic acid content of barley and brewers' spent grain (BSG) and the potential to incorporate phenolic extracts of BSG as antioxidants into fruit beverages'
McCarthy AL, O'Callaghan YC, Neugart S, Piggott CO, Connolly A, Jansen MA, Krumbein A, Schreiner M, FitzGerald RJ, O'Brien NM (2013) 'The hydroxycinnamic acid content of barley and brewers' spent grain (BSG) and the potential to incorporate phenolic extracts of BSG as antioxidants into fruit beverages'. Food chemistry, 141 (3):2567-2574 [DOI] [Details]
(2013)'Comparison of the Antioxidant Activity of Commercial Honeys, Before and After In-Vitro Digestion'
O'Sullivan, AM,O'Callaghan, YC,O'Connor, TR,O'Brien, NM (2013) 'Comparison of the Antioxidant Activity of Commercial Honeys, Before and After In-Vitro Digestion'. Polish Journal Of Food And Nutrition Sciences, 63 :167-171 [DOI] [Details]
(2013)'Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages'
Kenny, OM,McCarthy, CM,Brunton, NP,Hossain, MB,Rai, DK,Collins, SG,Jones, PW,Maguire, AR,O'Brien, NM (2013) 'Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages'. Life sciences, 92 :775-782 [DOI] [Details]
(2013)'The effect of domestic processing on the content and bioaccessibility of carotenoids from chili peppers (Capsicum species)'
Pugliese, A, Loizzo, MR, Tundis, R, O'Callaghan, Y, Galvin, K, Menichini, F, O'Brien, NM (2013) 'The effect of domestic processing on the content and bioaccessibility of carotenoids from chili peppers (Capsicum species)'. Food Chemistry, [Details]
(2013)'Assessment of the cytotoxic and apoptotic potential of potato glycoalkaloids in a number of cancer cell lines'
Kenny, O, Brunton, N, Rai, D, Collins, SG, Maguire, AR, Jones, P, O'Brien, NM (2013) 'Assessment of the cytotoxic and apoptotic potential of potato glycoalkaloids in a number of cancer cell lines'. Journal of Agricultural Science and Applications, [Details]
(2013)'In vitro investigation of the bioaccessibility of carotenoids from raw, frozen and boiled red chilli peppers (Capsicum annuum)'
Pugliese, A, O'Callaghan, YC, Tundis, R, Galvin, K, Menichini, F, O'Brien, NM, Loizzo, MR (2013) 'In vitro investigation of the bioaccessibility of carotenoids from raw, frozen and boiled red chilli peppers (Capsicum annuum)'. European Journal of Nutrition, [Details]
(2012)'Phenolic extracts of brewers' spent grain (BSG) as functional ingredients - Assessment of their DNA protective effect against oxidant-induced DNA single strand breaks in U937 cells'
McCarthy, AL,O'Callaghan, YC,Connolly, A,Piggott, CO,FitzGerald, RJ,O'Brien, NM (2012) 'Phenolic extracts of brewers' spent grain (BSG) as functional ingredients - Assessment of their DNA protective effect against oxidant-induced DNA single strand breaks in U937 cells'. Food Chemistry, 134 :641-646 [DOI] [Details]
(2012)'Oxidized Derivatives of Dihydrobrassicasterol: Cytotoxic and Apoptotic Potential in U937 and HepG2 Cells'
Kenny, O,O'Callaghan, Y,O'Connell, NM,McCarthy, FO,Maguire, AR,O'Brien, NM (2012) 'Oxidized Derivatives of Dihydrobrassicasterol: Cytotoxic and Apoptotic Potential in U937 and HepG2 Cells'. Journal of Agricultural and Food Chemistry, 60 :5952-5961 [DOI] [Details]
(2012)'Synthetic routes to campesterol and dihydrobrassicasterol: a first reported synthesis of the key phytosterol dihydrobrassicasterol'
O'Connell, NM,O'Callaghan, YC,O'Brien, NM,Maguire, AR,McCarthy, FO (2012) 'Synthetic routes to campesterol and dihydrobrassicasterol: a first reported synthesis of the key phytosterol dihydrobrassicasterol'. Tetrahedron, 68 :4995-5004 [DOI] [Details]
(2012)'Assessment of the ability of seaweed extracts to protect against hydrogen peroxide and tert-butyl hydroperoxide induced cellular damage in Caco-2 cells'
O'Sullivan, AM,O'Callaghan, YC,O'Grady, MN,Queguineur, B,Hanniffy, D,Troy, DJ,Kerry, JP,O'Brien, NM (2012) 'Assessment of the ability of seaweed extracts to protect against hydrogen peroxide and tert-butyl hydroperoxide induced cellular damage in Caco-2 cells'. Food Chemistry, 134 :1137-1140 [DOI] [Details]
(2011)'In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland'
O'Sullivan, A. M. and O'Callaghan, Y. C. and O'Grady, M. N. and Queguineur, B. and Hanniffy, D. and Troy, D. J. and Kerry, J. P. and O'Brien, N. M. (2011) 'In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland'. Food Chemistry, 126 (3):1064-1070 [Details]
(2011)'Extent of hydrolysis effects on casein hydrolysate bioactivity: Evaluation using the human Jurkat T cell line'
Lahart, Natasha and O'Callaghan, Yvonne and Aherne, S. Aisling and O'Sullivan, Dara and FitzGerald, Richard J. and O'Brien, Nora M. (2011) 'Extent of hydrolysis effects on casein hydrolysate bioactivity: Evaluation using the human Jurkat T cell line'. International Dairy Journal, 21 (10):777-782 [Details]
(2011)'Cytotoxic complexes of sodium oleate with beta-lactoglobulin'
Liskova, K, Auty, MAE, Chaurin, V, Min, S, Mok, KH, O'Brien, NM, Kelly, AL, Brodkorb, A (2011) 'Cytotoxic complexes of sodium oleate with beta-lactoglobulin'. European Journal of Lipid Science and Technology, 113 :1207-1218 [Details]
(2010)'Content and bioaccessibility of carotenoids from organic and non-organic baby foods'
Jiwan, M. A. and Duane, P. and O'Sullivan, L. and O'Brien, N. M. and Aherne, S. A. (2010) 'Content and bioaccessibility of carotenoids from organic and non-organic baby foods'. Journal of Food Composition and Analysis, 23 (4):346-352 [Details]
(2010)'Effect of alpha-lactalbumin denaturation on its potential anti-cancer properties'
Liskova, K, Kelly, AL, O'Brien, NM, Brodkorb, A (2010) 'Effect of alpha-lactalbumin denaturation on its potential anti-cancer properties'. Journal of Agricultural and Food Chemistry, [Details]
(2010)'Bioaccessibility, Uptake, and Transport of Carotenoids from Peppers (Capsicum Spp.) Using the Coupled in Vitro Digestion and Human Intestinal Caco-2 Cell Model'
O'Sullivan, Laurie and Jiwan, Marvin A. and Daly, Trevor and O'Brien, Nora M. and Aherne, S. Aisling (2010) 'Bioaccessibility, Uptake, and Transport of Carotenoids from Peppers (Capsicum Spp.) Using the Coupled in Vitro Digestion and Human Intestinal Caco-2 Cell Model'. Journal of Agricultural and Food Chemistry, 58 (9):5374-5379 [Details]
(2010)'Bioavailability of beta-carotene isomers from raw and cooked carrots using an in vitro digestion model coupled with a human intestinal Caco-2 cell model'
Aherne, S. Aisling and Daly, Trevor and Jiwan, Marvin A. and O'Sullivan, Laurie and O'Brien, Nora M. (2010) 'Bioavailability of beta-carotene isomers from raw and cooked carrots using an in vitro digestion model coupled with a human intestinal Caco-2 cell model'. Food Research International, 43 (5):1449-1454 [Details]
(2010)'Cytotoxic and Apoptotic Effects of the Oxidized Derivatives of Stigmasterol in the U937 Human Monocytic Cell Line'
O'Callaghan YC, Foley DA, O'Connell NM, McCarthy FO, Maguire AR, O'Brien NM; (2010) 'Cytotoxic and Apoptotic Effects of the Oxidized Derivatives of Stigmasterol in the U937 Human Monocytic Cell Line'. Journal of Agricultural and Food Chemistry, 58 :10793-10798 [DOI] [Details]
(2010)'Growth inhibitory effects of casein hydrolysates on human cancer cell lines'
Phelan, Martha and Aherne, S. Aisling and O'Sullivan, Dara and FitzGerald, Richard J. and O'Brien, Nora M. (2010) 'Growth inhibitory effects of casein hydrolysates on human cancer cell lines'. Journal of Dairy Research, 77 (2):176-182 [Details]
(2010)'Effects of cooking on the profile and micellarization of 9-cis-, 13-cis- and all-trans-beta-carotene in green vegetables'
O'Sullivan, L; Galvin, K; Aherne, SA; O'Brien, NM; (2010) 'Effects of cooking on the profile and micellarization of 9-cis-, 13-cis- and all-trans-beta-carotene in green vegetables'. Food Research International, 43 :1130-1135 [DOI] [Details]
(2010)'Synthesis and characterization of stigmasterol oxidation products'
Foley DA, O'Callaghan Y, O'Brien NM, McCarthy FO, Maguire AR; (2010) 'Synthesis and characterization of stigmasterol oxidation products'. Journal of Agricultural and Food Chemistry, 58 (2):1165-1173 [DOI] [Details]
(2010)'Bioactivity of ellagic acid-, lutein- or sesamol-enriched meat patties assessed using an in vitro digestion and Caco-2 cell model system'
Daly, T,Ryan, E,Aherne, SA,O'Grady, MN,Hayes, J,Allen, P,Kerry, JP,O'Brien, NM (2010) 'Bioactivity of ellagic acid-, lutein- or sesamol-enriched meat patties assessed using an in vitro digestion and Caco-2 cell model system'. Food Research International, 43 :753-760 [DOI] [Details]
(2010)'Effect of denaturation of alpha-lactalbumin on the formation of BAMLET (Bovine alpha-lactalbumin made lethal to tumor cells)'
Liskova, K, Kelly, AL, O'Brien, NM, Brodkorb, A (2010) 'Effect of denaturation of alpha-lactalbumin on the formation of BAMLET (Bovine alpha-lactalbumin made lethal to tumor cells)'. Food Chemistry, 58 :4421-4427 [Details]
(2010)'Carotenoid Content of Commonly Consumed Herbs and Assessment of Their Bioaccessibility Using an In Vitro Digestion Model'
Daly, T,Jiwan, MA,O'Brien, NM,Aherne, SA; (2010) 'Carotenoid Content of Commonly Consumed Herbs and Assessment of Their Bioaccessibility Using an In Vitro Digestion Model'. Plant Foods For Human Nutrition, 65 :164-169 [DOI] [Details]
(2009)'Effects of Contaminated Sediment From Cork Harbour, Ireland On The Cytochrome P450 System of Turbot'
Kilemade, M, Hartl, MGJ, O'Halloran, J, O'Brien, NM, Sheehan, D, Mothersill, C, van Pelt, FNAM; (2009) 'Effects of Contaminated Sediment From Cork Harbour, Ireland On The Cytochrome P450 System of Turbot'. Ecotoxicology and Environmental Safety, 72 (3):747-755 [DOI] [Details]
(2009)'Bioactivity of Herb-Enriched Beef Patties'
Ryan, E,Aherne, SA,O'Grady, MN,McGovern, L,Kerry, JP,O'Brien, NM (2009) 'Bioactivity of Herb-Enriched Beef Patties'. Journal Of Medicinal Food, 12 :893-901 [DOI] [Details]
(2009)'Investigation of beta-carotene and Lutein Transport in Caco-2 Cells: Carotenoid-carotenoid Interactions and Transport Inhibition by Ezetimibe'
O'Sullivan, L,Aherne, SA,O'Brien, NM; (2009) 'Investigation of beta-carotene and Lutein Transport in Caco-2 Cells: Carotenoid-carotenoid Interactions and Transport Inhibition by Ezetimibe'. International Journal For Vitamin and Nutrition Research, 79 :337-347 [DOI] [Details]
(2009)'The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide'
Lordan S, O'Brien NM, Mackrill JJ (2009) 'The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide'. Journal of Biochemical and Molecular Toxicology, 23 (5):324-332 [DOI] [Details]
(2009)'Bioactive Properties of Wood Knot Extracts on Cultured Human Cells'
Phelan, Martha and Aherne, S. Aisling and Wong, Alfred and O'Brien, Nora M. (2009) 'Bioactive Properties of Wood Knot Extracts on Cultured Human Cells'. Journal of Medicinal Food, 12 (6):1245-1251 [Details]
(2009)'The effects of salinity on the Manila clam (Ruditapes philippinarum) using the neutral red retention assay with adapted physiological saline solutions'
Coughlan, BM,Moroney, GA,van Pelt, FNAM,O'Brien, NM,Davenport, J,O'Halloran, J; (2009) 'The effects of salinity on the Manila clam (Ruditapes philippinarum) using the neutral red retention assay with adapted physiological saline solutions'. Marine Pollution Bulletinetin, 58 :1680-1684 [DOI] [Details]
(2009)'Potential Bioactive Effects of Casein Hydrolysates On Human Cultured Cells'
Phelan, M, Aherne-Bruce, SA, O'Sullivan, D, FitzGerald, RJ, O'Brien, NM; (2009) 'Potential Bioactive Effects of Casein Hydrolysates On Human Cultured Cells'. International Dairy Journal, 19 (5):279-285 [DOI] [Details]
(2009)'Lack of Genoprotective Effect of Phytosterols and Conjugated Linoleic Acids On Caco-2 Cells'
Daly, TJ, Aherne, SA, O'Connor, TP, O'Brien, NM; (2009) 'Lack of Genoprotective Effect of Phytosterols and Conjugated Linoleic Acids On Caco-2 Cells'. Food and Chemical Toxicology, 47 (8):1791-1796 [DOI] [Details]
(2009)'Geographical Location has Greater Impact on Carotenoid Content and Bioaccessibility from Tomatoes than Variety'
Aherne, SA,Jiwan, MA,Daly, T,O'Brien, NM; (2009) 'Geographical Location has Greater Impact on Carotenoid Content and Bioaccessibility from Tomatoes than Variety'. Plant Foods For Human Nutrition, 64 :250-256 [DOI] [Details]
(2009)'The Effect of Lutein, Sesamol, Ellagic Acid and Olive Leaf Extract On Lipid Oxidation and Oxymyoglobin Oxidation In Bovine and Porcine Muscle Model Systems'
Hayes, JE, Stepanyan, V, Allen, P, O'Grady, MN, O'Brien, NM, Kerry, JP; (2009) 'The Effect of Lutein, Sesamol, Ellagic Acid and Olive Leaf Extract On Lipid Oxidation and Oxymyoglobin Oxidation In Bovine and Porcine Muscle Model Systems'. Meat Science, 83 (2):201-208 [DOI] [Details]
(2008)'Addition of Grape Seed Extract and Bearberry to Porcine Diets: Influence On Quality Attributes of Raw and Cooked Pork'
O'Grady, MN, Carpenter, R, Lynch, PB, O'Brien, NM, Kerry, JP; (2008) 'Addition of Grape Seed Extract and Bearberry to Porcine Diets: Influence On Quality Attributes of Raw and Cooked Pork'. Meat Science, 78 (4):438-446 [DOI] [Details]
(2008)'Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells'
Aherne, SA,O'Brien, NM; (2008) 'Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells'. Molecular Nutrition & Food Research, 52 :664-673 [DOI] [Details]
(2008)'Carotenoid Micellarization Varies Greatly Between Individual and Mixed Vegetables With or Without The Addition of Fat or Fiber'
O'Connell, O, Ryan, L, O'Sullivan, L, Aherne-Bruce, SA, O'Brien, NM; (2008) 'Carotenoid Micellarization Varies Greatly Between Individual and Mixed Vegetables With or Without The Addition of Fat or Fiber'. International Journal For Vitamin and Nutrition Research, 78 (4-5):238-246 [DOI] [Details]
(2008)'Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells'
Lordan S, O'Neill C, O'Brien NM; (2008) 'Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells'. British Journal of Nutrition, 100 (2):287-296 [DOI] [Full Text] [Details]
(2008)'Involvement of Fas signalling in 7beta-hydroxycholesterol-and cholesterol-5beta,6beta-epoxide-induced apoptosis'
Lordan S, Mackrill JJ, O'Brien NM (2008) 'Involvement of Fas signalling in 7beta-hydroxycholesterol-and cholesterol-5beta,6beta-epoxide-induced apoptosis'. International Journal of Toxicology, 27 (3):279-285 [DOI] [Details]
(2008)'Micellarisation of carotenoids from raw and cooked vegetables'
Ryan, L,O'Connell, O,O'Sullivan, L,Aherne, SA,O'Brien, NM; (2008) 'Micellarisation of carotenoids from raw and cooked vegetables'. Plant Foods For Human Nutrition, 63 :127-133 [DOI] [Details]
(2008)'Plant stress and human health: Do human consumers benefit from UV-B acclimated crops?'
Jansen, Marcel A. K. and Hectors, Kathleen and O'Brien, Nora M. and Guisez, Yves and Potters, Geert (2008) 'Plant stress and human health: Do human consumers benefit from UV-B acclimated crops?'. Plant Science, 175 (4):449-458 [Details]
(2008)'Cellular transport of lutein is greater from uncooked rather than cooked spinach irrespective of whether it is fresh, frozen, or canned'
O'Sullivan, Laurie and Ryan, Lisa and Aherne, S. Aisling and O'Brien, Nora M. (2008) 'Cellular transport of lutein is greater from uncooked rather than cooked spinach irrespective of whether it is fresh, frozen, or canned'. Nutrition Research, 28 (8):532-538 [Details]
(2008)'Effects of Ingredient Incorporation Into Sausage Meat On The Micellarisation and Uptake of Alpha-Tocopherol By Caco-2 Human Intestinal Cells'
Kenny, O, O'Callaghan, Y, O'Brien, NM; (2008) 'Effects of Ingredient Incorporation Into Sausage Meat On The Micellarisation and Uptake of Alpha-Tocopherol By Caco-2 Human Intestinal Cells'. Food Science and Technology International, 14 (1):79-86 [DOI] [Details]
(2007)'Effects of Plant Extracts On Antioxidant Status and Oxidant-Induced Stress In Caco-2 Cells'
Aherne, SA, Kerry, JP, O'Brien, NM; (2007) 'Effects of Plant Extracts On Antioxidant Status and Oxidant-Induced Stress In Caco-2 Cells'. British Journal of Nutrition, 97 (2):321-328 [DOI] [Details]
(2007)'Xanthophyll carotenoids are more bioaccessible from fruits than dark green vegetables'
O'Connell, Orla F. and Ryan, Lisa and O'Brien, Nora M. (2007) 'Xanthophyll carotenoids are more bioaccessible from fruits than dark green vegetables'. Nutrition Research, 27 (5):258-264 [Details]
(2007)'Immunomodulatory effects of beta-sitosterol on human Jurkat'
Aherne, S. A. and Daly, T. and O'Connor, T. and O'Brien, N. M. (2007) 'Immunomodulatory effects of beta-sitosterol on human Jurkat'. Planta Medica, 73 (9):827-827 [Details]
(2007)'Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes'
Ryan, E,Galvin, K,O'Connor, TP,Maguire, AR,O'Brien, NM; (2007) 'Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes'. Plant Foods For Human Nutrition, 62 :85-91 [DOI] [Details]
(2007)'Death-Signaling Pathways In Human Myeloid Cells By Oxldl and Its Cytotoxic Components 7 Beta-Hydroxycholesterol and Cholesterol-5 Beta,6 Beta-Epoxide'
Lordan, S, O'Callaghan, YC, O'Brien, NM; (2007) 'Death-Signaling Pathways In Human Myeloid Cells By Oxldl and Its Cytotoxic Components 7 Beta-Hydroxycholesterol and Cholesterol-5 Beta,6 Beta-Epoxide'. Journal of Biochemical and Molecular Toxicology, 21 (6):362-372 [Details]
(2007)'Hepatic biomarkers of sediment-associated pollution in juvenile turbot, Scophthalmus maximus L'
Hartl, MGJ,Kilemade, M,Sheehan, D,Mothersill, C,O'Halloran, J,O'Brien, NM,van Pelt, FNAM; (2007) 'Hepatic biomarkers of sediment-associated pollution in juvenile turbot, Scophthalmus maximus L'. Marine Environmental Research, 64 :191-208 [DOI] [Details]
(2007)'Evaluation of The Antioxidant Potential of Grape Seed and Bearberry Extracts In Raw and Cooked Pork'
Carpenter, R, O'Grady, MN, O'Callaghan, YC, O'Brien, NM, Kerry, JP; (2007) 'Evaluation of The Antioxidant Potential of Grape Seed and Bearberry Extracts In Raw and Cooked Pork'. Meat Science, 76 (4):604-610 [DOI] [Details]
(2007)'In Vivo Exposure to Microcystins Induces Dna Damage In The Haemocytes of The Zebra Mussel, Dreissena Polymorpha, As Measured With The Comet Assay'
Juhel, G, O'Halloran, J, Culloty, SC, O'Riordan, RM, Davenport, J, O'Brien, NM, James, KF, Furey, A, Allis, O; (2007) 'In Vivo Exposure to Microcystins Induces Dna Damage In The Haemocytes of The Zebra Mussel, Dreissena Polymorpha, As Measured With The Comet Assay'. Environmental and Molecular Mutagenesis, 48 (1):22-29 [DOI] [Details]
(2006)'A two-species biomarker model for the assessment of sediment toxicity in the marine and estuarine environment using the comet assay'
Hartl MG, Kilemade M, Coughlan BM, O'Halloran J, van Pelt FN, Sheehan D, Mothersill C, and O'Brien NM.; (2006) 'A two-species biomarker model for the assessment of sediment toxicity in the marine and estuarine environment using the comet assay'. Journal of Environmental Science & Health Part A-Environmental Science & Engineering, 41 (5):939-953 [Details]
(2006)'Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells'
Carpenter, Rosemary and O'Callaghan, Yvonne C. and O'Grady, Michael N. and Kerry, Joseph P. and O'Brien, Nora M. (2006) 'Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells'. Journal of Medicinal Food, 9 (2):187-195 [Details]
(2006)'Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts'
Ryan, E. and Galvin, K. and O'Connor, T. P. and Maguire, A. R. and O'Brien, N. M. (2006) 'Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts'. International Journal of Food Sciences and Nutrition, 57 (3-4):219-228 [Details]
(2006)'Involvement of calcium in 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide-induced apoptosis'
Ryan, L. and O'Callaghan, Y. C. and O'Brien, N. M. (2006) 'Involvement of calcium in 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide-induced apoptosis'. International Journal of Toxicology, 25 (1):35-39 [Details]
(2006)'Fatty Acid Profile, Tocopherol, Squalene and Phytosterol Content of Brazil, Pecan, Pine, Pistachio and Cashew Nuts'
Ryan, E, Galvin, K, O'Connor, TP, Maguire, AR, O'Brien, NM; (2006) 'Fatty Acid Profile, Tocopherol, Squalene and Phytosterol Content of Brazil, Pecan, Pine, Pistachio and Cashew Nuts'. International Journal of Food Sciences and Nutrition, 57 (3-4):219-228 [DOI] [Details]
(2005)'Differential effects of mixtures of cholesterol oxidation products on bovine aortic endothelial cells and human monocytic U937 cells'
O'Sullivan, AJ,O'Callaghan, YC,O'Brien, NM; (2005) 'Differential effects of mixtures of cholesterol oxidation products on bovine aortic endothelial cells and human monocytic U937 cells'. International Journal of Toxicology, 24 :173-179 [DOI] [Details]
(2005)'Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives'
McCarthy FO, Chopra J, Ford A, Hogan SA, Kerry JP, O'Brien NM, Ryan E, Maguire AR; (2005) 'Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives'. Organic & Biomolecular Chemistry, 3 (16):3059-3065 [DOI] [Details]
(2005)'Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products'
E. Ryan;J. Chopra;F. McCarthy;A. R. Maguire;N. M. O'Brien; (2005) 'Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products'. British Journal of Nutrition, 94 :443-451 Globe icon [DOI] [Full Text] [Details]
(2005)'Assessing the potential of fish cell lines as tools for the cytotoxicity testing of estuarine sediment aqueous elutriates'
Davoren, M. and Ni-Shuilleabhain, S. and Hartl, M. G. J. and Sheehan, D. and O'Brien, N. M. and O'Halloran, J. and Van Pelt, Fnam and Mothersill, C. (2005) 'Assessing the potential of fish cell lines as tools for the cytotoxicity testing of estuarine sediment aqueous elutriates'. Toxicology in Vitro, 19 (3):421-431 [Details]
(2005)'The role of the mitochondria in apoptosis induced by 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide'
Ryan, L,O'Callaghan, YC,O'Brien, NM; (2005) 'The role of the mitochondria in apoptosis induced by 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide'. British Journal of Nutrition, 94 :519-525 [DOI] [Details]
(2005)'A test battery approach for the ecotoxicological evaluation of estuarine sediments'
Davoren, M,Shuilleabhain, SN,O'Halloran, J,Hartl, MGJ,Sheehan, D,O'Brien, NM,Van Pelt, FNAM,Mothersill, C (2005) 'A test battery approach for the ecotoxicological evaluation of estuarine sediments'. Ecotoxicology, 14 :741-755 [DOI] [Details]
(2005)'Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity'
Shuilleabhain, SN,Davoren, M,Mothersill, C,Sheehan, D,Hartl, MGJ,Kilemade, M,O'Brien, NM,O'Halloran, J,Van Pelt, FNAM,Lyng, FM; (2005) 'Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity'. Aquatic Toxicology, 73 :115-127 [DOI] [Details]
(2004)'Comparison of the apoptotic processes induced by the oxysterols 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide'
Ryan, L,O'Callaghan, YC,O'Brien, NM; (2004) 'Comparison of the apoptotic processes induced by the oxysterols 7 beta-hydroxycholesterol and cholesterol-5 beta,6 beta-epoxide'. Cell Biology and Toxicology, 20 :313-323 [Details]
(2004)'In vitro cytotoxicity testing of three zinc metal salts using established fish cell lines'
Ni Shuilleabhain, S,Mothersill, C,Sheehan, D,O'Brien, NM,O' Halloran, J,Van Pelt, FNAM,Davoren, M; (2004) 'In vitro cytotoxicity testing of three zinc metal salts using established fish cell lines'. Toxicology In Vitro, 18 :365-376 [DOI] [Details]
(2004)'Genotoxicity of field-collected inter-tidal sediments from Cork Harbor, Ireland, to juvenile turbot (Scophthalmus maximus L.) as measured by the Comet assay'
Kilemade, MF,Hartl, MGJ,Sheehan, D,Mothersill, C,van Pelt, FNAM,O'Halloran, J,O'Brien, NM; (2004) 'Genotoxicity of field-collected inter-tidal sediments from Cork Harbor, Ireland, to juvenile turbot (Scophthalmus maximus L.) as measured by the Comet assay'. Environmental and Molecular Mutagenesis, 44 :56-64 [DOI] [Details]
(2004)'Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription'
O'Leary, K. A. and de Pascual-Tereasa, S. and Needs, P. W. and Bao, Y. P. and O'Brien, N. M. and Williamson, G. (2004) 'Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription'. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 551 (1-2):245-254 [Details]
(2004)'Use of Tween 40 and Tween 80 to deliver a mixture of phytochemicals to human colonic adenocarcinoma cell (CaCo-2) monolayers'
O'Sullivan, S. M. and Woods, J. A. and O'Brien, N. M. (2004) 'Use of Tween 40 and Tween 80 to deliver a mixture of phytochemicals to human colonic adenocarcinoma cell (CaCo-2) monolayers'. British Journal of Nutrition, 91 (5):757-764 [Details]
(2004)'Phytosterols: lack of cytotoxicity but interference with beta-carotene uptake in Caco-2 cells in culture'
Fahy, D. M. and O'Callaghan, Y. C. and O'Brien, N. M. (2004) 'Phytosterols: lack of cytotoxicity but interference with beta-carotene uptake in Caco-2 cells in culture'. Food Additives and Contaminants, 21 (1):42-51 [Details]
(2004)'Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut'
Maguire, LS,O'Sullivan, SM,Galvin, K,O'Connor, TP,O'Brien, NM; (2004) 'Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut'. International Journal of Food Sciences and Nutrition, 55 :171-178 [DOI] [Details]
(2004)'Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments'
Hartl MG, Coughlan BM, Sheehan D, Mothersill C, van Pelt FN, O'Reilly SJ, Heffron JJ, O'Halloran J, O'Brien NM; (2004) 'Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments'. Marine Environmental Research, 57 (4):295-310 [DOI] [Details]
(2004)'An assessment of the pollutant status of surficial sediment in Cork Harbour in the South East of Ireland with particular reference to polycyclic aromatic hydrocarbons'
Kilemade M, Hartl MG, Sheehan D, Mothersill C, van Pelt FN, O'Brien NM, O'Halloran J; (2004) 'An assessment of the pollutant status of surficial sediment in Cork Harbour in the South East of Ireland with particular reference to polycyclic aromatic hydrocarbons'. Marine Pollution Bulletinetin, 49 (11-12):1084-1096 [DOI] [Details]
(2004)'Generation of an oxidative stress precedes caspase activation during 7 beta-hydroxycholesterol-induced apoptosis in U937 cells'
Ryan, L,O'Callaghan, YC,O'Brien, NM; (2004) 'Generation of an oxidative stress precedes caspase activation during 7 beta-hydroxycholesterol-induced apoptosis in U937 cells'. Journal of Biochemical and Molecular Toxicology, 18 :50-59 [DOI] [Details]
(2003)'Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: Modulatory effects of alpha- and gamma-tocopherol'
O'Sullivan, A. J. and O'Callaghan, Y. C. and Woods, J. A. and O'Brien, N. M. (2003) 'Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: Modulatory effects of alpha- and gamma-tocopherol'. Journal of Applied Toxicology, 23 (3):191-197 [Details]
(2003)'Variability of heat shock proteins and glutathione S-transferase in gill and digestive gland of blue mussel, Mytilus edulis'
Lyons, C, Dowling, V, Tedengren, M., Gardestrom, J., Hartl, GJ, O’Brien, NM, Van Peltt, FNAM, O’Halloran, Sheehan, D; (2003) 'Variability of heat shock proteins and glutathione S-transferase in gill and digestive gland of blue mussel, Mytilus edulis'. Marine Environmental Research, 56 (*):585-597 [Details]
(2003)'Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7beta-hydroxycholesterol, in cultured mammalian cells'
Maguire L, Konoplyannikov M, Ford A, Maguire AR, O'Brien NM; (2003) 'Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7beta-hydroxycholesterol, in cultured mammalian cells'. Journal of Nutrition, 90 (4):767-775 [Details]
(2003)'Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7 beta-hydroxycholesterol, in cultured mammalian cells'
Maguire, L. and Konoplyannikov, M. and Ford, A. and Maguire, A. R. and O'Brien, N. M. (2003) 'Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7 beta-hydroxycholesterol, in cultured mammalian cells'. British Journal of Nutrition, 90 (4):767-775 [Details]
(2003)'The effect of dietary supplementation with the citrus limonoids, limonin and nomilin on xenobiotic-metabolizing enzymes in the liver and small intestine of the rat'
Kelly, C,Jewell, C,O'Brien, NM; (2003) 'The effect of dietary supplementation with the citrus limonoids, limonin and nomilin on xenobiotic-metabolizing enzymes in the liver and small intestine of the rat'. Nutrition Research, 23 :681-690 [DOI] [Details]
(2003)'Metabolism of quercetin-7-and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism'
O'Leary, KA,Day, AJ,Needs, PW,Mellon, FA,O'Brien, NM,Williamson, G; (2003) 'Metabolism of quercetin-7-and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism'. Biochemical Pharmacology, 65 :479-491 [DOI] [Details]
(2002)'Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture'
Lyons, N. M. and O'Brien, N. M. (2002) 'Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture'. Journal of Dermatological Science, 30 (1):73-84 [Details]
(2002)'Squalene but not n-3 fatty acids protect against hydrogen peroxide-induced sister chromatid exchanges in Chinese hamster V79 cells'
O'Sullivan, L,Woods, JA,O'Brien, NM; (2002) 'Squalene but not n-3 fatty acids protect against hydrogen peroxide-induced sister chromatid exchanges in Chinese hamster V79 cells'. Nutrition Research, 22 :847-857 [DOI] [Details]
(2002)'Detecting genotoxicity using the comet assay following chronic exposure of Manila clam, Tapes semideussatus to polluted estuarine sediments'
Coughlan, BM; Hartl, MGJ; O'Reilly, SJ; Sheehan, D; Mothersill, C; van Pelt, FNAM; O'Halloran, J; O'Brien, NM.; (2002) 'Detecting genotoxicity using the comet assay following chronic exposure of Manila clam, Tapes semideussatus to polluted estuarine sediments'. Marine Pollution Bulletinetin, 44 (*):38-44 [Details]
(2002)'Characteristics of 7 beta-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937, and a human hepatoma cell line, HepG2'
O'Callaghan, YC,Woods, JA,O'Brien, NM; (2002) 'Characteristics of 7 beta-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937, and a human hepatoma cell line, HepG2'. Toxicology In Vitro, 16 :245-251 [DOI] [Details]
(2002)'Genotoxicity of fecal water in a free-living Irish population'
Woods, JA,Dunne, C,Collins, JK,Shanahan, F,O'Brien, NM; (2002) 'Genotoxicity of fecal water in a free-living Irish population'. Nutrition and Cancer-An International Journal, 42 :62-69 [Details]
(2001)'alpha-Tocopherol, but not gamma-tocopherol inhibits 7 beta-hydroxycholesterol-induced apoptosis in human U937 cells'
Lyons, NM,Woods, JA,O'Brien, NM; (2001) 'alpha-Tocopherol, but not gamma-tocopherol inhibits 7 beta-hydroxycholesterol-induced apoptosis in human U937 cells'. Free Radical Research, 35 :329-339 [Details]
(2001)'Susceptibility of LDL to oxidative modification in healthy volunteers supplemented with low doses of n-3 polyunsaturated fatty acids'
Higgins, S. and Carroll, Y. L. and McCarthy, S. N. and Corridan, B. M. and Roche, H. M. and Wallace, J. M. W. and O'Brien, N. M. and Morrissey, P. A. (2001) 'Susceptibility of LDL to oxidative modification in healthy volunteers supplemented with low doses of n-3 polyunsaturated fatty acids'. British Journal of Nutrition, 85 (1):23-31 [Details]
(2001)'Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols'
O'Callaghan, Y. C. and Woods, J. A. and O'Brien, N. M. (2001) 'Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols'. Cell Biology and Toxicology, 17 (2):127-137 [Details]
(2001)'Limitations of the single-cell gel electrophoresis assay to monitor apoptosis in U937 and HepG2 cells exposed to 7 beta-hydroxycholesterol'
O'Callaghan, YC,Woods, JA,O'Brien, NM; (2001) 'Limitations of the single-cell gel electrophoresis assay to monitor apoptosis in U937 and HepG2 cells exposed to 7 beta-hydroxycholesterol'. Biochemical Pharmacology, 61 :1217-1226 [Details]
(2001)'Flavonoid glucuronides are substrates for human liver beta-glucuronidase'
O'Leary, K. A. and Day, A. J. and Needs, P. W. and Sly, W. S. and O'Brien, N. M. and Williamson, G. (2001) 'Flavonoid glucuronides are substrates for human liver beta-glucuronidase'. Febs Letters, 503 (1):103-106 [Details]
(2001)'gamma-tocopherol is less effective than alpha-tocopherol in preventing oxidant-induced sister chromatid exchanges in Chinese hamster V79 cells'
O'Leary, KA,Woods, JA,O'Brien, NM; (2001) 'gamma-tocopherol is less effective than alpha-tocopherol in preventing oxidant-induced sister chromatid exchanges in Chinese hamster V79 cells'. Free Radical Research, 35 :917-924 [Details]
(2001)'Sedanolide, a natural phthalide from celery seed oil: Effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines'
Woods, J. A. and Jewell, C. and O'Brien, N. M. (2001) 'Sedanolide, a natural phthalide from celery seed oil: Effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines'. In Vitro & Molecular Toxicology-a Journal of Basic and Applied Research, 14 (3):233-240 [Details]
(2000)'Lack of effect of the flavonoids, myricetin, quercetin, and rutin, on repair of H(2)O(2)-induced DNA single-strand breaks in Caco-2, Hep G2, and V79 cells'
Aherne, S. A. and O'Brien, N. M. (2000) 'Lack of effect of the flavonoids, myricetin, quercetin, and rutin, on repair of H(2)O(2)-induced DNA single-strand breaks in Caco-2, Hep G2, and V79 cells'. Nutrition and Cancer-an International Journal, 38 (1):106-115 [Details]
(2000)'Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals'
O'Brien, N. M. and Woods, J. A. and Aherne, S. A. and O'Callaghan, Y. C. (2000) 'Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals'. Biochemical Society Transactions, 28 :22-26 [Details]
(2000)'Mechanism of protection by the flavonoids, quercetin and rutin, against tert-butylhydroperoxide- and menadione induced DNA single strand breaks in Caco-2 cells'
Aherne, SA,O'Brien, NM; (2000) 'Mechanism of protection by the flavonoids, quercetin and rutin, against tert-butylhydroperoxide- and menadione induced DNA single strand breaks in Caco-2 cells'. Free Radical Biology and Medicine, 29 :507-514 [Details]
(2000)'Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated fatty acids'
Higgins, S. and McCarthy, S. N. and Corridan, B. M. and Roche, H. M. and Wallace, J. M. W. and O'Brien, N. M. and Morrissey, P. A. (2000) 'Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated fatty acids'. Nutrition Research, 20 (8):1091-1102 [Details]
(2000)'Biological effects of dietary cholesterol oxidation products'
O'Brien, N. M. and O'Callaghan, Y. C. and Lyons, N. M. and Woods, J. A. (2000) 'Biological effects of dietary cholesterol oxidation products'. Irish Journal of Agricultural and Food Research, 39 (2):265-273 [Details]
(1999)'Preservation of comet assay slides: comparison with fresh slides'
Woods, JA,O'Leary, KA,McCarthy, RP,O'Brien, NM; (1999) 'Preservation of comet assay slides: comparison with fresh slides'. Mutation Research, 429 :181-187 [Details]
(1999)'Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat'
Jewell, C,O'Brien, NM; (1999) 'Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat'. British Journal of Nutrition, 81 :235-242 [Details]
(1999)'Use of microencapsulated fish oil as a means of increasing n-3 polyunsaturated fatty acid intake'
Higgins, S. and Carroll, Y. L. and O'Brien, N. M. and Morrissey, P. A. (1999) 'Use of microencapsulated fish oil as a means of increasing n-3 polyunsaturated fatty acid intake'. Journal of Human Nutrition and Dietetics, 12 (4):265-271 [Details]
(1999)'Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells'
Aherne, S. A. and O'Brien, N. M. (1999) 'Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells'. Nutrition and Cancer-an International Journal, 34 (2):160-166 [Details]
(1999)'The flavonoids, myricetin, quercetin and rutin, protect against cholestan-3 beta, 5 alpha, 6 beta-triol - Induced toxicity in Chinese hamster ovary cells in vitro'
Aherne, S. A. and O'Brien, N. M. (1999) 'The flavonoids, myricetin, quercetin and rutin, protect against cholestan-3 beta, 5 alpha, 6 beta-triol - Induced toxicity in Chinese hamster ovary cells in vitro'. Nutrition Research, 19 (5):749-760 [Details]
(1999)'Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts'
Higgins, S,Vasconcelos, MH,O'Brien, NM; (1999) 'Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts'. Mutagenesis, 14 :335-338 [Details]
(1999)'Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations'
O'Callaghan, Y. C. and Woods, J. A. and O'Brien, N. M. (1999) 'Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations'. European Journal of Nutrition, 38 (6):255-262 [Details]
(1998)'Dietary antioxidants in health and disease'
Morrissey, P.A. and O'Brien, N.M.; (1998) 'Dietary antioxidants in health and disease'. International Dairy Journal, 8 (*):463-472 [Details]
(1998)'Investigation of the potential genotoxicity of cholesterol oxidation products in two mammalian fibroblast cell lines'
Woods, J. A. and O'Brien, N. M. (1998) 'Investigation of the potential genotoxicity of cholesterol oxidation products in two mammalian fibroblast cell lines'. Nutrition and Cancer-an International Journal, 31 (3):192-198 [Details]
(1995)'Modulation of oxidative stress by beta-carotene in chicken embryo fibroblasts'
Lawlor, SM, O'Brien, NM (1995) 'Modulation of oxidative stress by beta-carotene in chicken embryo fibroblasts'. British Journal of Nutrition, [Details]
(1993)'Natural toxicants in the food supply: In vitro investigation of the potential mechanism of action of the dietary flavonoid quercetin'
O'Brien, Nora M. and Cronin, Susan M. and Morrissey, Patrick A. (1993) 'Natural toxicants in the food supply: In vitro investigation of the potential mechanism of action of the dietary flavonoid quercetin'. International Journal of Food Sciences and Nutrition, 44 (2):85-90 Globe icon [Details]

Book Chapters

YearPublication
(2014)'Nutritional aspects of cheese'
O'Callaghan, YC, O'Connor, TP, O'Brien, NM (2014) 'Nutritional aspects of cheese' In: Fundamentals of Cheese Science. Maryland, USA: Aspen Publication. [Details]
(2013)'Cheese in the context of diet and nutrition'
McCarthy, A, O'Connor, TP, O'Brien, NM (2013) 'Cheese in the context of diet and nutrition' In: Handbook of cheese in health: Production, Nutrition and Medical Sciences. Wageningen: Wageningen Academic Publishers. [Details]
(2011)'Milk Lipids: Nutritional significance'
O'Brien, NM; O'Connor, TP; (2011) 'Milk Lipids: Nutritional significance' In: Encyclopaedia of Dairy Science, 2nd edition. London: Elsevier Publishers. [Details]
(2011)'Butter and other milk fat products: Fat Replacers'
O'Connor, TP; O'Brien, NM; (2011) 'Butter and other milk fat products: Fat Replacers' In: Encyclopaedia of Dairy Science, 2nd Edition. London: Elsevier Publishers. [Details]
(2010)'Milk Lipids: Oxidation'
O'Brien, NM; O'Connor, TP; (2010) 'Milk Lipids: Oxidation' In: Encyclopaedia of Dairy Science, 2nd Edition. London: Elsevier Publishers. [Details]
(2006)'Nutritional aspects of cheese'
O'Brien, N.M.; (2006) 'Nutritional aspects of cheese' In: Cheese Problems Solved. [Details]
(2004)'Toxins in Cheese-Biogenic Amines and Mycotoxins'
O'Brien, N.M., O'Connor, T.P., O'Callaghan, J. and Dobson, A.D.W.; (2004) 'Toxins in Cheese-Biogenic Amines and Mycotoxins' In: Cheese: Chemistry, Physics and Microbiology,3rd Edition: General Aspects - Volume 1. [Details]
(2004)'Nutritional aspects of cheese'
O'Brien, N.M. and O'Connor, T.P.; (2004) 'Nutritional aspects of cheese' In: Cheese, chemistry, physics and microbiology, third edition. [Details]
(2004)'Carotenoids effects on cellular processes: Induction of phase I and phase II enzymes'
O'Brien, N.M. and O'Connor, T.P.; (2004) 'Carotenoids effects on cellular processes: Induction of phase I and phase II enzymes' In: Carotenoids in health and disease. [Details]
(2003)'Toxicology of cheese'
Dobson, A., O'Connor, T.P. and O'Brien, N.M.; (2003) 'Toxicology of cheese' In: Cheese: Chemistry, Physics and Microbiology. [Details]
(2002)'Lipids: nutritional significance'
O'Brien, N.M. and O'Connor, T.P.; (2002) 'Lipids: nutritional significance' In: Encyclopedia of dairy sciences. [Details]
(2002)'Formation and content of cholesterol oxidation products in meat and meat products'
Kerry, J., Gilroy, D. and O'Brien, N.M.; (2002) 'Formation and content of cholesterol oxidation products in meat and meat products' In: Sterol oxidation products in foods and biological samples: analysis, content and biological effects. [Details]
(2002)'Lipids: Oxidation'
O'Brien, N.M. and O'Connor, T.P.; (2002) 'Lipids: Oxidation' In: Encyclopedia of Dairy Sciences. [Details]
(2002)'Lipid analysis in dairy products'
O'Connor, T.P. and O'Brien, N.M.; (2002) 'Lipid analysis in dairy products' In: Encyclopedia of Dairy Sciences. [Details]
(2002)'Fat replacers'
O'Connor, T.P. and O'Brien, N.M.; (2002) 'Fat replacers' In: Encyclopedia of Dairy Sciences. [Details]
(2002)'Nutritional significance of dairy products'
O'Brien, N.M. and O'Connor, T.P.; (2002) 'Nutritional significance of dairy products' In: Encyclopedia of Dairy Sciences. [Details]
(2000)'Nutritional Aspects of Cheese'
O'connor, T.P. and O'Brien, N.M.; (2000) 'Nutritional Aspects of Cheese' In: Fundamentals of Cheese Science. [Details]
(1995)'Lipid Oxidation'
O,Connor, T.P. and O'Brien, N.M.; (1995) 'Lipid Oxidation' In: Advanced dairy chemistry, volume 2. [Details]
(1992)'Nutrition and Health'
O'Brien, N.M.; (1992) 'Nutrition and Health' In: Town and Gown: UCC Public Lecture Series. [Details]
(1991)'Significance of lipoxygenase in fruits and vegetables'
O'Connor, TP, O'Brien, NM (1991) 'Significance of lipoxygenase in fruits and vegetables' In: Food enzymology. London: Elsevier Applied Science. [Details]

Reviews

YearPublication
(2015)Involvement of oxysterols in age related diseases and ageing processes.
Zarrouk, A, Vejux, A, Mackrill, J, O'Callaghan, YC, Hammami, M, O'Brien, NM, Lizard, G (2015) Involvement of oxysterols in age related diseases and ageing processes. Reviews [Details]
(2014)Recent advances in Phytosterol Oxidation Products.
O'Callaghan, Y,McCarthy, FO,O'Brien, NM (2014) Recent advances in Phytosterol Oxidation Products. Reviews [DOI] [Details]
(2014)Brewers' spent grain; bioactivity of phenolic component, its role in animal nutrition and potential for incorporation in functional foods: a review.
McCarthy, AL, O'Callaghan, YC, Piggott, CO, FitzGerald, RJ, O'Brien, NM (2014) Brewers' spent grain; bioactivity of phenolic component, its role in animal nutrition and potential for incorporation in functional foods: a review. Reviews [Details]
(2013)Protein hydrolysates from agricultural crops- bioactivity and potential for functional food development.
McCarthy, AL, O'Callaghan, YC, O'Brien, NM (2013) Protein hydrolysates from agricultural crops- bioactivity and potential for functional food development. Reviews [Details]
(2013)Bioaccessibility of functional ingredients.
McCarthy, AL, O'Brien, NM (2013) Bioaccessibility of functional ingredients. Reviews [Details]
(2012)UV-B induced secondary plant metabolites - potential benefits for plant and human health.
Schreiner, M, Mewis, I, Huyskens-Keil, S, Jansen, MAK, Zrenner, R, Winkler, JB, O'Brien, NM, Krumbein, A (2012) UV-B induced secondary plant metabolites - potential benefits for plant and human health. Reviews [Details]
(2011)Bioactivities of glycolkaloids and their aglycones from solanum species.
Milner, SE, Brunton, NP, Jones, PW, O'Brien, NM, Collins, SG, Maguire, AR (2011) Bioactivities of glycolkaloids and their aglycones from solanum species. Reviews [Details]
(2009)Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects.
Ryan, E,McCarthy, FO,Maguire, AR,O'Brien, NM (2009) Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects. Reviews [DOI] [Details]
(2009)Casein-derived bioactive peptides: Absorption, metabolism, and biological effects.
Phelan, M, Aherne, SA, FitzGerald, R, O'Brien, NM (2009) Casein-derived bioactive peptides: Absorption, metabolism, and biological effects. Reviews [Details]
(2009)Oxysterols and mechanisms of apoptotic signalling: implications in the pathology of degenerative diseases.
Lordan, S, Mackrill, JJ, O'Brien, NM (2009) Oxysterols and mechanisms of apoptotic signalling: implications in the pathology of degenerative diseases. Reviews [Details]
(2005)Oxidised products of cholesterol: Their role in apoptosis.
Ryan, L, O'Callaghan, YC, O'Brien, NM (2005) Oxidised products of cholesterol: Their role in apoptosis. Reviews [Details]
(2004)The importance of nutrition and diet in cancer prevention.
O'Brien, NM, O'Connor, TP (2004) The importance of nutrition and diet in cancer prevention. Reviews [Details]
(2004)Potential uses and benefits of plant sterols (phytosterols and phytostanols): future directions.
O'Brien, NM (2004) Potential uses and benefits of plant sterols (phytosterols and phytostanols): future directions. Reviews [Details]
(2003)Diet, nutrition and cancer prevention.
O'Brien, NM, O'Connor, TP (2003) Diet, nutrition and cancer prevention. Reviews [Details]
(2002)Nutrition and cancer.
O'Brien, NM, O'Connor, TP (2002) Nutrition and cancer. Reviews [Details]
(2001)Dietary flavonols: chemistry, food content and metabolism.
Aherne, SA, O'Brien, NM (2001) Dietary flavonols: chemistry, food content and metabolism. Reviews [Details]
(2001)A critical evaluation of the application of biomarkers in epidemiological studies on diet and health.
Wild, CP,Andersson, C,O'Brien, NM,Wilson, L,Woods, JA (2001) A critical evaluation of the application of biomarkers in epidemiological studies on diet and health. Reviews [Details]
(2001)Nutrition and health.
O'Brien, NM (2001) Nutrition and health. Reviews [Details]
(1998)Dietary antioxidants in health and disease.
Morrissey, PA, O'Brien, NM (1998) Dietary antioxidants in health and disease. Reviews [Details]
(1996)Cheese: physical, chemical and nutritional aspects.
Fox, PF, O'Connor, TP, Guinee, T, McSweeney, P, O'Brien, NM (1996) Cheese: physical, chemical and nutritional aspects. Reviews [Details]
(1994)Education for a lifetime of learning.
O'Connor, TP, O'Brien, NM (1994) Education for a lifetime of learning. Reviews [Details]
(1993)Milk, cheese and dental caries.
O'Brien, N.M. and O'Connot T.P.; (1993) Milk, cheese and dental caries. Reviews [Details]
(1993)Natural toxicants in the food supply: in vitro investigation of the potential mechanism of action of the dietary flavonoid quercetin.
O'Brien N.M. Cronin S.M. and Morrissey P.A.; (1993) Natural toxicants in the food supply: in vitro investigation of the potential mechanism of action of the dietary flavonoid quercetin. Reviews [Details]

Education

 YearInstitutionQualificationSubject
1981University College Cork BScDairy Science
1983University of Minnesota, USA MSHuman Nutrition
1987Cornell University, USA PhDNutritional Biochemistry

Employment

 EmployerPositionFrom / To
University College Cork Professor Scale 201-JAN-05 /
University College Cork Senior Lecturer01-JAN-99 / 01-JAN-05
University College Cork Lecturer01-DEC-89 / 01-JAN-99
University of Louvain, Belgium Postdoctoral Research Fellow01-JAN-88 / 01-JAN-89

Honours and Awards

 YearTitleAwarding Body
1980Undergraduate Scholarship
1981Undergraduate Scholarship
1978College Scholar, University College Cork
2000Royal Irish Academy Award in Nutritional Sciences
1988International Institute of Cellular and Molecular Pathology
1987Graduate Student Travel Award
1983Finalist-American Institute of Nutrition
1982Dairy Science Bursary
1979Undergraduate Scholarship

Professional Associations

 AssociationFunctionFrom / To
The Nutrition Society *01-JAN-97 / 31-DEC-14
The Irish Society of Toxicology *30-DEC-99 / 31-DEC-11
The International Carotenoid Society *30-DEC-99 / 31-DEC-14
American Oil Chemists Society (AOCS) member01-NOV-14 / 31-DEC-15

Committees

 CommitteeFunctionFrom / To
Irish Council for Bioethics Member2002 / 2005
Food Safety Promotion Board: Scientific Advisory Committee (North-South Committee) Member2001 / 2005
Royal Irish Academy: National Committee for Nutritional Sciences Member1998 / 2003
Food Safety Authority of Ireland- Committee on Food Additives, Contaminants and Irradiated Foods Memeber1999 / 2001
Management Committee of an EU Concerted Action Project entitled: Biomarkers of Exposure and Effect in Relation to Quality of Life and Human Risk Assessment Member1996 / 1998
External Assessor on Promotion Board - Lecturer to Senior Lecturer grade. External Assessor2008 / 2008

Journal Activities

 JournalRoleTo / From
Nutrition Research Member of Editorial Board01-JAN-08 -
British Journal Of Nutrition Referee01-JAN-03 - 01-JAN-08
Journal Of Nutrition Referee01-JAN-03 - 01-JAN-05
Journal Of Agricultural And Food Chemistry Referee01-JAN-03 - 01-JAN-08
European Journal Of Nutrition Referee01-JAN-03 - 01-JAN-08
Biochimica Et Biophysica Acta Referee01-JAN-03 - 01-JAN-08
Cell Biology And Toxicology Referee01-JAN-03 - 01-JAN-08
International Journal Of Vitamin And Nutrition Research Referee01-JAN-03 - 01-JAN-08
Toxicology In Vitro Referee01-JAN-03 -
Cancer Letters Referee01-JAN-03 - 01-JAN-08
Nutrition And Cancer Referee01-JAN-03 - 01-JAN-08
International Journal Of Food Science And Nutrition Referee01-JAN-03 - 01-JAN-08
Cell Biology And Toxicology Referee01-JAN-03 - 01-JAN-05
Cell Death And Differentiation Referee01-JAN-03 - 01-JAN-05
Plant Food Hum Nutr Member of Editorial Board01-JAN-10 -

Teaching Interests

Current Postgraduate Students

 StudentDegree TypePrimary
Holland Margaret Veronica Masters Degree by ResearchYes
Roba Kedir Teji Doctoral DegreeYes

Modules Taught

 Term (ID))TitleLinkSubject
2015Integration and Regulation of Nutrient Metabolism NT6107Integration and Regulation of Nutrient Metabolism
2015Food Security and Implications for Human Nutrition NT6110Food Security and Implications for Human Nutrition
2015Human Nutrition in the Developing World NT4008Human Nutrition in the Developing World
2015Topics in Nutrition and Food Toxicology NT4010Topics in Nutrition and Food Toxicology
2015Advanced Nutrient Metabolism NT4002Advanced Nutrient Metabolism
2015Food Toxicology NT3002Food Toxicology